Effects of chronic Akt activation on glucose uptake in the heart

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 5, 2006, Pages

  Matsui, Takashi ^a   Nagoshi, Tomohisa ^a   Hong, Eun Gyoung ^b   Luptak, Ivan ^c   Hartil, Kirsten ^d   Li, Ling ^a   Gorovits, Naira ^d   Charron, Maureen J ^d   Kim, Jason K ^b   Tian, Rong ^c   Rosenzweig, Anthony ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Glucose transporters; Heart; Transgenic mice

Indexed keywords

GLUCOSE TRANSPORTER 4; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HEART CONTRACTION; HEART FAILURE; HISTOCHEMISTRY; INSULIN RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOLEMMA; TRANSGENE;

ANIMALS; CELL MEMBRANE; DEOXYGLUCOSE; FEMALE; GENE EXPRESSION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; HEART; HEXOKINASE; INSULIN; INTRACELLULAR MEMBRANES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; PERFUSION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 33646397009     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00564.2004     Document Type: Article

References (43)

1. Arad M, Maron BJ, Gorham JM, Johnson WH Jr, Saul JP, Perez-Atayde AR, Spirito P, Wright GB, Kanter RJ, Seidman CE, and Seidman JG. Glycogen storage diseases presenting as hypertrophic cardiomyopathy. N Engl J Med 352: 362-372, 2005.
2. Becker C, Sevilla L, Tomas E, Palacin M, Zorzano A, and Fischer Y. The endosomal compartment is an insulin-sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes. Endocrinology 142: 5267-5276, 2001.
3. Chang PY, Jensen J, Printz RL, Granner DK, Ivy JL, and Moller DE. Overexpression of hexokinase II in transgenic mice. Evidence that increased phosphorylation augments muscle glucose uptake. J Biol Chem 271: 14834-14839, 1996.
4. Coffer PJ, Jin J, and Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 335: 1-13, 1998.
5. Cong LN, Chen H, Li Y, Zhou L, McGibbon MA, Taylor SI, and Quon MJ. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 11: 1881-1890, 1997.
6. Cook SA, Matsui T, Li L, and Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J Biol Chem 277: 22528-22533, 2002.
7. Cross DA, Alessi DR, Cohen P, Andjelkovich M, and Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995.
8. Cross DA, Watt PW, Shaw M, van der Kaay J, Downes CP, Holder JC, and Cohen P. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett 406: 211-215, 1997.
9. Depre C, Vanoverschelde JL, and Taegtmeyer H. Glucose for the heart. Circulation 99: 578-588, 1999.
10. Doege H, Schurmann A, Bahrenberg G, Brauers A, and Joost HG. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J Biol Chem 275: 16275-16280, 2000.
11. Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, and Rockman HA. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105: 85-92, 2002.
12. Fischer Y, Thomas J, Sevilla L, Munoz P, Becker C, Holman G, Kozka IJ, Palacin M, Testar X, Kammermeier H, and Zorzano A. Insulin-induced recruitment of glucose transporter 4 (GLUT4) and GLUT1 in isolated rat cardiac myocytes. Evidence of the existence of different intracellular GLUT4 vesicle populations. J Biol Chem 272: 7085-7092, 1997.
13. Flores-Riveros JR, McLenithan JC, Ezaki O, and Lane MD. Insulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: effects on transcription and mRNA turnover. Proc Natl Acad Sci USA 90: 512-516, 1993.
14. Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, Laakso M, and Wasserman DH. Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice. Am J Physiol Endocrinol Metab 285: E958-E963, 2003.
15. Hajduch E, Alessi DR, Hemmings BA, and Hundal HS. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47: 1006-1013, 1998.
16. Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, and Molkentin JD. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation 103: 670-677, 2001.
17. Hill MM, Clark SF, Tucker DF, Birnbaum MJ, James DE, and Macaulay SL. A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol 19: 7771-7781, 1999.
18. Huang C, Somwar R, Patel N, Niu W, Torok D, and Klip A. Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes 51: 2090-2098, 2002.
19. Isgaard J, Wahlander H, Adams MA, and Friberg P. Increased expression of growth hormone receptor mRNA and insulin-like growth factor-I mRNA in volume-overloaded hearts. Hypertension 23: 884-888, 1994.
20. Kim HJ, Higashimori T, Park SY, Choi H, Dong J, Kim YJ, Noh HL, Cho YR, Cline G, Kim YB, and Kim JK. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53: 1060-1067, 2004.
21. Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, and Kahn BB. Muscle-specific deletion of the glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol 25: 9713-9723, 2005.
22. Kohn AD, Summers SA, Birnbaum MJ, and Roth RA. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31372-31378, 1996.
23. Kupriyanova TA and Kandror KV. Cellugyrin is a marker for a distinct population of intracellular Glut4-containing vesicles. J Biol Chem 275: 36263-36268, 2000.
24. Laybutt DR, Thompson AL, Cooney GJ, and Kraegen EW. Selective chronic regulation of GLUT1 and GLUT4 content by insulin, glucose, and lipid in rat cardiac muscle in vivo. Am J Physiol Heart Circ Physiol 273: H1309-H1316, 1997.
25. Liang Q, Donthi RV, Kralik PM, and Epstein PN. Elevated hexokinase increases cardiac glycolysis in transgenic mice. Cardiovasc Res 53: 423-430, 2002.
26. Manchester J, Kong X, Nerbonne J, Lowry OH, and Lawrence JC Jr. Glucose transport and phosphorylation in single cardiac myocytes: rate-limiting steps in glucose metabolism. Am J Physiol Endocrinol Metab 266: E326-E333, 1994.
27. Marette A, Richardson JM, Ramlal T, Balon TW, Vranic M, Pessin JE, and Klip A. Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am J Physiol Cell Physiol 263: C443-C452, 1992.
28. Matsui T, Li L, del Monte F, Fukui Y, Franke TF, Hajjar RJ, and Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100: 2373-2379, 1999.
29. Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, and Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 277: 22896-22901, 2002.
30. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, and Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104: 330-335, 2001.
31. McFalls EO, Murad B, Liow JS, Gannon MC, Haspel HC, Lange A, Marx D, Sikora J, and Ward HB. Glucose uptake and glycogen levels are increased in pig heart after repetitive ischemia. Am J Physiol Heart Circ Physiol 282: H205-H211, 2002.
32. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, Del Monte F, Gwathmey JK, Grazette L, Hemmings B, Kass DA, Champion HC, and Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest 115: 2128-2138, 2005.
33. Owen P, Dennis S, and Opie LH. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Circ Res 66: 344-354, 1990.
34. Reiss K, Kajstura J, Zhang X, Li P, Szoke E, Olivetti G, and Anversa P. Acute myocardial infarction leads to upregulation of the IGF-1 autocrine system, DNA replication, and nuclear mitotic division in the remaining viable cardiac myocytes. Exp Cell Res 213: 463-472, 1994.
35. Russell RR, 3rd Yin R, Caplan MJ, Hu X, Ren J, Shulman GI, Sinusas AJ, and Young LH. Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation 98: 2180-2186, 1998.
36. Sargeant RJ and Paquet MR. Effect of insulin on the rates of synthesis and degradation of GLUT1 and GLUT4 glucose transporters in 3T3-L1 adipocytes. Biochem J 290: 913-919, 1993.
37. Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, and Izumo S. Akt/Protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 22: 2799-2809, 2002.
38. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 106: 171-176, 2000.
39. Taha C, Liu Z, Jin J, Al-Hasani H, Sonenberg N, and Klip A. Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation. J Biol Chem 274: 33085-33091, 1999.
40. Tian R and Abel ED. Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis. Circulation 103: 2961-2966, 2001.
41. Tian R, Musi N, D'Agostino J, Hirshman MF, and Goodyear LJ. Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 104: 1664-1669, 2001.
42. Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, and Klip A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19: 4008-4018, 1999.
43. Zhou M, Sevilla L, Vallega G, Chen P, Palacin M, Zorzano A, Pilch PF, and Kandror KV. Insulin-dependent protein trafficking in skeletal muscle cells. Am J Physiol Endocrinol Metab 275: E187-E196, 1998.