메뉴 건너뛰기




Volumn 122, Issue 18, 2009, Pages 3272-3281

Loss of anchorage in checkpoint-deficient cells increases genomic instability and promotes oncogenic transformation

Author keywords

Anchorage; Genomic stability; LT; P27

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 70350365289     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.047126     Document Type: Article
Times cited : (9)

References (43)
  • 1
    • 0035253672 scopus 로고    scopus 로고
    • Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression
    • Assoian, R. K. and Schwartz, M. A. (2001). Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 11, 48-53.
    • (2001) Curr. Opin. Genet. Dev , vol.11 , pp. 48-53
    • Assoian, R.K.1    Schwartz, M.A.2
  • 2
    • 46049115251 scopus 로고    scopus 로고
    • Growth control by intracellular tension and extracellular stiffness
    • Assoian, R. K. and Klein, E. A. (2008). Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol. 18, 347-352.
    • (2008) Trends Cell Biol , vol.18 , pp. 347-352
    • Assoian, R.K.1    Klein, E.A.2
  • 5
    • 52549115459 scopus 로고    scopus 로고
    • Replication licensing and cancer, a fatal entanglement?
    • Blow, J. and Gillespie, P. (2008). Replication licensing and cancer, a fatal entanglement? Nat. Rev. Cancer 8, 799-806.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 799-806
    • Blow, J.1    Gillespie, P.2
  • 6
    • 33646896769 scopus 로고    scopus 로고
    • Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms
    • Bryant, P., Zheng, Q. and Pumiglia, K. (2006). Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms. Mol. Cell. Biol. 26, 4201-4213.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 4201-4213
    • Bryant, P.1    Zheng, Q.2    Pumiglia, K.3
  • 7
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • Chu, I., Hengst, L. and Slingerland, J. (2008). The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat. Rev. Cancer 8, 253-267.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 253-267
    • Chu, I.1    Hengst, L.2    Slingerland, J.3
  • 8
    • 0036884829 scopus 로고    scopus 로고
    • The retinoblastoma tumour suppressor in development and cancer
    • Classon, M. and Harlow, E. (2002). The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer 2, 910-917.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 910-917
    • Classon, M.1    Harlow, E.2
  • 10
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • Elenbaas, B. and Weinberg, R. A. (2001). Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp. Cell Res. 264, 169-184.
    • (2001) Exp. Cell Res , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 11
    • 0030027049 scopus 로고    scopus 로고
    • Dependence of cyclin E-CDK2 kinase activity on cell anchorage
    • Fang, F., Orend, G., Watanabe, N., Hunter, T. and Ruoslahti, E. (1996). Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science 271, 499-502.
    • (1996) Science , vol.271 , pp. 499-502
    • Fang, F.1    Orend, G.2    Watanabe, N.3    Hunter, T.4    Ruoslahti, E.5
  • 12
    • 0016318441 scopus 로고
    • Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium
    • Freedman, V. H. and Shin, S. I. (1974). Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3, 355-359.
    • (1974) Cell , vol.3 , pp. 355-359
    • Freedman, V.H.1    Shin, S.I.2
  • 13
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S. and Francis, H. (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
    • (1994) J. Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.1    Francis, H.2
  • 17
    • 0027752979 scopus 로고
    • A link between cyclin A expression and adhesion-dependent cell cycle progression
    • Guadagno, T. M., Ohtsubo, M., Roberts, J. M. and Assoian, R. K. (1993). A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262, 1572-1575.
    • (1993) Science , vol.262 , pp. 1572-1575
    • Guadagno, T.M.1    Ohtsubo, M.2    Roberts, J.M.3    Assoian, R.K.4
  • 18
    • 0037079003 scopus 로고    scopus 로고
    • Rules for making human tumor cells
    • Hahn, W. C. and Weinberg, R. A. (2002). Rules for making human tumor cells. N. Engl. J. Med. 347, 1593-1603.
    • (2002) N. Engl. J. Med , vol.347 , pp. 1593-1603
    • Hahn, W.C.1    Weinberg, R.A.2
  • 20
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis, T., Gorgoulis, V. and Bartek, J. (2008). An oncogene-induced DNA damage model for cancer development. Science 319, 1352-1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.1    Gorgoulis, V.2    Bartek, J.3
  • 21
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. and Weinberg, R. (2000). The hallmarks of cancer. Cell 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.2
  • 22
    • 1342301636 scopus 로고    scopus 로고
    • Efficient down-regulation of cyclin A-associated activity and expression in suspended primary keratinocytes requires p21(Cip1)
    • Hauser, P., Ma, L., Agrawal, D., Haura, E., Cress, W. D. and Pledger, W. J. (2004). Efficient down-regulation of cyclin A-associated activity and expression in suspended primary keratinocytes requires p21(Cip1). Mol. Cancer Res. 2, 96-104.
    • (2004) Mol. Cancer Res , vol.2 , pp. 96-104
    • Hauser, P.1    Ma, L.2    Agrawal, D.3    Haura, E.4    Cress, W.D.5    Pledger, W.J.6
  • 24
    • 30344463835 scopus 로고    scopus 로고
    • ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G., Lukas, J. and Jackson, S. (2005). ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45.
    • (2005) Nat. Cell Biol , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.5    Lukas, J.6    Jackson, S.7
  • 25
    • 0030863161 scopus 로고    scopus 로고
    • Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway
    • Kawada, M., Yamagoe, S., Murakami, Y., Suzuki, K., Mizuno, S. and Uehara, Y. (1997). Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway. Oncogene 15, 629-637.
    • (1997) Oncogene , vol.15 , pp. 629-637
    • Kawada, M.1    Yamagoe, S.2    Murakami, Y.3    Suzuki, K.4    Mizuno, S.5    Uehara, Y.6
  • 26
    • 0031594320 scopus 로고    scopus 로고
    • Up-regulation of p27Kip1 correlates inversely with anchorage-independent growth of human cancer cell lines
    • Kawada, M., Uehara, Y., Mizuno, S., Yamori, T. and Tsuruo, T. (1998). Up-regulation of p27Kip1 correlates inversely with anchorage-independent growth of human cancer cell lines. Jpn. J. Cancer Res. 89, 110-115.
    • (1998) Jpn. J. Cancer Res , vol.89 , pp. 110-115
    • Kawada, M.1    Uehara, Y.2    Mizuno, S.3    Yamori, T.4    Tsuruo, T.5
  • 29
    • 0030113694 scopus 로고    scopus 로고
    • E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest
    • Mann, D. J. and Jones, N. C. (1996). E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest. Curr. Biol. 6, 474-483.
    • (1996) Curr. Biol , vol.6 , pp. 474-483
    • Mann, D.J.1    Jones, N.C.2
  • 30
    • 34648840189 scopus 로고    scopus 로고
    • Loss of the retinoblastoma tumor suppressor: Differential action on transcriptional programs related to cell cycle control and immune function
    • Markey, M. P., Bergseid, J., Bosco, E. E., Stengel, K., Xu, H., Mayhew, C. N., Schwemberger, S. J., Braden, W. A., Jiang, Y., Babcock, G. F. et al. (2007). Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function. Oncogene 26, 6307-6318.
    • (2007) Oncogene , vol.26 , pp. 6307-6318
    • Markey, M.P.1    Bergseid, J.2    Bosco, E.E.3    Stengel, K.4    Xu, H.5    Mayhew, C.N.6    Schwemberger, S.J.7    Braden, W.A.8    Jiang, Y.9    Babcock, G.F.10
  • 32
    • 0037377736 scopus 로고    scopus 로고
    • Dissecting the contribution of p16(INK4A) and the Rb family to the Ras transformed phenotype
    • Mitchell, P. J., Perez-Nadales, E., Malcolm, D. S. and Lloyd, A. C. (2003). Dissecting the contribution of p16(INK4A) and the Rb family to the Ras transformed phenotype. Mol. Cell. Biol. 23, 2530-2542.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 2530-2542
    • Mitchell, P.J.1    Perez-Nadales, E.2    Malcolm, D.S.3    Lloyd, A.C.4
  • 33
    • 39549110810 scopus 로고    scopus 로고
    • Preventing DNA over-replication: A Cdk perspective
    • Porter, A. (2008). Preventing DNA over-replication: a Cdk perspective. Cell Div. 3, 3.
    • (2008) Cell Div , vol.3 , pp. 3
    • Porter, A.1
  • 34
    • 9244263076 scopus 로고    scopus 로고
    • Aneuploidy and cancer
    • Rajagopalan, H. and Lengauer, C. (2004). Aneuploidy and cancer. Nature 432, 338-341.
    • (2004) Nature , vol.432 , pp. 338-341
    • Rajagopalan, H.1    Lengauer, C.2
  • 35
    • 0035114576 scopus 로고    scopus 로고
    • Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
    • Ramirez, R. D., Morales, C. P., Herbert, B. S., Rohde, J. M., Passons, C., Shay, J. W. and Wright, W. E. (2001). Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15, 398-403.
    • (2001) Genes Dev , vol.15 , pp. 398-403
    • Ramirez, R.D.1    Morales, C.P.2    Herbert, B.S.3    Rohde, J.M.4    Passons, C.5    Shay, J.W.6    Wright, W.E.7
  • 36
    • 0032589393 scopus 로고    scopus 로고
    • Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
    • Roovers, K., Davey, G., Zhu, X., Bottazzi, M. E. and Assoian, R. K. (1999). Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol. Biol. Cell 10, 3197-3204.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3197-3204
    • Roovers, K.1    Davey, G.2    Zhu, X.3    Bottazzi, M.E.4    Assoian, R.K.5
  • 37
    • 0034902905 scopus 로고    scopus 로고
    • Integrins and cell proliferation: Regulation of cyclin-dependent kinases via cytoplasmic signaling pathways
    • Schwartz, M. A. and Assoian, R. K. (2001). Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. J. Cell Sci. 114, 2553-2560.
    • (2001) J. Cell Sci , vol.114 , pp. 2553-2560
    • Schwartz, M.A.1    Assoian, R.K.2
  • 38
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr, C. and McCormick, F. (2002). The RB and p53 pathways in cancer. Cancer Cell 2, 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.1    McCormick, F.2
  • 39
    • 34548246559 scopus 로고    scopus 로고
    • RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors
    • Srinivasan, S. V., Mayhew, C. N., Schwemberger, S., Zagorski, W. and Knudsen, E. S. (2007). RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors. J. Biol. Chem. 282, 23867-23877.
    • (2007) J. Biol. Chem , vol.282 , pp. 23867-23877
    • Srinivasan, S.V.1    Mayhew, C.N.2    Schwemberger, S.3    Zagorski, W.4    Knudsen, E.S.5
  • 40
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty, T. D. and Coussens, L. M. (2006). Tumor stroma and regulation of cancer development. Annu. Rev. Pathol. 1, 119-150.
    • (2006) Annu. Rev. Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 41
    • 33751293168 scopus 로고    scopus 로고
    • Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis
    • Tort, F., Bartkova, J., Sehested, M., Orntoft, T., Lukas, J. and Bartek, J. (2006). Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res. 66, 10258-10263.
    • (2006) Cancer Res , vol.66 , pp. 10258-10263
    • Tort, F.1    Bartkova, J.2    Sehested, M.3    Orntoft, T.4    Lukas, J.5    Bartek, J.6
  • 43
    • 0029876639 scopus 로고    scopus 로고
    • Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
    • Zhu, X., Ohtsubo, M., Böhmer, R. M., Roberts, J. M. and Assoian, R. K. (1996). Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133, 391-403.
    • (1996) J. Cell Biol , vol.133 , pp. 391-403
    • Zhu, X.1    Ohtsubo, M.2    Böhmer, R.M.3    Roberts, J.M.4    Assoian, R.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.