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Volumn 20, Issue 1, 2004, Pages 23-28

Metformin in the treatment of non-alcoholic steatohepatitis: A pilot open label trial

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LACTIC ACID; METFORMIN;

EID: 3142670354     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2004.02025.x     Document Type: Article
Times cited : (323)

References (35)
  • 1
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano RT, McGill DB. Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 342-8.
    • (1980) Mayo Clin Proc , vol.55 , pp. 342-348
    • Ludwig, J.1    Viggiano, R.T.2    McGill, D.B.3
  • 4
    • 0028070562 scopus 로고
    • Nonalcoholic steatohepatitis: An expanded clinical entity
    • Bacon BR, Farahvash MJ, Janney CG. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-9.
    • (1994) Gastroenterology , vol.107 , pp. 1103-1109
    • Bacon, B.R.1    Farahvash, M.J.2    Janney, C.G.3
  • 5
    • 0027999941 scopus 로고
    • Prevalence of chronic liver disease in the general population of northern Italy: The Dyonisos study
    • Bellentani S, Tiribelli C, Saccoccio G, et al. Prevalence of chronic liver disease in the general population of northern Italy: the Dyonisos study. Hepatology 1994; 20: 1442-9.
    • (1994) Hepatology , vol.20 , pp. 1442-1449
    • Bellentani, S.1    Tiribelli, C.2    Saccoccio, G.3
  • 6
    • 0028875908 scopus 로고
    • A natural history of nonalcoholic fatty liver: A follow-up study
    • Teli M, James OF, Burt AD, Bennett MK, Day CP. A natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995; 22: 1714-7.
    • (1995) Hepatology , vol.22 , pp. 1714-1717
    • Teli, M.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 7
    • 0031947715 scopus 로고    scopus 로고
    • James of Steatohepatitis: A tale of two "hits"
    • Day CP. James Of Steatohepatitis: a tale of two "hits". Gastroenterology 1998; 114: 842-5.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1
  • 8
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical pathological severity
    • Matteoni C, Younossi ZM, McCullough A. Nonalcoholic fatty liver disease: a spectrum of clinical pathological severity. Gastroenterology 1999; 116: 1413-9.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.1    Younossi, Z.M.2    McCullough, A.3
  • 9
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Deach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30: 1356-62.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Deach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 11
    • 0033797838 scopus 로고    scopus 로고
    • Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: A case-control study
    • Poonawala A, Nair S, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. Hepatology 2000; 32: 689-92.
    • (2000) Hepatology , vol.32 , pp. 689-692
    • Poonawala, A.1    Nair, S.2    Thuluvath, P.J.3
  • 12
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing muclear SREP-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing muclear SREP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998; 12: 3182s-94s.
    • (1998) Genes Dev , vol.12
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3
  • 13
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
    • Lindor KD, Kowdley KV, Heathcote EJ, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 2004; 39: 770-8.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 14
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • Marchesini G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107: 450-5.
    • (1999) Am J Med , vol.107 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 15
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-92.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 16
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999; 401: 73-6.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 17
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • Promrat K, Lutchman G, Uwaifo GI, et al. A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology 2004; 39: 188-96.
    • (2004) Hepatology , vol.39 , pp. 188-196
    • Promrat, K.1    Lutchman, G.2    Uwaifo, G.I.3
  • 18
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003; 38: 1008-17.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 19
    • 0033988825 scopus 로고    scopus 로고
    • Hepatotoxicity due to troglitazone: Report of two cases and review of adverse events reported to the United States Food and drug Administration
    • Kohlroser J, Mathai J, Reichheld J, Banner BF, Bonkovsky HL. Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and drug Administration. Am J Gastroenterol 2000; 95: 272-6.
    • (2000) Am J Gastroenterol , vol.95 , pp. 272-276
    • Kohlroser, J.1    Mathai, J.2    Reichheld, J.3    Banner, B.F.4    Bonkovsky, H.L.5
  • 22
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA. Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-8.
    • (1985) Diabetologia , vol.28 , pp. 412-418
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 23
    • 0035182026 scopus 로고    scopus 로고
    • Repeatability characteristics of simple indices of insulin resistance: Implications for research applications
    • Mather KJ, Hunt AE, Steinberg HO, et al. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 2001; 86: 5457-64.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5457-5464
    • Mather, K.J.1    Hunt, A.E.2    Steinberg, H.O.3
  • 24
    • 0034456568 scopus 로고    scopus 로고
    • Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
    • Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402-10.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2402-2410
    • Katz, A.1    Nambi, S.S.2    Mather, K.3
  • 26
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo PN. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.N.1
  • 28
    • 0029133235 scopus 로고
    • Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
    • Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 1995; 333: 550-4.
    • (1995) N Engl J Med , vol.333 , pp. 550-554
    • Stumvoll, M.1    Nurjhan, N.2    Perriello, G.3    Dailey, G.4    Gerich, J.E.5
  • 29
    • 0033673203 scopus 로고    scopus 로고
    • Mechanism by which metformin reduces glucose production in type 2 diabetes
    • Hundal RS, Krssak M, Dufour S, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 2000; 49: 2063-9.
    • (2000) Diabetes , vol.49 , pp. 2063-2069
    • Hundal, R.S.1    Krssak, M.2    Dufour, S.3
  • 30
    • 0028129862 scopus 로고
    • Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM
    • Galuska D, Nolte LA, Zierath JR, Wallberg-Henriksson H. Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM. Diabetologia 1994; 37: 826-32.
    • (1994) Diabetologia , vol.37 , pp. 826-832
    • Galuska, D.1    Nolte, L.A.2    Zierath, J.R.3    Wallberg-Henriksson, H.4
  • 31
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase: Fuel gauge of the mammalian cell?
    • Hardie DG, Carling D. The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur J Biochem 1997; 246: 259-73.
    • (1997) Eur J Biochem , vol.246 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 32
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108: 1167-74.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 33
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 2000; 6: 77-86.
    • (2000) Mol Cell , vol.6 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3    Bashmakov, Y.4    Brown, M.S.5    Goldstein, J.L.6
  • 34
    • 0034682474 scopus 로고    scopus 로고
    • Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
    • Kakuma T, Lee Y, Higa M, et al. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci USA 2000; 97: 8536-41.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8536-8541
    • Kakuma, T.1    Lee, Y.2    Higa, M.3
  • 35
    • 0032409985 scopus 로고    scopus 로고
    • Thiazolidinediones and insulin resistance: Peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene
    • Ribon V, Johnson JH, Camp HS, Saltiel AR. Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. Proc Natl Acad Sci USA 1998; 95:14751-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14751-14756
    • Ribon, V.1    Johnson, J.H.2    Camp, H.S.3    Saltiel, A.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.