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Volumn 28, Issue 4, 2008, Pages 407-426

Role of fatty acids in the pathogenesis of obesity and fatty liver: Impact of bariatric surgery

Author keywords

Hepatic steatosis; NAFLD; NASH; Nonalcoholic fatty liver disease; Obesity; Steatohepatitis; Type 2 diabetes mellitus

Indexed keywords

GHRELIN; LEPTIN; LONG CHAIN FATTY ACID; OLEIC ACID; PEPTIDE YY;

EID: 56649115813     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0028-1091985     Document Type: Review
Times cited : (75)

References (210)
  • 1
    • 56649083987 scopus 로고    scopus 로고
    • The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity - 2001. Washington, DC: Goverment Printing Office, U.S. Department of Health and Human Services; 2001
    • The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity - 2001. Washington, DC: Goverment Printing Office, U.S. Department of Health and Human Services; 2001
  • 3
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002;288(14):1723-1727
    • (2002) JAMA , vol.288 , Issue.14 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 5
    • 33748648158 scopus 로고    scopus 로고
    • State-specific prevalence of obesity among adults - United States, 2005
    • State-specific prevalence of obesity among adults - United States, 2005. MMWR Morb Mortal Wkly Rep 2006;55(36):985-988
    • (2006) MMWR Morb Mortal Wkly Rep , vol.55 , Issue.36 , pp. 985-988
  • 6
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless IR, Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990;12(5):1106-1110
    • (1990) Hepatology , vol.12 , Issue.5 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 7
    • 0038805259 scopus 로고    scopus 로고
    • The prevalence and etiology of elevated aminotransferase levels in the United States
    • Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003;98(5):960-967
    • (2003) Am J Gastroenterol , vol.98 , Issue.5 , pp. 960-967
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 8
    • 0037221394 scopus 로고    scopus 로고
    • Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States
    • Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003;124(1):71-79
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 71-79
    • Ruhl, C.E.1    Everhart, J.E.2
  • 9
    • 4344582117 scopus 로고    scopus 로고
    • Epidemiology of nonalcoholic fatty liver
    • Ruhl CE, Everhart JE. Epidemiology of nonalcoholic fatty liver. Clin Liver Dis 2004;8(3):501-519
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 501-519
    • Ruhl, C.E.1    Everhart, J.E.2
  • 10
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40(6):1387-1395
    • (2004) Hepatology , vol.40 , Issue.6 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 11
    • 33747517955 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease in adults
    • Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006;40(suppl 1):S5-S10
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • Clark, J.M.1
  • 12
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 2000;404(6778):635-643
    • (2000) Nature , vol.404 , Issue.6778 , pp. 635-643
    • Kopelman, P.G.1
  • 14
    • 44949262355 scopus 로고    scopus 로고
    • Obesity among adults in the United States: No change since 2003-2004
    • Hyattsville, MD: National Center for Health Statistics;
    • Ogden CL, McDowell MA, Flegal KM. Obesity among adults in the United States: no change since 2003-2004. NCHS Data Brief #1. Hyattsville, MD: National Center for Health Statistics; 2007
    • (2007) NCHS Data Brief , Issue.1
    • Ogden, C.L.1    McDowell, M.A.2    Flegal, K.M.3
  • 15
    • 27844472511 scopus 로고    scopus 로고
    • Causes of cancer in the world: Comparative risk assessment of nine behavioural and environmental risk factors
    • Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 2005;366(9499):1784-1793
    • (2005) Lancet , vol.366 , Issue.9499 , pp. 1784-1793
    • Danaei, G.1    Vander Hoorn, S.2    Lopez, A.D.3    Murray, C.J.4    Ezzati, M.5
  • 16
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41(6):1313-1321
    • (2005) Hepatology , vol.41 , Issue.6 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 18
    • 36249009634 scopus 로고    scopus 로고
    • Pathology of nonalcoholic fatty liver disease
    • Yeh MM, Brunt EM. Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol 2007;128(5):837-847
    • (2007) Am J Clin Pathol , vol.128 , Issue.5 , pp. 837-847
    • Yeh, M.M.1    Brunt, E.M.2
  • 19
    • 0035083842 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Definition and pathology
    • Brunt EM. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 2001;21(1):3-16
    • (2001) Semin Liver Dis , vol.21 , Issue.1 , pp. 3-16
    • Brunt, E.M.1
  • 20
    • 4444290464 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Histologic features and clinical correlations with 30 blinded biopsy specimens
    • Brunt EM, Neuschwander-Tetri BA, Oliver D, Wehmeier KR, Bacon BR. Nonalcoholic steatohepatitis: histologic features and clinical correlations with 30 blinded biopsy specimens. Hum Pathol 2004;35(9):1070-1082
    • (2004) Hum Pathol , vol.35 , Issue.9 , pp. 1070-1082
    • Brunt, E.M.1    Neuschwander-Tetri, B.A.2    Oliver, D.3    Wehmeier, K.R.4    Bacon, B.R.5
  • 21
    • 33746383056 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Pathologic features and differential diagnosis
    • Brunt EM. Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Semin Diagn Pathol 2005;22(4):330-338
    • (2005) Semin Diagn Pathol , vol.22 , Issue.4 , pp. 330-338
    • Brunt, E.M.1
  • 22
    • 0009805141 scopus 로고
    • Alcoholic hepatitis vs nonalcoholic steatohepatitis
    • Thung SN, Gerber MA, eds, New York: Igaku-Shoin;
    • Thung SN, Gerber M. Alcoholic hepatitis vs nonalcoholic steatohepatitis. In: Thung SN, Gerber MA, eds. Differential Diagnosis in Pathology: Liver Disorders. New York: Igaku-Shoin; 1995:24-36
    • (1995) Differential Diagnosis in Pathology: Liver Disorders , pp. 24-36
    • Thung, S.N.1    Gerber, M.2
  • 23
    • 9044219843 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients
    • Pinto HC, Baptista A, Camilo ME, Valente A, Saragoca A, de Moura MC. Nonalcoholic steatohepatitis: clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. Dig Dis Sci 1996;41(1):172-179
    • (1996) Dig Dis Sci , vol.41 , Issue.1 , pp. 172-179
    • Pinto, H.C.1    Baptista, A.2    Camilo, M.E.3    Valente, A.4    Saragoca, A.5    de Moura, M.C.6
  • 25
    • 33746985011 scopus 로고    scopus 로고
    • Leclercq IA, Horsmans Y. Cell biology of NASH: fibrosis and cell proliferation. In: Farrell GC, George J, Hall P de la M, McCullough AK, eds. Fatty Liver Disease: NASH and Related Disorders. Oxford: Blackwell; 2005:143-158
    • Leclercq IA, Horsmans Y. Cell biology of NASH: fibrosis and cell proliferation. In: Farrell GC, George J, Hall P de la M, McCullough AK, eds. Fatty Liver Disease: NASH and Related Disorders. Oxford: Blackwell; 2005:143-158
  • 26
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990;11(1):74-80
    • (1990) Hepatology , vol.11 , Issue.1 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 27
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 1995;22(6):1714-1719
    • (1995) Hepatology , vol.22 , Issue.6 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 29
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • Fassio E, Alvarez E, Dominguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004;40(4):820-826
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 30
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
    • Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 2005;42(1):132-138
    • (2005) J Hepatol , vol.42 , Issue.1 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 31
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129(1):113-121
    • (2005) Gastroenterology , vol.129 , Issue.1 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 33
    • 0038142845 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An underrecognized cause of cryptogenic cirrhosis
    • Clark JM, Diehl AM. Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 2003;289(22):3000-3004
    • (2003) JAMA , vol.289 , Issue.22 , pp. 3000-3004
    • Clark, J.M.1    Diehl, A.M.2
  • 34
    • 1642355723 scopus 로고    scopus 로고
    • The spectrum expanded: Cryptogenic cirrhosis and the natural history of nonalcoholic fatty liver disease
    • Caldwell SH, Crespo DM. The spectrum expanded: cryptogenic cirrhosis and the natural history of nonalcoholic fatty liver disease. J Hepatol 2004;40(4):578-584
    • (2004) J Hepatol , vol.40 , Issue.4 , pp. 578-584
    • Caldwell, S.H.1    Crespo, D.M.2
  • 35
    • 37149046924 scopus 로고    scopus 로고
    • Caldwell SHHA. The clinical outcome of NAFLD including cryptogenic cirrhosis. In: Farrell GC, George J, Hall P de la M, McCullough AK, eds. Fatty Liver Disease: NASH and Related Disorders. Oxford: Blackwell; 2005:168-180
    • Caldwell SHHA. The clinical outcome of NAFLD including cryptogenic cirrhosis. In: Farrell GC, George J, Hall P de la M, McCullough AK, eds. Fatty Liver Disease: NASH and Related Disorders. Oxford: Blackwell; 2005:168-180
  • 36
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006;43(suppl 1):S99-S112
    • (2006) Hepatology , vol.43 , Issue.SUPPL. 1
    • Farrell, G.C.1    Larter, C.Z.2
  • 37
    • 0034925012 scopus 로고    scopus 로고
    • Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease
    • Charlton M, Kasparova P, Weston S, et al. Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease. Liver Transpl 2001;7(7):608-614
    • (2001) Liver Transpl , vol.7 , Issue.7 , pp. 608-614
    • Charlton, M.1    Kasparova, P.2    Weston, S.3
  • 38
    • 2442545703 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease, nonalcoholic steatohepatitis and orthotopic liver transplantation
    • Burke A, Lucey MR. Non-alcoholic fatty liver disease, nonalcoholic steatohepatitis and orthotopic liver transplantation. Am J Transplant 2004;4(5):686-693
    • (2004) Am J Transplant , vol.4 , Issue.5 , pp. 686-693
    • Burke, A.1    Lucey, M.R.2
  • 39
    • 11144264156 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A review of current understanding and future impact
    • Charlton M. Nonalcoholic fatty liver disease: a review of current understanding and future impact. Clin Gastroenterol Hepatol 2004;2(12):1048-1058
    • (2004) Clin Gastroenterol Hepatol , vol.2 , Issue.12 , pp. 1048-1058
    • Charlton, M.1
  • 41
    • 56649106415 scopus 로고    scopus 로고
    • Effects of weight loss on nonalcoholic fatty liver disease
    • Rafiq N, Younossi ZM. Effects of weight loss on nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:427-433
    • (2008) Semin Liver Dis , vol.28 , pp. 427-433
    • Rafiq, N.1    Younossi, Z.M.2
  • 42
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355(22):2297-2307
    • (2006) N Engl J Med , vol.355 , Issue.22 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 43
    • 11144248127 scopus 로고    scopus 로고
    • Hepatotoxicity of drugs used for treatment of obesity and its comorbidities
    • Ghali P, Lindor KD. Hepatotoxicity of drugs used for treatment of obesity and its comorbidities. Semin Liver Dis 2004;24(4):389-397
    • (2004) Semin Liver Dis , vol.24 , Issue.4 , pp. 389-397
    • Ghali, P.1    Lindor, K.D.2
  • 44
    • 29244444549 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and the metabolic syndrome
    • Neuschwander-Tetri BA. Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci 2005;330(6):326-335
    • (2005) Am J Med Sci , vol.330 , Issue.6 , pp. 326-335
    • Neuschwander-Tetri, B.A.1
  • 45
    • 34547472585 scopus 로고    scopus 로고
    • Managing nonalcoholic fatty liver disease: Recommendations for family physicians
    • Grattagliano I, Portincasa P, Palmieri VO, Palasciano G. Managing nonalcoholic fatty liver disease: recommendations for family physicians. Can Fam Physician 2007;53(5):857-863
    • (2007) Can Fam Physician , vol.53 , Issue.5 , pp. 857-863
    • Grattagliano, I.1    Portincasa, P.2    Palmieri, V.O.3    Palasciano, G.4
  • 46
    • 34249745682 scopus 로고    scopus 로고
    • Medical treatment of non-alcoholic steatohepatitis
    • ix
    • Kadayifci A, Merriman RB, Bass NM. Medical treatment of non-alcoholic steatohepatitis. Clin Liver Dis 2007;11(1):119-140 ix
    • (2007) Clin Liver Dis , vol.11 , Issue.1 , pp. 119-140
    • Kadayifci, A.1    Merriman, R.B.2    Bass, N.M.3
  • 47
    • 33748179703 scopus 로고    scopus 로고
    • Weight loss as a treatment for nonalcoholic fatty liver disease
    • Clark JM. Weight loss as a treatment for nonalcoholic fatty liver disease. J Clin Gastroenterol 2006;40(suppl 1):S39-S43
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • Clark, J.M.1
  • 48
    • 0022723903 scopus 로고
    • Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding
    • Stremmel W, Berk PD. Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding. Proc Natl Acad Sci U S A 1986;83(10):3086-3090
    • (1986) Proc Natl Acad Sci U S A , vol.83 , Issue.10 , pp. 3086-3090
    • Stremmel, W.1    Berk, P.D.2
  • 49
    • 2142730490 scopus 로고
    • Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut
    • Schwieterman W, Sorrentino D, Potter BJ, et al. Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut. Proc Natl Acad Sci U S A 1988;85(2):359-363
    • (1988) Proc Natl Acad Sci U S A , vol.85 , Issue.2 , pp. 359-363
    • Schwieterman, W.1    Sorrentino, D.2    Potter, B.J.3
  • 50
    • 0023680059 scopus 로고
    • Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut
    • Sorrentino D, Stump D, Potter BJ, et al. Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut. J Clin Invest 1988;82(3):928-935
    • (1988) J Clin Invest , vol.82 , Issue.3 , pp. 928-935
    • Sorrentino, D.1    Stump, D.2    Potter, B.J.3
  • 51
    • 0024244050 scopus 로고
    • Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein
    • Stremmel W. Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein. J Clin Invest 1988;82(6):2001-2010
    • (1988) J Clin Invest , vol.82 , Issue.6 , pp. 2001-2010
    • Stremmel, W.1
  • 53
    • 0027077992 scopus 로고
    • Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytes
    • Stump DD, Nunes RM, Sorrentino D, Isola LM, Berk PD. Characteristics of oleate binding to liver plasma membranes and its uptake by isolated hepatocytes. J Hepatol 1992;16(3):304-315
    • (1992) J Hepatol , vol.16 , Issue.3 , pp. 304-315
    • Stump, D.D.1    Nunes, R.M.2    Sorrentino, D.3    Isola, L.M.4    Berk, P.D.5
  • 54
    • 0032952704 scopus 로고    scopus 로고
    • Mechanisms of cellular uptake of long chain free fatty acids
    • Berk PD, Stump DD. Mechanisms of cellular uptake of long chain free fatty acids. Mol Cell Biochem 1999;192 (1-2):17-31
    • (1999) Mol Cell Biochem , vol.192 , Issue.1-2 , pp. 17-31
    • Berk, P.D.1    Stump, D.D.2
  • 55
    • 0035059742 scopus 로고    scopus 로고
    • Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake
    • Stump DD, Fan X, Berk PD. Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake. J Lipid Res 2001;42(4):509-520
    • (2001) J Lipid Res , vol.42 , Issue.4 , pp. 509-520
    • Stump, D.D.1    Fan, X.2    Berk, P.D.3
  • 56
    • 0025834647 scopus 로고
    • Synthesis of a metabolically stable modified long-chain fatty acid salt and its photolabile derivative
    • Stoll GH, Voges R, Gerok W, Kurz G. Synthesis of a metabolically stable modified long-chain fatty acid salt and its photolabile derivative. J Lipid Res 1991;32(5):843-857
    • (1991) J Lipid Res , vol.32 , Issue.5 , pp. 843-857
    • Stoll, G.H.1    Voges, R.2    Gerok, W.3    Kurz, G.4
  • 57
    • 0034069724 scopus 로고    scopus 로고
    • Transport of heptafluorostearate across model membranes: Membrane transport of long-chain fatty acid anions I
    • Schmider W, Fahr A, Blum HE, Kurz G. Transport of heptafluorostearate across model membranes: membrane transport of long-chain fatty acid anions I. J Lipid Res 2000;41(5):775-787
    • (2000) J Lipid Res , vol.41 , Issue.5 , pp. 775-787
    • Schmider, W.1    Fahr, A.2    Blum, H.E.3    Kurz, G.4
  • 58
    • 0019778896 scopus 로고
    • Mechanism of long chain fatty acid permeation in the isolated adipocyte
    • Abumrad NA, Perkins RC, Park JH, Park CR. Mechanism of long chain fatty acid permeation in the isolated adipocyte. J Biol Chem 1981;256(17):9183-9191
    • (1981) J Biol Chem , vol.256 , Issue.17 , pp. 9183-9191
    • Abumrad, N.A.1    Perkins, R.C.2    Park, J.H.3    Park, C.R.4
  • 59
    • 0021196072 scopus 로고
    • Permeation of long-chain fatty acid into adipocytes: Kinetics, specificity, and evidence for involvement of a membrane protein
    • Abumrad NA, Park JH, Park CR. Permeation of long-chain fatty acid into adipocytes: kinetics, specificity, and evidence for involvement of a membrane protein. J Biol Chem 1984;259(14):8945-8953
    • (1984) J Biol Chem , vol.259 , Issue.14 , pp. 8945-8953
    • Abumrad, N.A.1    Park, J.H.2    Park, C.R.3
  • 60
    • 0024564251 scopus 로고
    • Hepatic oleate uptake: Electrochemical driving forces in intact rat liver
    • Weisiger RA, Fitz JG, Scharschmidt BF. Hepatic oleate uptake: electrochemical driving forces in intact rat liver. J Clin Invest 1989;83(2):411-420
    • (1989) J Clin Invest , vol.83 , Issue.2 , pp. 411-420
    • Weisiger, R.A.1    Fitz, J.G.2    Scharschmidt, B.F.3
  • 62
    • 0032998539 scopus 로고    scopus 로고
    • Protein-mediated palmitate uptake and expression of fatty acid transport proteins in heart giant vesicles
    • Luiken JJ, Turcotte LP, Bonen A. Protein-mediated palmitate uptake and expression of fatty acid transport proteins in heart giant vesicles. J Lipid Res 1999;40(6):1007-1016
    • (1999) J Lipid Res , vol.40 , Issue.6 , pp. 1007-1016
    • Luiken, J.J.1    Turcotte, L.P.2    Bonen, A.3
  • 63
    • 0034296821 scopus 로고    scopus 로고
    • Fatty acid transport proteins facilitate fatty acid uptake in skeletal muscle
    • Luiken JJ, Glatz JF, Bonen A. Fatty acid transport proteins facilitate fatty acid uptake in skeletal muscle. Can J Appl Physiol 2000;25(5):333-352
    • (2000) Can J Appl Physiol , vol.25 , Issue.5 , pp. 333-352
    • Luiken, J.J.1    Glatz, J.F.2    Bonen, A.3
  • 64
    • 4143068282 scopus 로고    scopus 로고
    • Fatty acid transport in adipocytes monitored by imaging intracellular free fatty acid levels
    • Kampf JP, Kleinfeld AM. Fatty acid transport in adipocytes monitored by imaging intracellular free fatty acid levels. J Biol Chem 2004;279(34):35775- 35780
    • (2004) J Biol Chem , vol.279 , Issue.34 , pp. 35775-35780
    • Kampf, J.P.1    Kleinfeld, A.M.2
  • 65
    • 7244236562 scopus 로고    scopus 로고
    • Transport of 13C-oleate in adipocytes measured using multi imaging mass spectrometry
    • Kleinfeld AM, Kampf JP, Lechene C. Transport of 13C-oleate in adipocytes measured using multi imaging mass spectrometry. J Am Soc Mass Spectrom 2004;15(11):1572-1580
    • (2004) J Am Soc Mass Spectrom , vol.15 , Issue.11 , pp. 1572-1580
    • Kleinfeld, A.M.1    Kampf, J.P.2    Lechene, C.3
  • 66
    • 2942757964 scopus 로고
    • Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes
    • Stremmel W, Strohmeyer G, Borchard F, Kochwa S, Berk PD. Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes. Proc Natl Acad Sci U S A 1985;82(1):4-8
    • (1985) Proc Natl Acad Sci U S A , vol.82 , Issue.1 , pp. 4-8
    • Stremmel, W.1    Strohmeyer, G.2    Borchard, F.3    Kochwa, S.4    Berk, P.D.5
  • 67
    • 4344559322 scopus 로고    scopus 로고
    • Cellular uptake of long chain free fatty acids: The structure and function of plasma membrane fatty acid binding protein
    • Bradbury MW, Berk PD. Cellular uptake of long chain free fatty acids: the structure and function of plasma membrane fatty acid binding protein. Adv Mol Cell Biol 2004;33:47-81
    • (2004) Adv Mol Cell Biol , vol.33 , pp. 47-81
    • Bradbury, M.W.1    Berk, P.D.2
  • 68
    • 0025373184 scopus 로고
    • Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related
    • Berk PD, Wada H, Horio Y, et al. Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related. Proc Natl Acad Sci U S A 1990;87(9):3484-3488
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.9 , pp. 3484-3488
    • Berk, P.D.1    Wada, H.2    Horio, Y.3
  • 69
    • 0027143338 scopus 로고
    • Comparison of plasma membrane FABP and mitochondrial isoform of aspartate aminotransferase from rat liver
    • Stump DD, Zhou SL, Berk PD. Comparison of plasma membrane FABP and mitochondrial isoform of aspartate aminotransferase from rat liver. Am J Physiol 1993;265 (5 Pt 1):G894-G902
    • (1993) Am J Physiol , vol.265 , Issue.5 PART 1
    • Stump, D.D.1    Zhou, S.L.2    Berk, P.D.3
  • 70
    • 0027240176 scopus 로고
    • Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation: Homology with human CD36
    • Abumrad NA, el-Maghrabi MR, Amri EZ, Lopez E, Grimaldi PA. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation: homology with human CD36. J Biol Chem 1993;268(24):17665-17668
    • (1993) J Biol Chem , vol.268 , Issue.24 , pp. 17665-17668
    • Abumrad, N.A.1    el-Maghrabi, M.R.2    Amri, E.Z.3    Lopez, E.4    Grimaldi, P.A.5
  • 71
    • 0028152492 scopus 로고
    • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
    • Schaffer JE, Lodish HF. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 1994;79(3):427-436
    • (1994) Cell , vol.79 , Issue.3 , pp. 427-436
    • Schaffer, J.E.1    Lodish, H.F.2
  • 72
    • 0032555136 scopus 로고    scopus 로고
    • A family of fatty acid transporters conserved from mycobacterium to man
    • Hirsch D, Stahl A, Lodish HF. A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A 1998;95(15):8625-8629
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.15 , pp. 8625-8629
    • Hirsch, D.1    Stahl, A.2    Lodish, H.F.3
  • 75
    • 0036737860 scopus 로고    scopus 로고
    • Uptake of long-chain fatty acids in HepG2 cells involves caveolae: Analysis of a novel pathway
    • Pohl J, Ring A, Stremmel W. Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res 2002;43(9):1390-1399
    • (2002) J Lipid Res , vol.43 , Issue.9 , pp. 1390-1399
    • Pohl, J.1    Ring, A.2    Stremmel, W.3
  • 76
    • 36148964726 scopus 로고    scopus 로고
    • Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump
    • Kampf JP, Parmley D, Kleinfeld AM. Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump. Am J Physiol Endocrinol Metab 2007;293(5):E1207-E1214
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , Issue.5
    • Kampf, J.P.1    Parmley, D.2    Kleinfeld, A.M.3
  • 77
    • 0030991677 scopus 로고    scopus 로고
    • Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus
    • Berk PD, Zhou SL, Kiang CL, Stump D, Bradbury M, Isola LM. Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. J Biol Chem 1997;272(13):8830-8835
    • (1997) J Biol Chem , vol.272 , Issue.13 , pp. 8830-8835
    • Berk, P.D.1    Zhou, S.L.2    Kiang, C.L.3    Stump, D.4    Bradbury, M.5    Isola, L.M.6
  • 78
    • 0030342523 scopus 로고    scopus 로고
    • Regulated membrane transport of free fatty acids in adipocytes: Role in obesity and non-insulin dependent diabetes mellitus
    • discussion 41-43
    • Berk PD, Zhou SL, Bradbury M, Stump D, Kiang CL, Isola LM. Regulated membrane transport of free fatty acids in adipocytes: role in obesity and non-insulin dependent diabetes mellitus. Trans Am Clin Climatol Assoc 1997;108:26-40; discussion 41-43
    • (1997) Trans Am Clin Climatol Assoc , vol.108 , pp. 26-40
    • Berk, P.D.1    Zhou, S.L.2    Bradbury, M.3    Stump, D.4    Kiang, C.L.5    Isola, L.M.6
  • 79
    • 0033214662 scopus 로고    scopus 로고
    • Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents
    • Berk PD, Zhou S, Kiang C, Stump DD, Fan X, Bradbury MW. Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J Biol Chem 1999;274(40):28626-28631
    • (1999) J Biol Chem , vol.274 , Issue.40 , pp. 28626-28631
    • Berk, P.D.1    Zhou, S.2    Kiang, C.3    Stump, D.D.4    Fan, X.5    Bradbury, M.W.6
  • 80
    • 13244292279 scopus 로고    scopus 로고
    • Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity
    • Petrescu O, Fan X, Gentileschi P, et al. Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity. Int J Obes (Lond) 2005;29(2):196-203
    • (2005) Int J Obes (Lond) , vol.29 , Issue.2 , pp. 196-203
    • Petrescu, O.1    Fan, X.2    Gentileschi, P.3
  • 81
    • 4344589923 scopus 로고    scopus 로고
    • Lipid metabolism in hepatic steatosis
    • xi
    • Bradbury MW, Berk PD. Lipid metabolism in hepatic steatosis. Clin Liver Dis 2004;8(3):639-671 xi
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 639-671
    • Bradbury, M.W.1    Berk, P.D.2
  • 82
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379(6566):632-635
    • (1996) Nature , vol.379 , Issue.6566 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3
  • 83
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua SC Jr, Chung WK, Wu-Peng XS, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271(5251):994-996
    • (1996) Science , vol.271 , Issue.5251 , pp. 994-996
    • Chua Jr, S.C.1    Chung, W.K.2    Wu-Peng, X.S.3
  • 84
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372(6505):425-432
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 85
    • 0042420011 scopus 로고    scopus 로고
    • Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes
    • Fan X, Bradbury MW, Berk PD. Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes. J Nutr 2003;133(9):2707-2715
    • (2003) J Nutr , vol.133 , Issue.9 , pp. 2707-2715
    • Fan, X.1    Bradbury, M.W.2    Berk, P.D.3
  • 86
    • 0035937174 scopus 로고    scopus 로고
    • Liporegulation in diet-induced obesity: The antisteatotic role of hyperleptinemia
    • Lee Y, Wang MY, Kakuma T, et al. Liporegulation in diet-induced obesity: the antisteatotic role of hyperleptinemia. J Biol Chem 2001;276(8):5629-5635
    • (2001) J Biol Chem , vol.276 , Issue.8 , pp. 5629-5635
    • Lee, Y.1    Wang, M.Y.2    Kakuma, T.3
  • 87
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger RH. Lipotoxic diseases. Annu Rev Med 2002;53:319-336
    • (2002) Annu Rev Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 88
    • 0037636366 scopus 로고    scopus 로고
    • The physiology of cellular liporegulation
    • Unger RH. The physiology of cellular liporegulation. Annu Rev Physiol 2003;65:333-347
    • (2003) Annu Rev Physiol , vol.65 , pp. 333-347
    • Unger, R.H.1
  • 89
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269(5223):543-546
    • (1995) Science , vol.269 , Issue.5223 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 90
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269(5223):540-543
    • (1995) Science , vol.269 , Issue.5223 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 91
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269(5223):546-549
    • (1995) Science , vol.269 , Issue.5223 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 93
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resistance
    • Myers MG, Cowley MA, Munzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 2008;70:537-556
    • (2008) Annu Rev Physiol , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 94
    • 26944442471 scopus 로고    scopus 로고
    • Molecular mechanisms associated with leptin resistance: N-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain
    • Oh-I S, Shimizu H, Sato T, Uehara Y, Okada S, Mori M. Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain. Cell Metab 2005;1(5):331-341
    • (2005) Cell Metab , vol.1 , Issue.5 , pp. 331-341
    • Oh-I, S.1    Shimizu, H.2    Sato, T.3    Uehara, Y.4    Okada, S.5    Mori, M.6
  • 95
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 2001;276(18):14890- 14895
    • (2001) J Biol Chem , vol.276 , Issue.18 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 96
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: New perspective on obesity and related disorders
    • Unger RH, Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 2001;15(2):312-321
    • (2001) FASEB J , vol.15 , Issue.2 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 97
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction - the role of ectopic lipids in the metabolic syndrome
    • Unger RH. Minireview: weapons of lean body mass destruction - the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144(12):5159-5165
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5159-5165
    • Unger, R.H.1
  • 98
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: When tissues overeat
    • Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 2003;14(3):281-287
    • (2003) Curr Opin Lipidol , vol.14 , Issue.3 , pp. 281-287
    • Schaffer, J.E.1
  • 99
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999;401(6748):73-76
    • (1999) Nature , vol.401 , Issue.6748 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 100
    • 2942657650 scopus 로고    scopus 로고
    • Medical consequences of obesity
    • Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab 2004;89(6):2583-2589
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2583-2589
    • Bray, G.A.1
  • 101
    • 0027512732 scopus 로고
    • Role of insulin resistance in human disease (syndrome X): An expanded definition
    • Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993;44:121-131
    • (1993) Annu Rev Med , vol.44 , pp. 121-131
    • Reaven, G.M.1
  • 102
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995;75(3):473-486
    • (1995) Physiol Rev , vol.75 , Issue.3 , pp. 473-486
    • Reaven, G.M.1
  • 103
    • 16544391119 scopus 로고    scopus 로고
    • Slaying the metabolic syndrome: Are we battling the Hydra or the Chimera?
    • Dunbar RL, Rader DJ. Slaying the metabolic syndrome: are we battling the Hydra or the Chimera? Minerva Endocrinol 2004;29(3):89-111
    • (2004) Minerva Endocrinol , vol.29 , Issue.3 , pp. 89-111
    • Dunbar, R.L.1    Rader, D.J.2
  • 104
    • 0037118703 scopus 로고    scopus 로고
    • Metabolic syndrome: Pathophysiology and implications for management of cardiovascular disease
    • Reaven G. Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation 2002;106(3):286-288
    • (2002) Circulation , vol.106 , Issue.3 , pp. 286-288
    • Reaven, G.1
  • 105
    • 15544387164 scopus 로고    scopus 로고
    • Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: Implications for controlling dietary carbohydrates: a review
    • Freedland ES. Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review. Nutr Metab (Lond) 2004;1(1):12
    • (2004) Nutr Metab (Lond) , vol.1 , Issue.1 , pp. 12
    • Freedland, E.S.1
  • 106
    • 4344629376 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in individuals with severe obesity
    • Haynes P, Liangpunsakul S, Chalasani N. Nonalcoholic fatty liver disease in individuals with severe obesity. Clin Liver Dis 2004;8(3):535-547
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 535-547
    • Haynes, P.1    Liangpunsakul, S.2    Chalasani, N.3
  • 107
    • 4344628553 scopus 로고    scopus 로고
    • Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease
    • ix
    • Choudhury J, Sanyal AJ. Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease. Clin Liver Dis 2004;8(3):575-594 ix
    • (2004) Clin Liver Dis , vol.8 , Issue.3 , pp. 575-594
    • Choudhury, J.1    Sanyal, A.J.2
  • 108
    • 0033329864 scopus 로고    scopus 로고
    • Liver pathology and the metabolic syndrome X in severe obesity
    • Marceau P, Biron S, Hould FS, et al. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab 1999;84(5):1513-1517
    • (1999) J Clin Endocrinol Metab , vol.84 , Issue.5 , pp. 1513-1517
    • Marceau, P.1    Biron, S.2    Hould, F.S.3
  • 109
    • 18244385511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
    • Pagano G, Pacini G, Musso G, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002;35(2):367-372
    • (2002) Hepatology , vol.35 , Issue.2 , pp. 367-372
    • Pagano, G.1    Pacini, G.2    Musso, G.3
  • 110
    • 16244381893 scopus 로고    scopus 로고
    • The inflammatory syndrome: The role of adipose tissue cytokines in metabolic disorders linked to obesity
    • Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 2004;15(11):2792- 2800
    • (2004) J Am Soc Nephrol , vol.15 , Issue.11 , pp. 2792-2800
    • Wisse, B.E.1
  • 111
    • 11144237718 scopus 로고    scopus 로고
    • Association between elevated liver enzymes and C-reactive protein: Possible hepatic contribution to systemic inflammation in the metabolic syndrome
    • Kerner A, Avizohar O, Sella R, et al. Association between elevated liver enzymes and C-reactive protein: possible hepatic contribution to systemic inflammation in the metabolic syndrome. Arterioscler Thromb Vasc Biol 2005;25(1):193-197
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , Issue.1 , pp. 193-197
    • Kerner, A.1    Avizohar, O.2    Sella, R.3
  • 113
    • 0037126526 scopus 로고    scopus 로고
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • Third Report of the National Cholesterol Education Program NCEP
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106(25):3143-3421
    • (2002) Circulation , vol.106 , Issue.25 , pp. 3143-3421
  • 114
    • 1842831084 scopus 로고    scopus 로고
    • Grundy SM, Hansen B, Smith SC Jr, Cleeman JI, Kahn RA. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol 2004;24(2):e19-e24
    • Grundy SM, Hansen B, Smith SC Jr, Cleeman JI, Kahn RA. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol 2004;24(2):e19-e24
  • 115
    • 1842842014 scopus 로고    scopus 로고
    • Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 2004;24(2):e13-e18
    • Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 2004;24(2):e13-e18
  • 116
    • 24144484876 scopus 로고    scopus 로고
    • The metabolic syndrome: Time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005;28(9):2289-2304
    • (2005) Diabetes Care , vol.28 , Issue.9 , pp. 2289-2304
    • Kahn, R.1    Buse, J.2    Ferrannini, E.3    Stern, M.4
  • 117
    • 34547327365 scopus 로고    scopus 로고
    • The individual components of the metabolic syndrome: Is there a raison d'etre?
    • Reaven GM. The individual components of the metabolic syndrome: is there a raison d'etre? J Am Coll Nutr 2007;26(3):191-195
    • (2007) J Am Coll Nutr , vol.26 , Issue.3 , pp. 191-195
    • Reaven, G.M.1
  • 119
    • 29144523498 scopus 로고    scopus 로고
    • Lessons from animal models of NASH
    • Diehl AM. Lessons from animal models of NASH. Hepatol Res 2005;33(2):138-144
    • (2005) Hepatol Res , vol.33 , Issue.2 , pp. 138-144
    • Diehl, A.M.1
  • 120
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K, Yang L, McCall S, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007;45(6):1366-1374
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3
  • 121
    • 0031900079 scopus 로고    scopus 로고
    • Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells
    • Zhou SL, Gordon RE, Bradbury M, Stump D, Kiang CL, Berk PD. Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells. Hepatology 1998;27(4):1064-1074
    • (1998) Hepatology , vol.27 , Issue.4 , pp. 1064-1074
    • Zhou, S.L.1    Gordon, R.E.2    Bradbury, M.3    Stump, D.4    Kiang, C.L.5    Berk, P.D.6
  • 122
    • 33646839278 scopus 로고    scopus 로고
    • Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings
    • discussion 345
    • Berk PD, Zhou S, Bradbury MW. Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. Trans Am Clin Climatol Assoc 2005;116:335-344; discussion 345
    • (2005) Trans Am Clin Climatol Assoc , vol.116 , pp. 335-344
    • Berk, P.D.1    Zhou, S.2    Bradbury, M.W.3
  • 123
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998;114(4):842-845
    • (1998) Gastroenterology , vol.114 , Issue.4 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 124
    • 33748150370 scopus 로고    scopus 로고
    • Pathophysiology of nonalcoholic steatohepatitis
    • McCullough AJ. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006;40(suppl 1):S17-S29
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • McCullough, A.J.1
  • 125
    • 33748169641 scopus 로고    scopus 로고
    • Genetic influences in nonalcoholic fatty liver disease
    • Merriman RB, Aouizerat BE, Bass NM. Genetic influences in nonalcoholic fatty liver disease. J Clin Gastroenterol 2006;40(suppl 1):S30-S33
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • Merriman, R.B.1    Aouizerat, B.E.2    Bass, N.M.3
  • 126
    • 40949141493 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    • Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med 2008;44(7):1259-1272
    • (2008) Free Radic Biol Med , vol.44 , Issue.7 , pp. 1259-1272
    • Mantena, S.K.1    King, A.L.2    Andringa, K.K.3    Eccleston, H.B.4    Bailey, S.M.5
  • 127
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:360-369
    • (2008) Semin Liver Dis , vol.28 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 128
    • 56649083495 scopus 로고    scopus 로고
    • Mechanisms of disease progression in nonalcoholic fatty liver disease
    • Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:370-379
    • (2008) Semin Liver Dis , vol.28 , pp. 370-379
    • Jou, J.1    Choi, S.S.2    Diehl, A.M.3
  • 129
    • 33846529926 scopus 로고    scopus 로고
    • Noninvasive indices of fibrosis in NAFLD: Starting to think about a three-hit (at least) phenomenon
    • Charlton M. Noninvasive indices of fibrosis in NAFLD: starting to think about a three-hit (at least) phenomenon. Am J Gastroenterol 2007;102(2):409-411
    • (2007) Am J Gastroenterol , vol.102 , Issue.2 , pp. 409-411
    • Charlton, M.1
  • 130
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
    • Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 2000;105(8):1067-1075
    • (2000) J Clin Invest , vol.105 , Issue.8 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 131
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis: II. Cytochrome P-450 enzymes and oxidative stress
    • Robertson G, Leclercq I, Farrell GC. Nonalcoholic steatosis and steatohepatitis: II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 2001;281(5):G1135-G1139
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281 , Issue.5
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 132
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120(5):1183-1192
    • (2001) Gastroenterology , vol.120 , Issue.5 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 133
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002;35(2):373-379
    • (2002) Hepatology , vol.35 , Issue.2 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 134
    • 0036329894 scopus 로고    scopus 로고
    • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?
    • Chitturi S, Farrell G, Frost L, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 2002;36(2):403-409
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 403-409
    • Chitturi, S.1    Farrell, G.2    Frost, L.3
  • 136
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri P, Baillie RA, Wiest MM, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007;46(4):1081-1090
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1081-1090
    • Puri, P.1    Baillie, R.A.2    Wiest, M.M.3
  • 137
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • Puri P, Mirshahi F, Cheung O, et al. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008;134(2):568-576
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3
  • 138
    • 0035490242 scopus 로고    scopus 로고
    • Drug treatment of obesity
    • Bray GA. Drug treatment of obesity. Rev Endocr Metab Disord 2001;2(4):403-418
    • (2001) Rev Endocr Metab Disord , vol.2 , Issue.4 , pp. 403-418
    • Bray, G.A.1
  • 140
    • 0034750737 scopus 로고    scopus 로고
    • Longterm weight-loss maintenance: A meta-analysis of US studies
    • Anderson JW, Konz EC, Frederich RC, Wood CL. Longterm weight-loss maintenance: a meta-analysis of US studies. Am J Clin Nutr 2001;74(5):579-584
    • (2001) Am J Clin Nutr , vol.74 , Issue.5 , pp. 579-584
    • Anderson, J.W.1    Konz, E.C.2    Frederich, R.C.3    Wood, C.L.4
  • 141
    • 0034067633 scopus 로고    scopus 로고
    • Behavioral treatment of obesity
    • vii
    • Wadden TA, Foster GD. Behavioral treatment of obesity. Med Clin North Am 2000;84(2):441-461 vii
    • (2000) Med Clin North Am , vol.84 , Issue.2 , pp. 441-461
    • Wadden, T.A.1    Foster, G.D.2
  • 142
    • 0003525629 scopus 로고    scopus 로고
    • Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The Evidence Report
    • National Institutes of Health
    • National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The Evidence Report. Obes Res 1998;6(suppl 2):51S-209S
    • (1998) Obes Res , vol.6 , Issue.SUPPL. 2
  • 143
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332(10):621-628
    • (1995) N Engl J Med , vol.332 , Issue.10 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 144
    • 0033736323 scopus 로고    scopus 로고
    • Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory
    • Weinsier RL, Nagy TR, Hunter GR, Darnell BE, Hensrud DD, Weiss HL. Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Am J Clin Nutr 2000;72(5):1088-1094
    • (2000) Am J Clin Nutr , vol.72 , Issue.5 , pp. 1088-1094
    • Weinsier, R.L.1    Nagy, T.R.2    Hunter, G.R.3    Darnell, B.E.4    Hensrud, D.D.5    Weiss, H.L.6
  • 145
    • 0014188375 scopus 로고
    • Gastric bypass in obesity
    • Mason EE, Ito C. Gastric bypass in obesity. Surg Clin North Am 1967;47(6):1345-1351
    • (1967) Surg Clin North Am , vol.47 , Issue.6 , pp. 1345-1351
    • Mason, E.E.1    Ito, C.2
  • 146
    • 84951652783 scopus 로고
    • Gastrointestinal surgery for severe obesity
    • Hubbard VS, Hall WH. Gastrointestinal surgery for severe obesity. Obes Surg 1991;1(3):257-265
    • (1991) Obes Surg , vol.1 , Issue.3 , pp. 257-265
    • Hubbard, V.S.1    Hall, W.H.2
  • 147
    • 34547615825 scopus 로고    scopus 로고
    • Agency for Healthcare Research and Quality (AHRQ), Bariatric Surgery Utilization and Outcomes in 1998 and 2004
    • Rockville, MD: Agency or Healthcare Quality and Research;
    • Zhao Y, Encinosa W. Agency for Healthcare Research and Quality (AHRQ), Bariatric Surgery Utilization and Outcomes in 1998 and 2004. Statistical Brief # 23. Rockville, MD: Agency or Healthcare Quality and Research; 2007
    • (2007) Statistical Brief , Issue.23
    • Zhao, Y.1    Encinosa, W.2
  • 148
    • 56649093248 scopus 로고    scopus 로고
    • NIDDK Working group on bariatric surgery: executive summary , American Society for Bariatric Surgery. Rationale for the surgical treatment of morbid obesity. Available at:, Accessed April 14, 2008
    • NIDDK Working group on bariatric surgery: executive summary (2002). American Society for Bariatric Surgery. Rationale for the surgical treatment of morbid obesity. Available at: http://www.asbs.org/html/rationale/rationale.html. Accessed April 14, 2008
    • (2002)
  • 149
    • 0034821829 scopus 로고    scopus 로고
    • Gastric bypass
    • Brolin RE. Gastric bypass. Surg Clin North Am 2001;81(5):1077-1095
    • (2001) Surg Clin North Am , vol.81 , Issue.5 , pp. 1077-1095
    • Brolin, R.E.1
  • 150
    • 0029130754 scopus 로고
    • Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus
    • discussion 350-352
    • Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg 1995;222(3):339-350; discussion 350-352
    • (1995) Ann Surg , vol.222 , Issue.3 , pp. 339-350
    • Pories, W.J.1    Swanson, M.S.2    MacDonald, K.G.3
  • 151
    • 0036829857 scopus 로고    scopus 로고
    • Potential of surgery for curing type 2 diabetes mellitus
    • Rubino F, Gagner M. Potential of surgery for curing type 2 diabetes mellitus. Ann Surg 2002;236(5):554-559
    • (2002) Ann Surg , vol.236 , Issue.5 , pp. 554-559
    • Rubino, F.1    Gagner, M.2
  • 153
    • 34247846358 scopus 로고    scopus 로고
    • Bariatric surgery: A review of procedures and outcomes
    • Elder KA, Wolfe BM. Bariatric surgery: a review of procedures and outcomes. Gastroenterology 2007;132(6):2253-2271
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2253-2271
    • Elder, K.A.1    Wolfe, B.M.2
  • 154
    • 0036968592 scopus 로고    scopus 로고
    • A bariatric surgery algorithm
    • discussion 747-750
    • Buchwald H. A bariatric surgery algorithm. Obes Surg 2002;12(6):733-746; discussion 747-750
    • (2002) Obes Surg , vol.12 , Issue.6 , pp. 733-746
    • Buchwald, H.1
  • 155
    • 33645543470 scopus 로고    scopus 로고
    • Choosing the right laparoscopic bariatric surgical procedure
    • Inabnet WB, DeMaria EJ, Ikramuddin S, eds, Philadelphia: Lippincott Williams and Wilkins;
    • Regan J, Selzer DJ, Inabnet WB. Choosing the right laparoscopic bariatric surgical procedure. In: Inabnet WB, DeMaria EJ, Ikramuddin S, eds. Laparoscopic Bariatric Surgery. Philadelphia: Lippincott Williams and Wilkins; 2004:47-54
    • (2004) Laparoscopic Bariatric Surgery , pp. 47-54
    • Regan, J.1    Selzer, D.J.2    Inabnet, W.B.3
  • 156
    • 33947398857 scopus 로고    scopus 로고
    • Safety and efficacy of bariatric surgery: Longitudinal assessment of bariatric surgery
    • Belle SH, Berk PD, Courcoulas AP, et al. Safety and efficacy of bariatric surgery: longitudinal assessment of bariatric surgery. Surg Obes Relat Dis 2007;3(2):116-126
    • (2007) Surg Obes Relat Dis , vol.3 , Issue.2 , pp. 116-126
    • Belle, S.H.1    Berk, P.D.2    Courcoulas, A.P.3
  • 157
    • 23344454475 scopus 로고    scopus 로고
    • Laparoscopic adjustable gastric banding: Evolving clinical experience
    • vii
    • DeMaria EJ, Jamal MK. Laparoscopic adjustable gastric banding: evolving clinical experience. Surg Clin North Am 2005;85(4):773-787 vii
    • (2005) Surg Clin North Am , vol.85 , Issue.4 , pp. 773-787
    • DeMaria, E.J.1    Jamal, M.K.2
  • 158
    • 33751046378 scopus 로고    scopus 로고
    • Laparoscopic sleeve gastrectomy with second stage biliopancreatic diversion and duodenal switch in the superobese
    • Inabnet WB, DeMaria EJ, Ikramuddin S, eds, Philadelphia: Lippincott Williams and Wilkins;
    • Gagner M, Inabnet WB, Pomp A. Laparoscopic sleeve gastrectomy with second stage biliopancreatic diversion and duodenal switch in the superobese. In: Inabnet WB, DeMaria EJ, Ikramuddin S, eds. Laparoscopic Bariatric Surgery. Philadelphia: Lippincott Williams and Wilkins; 2004:143-150
    • (2004) Laparoscopic Bariatric Surgery , pp. 143-150
    • Gagner, M.1    Inabnet, W.B.2    Pomp, A.3
  • 159
    • 11144225926 scopus 로고    scopus 로고
    • Gut peptides and other regulators in obesity
    • Scharf MT, Ahima RS. Gut peptides and other regulators in obesity. Semin Liver Dis 2004;24(4):335-347
    • (2004) Semin Liver Dis , vol.24 , Issue.4 , pp. 335-347
    • Scharf, M.T.1    Ahima, R.S.2
  • 160
    • 33845595901 scopus 로고    scopus 로고
    • Gut peptides in the regulation of food intake and energy homeostasis
    • Murphy KG, Dhillo WS, Bloom SR. Gut peptides in the regulation of food intake and energy homeostasis. Endocr Rev 2006;27(7):719-727
    • (2006) Endocr Rev , vol.27 , Issue.7 , pp. 719-727
    • Murphy, K.G.1    Dhillo, W.S.2    Bloom, S.R.3
  • 161
    • 34247899152 scopus 로고    scopus 로고
    • Gut hormones and appetite control
    • Wren AM, Bloom SR. Gut hormones and appetite control. Gastroenterology 2007;132(6):2116-2130
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2116-2130
    • Wren, A.M.1    Bloom, S.R.2
  • 163
    • 33747507644 scopus 로고    scopus 로고
    • de Fatima Haueisen Sander Diniz M, de Azeredo Passos VM, Diniz MT. Gut-brain communication: how does it stand after bariatric surgery? Curr Opin Clin Nutr Metab Care 2006;9(5):629-636
    • de Fatima Haueisen Sander Diniz M, de Azeredo Passos VM, Diniz MT. Gut-brain communication: how does it stand after bariatric surgery? Curr Opin Clin Nutr Metab Care 2006;9(5):629-636
  • 164
    • 30144444692 scopus 로고    scopus 로고
    • Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    • le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006;243(1):108-114
    • (2006) Ann Surg , vol.243 , Issue.1 , pp. 108-114
    • le Roux, C.W.1    Aylwin, S.J.2    Batterham, R.L.3
  • 165
    • 35649021752 scopus 로고    scopus 로고
    • Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass
    • le Roux CW, Welbourn R, Werling M, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007;246(5):780-785
    • (2007) Ann Surg , vol.246 , Issue.5 , pp. 780-785
    • le Roux, C.W.1    Welbourn, R.2    Werling, M.3
  • 166
    • 0035216623 scopus 로고    scopus 로고
    • Ghrelin enhances appetite and increases food intake in humans
    • Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001;86(12):5992
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.12 , pp. 5992
    • Wren, A.M.1    Seal, L.J.2    Cohen, M.A.3
  • 167
    • 0037162116 scopus 로고    scopus 로고
    • Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    • Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002;346(21):1623-1630
    • (2002) N Engl J Med , vol.346 , Issue.21 , pp. 1623-1630
    • Cummings, D.E.1    Weigle, D.S.2    Frayo, R.S.3
  • 168
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409(6817):194-198
    • (2001) Nature , vol.409 , Issue.6817 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 169
    • 33846840894 scopus 로고    scopus 로고
    • Korner J, Inabnet W, Conwell IM, et al. Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels. Obesity (Silver Spring) 2006;14(9):1553-1561
    • Korner J, Inabnet W, Conwell IM, et al. Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels. Obesity (Silver Spring) 2006;14(9):1553-1561
  • 170
    • 40949159265 scopus 로고    scopus 로고
    • Different effects of vertical banded gastroplasty and Roux-en-Y gastric bypass on meal inhibition of ghrelin secretion in morbidly obese patients
    • Foschi D, Corsi F, Colombo F, et al. Different effects of vertical banded gastroplasty and Roux-en-Y gastric bypass on meal inhibition of ghrelin secretion in morbidly obese patients. J Invest Surg 2008;21(2):77-81
    • (2008) J Invest Surg , vol.21 , Issue.2 , pp. 77-81
    • Foschi, D.1    Corsi, F.2    Colombo, F.3
  • 171
    • 33751044842 scopus 로고    scopus 로고
    • Serum ghrelin, leptin and adiponectin levels before and after weight loss: Comparison of three methods of treatment - a prospective study
    • Kotidis EV, Koliakos GG, Baltzopoulos VG, Ioannidis KN, Yovos JG, Papavramidis ST. Serum ghrelin, leptin and adiponectin levels before and after weight loss: comparison of three methods of treatment - a prospective study. Obes Surg 2006;16(11):1425-1432
    • (2006) Obes Surg , vol.16 , Issue.11 , pp. 1425-1432
    • Kotidis, E.V.1    Koliakos, G.G.2    Baltzopoulos, V.G.3    Ioannidis, K.N.4    Yovos, J.G.5    Papavramidis, S.T.6
  • 172
    • 33748158800 scopus 로고    scopus 로고
    • Chan JL, Mun EC, Stoyneva V, Mantzoros CS, Goldfine AB. Peptide YY levels are elevated after gastric bypass surgery. Obesity (Silver Spring) 2006;14(2):194-198
    • Chan JL, Mun EC, Stoyneva V, Mantzoros CS, Goldfine AB. Peptide YY levels are elevated after gastric bypass surgery. Obesity (Silver Spring) 2006;14(2):194-198
  • 173
    • 0031973168 scopus 로고    scopus 로고
    • Unsuspected cirrhosis discovered during elective obesity operations
    • Brolin RE, Bradley LJ, Taliwal RV. Unsuspected cirrhosis discovered during elective obesity operations. Arch Surg 1998;133(1):84-88
    • (1998) Arch Surg , vol.133 , Issue.1 , pp. 84-88
    • Brolin, R.E.1    Bradley, L.J.2    Taliwal, R.V.3
  • 174
    • 0014937883 scopus 로고
    • Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small-bowel bypass
    • Drenick EJ, Simmons F, Murphy JF. Effect on hepatic morphology of treatment of obesity by fasting, reducing diets and small-bowel bypass. N Engl J Med 1970;282(15):829-834
    • (1970) N Engl J Med , vol.282 , Issue.15 , pp. 829-834
    • Drenick, E.J.1    Simmons, F.2    Murphy, J.F.3
  • 175
    • 0017109834 scopus 로고
    • Hepatic lesions of central pericellular fibrosis in morbid obesity, and after jejunoileal bypass
    • Marubbio AT Jr, Buchwald H, Schwartz MZ, Varco R. Hepatic lesions of central pericellular fibrosis in morbid obesity, and after jejunoileal bypass. Am J Clin Pathol 1976;66(4):684-691
    • (1976) Am J Clin Pathol , vol.66 , Issue.4 , pp. 684-691
    • Marubbio Jr, A.T.1    Buchwald, H.2    Schwartz, M.Z.3    Varco, R.4
  • 177
    • 0023424131 scopus 로고
    • Pattern of progression in liver injury following jejunoileal bypass for morbid obesity
    • Vyberg M, Ravn V, Andersen B. Pattern of progression in liver injury following jejunoileal bypass for morbid obesity. Liver 1987;7(5):271-276
    • (1987) Liver , vol.7 , Issue.5 , pp. 271-276
    • Vyberg, M.1    Ravn, V.2    Andersen, B.3
  • 178
    • 0020640152 scopus 로고
    • Jejunoileal bypass for morbid obesity: Late follow-up in 100 cases
    • Hocking MP, Duerson MC, O'Leary JP, Woodward ER. Jejunoileal bypass for morbid obesity: late follow-up in 100 cases. N Engl J Med 1983;308(17):995-999
    • (1983) N Engl J Med , vol.308 , Issue.17 , pp. 995-999
    • Hocking, M.P.1    Duerson, M.C.2    O'Leary, J.P.3    Woodward, E.R.4
  • 180
    • 0017029372 scopus 로고
    • Intestinal bypass surgery for morbid obesity: Long-term results
    • DeWind LT, Payne JH. Intestinal bypass surgery for morbid obesity: long-term results. JAMA 1976;236(20):2298-2301
    • (1976) JAMA , vol.236 , Issue.20 , pp. 2298-2301
    • DeWind, L.T.1    Payne, J.H.2
  • 181
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese subjects
    • Andersen T, Gluud C, Franzmann MB, Christoffersen P. Hepatic effects of dietary weight loss in morbidly obese subjects. J Hepatol 1991;12(2):224-229
    • (1991) J Hepatol , vol.12 , Issue.2 , pp. 224-229
    • Andersen, T.1    Gluud, C.2    Franzmann, M.B.3    Christoffersen, P.4
  • 182
    • 0020065283 scopus 로고
    • Hepatic steatosis after intestinal bypass: Prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition
    • Drenick EJ, Fisler J, Johnson D. Hepatic steatosis after intestinal bypass: prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition. Gastroenterology 1982;82(3):535-548
    • (1982) Gastroenterology , vol.82 , Issue.3 , pp. 535-548
    • Drenick, E.J.1    Fisler, J.2    Johnson, D.3
  • 183
    • 33644636619 scopus 로고    scopus 로고
    • Molecular mechanisms of alcohol-induced hepatic fibrosis
    • Siegmund SV, Dooley S, Brenner DA. Molecular mechanisms of alcohol-induced hepatic fibrosis. Dig Dis 2005;23(3-4):264-274
    • (2005) Dig Dis , vol.23 , Issue.3-4 , pp. 264-274
    • Siegmund, S.V.1    Dooley, S.2    Brenner, D.A.3
  • 184
    • 38449120093 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: Evidence for the potential role of endotoxin in the pathogenesis of nonalcoholic steatohepatitis
    • Ruiz AG, Casafont F, Crespo J, et al. Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of nonalcoholic steatohepatitis. Obes Surg 2007;17(10):1374-1380
    • (2007) Obes Surg , vol.17 , Issue.10 , pp. 1374-1380
    • Ruiz, A.G.1    Casafont, F.2    Crespo, J.3
  • 185
    • 33748927122 scopus 로고    scopus 로고
    • Hepatic outcomes after jejunoileal bypass: Is there a publication bias?
    • Meinhardt NG, Souto KE, Ulbrich-Kulczynski JM, Stein AT. Hepatic outcomes after jejunoileal bypass: is there a publication bias? Obes Surg 2006;16(9):1171-1178
    • (2006) Obes Surg , vol.16 , Issue.9 , pp. 1171-1178
    • Meinhardt, N.G.1    Souto, K.E.2    Ulbrich-Kulczynski, J.M.3    Stein, A.T.4
  • 186
    • 0027976432 scopus 로고
    • Long-term follow-up of jejunoileal bypass patients with preoperative cirrhosis of the liver
    • Wills CE. Long-term follow-up of jejunoileal bypass patients with preoperative cirrhosis of the liver. Obes Surg 1994;4(1):37-39
    • (1994) Obes Surg , vol.4 , Issue.1 , pp. 37-39
    • Wills, C.E.1
  • 187
    • 0025549042 scopus 로고
    • Regression of liver steatosis following gastroplasty or gastric bypass for morbid obesity
    • Ranlov I, Hardt F. Regression of liver steatosis following gastroplasty or gastric bypass for morbid obesity. Digestion 1990;47(4):208-214
    • (1990) Digestion , vol.47 , Issue.4 , pp. 208-214
    • Ranlov, I.1    Hardt, F.2
  • 188
    • 0026525919 scopus 로고
    • Steatohepatitis and fatal hepatic failure after biliopancreatic diversion
    • Grimm IS, Schindler W, Haluszka O. Steatohepatitis and fatal hepatic failure after biliopancreatic diversion. Am J Gastroenterol 1992;87(6):775-779
    • (1992) Am J Gastroenterol , vol.87 , Issue.6 , pp. 775-779
    • Grimm, I.S.1    Schindler, W.2    Haluszka, O.3
  • 189
    • 0028998719 scopus 로고
    • Regression of hepatic steatosis in morbidly obese persons after gastric bypass
    • Silverman EM, Sapala JA, Appelman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol 1995;104(1):23-31
    • (1995) Am J Clin Pathol , vol.104 , Issue.1 , pp. 23-31
    • Silverman, E.M.1    Sapala, J.A.2    Appelman, H.D.3
  • 190
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • Dixon JB, Bhathal PS, Hughes NR, O'Brien PE. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 2004;39(6):1647-1654
    • (2004) Hepatology , vol.39 , Issue.6 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O'Brien, P.E.4
  • 191
    • 0031913573 scopus 로고    scopus 로고
    • Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty
    • Luyckx FH, Desaive C, Thiry A, et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord 1998;22(3):222-226
    • (1998) Int J Obes Relat Metab Disord , vol.22 , Issue.3 , pp. 222-226
    • Luyckx, F.H.1    Desaive, C.2    Thiry, A.3
  • 192
    • 0348047323 scopus 로고    scopus 로고
    • Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis
    • Kral JG, Thung SN, Biron S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery 2004;135(1):48-58
    • (2004) Surgery , vol.135 , Issue.1 , pp. 48-58
    • Kral, J.G.1    Thung, S.N.2    Biron, S.3
  • 193
    • 32044451685 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease
    • Clark JM, Alkhuraishi AR, Solga SF, Alli P, Diehl AM, Magnuson TH. Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease. Obes Res 2005;13(7):1180-1186
    • (2005) Obes Res , vol.13 , Issue.7 , pp. 1180-1186
    • Clark, J.M.1    Alkhuraishi, A.R.2    Solga, S.F.3    Alli, P.4    Diehl, A.M.5    Magnuson, T.H.6
  • 194
    • 25844522508 scopus 로고    scopus 로고
    • Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity
    • Stratopoulos C, Papakonstantinou A, Terzis I, et al. Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity. Obes Surg 2005;15(8):1154-1160
    • (2005) Obes Surg , vol.15 , Issue.8 , pp. 1154-1160
    • Stratopoulos, C.1    Papakonstantinou, A.2    Terzis, I.3
  • 195
    • 26444467171 scopus 로고    scopus 로고
    • Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome
    • discussion 618-620
    • Mattar SG, Velcu LM, Rabinovitz M, et al. Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg 2005;242(4):610-617; discussion 618-620
    • (2005) Ann Surg , vol.242 , Issue.4 , pp. 610-617
    • Mattar, S.G.1    Velcu, L.M.2    Rabinovitz, M.3
  • 196
    • 21344458564 scopus 로고    scopus 로고
    • Histological behavior of hepatic steatosis in morbidly obese patients after weight loss induced by bariatric surgery
    • Mottin CC, Moretto M, Padoin AV, et al. Histological behavior of hepatic steatosis in morbidly obese patients after weight loss induced by bariatric surgery. Obes Surg 2005;15(6):788-793
    • (2005) Obes Surg , vol.15 , Issue.6 , pp. 788-793
    • Mottin, C.C.1    Moretto, M.2    Padoin, A.V.3
  • 197
    • 33645283607 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass improves the nonalcoholic steatohepatitis (NASH) of morbid obesity
    • de Almeida SR, Rocha PR, Sanches MD, et al. Roux-en-Y gastric bypass improves the nonalcoholic steatohepatitis (NASH) of morbid obesity. Obes Surg 2006;16(3):270-278
    • (2006) Obes Surg , vol.16 , Issue.3 , pp. 270-278
    • de Almeida, S.R.1    Rocha, P.R.2    Sanches, M.D.3
  • 198
    • 33646339636 scopus 로고    scopus 로고
    • Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease
    • Klein S, Mittendorfer B, Eagon JC, et al. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology 2006;130(6):1564-1572
    • (2006) Gastroenterology , vol.130 , Issue.6 , pp. 1564-1572
    • Klein, S.1    Mittendorfer, B.2    Eagon, J.C.3
  • 199
  • 201
    • 33646346335 scopus 로고    scopus 로고
    • The evolution of severe steatosis after bariatric surgery is related to insulin resistance
    • Mathurin P, Gonzalez F, Kerdraon O, et al. The evolution of severe steatosis after bariatric surgery is related to insulin resistance. Gastroenterology 2006;130(6):1617-1624
    • (2006) Gastroenterology , vol.130 , Issue.6 , pp. 1617-1624
    • Mathurin, P.1    Gonzalez, F.2    Kerdraon, O.3
  • 202
    • 33646861774 scopus 로고    scopus 로고
    • Histological findings in the liver before and after gastric bypass
    • Csendes A, Smok G, Burgos AM. Histological findings in the liver before and after gastric bypass. Obes Surg 2006;16(5):607-611
    • (2006) Obes Surg , vol.16 , Issue.5 , pp. 607-611
    • Csendes, A.1    Smok, G.2    Burgos, A.M.3
  • 203
    • 33750571872 scopus 로고    scopus 로고
    • Weight loss and nonalcoholic fatty liver disease: Falls in gamma-glutamyl transferase concentrations are associated with histologic improvement
    • Dixon JB, Bhathal PS, O'Brien PE. Weight loss and nonalcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement. Obes Surg 2006;16(10):1278-1286
    • (2006) Obes Surg , vol.16 , Issue.10 , pp. 1278-1286
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 204
    • 34249791215 scopus 로고    scopus 로고
    • Resolution of nonalcoholic steatohepatits after gastric bypass surgery
    • Liu X, Lazenby AJ, Clements RH, Jhala N, Abrams GA. Resolution of nonalcoholic steatohepatits after gastric bypass surgery. Obes Surg 2007;17(4):486-492
    • (2007) Obes Surg , vol.17 , Issue.4 , pp. 486-492
    • Liu, X.1    Lazenby, A.J.2    Clements, R.H.3    Jhala, N.4    Abrams, G.A.5
  • 205
    • 33947247615 scopus 로고    scopus 로고
    • Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years
    • Furuya CK Jr, de Oliveira CP, de Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol 2007;22(4):510-514
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.4 , pp. 510-514
    • Furuya Jr, C.K.1    de Oliveira, C.P.2    de Mello, E.S.3
  • 206
    • 6944235078 scopus 로고    scopus 로고
    • Impact of gastric bypass operation on survival: A population-based analysis
    • Flum DR, Dellinger EP. Impact of gastric bypass operation on survival: a population-based analysis. J Am Coll Surg 2004;199(4):543-551
    • (2004) J Am Coll Surg , vol.199 , Issue.4 , pp. 543-551
    • Flum, D.R.1    Dellinger, E.P.2
  • 207
    • 4143075821 scopus 로고    scopus 로고
    • The impact of weight reduction surgery on health-care costs in morbidly obese patients
    • Sampalis JS, Liberman M, Auger S, Christou NV. The impact of weight reduction surgery on health-care costs in morbidly obese patients. Obes Surg 2004;14(7):939-947
    • (2004) Obes Surg , vol.14 , Issue.7 , pp. 939-947
    • Sampalis, J.S.1    Liberman, M.2    Auger, S.3    Christou, N.V.4
  • 208
    • 34548075820 scopus 로고    scopus 로고
    • Long-term mortality after gastric bypass surgery
    • Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007;357(8):753-761
    • (2007) N Engl J Med , vol.357 , Issue.8 , pp. 753-761
    • Adams, T.D.1    Gress, R.E.2    Smith, S.C.3
  • 209
    • 34548090763 scopus 로고    scopus 로고
    • Effects of bariatric surgery on mortality in Swedish obese subjects
    • Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007;357(8):741-752
    • (2007) N Engl J Med , vol.357 , Issue.8 , pp. 741-752
    • Sjostrom, L.1    Narbro, K.2    Sjostrom, C.D.3
  • 210
    • 34548087021 scopus 로고    scopus 로고
    • The missing link: Lose weight, live longer
    • Bray GA. The missing link: lose weight, live longer. N Engl J Med 2007;357(8):818-820
    • (2007) N Engl J Med , vol.357 , Issue.8 , pp. 818-820
    • Bray, G.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.