Dependence of cyclin E-CDK2 kinase activity on cell anchorage

Science

Volumn 271, Issue 5248, 1996, Pages 499-502

  Fang, Fang ^a,c   Orend, Gertraud ^a   Watanabe, Nobumoto ^b   Hunter, Tony ^b   Ruoslahti, Erkki ^a  

^a BURNHAM INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; THREONINE;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL ADHESION; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL SURVIVAL; CELL SUSPENSION; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0030027049     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.271.5248.499     Document Type: Article

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50. We thank J Wang for the glutatathione-S-transferase-pRb (768-928) fusion protein, and M. Pagano, S. Reed, S. Elledge, W. Harper, R. Brent, and R. Poon for antibodies and other help with this work. Supported by grants CA 60725, CA 67224, and CA 28896 and Cancer Center Support Grant CA 30199 (E P.), as well as grant CA 37980 (T H ), from the National Cancer Institute. T.H. is an American Cancer Society research professor N W. is a staff scientist of the Tsukuba Life Science Center at the Institute of Physical and Chemical Research (RIKEN) in Tsukuba, Japan, and is a recipient of a long-term fellowship from the Human Frontier Science Program. G.O was supported by a fellowship from the Deutsche Forschungsgemeinschaft, Germany.