The pims and outs of survival signaling: Role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

Genes and Development

Volumn 17, Issue 15, 2003, Pages 1813-1816

  White, Eileen ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 3; PIM 2 PROTEIN KINASE; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BID; PROTEIN KINASE; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; CARCINOGENESIS; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINE RELEASE; DEREGULATION; DNA MICROARRAY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENOMICS; HEMATOPOIETIC CELL; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CYTOKINES; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; MODELS, BIOLOGICAL; NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION;

EID: 0043127142     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1123103     Document Type: Review

References (26)

1. Adams, J.M., Harris, A.W., Pinkert, C.A., Corcoran, L.M., Alexander, W.S., Cory, S., Palmiter, R.D., and Brinster, R.L. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318: 533-538.
2. Allen, J.D. and Berns, A. 1996. Complementation tagging of cooperating oncogenes in knockout mice. Semin. Cancer Biol. 7: 299-306.
3. Allen, J., Verhoeven, E., Domen, J., van der Valk, M., and Berns, A. 1997. Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene 15: 1133-1141.
4. Askew, D.S., Ashmun, R.A., Simmons, B.C., and Cleveland, J.L. 1991. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6: 1915-1922.
5. Bouillet, P., Metcalf, D., Huang, D.C.S., Tarlinton, D.M., Kay, T.W.H., Köntgen, F., Adams, J.M., and Strasser, A. 1999. Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738.
6. Bouillet, P., Cory, S., Zhang, L.-C., Strasser, A., and Adams, J.M. 2001. Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev. Cell 1: 645-653.
7. Breuer, M.L., Cuypers, H.T., and Berns, A. 1989. Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J. 8: 743-748.
8. Cory, S. and Adams, J.M. 2002. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2: 647-656.
9. Datta, S.R., Ranger, A.M., Lin, M.Z., Sturgill, J.F., Ma, Y.C., Cowan, C.W., Dikkes, P., Korsmeyer, S.J., and Greenberg, M.E. 2002. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3: 631-643.
10. Dijkeers, P.F., Birkenkamp, K.U., Lam, E.W.F., Thomas, S.B., Lammers, J.W., Koenderman, L., and Coffer, P.J. 2002. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156: 531-542.
11. Eischen, C.M., Weber, J.D., Roussel, M.F., Sherr, C.J., and Cleveland, J.L. 1999. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes & Dev. 13: 2658-2669.
12. Evan, G.I., Whyllie, A.H., Gilbert, C.S., Littlewood, T.D., Land, H., Brooks, M., Waters, C.M., Penn, L.Z., and Hancock, D.C. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128.
13. Fanidi, A., Harrington, E.A., and Evan, G.I. 1992. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature 359: 554-556.
14. Fox, C.J., Hammerman, P.S., Cinalli, R.M., Master, S.R., Chodosh, L.A., and Thompson, C.B. 2003. The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes & Dev. (this issue).
15. Lei, K. and Davis, R.J. 2003. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc. Natl. Acad. Sci. 100: 2432-2437.
16. Mikkers, H., Allen, J., Knipscheer, P., Romeyn, L., Hart, A., Vink, E., and Berns, A. 2002. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat. Genet. 32: 153-159.
17. Plas, D.R. and Thompson, C.B. 2002. Cell metabolism in the regulation of programmed cell death. Trends Endo. & Met. 13: 74-78.
18. Schmitt, C.A., McCurrach, M.E., de Stanchina, E., Wallace-Brodeur, R.R., and Lowe, S.W. 1999. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes & Dev. 13: 2670-2677.
19. Schmitt, C.A., Fridman, J.S., Yang, M., Baranov, E., Hoffman, R.M., and Lowe, S.W. 2002. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1: 289-298.
20. Shinjo, T., Kuribara, R., Inukai, T., Hosoi, H., Kinoshita, T., Miyajima, A., Houghton, P.J., Look, A.T., Ozawa, K., and Inaba., T. 2001. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol. Cell. Biol. 21: 854-864.
21. Strasser, A., Harris, A.W., Bath, M.L., and Cory, S. 1990. Novel primitive lymphoid turnouts induced in transgenic mice by cooperation between myc and bcl-2. Nature 348: 331-333.
22. van der Lugt, N.M., Domen, J., Verhoeven, E., Linders, K., van der Gulden, H., and Berns, A. 1995. Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2. EMBO J. 14: 2536-2544.
23. Vaux, D.L., Cory, S., and Adams, J.M. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442.
24. Verbeek, S., van Lohuizen, M., van der Valk, M., Domen, J., Kraal, G., and Berns, A. 1991. Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol. Cell Biol. 11: 1176-1179.
25. Weston, C.R., Balmanno, K., Chalmers, C., Hadfield, K., Molton, S.A., Ley, R., Wagner, E.F., and Cook, S.J. 2002. Activation of ERK1/2 by ARaf-1: ER represses Bim expression independently of the JNK or P13K pathways. Oncogene 22: 1281-1293.
26. Yu, J., Wang, Z., Kinzler, K.W., Vogelstein, B., and Zhang, L. 2003. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc. Natl. Acad. Sci. 100: 1931-1936.