Mapping preconditioning's signaling pathways: An engineering approach

Annals of the New York Academy of Sciences

Volumn 1123, Issue , 2008, Pages 187-196

  Downey, James M ^a   Krieg, Thomas ^b   Cohen, Michael V ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Adenosine receptor; ATP sensitive potassium channels; EGF receptor; Free radicals; Ischemia; Mitochondria; Nitric oxide; Permeability transition pores; Protein kinase C and G; Redox signaling

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; BRADYKININ; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FREE RADICAL; GUANYLATE CYCLASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; OPIATE; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE;

BIOCHEMISTRY; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME RELEASE; GENE MAPPING; GENETIC ENGINEERING; HEART MUSCLE CELL; ISCHEMIA; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 41149084540     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1420.022     Document Type: Conference Paper

References (54)

1. 1 adenosine receptors in rabbit heart. Circulation 84: 350-356.
2. YTREHUS, K., Y. LIU & J. M. DOWNEY. 1994. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am. J. Physiol. 266: H1145-H1152.
3. GROSS, G.J. & J.A. AUCHAMPACH. 1992. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ. Res. 70: 223-233.
4. 2b-dependent signaling during early reperfusion. J. Mol. Cell Cardiol. 43: 262-271.
5. YANG, X.-M. et al. 2004. NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J. Mol. Cell. Cardiol. 36: 411-421.
6. LI, G.C. et al. 1990. Myocardial protection with preconditioning. Circulation 82: 609-619.
7. VAN WINKLE, D.M. et al. 1991. The natural history of preconditioning: cardioprotection depends on duration of transient ischemia and time to subsequent ischemia. Coron. Artery Dis. 2: 613-619.
8. WALL, T.M., R. SHEEHY & J.C. HARTMAN. 1994. Role of bradykinin in myocardial preconditioning. J. Pharmacol. Exp. Ther. 270: 681-689.
9. SCHULTZ, J.E.J., A.K. HSU & G.J. GROSS. 1996. Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circ. Res. 78: 1100-1104.
10. GOTO, M. et al. 1995. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ. Res. 77: 611-621.
11. ATP channels. Circ. Res. 89: 273-278.
12. HAUSENLOY, D.J. et al. 2004. Preconditioning protects by inhibiting the mitochondrial permeability transition. Am. J. Physiol. 287: H841-H849.
13. BERNARDI, P. et al. 2006. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 273: 2077-2099.
14. YTREHUS, K. et al. 1994. Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing. Am. J. Physiol. 267: H2383-H2390.
15. ARMSTRONG, S., J.M. DOWNEY & C.E. GANOTE. 1994. Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc. Res. 28: 72-77.
16. AKAO, M. et al. 2003. Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes. Circ. Res. 92: 186-194.
17. XU, Z. et al. 2005. Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovasc. Res. 65: 803-812.
18. FÖRSTER, K. et al. 2006. NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Basic Res. Cardiol. 101: 319-326.
19. + channels: possible mechanism of cardioprotection. Circ. Res. 81: 1072-1082.
20. ATP channels triggers the preconditioned state by generating free radicals. Circ. Res. 87: 460-466.
21. KRENZ, M. et al. 2002. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res. Cardiol. 97: 365-373.
22. ATP channel opening. J. Mol. Cell. Cardiol. 35: 653-660.
23. MOCHLY-ROSEN, D., A.I. BASBAUM & D.E. KOSHLAND, JR. 1987. Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain. Proc. Natl. Acad. Sci. 84: 4660-4664.
24. PING, P. et al. 1997. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ. Res. 81: 404-414.
25. ATP channels, and ERK. Am. J. Physiol. 286: H1433-H1440.
26. YANG, X.-M. et al. 1997. Protection of ischemic preconditioning is dependent upon a critical timing sequence of protein kinase C activation. J. Mol. Cell. Cardiol. 29: 991-999.
27. TONG, H. et al. 2000. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ. Res. 87: 309-315.
28. QIN, Q., J.M. DOWNEY & M.V. COHEN. 2003. Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase. Am. J. Physiol. 284: H727-H734.
29. KRIEG, T. et al. 2002. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am. J. Physiol. 283: H2322-H2330.
30. KRIEG, T. et al. 2004. Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF. J. Mol. Cell. Cardiol. 36: 435-443.
31. COHEN, M.V. et al. 2007. Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways. J. Mol. Cell. Cardiol. 42: 842-851.
32. ATP channels in preconditioning. J. Mol. Cell. Cardiol. 35: 569-575.
33. BOLLI, R. et al. 1989. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion: evidence thatmyocardial "stunning" is a manifestation of reperfusion injury. Circ. Res. 65: 607-622.
34. ALTUǦ, S. et al. 2000. Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts. Br. J. Pharmacol. 130: 125-131.
35. GOPALAKRISHNA, R. & S. JAKEN. 2000. Protein kinase C signaling and oxidative stress. Free Radic. Biol. Med. 28: 1349-1361.
36. KORICHNEVA, I. et al. 2002. Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen. J. Biol. Chem. 277: 44327-44331.
37. NATARAJAN, V. et al. 1993. Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide. J. Biol. Chem. 268: 930-937.
38. BAINES, C.P., M. GOTO & J.M. DOWNEY. 1997. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. J. Mol. Cell Cardiol. 29: 207-216.
39. TRITTO, I. et al. 1997. Oxygen radicals can induce preconditioning in rabbit hearts. Circ. Res. 80: 743-748.
40. ATP channel opening and leads to cardioprotection. Am. J. Physiol. 286: H468-H476.
41. FULTON, D. et al. 1999. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601.
42. ATP-dependent mechanism. Am. J. Physiol. 287: H712-H718.
43. KRIEG, T. et al. 2004. Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am. J. Physiol. 287: H2606-H2611.
44. KRIEG, T. et al. 2005. Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart. Am. J. Physiol. 288: H1976-H1981.
45. COHEN, M.V., X.-M. YANG & J.M. DOWNEY. 2006. Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies. Cardiovasc. Res. 70: 231-239.
46. COSTA, A.D.T. et al. 2005. Protein kinase G transmits the cardioprotective signal from cytosol tomitochondria. Circ. Res. 97: 329-336.
47. HAUSENLOY, D.J. et al. 2005. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am. J. Physiol. 288: H971-H976.
48. JUHASZOVA, M. et al. 2004. Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J. Clin. Invest. 113: 1535-1549.
49. SOLENKOVA, N.V. et al. 2006. Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. Am. J. Physiol. 290: H441-H449.
50. 2b receptor cascade. Cardiovasc. Res. 70: 308-314.
51. 2B adenosine receptors. Circulation 115: 1581-1590.
52. ZHAO, Z.-Q. et al. 2003. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am. J. Physiol. 285: H579-H588.
53. COHEN, M.V., X.-M. YANG & J. M. DOWNEY. 2007. The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis. Circulation 115: 1895-1903.
54. TISSIER, R., M.V. COHEN & J.M. DOWNEY. 2007. Protecting the acutely ischemic myocardium beyond reperfusion therapies: are we any closer to realizing the dream of infarct size elimination? Arch. Mal. Coeur. Vaiss. 100: 794-802.