메뉴 건너뛰기




Volumn 512, Issue 1, 2002, Pages 1-35

A survey of EPA/OPP and open literature on selected pesticide chemicals - III. Mutagenicity and carcinogenicity of benomyl and carbendazim

Author keywords

Aneuploidy; Benomyl; Carcinogenicity; Mode of action; Mutagenicity; Pesticides

Indexed keywords

BENOMYL; CARBENDAZIM; PESTICIDE;

EID: 0036709215     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(02)00026-1     Document Type: Review
Times cited : (82)

References (174)
  • 1
    • 0005104259 scopus 로고    scopus 로고
    • Federal Register, Preliminary notice of determination concluding the rebuttable presumption against registration of pesticide products containing benomyl availability of position document, 42 FR 61788, 30 August 1979
    • Federal Register, Preliminary notice of determination concluding the rebuttable presumption against registration of pesticide products containing benomyl availability of position document, 42 FR 61788, 30 August 1979.
  • 2
    • 31844443695 scopus 로고
    • The environment and disease: Association or causation?
    • Hill A.B. The environment and disease: association or causation? Proc. R. Soc. Med. 58:1965;295-300.
    • (1965) Proc. R. Soc. Med. , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 3
    • 0003662518 scopus 로고    scopus 로고
    • National Center for Environmental Assessment, Office of Research and Development, NCEA-F-0644, July
    • USEPA, Draft Guidelines for Carcinogen Risk Assessment, National Center for Environmental Assessment, Office of Research and Development, NCEA-F-0644, July 1999.
    • (1999) Draft Guidelines for Carcinogen Risk Assessment
  • 4
    • 13844323157 scopus 로고
    • A survey of EPA/OPP and open literature data on selected pesticide chemicals tested for mutagenicity. I. Introduction and first 10 chemicals
    • Dearfield K.L., Stack H.F., Quest J.A., Whiting R.J., Waters M.D. A survey of EPA/OPP and open literature data on selected pesticide chemicals tested for mutagenicity. I. Introduction and first 10 chemicals. Mutat. Res. 297:1993;197-233.
    • (1993) Mutat. Res. , vol.297 , pp. 197-233
    • Dearfield, K.L.1    Stack, H.F.2    Quest, J.A.3    Whiting, R.J.4    Waters, M.D.5
  • 5
    • 0005104260 scopus 로고
    • Metabolism of fungicides in mammals
    • D.H. Hutson, G.D. Paulson (Eds.), The Mammalian Metabolism of Agrochemicals
    • H. Kaneko, N. Isobe, J. Miyamoto, Metabolism of fungicides in mammals, in: D.H. Hutson, G.D. Paulson (Eds.), The Mammalian Metabolism of Agrochemicals; Prog. Pestic. Biochem. Toxicol. 8 (1995) 197-266.
    • (1995) Prog. Pestic. Biochem. Toxicol. , vol.8 , pp. 197-266
    • Kaneko, H.1    Isobe, N.2    Miyamoto, J.3
  • 6
    • 0018776358 scopus 로고
    • Metabolism of the butylcarbamoyl moiety of benomyl in rats
    • Axness M.E., Fleeker J. Metabolism of the butylcarbamoyl moiety of benomyl in rats. Pestic. Biochem. Physiol. 11:1979;1-12.
    • (1979) Pestic. Biochem. Physiol. , vol.11 , pp. 1-12
    • Axness, M.E.1    Fleeker, J.2
  • 7
    • 0023889562 scopus 로고
    • Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds
    • Waters M.D., Stack H.F., Brady A.L., Lohman P.H.M., Haroun L., Vainio H. Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds. Mutat. Res. 205:1988;295-312.
    • (1988) Mutat. Res. , vol.205 , pp. 295-312
    • Waters, M.D.1    Stack, H.F.2    Brady, A.L.3    Lohman, P.H.M.4    Haroun, L.5    Vainio, H.6
  • 8
    • 0022630169 scopus 로고
    • Genetic activity profiles of chemicals selected from the aneuploidy data base
    • Waters M.D., Stack H.F., Mavournin K.H., Dellarco V.L. Genetic activity profiles of chemicals selected from the aneuploidy data base. Mutat. Res. 167:1986;171-188.
    • (1986) Mutat. Res. , vol.167 , pp. 171-188
    • Waters, M.D.1    Stack, H.F.2    Mavournin, K.H.3    Dellarco, V.L.4
  • 9
    • 0019291735 scopus 로고
    • Guidelines for simple, sensitive, significant test for carcinogenic effects in long-term animal experiments - Monograph on the long- and short-term screening assays for carcinogens: A critical appraisal
    • Lyon, France
    • R. Peto, M. Pike, P. Day, P. Gray, S. Parish, J. Peto, S. Richard, J. Wahrendorf, Guidelines for simple, sensitive, significant test for carcinogenic effects in long-term animal experiments-Monograph on the long- and short-term screening assays for carcinogens: A critical appraisal, International Agency on Research on Cancer Monograph, Suppl. 2, Lyon, France, 1980, pp. 311-426.
    • (1980) International Agency on Research on Cancer Monograph , Issue.SUPPL. 2 , pp. 311-426
    • Peto, R.1    Pike, M.2    Day, P.3    Gray, P.4    Parish, S.5    Peto, J.6    Richard, S.7    Wahrendorf, J.8
  • 10
    • 0005014144 scopus 로고    scopus 로고
    • DuPont, Response of E.I. DuPont de Nemours and Company to toxicology-related issues in the EPA's draft reregistration eligibility review and tolerance reassessment documents for the pesticide benomyl, Laboratory project no. 4413, Unpublished submission to US Environmental Protection Agency, Office of Pesticides Programs, Washington, DC 20460, USA, MRID no. 45148705, 2000
    • DuPont, Response of E.I. DuPont de Nemours and Company to toxicology-related issues in the EPA's draft reregistration eligibility review and tolerance reassessment documents for the pesticide benomyl, Laboratory project no. 4413, Unpublished submission to US Environmental Protection Agency, Office of Pesticides Programs, Washington, DC 20460, USA, MRID no. 45148705, 2000.
  • 11
    • 0005062612 scopus 로고    scopus 로고
    • DuPont, Unpublished submission to US Environmental Protection Agency, Office of Pollution Prevention and Toxics Substances, Washington, DC 20460, USA, under TSCA 8(d), #86-910000415S, 1983
    • DuPont, Unpublished submission to US Environmental Protection Agency, Office of Pollution Prevention and Toxics Substances, Washington, DC 20460, USA, under TSCA 8(d), #86-910000415S, 1983.
  • 14
    • 0005096295 scopus 로고
    • Final report; report no. R4936 660-80, Unpublished report by Central Institute for Nutrition and Food Research, MRID no. 00153420 reviewed in HED document no. 005531
    • R. Beems, H. Til, C. Van der Heijden, Carcinogenicity Study with Carbendazim in Mice, Final report; report no. R4936 660-80, Unpublished report by Central Institute for Nutrition and Food Research, MRID no. 00153420 reviewed in HED document no. 005531, 1976.
    • (1976) Carcinogenicity Study with Carbendazim in Mice
    • Beems, R.1    Til, H.2    Van der Heijden, C.3
  • 15
    • 0005067873 scopus 로고
    • Final report; project no. 3207-001, report no. 70-82 660-80, Unpublished report by Haskell Laboratory, MRID no. 00154676 reviewed in HED document no. 004679
    • C. Wood, Long-term Feeding Study with 2-benzimidazolecarbamic Acid, Methyl Ester [MBC, INE-965] in Mice, Final report; project no. 3207-001, report no. 70-82 660-80, Unpublished report by Haskell Laboratory, MRID no. 00154676 reviewed in HED document no. 004679, 1982.
    • (1982) Long-term Feeding Study with 2-benzimidazolecarbamic Acid, Methyl Ester [MBC, INE-965] in Mice
    • Wood, C.1
  • 16
    • 0005085414 scopus 로고
    • Final report; study nos. 3194: 3207:20-82, Unpublished report by Haskell Laboratory, MRID no. 41607904 reviewed in HED document no. 010723
    • S.R. Frame, C.S. Van Pelt, Oncogenicity Studies with Benomyl and MBC in Mice (supplemental peer review), Final report; study nos. 3194: 3207:20-82, Unpublished report by Haskell Laboratory, MRID no. 41607904 reviewed in HED document no. 010723, 1990.
    • (1990) Oncogenicity Studies with Benomyl and MBC in Mice (supplemental peer review)
    • Frame, S.R.1    Van Pelt, C.S.2
  • 22
    • 0343072811 scopus 로고
    • Considerations in the US Environmental Protection Agency's testing approach for mutagenicity
    • Dearfield K.L., Auletta A.E., Cimino M.C., Moore M.M. Considerations in the US Environmental Protection Agency's testing approach for mutagenicity. Mutat. Res. 258:1991;259-283.
    • (1991) Mutat. Res. , vol.258 , pp. 259-283
    • Dearfield, K.L.1    Auletta, A.E.2    Cimino, M.C.3    Moore, M.M.4
  • 23
    • 0021821065 scopus 로고
    • Aneuploidy and health risk assessment: Current status and future directions
    • Dellarco V.L., Mavournin K.H., Tice R.R. Aneuploidy and health risk assessment: current status and future directions. Environ. Mutagen. 7:1985;405-424.
    • (1985) Environ. Mutagen. , vol.7 , pp. 405-424
    • Dellarco, V.L.1    Mavournin, K.H.2    Tice, R.R.3
  • 24
    • 0033984316 scopus 로고    scopus 로고
    • Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization
    • Bentley K.S., Kirkland D., Murphy M., Marshall R. Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization. Mutat. Res. 464:2000;41-51.
    • (2000) Mutat. Res. , vol.464 , pp. 41-51
    • Bentley, K.S.1    Kirkland, D.2    Murphy, M.3    Marshall, R.4
  • 25
    • 0029590246 scopus 로고
    • Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes
    • Elhajouji A., Van Hummelen P., Kirsch-Volders M. Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen. 26:1995;292-304.
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 292-304
    • Elhajouji, A.1    Van Hummelen, P.2    Kirsch-Volders, M.3
  • 26
    • 0005012440 scopus 로고    scopus 로고
    • A. Elhajouji, Thresholds for aneuploidy with MBC, Personal communications via electronic mail: Dr. Azeddine Elhajouji, University of Brussels, Brussels, Belgium to Nancy E. McCarroll, Office of Pesticide Programs, Health Effects Division, Washington, DC, USA, 23 March 2000
    • A. Elhajouji, Thresholds for aneuploidy with MBC, Personal communications via electronic mail: Dr. Azeddine Elhajouji, University of Brussels, Brussels, Belgium to Nancy E. McCarroll, Office of Pesticide Programs, Health Effects Division, Washington, DC, USA, 23 March 2000.
  • 27
    • 0025094463 scopus 로고
    • Use of a cell hybrid test system to demonstrate that benomyl induces aneuploidy and polyploidy
    • Zelesco P.A., Barbieri I., Graves J.A.M. Use of a cell hybrid test system to demonstrate that benomyl induces aneuploidy and polyploidy. Mutat. Res. 242:1990;329-335.
    • (1990) Mutat. Res. , vol.242 , pp. 329-335
    • Zelesco, P.A.1    Barbieri, I.2    Graves, J.A.M.3
  • 29
    • 0017142494 scopus 로고
    • The mutagenicity of benzimidazole and benzimidazole derivatives. VI. Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster, MRID no. 41051510 reviewed in HED document no. 004679
    • Seiler J.P. The mutagenicity of benzimidazole and benzimidazole derivatives. VI. Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster, MRID no. 41051510 reviewed in HED document no. 004679. Mutat. Res. 40:1976;339-348.
    • (1976) Mutat. Res. , vol.40 , pp. 339-348
    • Seiler, J.P.1
  • 31
    • 0003913690 scopus 로고
    • Final report; study no. IET 89-0046, Unpublished report by Institute of Environmental Toxicology, MRID no. 41607902 reviewed in HED document no. 010723
    • Y. Sasaki, Benomyl: Micronucleus Test in Mice, Final report; study no. IET 89-0046, Unpublished report by Institute of Environmental Toxicology, MRID no. 41607902 reviewed in HED document no. 010723, 1990.
    • (1990) Benomyl: Micronucleus Test in Mice
    • Sasaki, Y.1
  • 34
    • 0019876086 scopus 로고
    • Purification of yeast tubulin by self-assembly in vitro
    • Kilmartin J.M. Purification of yeast tubulin by self-assembly in vitro. Biol. Chem. 20:1981;3629-3633.
    • (1981) Biol. Chem. , vol.20 , pp. 3629-3633
    • Kilmartin, J.M.1
  • 36
    • 0027518931 scopus 로고
    • Analysis of the six additional chemicals for in vitro assays of the European Economic Communities' EEC Aneuploidy Programme using Saccharomyces cerevisiae D61.M and the in vitro porcine brain tubulin assembly assay
    • Albertini S., Brunner M., Wurgler F.E. Analysis of the six additional chemicals for in vitro assays of the European Economic Communities' EEC Aneuploidy Programme using Saccharomyces cerevisiae D61.M and the in vitro porcine brain tubulin assembly assay. Environ. Mol. Mutagen. 21:1993;180-192.
    • (1993) Environ. Mol. Mutagen. , vol.21 , pp. 180-192
    • Albertini, S.1    Brunner, M.2    Wurgler, F.E.3
  • 37
    • 0017258691 scopus 로고
    • A new culture model facilitating rapid quantitative testing of mitotic spindle inhibition in mammalian cells
    • DeBrabander M., Van de Veire R., Aerts F., Geneus S., Hoebeke J. A new culture model facilitating rapid quantitative testing of mitotic spindle inhibition in mammalian cells. J. Natl. Cancer Inst. 56:1976;357-363.
    • (1976) J. Natl. Cancer Inst. , vol.56 , pp. 357-363
    • DeBrabander, M.1    Van de Veire, R.2    Aerts, F.3    Geneus, S.4    Hoebeke, J.5
  • 38
    • 0022307022 scopus 로고
    • Chemical probes and possible targets for the induction of aneuploidy
    • V.L. Dellarco, P.E. Voytek, A. Hollander (Eds.), Plenum, New York
    • J.C. Liang, B.R. Brinkley, Chemical probes and possible targets for the induction of aneuploidy, in: V.L. Dellarco, P.E. Voytek, A. Hollander (Eds.), Aneuploidy: Etiology and Mechanisms, Vol. 36, Plenum, New York, 1985, pp. 491-505.
    • (1985) Aneuploidy: Etiology and Mechanisms , vol.36 , pp. 491-505
    • Liang, J.C.1    Brinkley, B.R.2
  • 39
    • 0031062307 scopus 로고    scopus 로고
    • The role of the benomyl metabolite carbendazim in benomyl-induced testicular toxicity
    • Lim J., Miller M.G. The role of the benomyl metabolite carbendazim in benomyl-induced testicular toxicity. Toxicol. Appl. Pharmacol. 142:1997;401-410.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 401-410
    • Lim, J.1    Miller, M.G.2
  • 40
    • 0035147136 scopus 로고    scopus 로고
    • The role of GTP binding and microtubule-associated proteins in the inhibition of microtubule assembly by carbendazim
    • Winder B.S., Strandgaard C.S., Miller M.G. The role of GTP binding and microtubule-associated proteins in the inhibition of microtubule assembly by carbendazim. Toxicol. Sci. 59:2001;138-146.
    • (2001) Toxicol. Sci. , vol.59 , pp. 138-146
    • Winder, B.S.1    Strandgaard, C.S.2    Miller, M.G.3
  • 41
    • 77957186784 scopus 로고
    • The fungicide benomyl (methyl 1-[butylcarbamoyl]-2-benzimidazolecarbamate) causes testicular dysfunction by inducing the sloughing of germ cells and occlusion of efferent ductules
    • Hess R.A., Moore B.J., Forrer J., Linder R.E., Abuel-Atta A.A. The fungicide benomyl (methyl 1-[butylcarbamoyl]-2-benzimidazolecarbamate) causes testicular dysfunction by inducing the sloughing of germ cells and occlusion of efferent ductules. Fundam. Appl. Toxicol. 17:1991;733-745.
    • (1991) Fundam. Appl. Toxicol. , vol.17 , pp. 733-745
    • Hess, R.A.1    Moore, B.J.2    Forrer, J.3    Linder, R.E.4    Abuel-Atta, A.A.5
  • 42
    • 0026498151 scopus 로고
    • Acute and long-term effects of a single dose of the fungicide carbendazim (methyl 2-benzimidazole carbamate) on the male reproductive system in the rat
    • Nakai M., Hess R.A., Moore B.J., Guttroff R.F., Strader L.F., Linder R.E. Acute and long-term effects of a single dose of the fungicide carbendazim (methyl 2-benzimidazole carbamate) on the male reproductive system in the rat. J. Androl. 13:1992;507-517.
    • (1992) J. Androl. , vol.13 , pp. 507-517
    • Nakai, M.1    Hess, R.A.2    Moore, B.J.3    Guttroff, R.F.4    Strader, L.F.5    Linder, R.E.6
  • 43
    • 0019403502 scopus 로고
    • Effects of the microtubule disrupting agents, colchicine and vinblastine, on seminiferous tubule structure in the rat
    • Russell L.D., Malone J.P., MacCurdy D.S. Effects of the microtubule disrupting agents, colchicine and vinblastine, on seminiferous tubule structure in the rat. Tissue Cell. 13:1981;349-367.
    • (1981) Tissue Cell , vol.13 , pp. 349-367
    • Russell, L.D.1    Malone, J.P.2    MacCurdy, D.S.3
  • 44
    • 0035168394 scopus 로고    scopus 로고
    • The in vivo gut micronucleus test detects clastogens and aneugens given by gavage
    • Vanhauwaert A., Vanparys P., Kirsch-Volders M. The in vivo gut micronucleus test detects clastogens and aneugens given by gavage. Mutagenesis. 16:2001;39-50.
    • (2001) Mutagenesis , vol.16 , pp. 39-50
    • Vanhauwaert, A.1    Vanparys, P.2    Kirsch-Volders, M.3
  • 45
    • 0035400373 scopus 로고    scopus 로고
    • Continuing ability of the rodent bone marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals
    • Ashby J., Tinwell H. Continuing ability of the rodent bone marrow micronucleus assay to act as a predictor of the possible germ cell mutagenicity of chemicals. Mutat. Res. 478:2001;211-213.
    • (2001) Mutat. Res. , vol.478 , pp. 211-213
    • Ashby, J.1    Tinwell, H.2
  • 46
    • 0005046105 scopus 로고
    • Pathology report no. 129-69, Unpublished study received 10 July 1971, under 1F1031 submitted by E.I. Dupont de Nemours and Company, Wilmington, Del.: CDL:091862-A
    • K.P. Lee, Benzimidazolecarbamic Acid, Methyl Ester, [INT-1991]: 2-Year Feeding Study-Dogs, Pathology report no. 129-69, Unpublished study received 10 July 1971, under 1F1031 submitted by E.I. Dupont de Nemours and Company, Wilmington, Del.: CDL:091862-A, 1970.
    • (1970) Benzimidazolecarbamic Acid, Methyl Ester, [INT-1991]: 2-Year Feeding Study - Dogs
    • Lee, K.P.1
  • 50
    • 0005088291 scopus 로고
    • Final report; study no. 324-90, Unpublished report by Haskell Laboratory, MRID no. 41607903 reviewed in HED document no. 010723
    • C.S. Van Pelt, Twenty-eight-day Feeding Study with Benomyl in Mice, Final report; study no. 324-90, Unpublished report by Haskell Laboratory, MRID no. 41607903 reviewed in HED document no. 010723, 1990.
    • (1990) Twenty-eight-day Feeding Study with Benomyl in Mice
    • Van Pelt, C.S.1
  • 51
    • 0026603074 scopus 로고
    • Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan
    • Wilson D.M., Goldsworthy T.L., Popp J.A., Butterworth B.E. Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan. Environ. Mol. Mutagen. 19:1992;209-222.
    • (1992) Environ. Mol. Mutagen. , vol.19 , pp. 209-222
    • Wilson, D.M.1    Goldsworthy, T.L.2    Popp, J.A.3    Butterworth, B.E.4
  • 52
    • 0026094912 scopus 로고
    • The role of cell proliferation in multistage carcinogenesis
    • B.E. Butterworth, T.L. Goldsworthy, The role of cell proliferation in multistage carcinogenesis, Cell Prolif. (1991) 683-687.
    • (1991) Cell Prolif. , pp. 683-687
    • Butterworth, B.E.1    Goldsworthy, T.L.2
  • 53
    • 0021078832 scopus 로고
    • Growth factors, cell proliferation and cancer: An overview
    • Rozengurth E. Growth factors, cell proliferation and cancer: an overview. Mol. Biol. Med. 1:1983;169-181.
    • (1983) Mol. Biol. Med. , vol.1 , pp. 169-181
    • Rozengurth, E.1
  • 54
    • 0031746241 scopus 로고    scopus 로고
    • Mechanism of benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice
    • Staub R.E., Quistad G.B., Casida J.E. Mechanism of benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice. Chem. Res. Toxicol. 11:1998;535-543.
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 535-543
    • Staub, R.E.1    Quistad, G.B.2    Casida, J.E.3
  • 55
    • 0033400285 scopus 로고    scopus 로고
    • Identification of S-(N-butylcarbamoyl)glutathione, a reactive carbamoylating metabolite of tolbutamide in the rat, and evaluation of its inhibitory effects on glutathione reductase in vitro
    • Guan X., Davis M.R., Tang C., Jochheim C.M., Jin L., Baillie T.A. Identification of S-(N-butylcarbamoyl)glutathione, a reactive carbamoylating metabolite of tolbutamide in the rat, and evaluation of its inhibitory effects on glutathione reductase in vitro. Chem. Res. Toxicol. 12:1999;1138-1143.
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 1138-1143
    • Guan, X.1    Davis, M.R.2    Tang, C.3    Jochheim, C.M.4    Jin, L.5    Baillie, T.A.6
  • 56
    • 0030847352 scopus 로고    scopus 로고
    • Carbendazim and n-butylisocyanate: Metabolites responsible for benomyl double action on cytochrome P450 in HepG2 cells
    • Radice S., Marabini L., Gervasoni M., Ferraris M. Carbendazim and n-butylisocyanate: metabolites responsible for benomyl double action on cytochrome P450 in HepG2 cells. Toxicology. 123:1997;135-142.
    • (1997) Toxicology , vol.123 , pp. 135-142
    • Radice, S.1    Marabini, L.2    Gervasoni, M.3    Ferraris, M.4
  • 59
    • 0022630579 scopus 로고
    • Chemically induced aneuploidy in mammalian cells: Mechanisms and biological significance in cancer
    • Oshimura M., Barrett J.C. Chemically induced aneuploidy in mammalian cells: mechanisms and biological significance in cancer. Environ. Mutat. 8:1986;129-159.
    • (1986) Environ. Mutat. , vol.8 , pp. 129-159
    • Oshimura, M.1    Barrett, J.C.2
  • 61
    • 0032445198 scopus 로고    scopus 로고
    • Trichlorfon exposure, spindle formation and non-disjunction in mammalian oocytes
    • Yin H., Betzendahl I., Eichenlaub-Ritter U. Trichlorfon exposure, spindle formation and non-disjunction in mammalian oocytes. Chromosoma. 107:1998;514-522.
    • (1998) Chromosoma , vol.107 , pp. 514-522
    • Yin, H.1    Betzendahl, I.2    Eichenlaub-Ritter, U.3
  • 63
    • 0032006405 scopus 로고    scopus 로고
    • Benzene metabolites induce the loss and long arm deletions of chromosomes 5 and 7 in human lymphocytes
    • Zhang L., Wang Y., Shang N., Smith M.T. Benzene metabolites induce the loss and long arm deletions of chromosomes 5 and 7 in human lymphocytes. Leuk. Res. 22(2):1998;105-113.
    • (1998) Leuk. Res. , vol.22 , Issue.2 , pp. 105-113
    • Zhang, L.1    Wang, Y.2    Shang, N.3    Smith, M.T.4
  • 64
    • 0027960093 scopus 로고
    • Thresholds for aneuploidy-inducing chemicals
    • Parry J.M., Fielder R.J., McDonald A. Thresholds for aneuploidy-inducing chemicals. Mutagenesis. 9:1994;503-504.
    • (1994) Mutagenesis , vol.9 , pp. 503-504
    • Parry, J.M.1    Fielder, R.J.2    McDonald, A.3
  • 67
    • 0344135585 scopus 로고    scopus 로고
    • Abnormal chromosome 8 copy number in stages I-IV breast cancer studies by fluorescence in situ hybridization
    • Mark H.F., Taylor W., Brown S., Samy M., Sun C.L., Santoro K., Bland K.L. Abnormal chromosome 8 copy number in stages I-IV breast cancer studies by fluorescence in situ hybridization. Cancer Genet. Cytogenet. 108(1):1999;1-5.
    • (1999) Cancer Genet. Cytogenet. , vol.108 , Issue.1 , pp. 1-5
    • Mark, H.F.1    Taylor, W.2    Brown, S.3    Samy, M.4    Sun, C.L.5    Santoro, K.6    Bland, K.L.7
  • 68
    • 0031979655 scopus 로고    scopus 로고
    • Aneuploidy of chromosome 8 as detected by interphase fluorescence in situ hybridization is a recurrent finding in primary and metastatic breast cancer
    • Roka S., Fiegl M., Zojer N., Filipits M., Schuster R., Steiner B., Jakesz R., Huber H., Drach J. Aneuploidy of chromosome 8 as detected by interphase fluorescence in situ hybridization is a recurrent finding in primary and metastatic breast cancer. Breast Cancer Res. Treat. 48(2):1998;125-133.
    • (1998) Breast Cancer Res. Treat. , vol.48 , Issue.2 , pp. 125-133
    • Roka, S.1    Fiegl, M.2    Zojer, N.3    Filipits, M.4    Schuster, R.5    Steiner, B.6    Jakesz, R.7    Huber, H.8    Drach, J.9
  • 70
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 61:1990;759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 71
    • 0032506125 scopus 로고    scopus 로고
    • Genetic instability of cancer cells is proportional to their degree of aneuploidy
    • Duesberg P., Rausch C., Rasnick D., Hehlmann R. Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc. Natl. Acad. Sci. U.S.A. 95(23):1998;13692-13697.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.23 , pp. 13692-13697
    • Duesberg, P.1    Rausch, C.2    Rasnick, D.3    Hehlmann, R.4
  • 73
    • 0005098820 scopus 로고
    • Final report; study no. 560-80, Unpublished report by Haskell Laboratory reviewed in HED document nos. 003744, 004679
    • A.L. Horst, D.F. Krahn, Mutagenicity Evaluation in Salmonella typhimurium, Final report; study no. 560-80, Unpublished report by Haskell Laboratory reviewed in HED document nos. 003744, 004679, 1980.
    • (1980) Mutagenicity Evaluation in Salmonella typhimurium
    • Horst, A.L.1    Krahn, D.F.2
  • 74
    • 0005051663 scopus 로고
    • Final report; study no. 434-81, Unpublished report by Haskell Laboratory, MRID no. 00103119 reviewed in HED document no. 003744
    • D. Krahn, S. Donovan, Mutagenicity Evaluation in Salmonella typhimurium, Final report; study no. 434-81, Unpublished report by Haskell Laboratory, MRID no. 00103119 reviewed in HED document no. 003744, 1981.
    • (1981) Mutagenicity Evaluation in Salmonella typhimurium
    • Krahn, D.1    Donovan, S.2
  • 75
    • 0005012449 scopus 로고
    • Final report; study no. not listed, Unpublished report by Dow Chemical USA; CDL: 248984-B, MRID no. 00123282 reviewed in HED document no. 00003744
    • A. Carere V. Ortali, G. Cardamone, et al., Microbiological Mutagenicity Studies of Pesticides in Virto, Final report; study no. not listed, Unpublished report by Dow Chemical USA; CDL: 248984-B, MRID no. 00123282 reviewed in HED document no. 00003744, 1981.
    • (1981) Microbiological Mutagenicity Studies of Pesticides in Virto
    • Carere, A.1    Ortali, V.2    Cardamone, G.3
  • 78
    • 0005012451 scopus 로고
    • Final report; study no. 438-80, Unpublished report by Haskell Laboratory, MRID no. 00038808 reviewed in HED document no. 004679
    • K. Fitzpatrick, D.F. Krahn, Chinese Hamster Ovary Cell Assay for Mutagenicity, Final report; study no. 438-80, Unpublished report by Haskell Laboratory, MRID no. 00038808 reviewed in HED document no. 004679, 1980.
    • (1980) Chinese Hamster Ovary Cell Assay for Mutagenicity
    • Fitzpatrick, K.1    Krahn, D.F.2
  • 79
    • 0005017413 scopus 로고
    • Final report; study no. IET 88-0043, Unpublished report by Institute of Environmental Toxicology, MRID no. 41184601 reviewed in HED document no. 007649
    • Y. Sasaki, Benomyl: In Vitro Cytogenetic Test, Final report; study no. IET 88-0043, Unpublished report by Institute of Environmental Toxicology, MRID no. 41184601 reviewed in HED document no. 007649, 1988.
    • (1988) Benomyl: In Vitro Cytogenetic Test
    • Sasaki, Y.1
  • 81
    • 0003913690 scopus 로고
    • Final report; study no. IET 89-0046, Unpublished report by Institute of Environmental Toxicology, MRID no. 41607902 reviewed in HED document no. 010723
    • Y. Sasaki, Benomyl: Micronucleus Test in Mice, Final report; study no. IET 89-0046, Unpublished report by Institute of Environmental Toxicology, MRID no. 41607902 reviewed in HED document no. 010723, 1990.
    • (1990) Benomyl: Micronucleus Test in Mice
    • Sasaki, Y.1
  • 82
    • 0005051014 scopus 로고
    • Final report no. 8925-001:401-90:550, Unpublished report by E.I. DuPont de Nemours and Company, MRID no. 41607901 reviewed in HED document no. 010723
    • R. Stahl, In Vivo Evaluation of [INT-1991-259] for Chromosome Aberrations in Mouse Bone Marrow, Final report no. 8925-001:401-90:550, Unpublished report by E.I. DuPont de Nemours and Company, MRID no. 41607901 reviewed in HED document no. 010723, 1990.
    • (1990) In Vivo Evaluation of [INT-1991-259] for Chromosome Aberrations in Mouse Bone Marrow
    • Stahl, R.1
  • 83
    • 0020440562 scopus 로고
    • Benomyl - An investigation of its mutagenic effect in bacteriophage T4D
    • Kvelland I. Benomyl - an investigation of its mutagenic effect in bacteriophage T4D. Hereditas. 97:1982;307-309.
    • (1982) Hereditas , vol.97 , pp. 307-309
    • Kvelland, I.1
  • 85
    • 0020681292 scopus 로고
    • Further mutagenicity studies on pesticides in bacterial reversion assay systems
    • Moriya M., Ohta T., Watanabe K., Miyazawa T., Kato K., Shirasu Y. Further mutagenicity studies on pesticides in bacterial reversion assay systems. Mutat. Res. 116:1983;185-216.
    • (1983) Mutat. Res. , vol.116 , pp. 185-216
    • Moriya, M.1    Ohta, T.2    Watanabe, K.3    Miyazawa, T.4    Kato, K.5    Shirasu, Y.6
  • 86
    • 0020368633 scopus 로고
    • Significance of plant metabolism in the mutagenicity and toxicity of pesticides
    • Wildeman A.G., Nazar R.N. Significance of plant metabolism in the mutagenicity and toxicity of pesticides. Can. J. Genet. Cytol. 24:1982;437-449.
    • (1982) Can. J. Genet. Cytol. , vol.24 , pp. 437-449
    • Wildeman, A.G.1    Nazar, R.N.2
  • 87
    • 0018179951 scopus 로고
    • Mutagenicity testing of benomyl, methyl-2-benzimidazole carbamate, streptozotocin and N-methyl-N′-nitro-N-nitrosoguanidine in Salmonella typhimurium in vitro and in rodent host-mediated assays
    • Ficsor G., Bordas S., Stewart S.J. Mutagenicity testing of benomyl, methyl-2-benzimidazole carbamate, streptozotocin and N-methyl-N′-nitro-N-nitrosoguanidine in Salmonella typhimurium in vitro and in rodent host-mediated assays. Mutat. Res. 51:1978;151-164.
    • (1978) Mutat. Res. , vol.51 , pp. 151-164
    • Ficsor, G.1    Bordas, S.2    Stewart, S.J.3
  • 89
    • 0028065966 scopus 로고
    • Evaluation of carbendazim for gene mutations in the Salmonella/Ames plate-incorporation assay: The role of aminophenazine impurities
    • Sarrif A.M., Arce G.T., Krahn D.F., O'Neil R.M., Reynolds V.L. Evaluation of carbendazim for gene mutations in the Salmonella/Ames plate-incorporation assay: the role of aminophenazine impurities. Mutat. Res. 321:1994;43-56.
    • (1994) Mutat. Res. , vol.321 , pp. 43-56
    • Sarrif, A.M.1    Arce, G.T.2    Krahn, D.F.3    O'Neil, R.M.4    Reynolds, V.L.5
  • 90
    • 0015925309 scopus 로고
    • A survey on the mutagenicity of various pesticides
    • Seiler J.P. A survey on the mutagenicity of various pesticides. Experientia. 29:1973;622-623.
    • (1973) Experientia , vol.29 , pp. 622-623
    • Seiler, J.P.1
  • 93
    • 0019239447 scopus 로고
    • Mutagenicity of pesticides evaluated by means of gene-conversion in Saccharomyces cerevisiae and in Aspergillus nidulans
    • de Bertoldi M., Griselli M., Giovannetti M., Barale R. Mutagenicity of pesticides evaluated by means of gene-conversion in Saccharomyces cerevisiae and in Aspergillus nidulans. Environ. Mutagen. 2:1980;359-370.
    • (1980) Environ. Mutagen. , vol.2 , pp. 359-370
    • De Bertoldi, M.1    Griselli, M.2    Giovannetti, M.3    Barale, R.4
  • 95
    • 0027975855 scopus 로고
    • Genotoxicity assay of five pesticides and their mixtures in Saccharomyces cerevisiae D7
    • Bianchi L., Zannoli A., Pizzala R., Stivala L.A., Chiesara E. Genotoxicity assay of five pesticides and their mixtures in Saccharomyces cerevisiae D7. Mutat. Res. 321:1994;203-211.
    • (1994) Mutat. Res. , vol.321 , pp. 203-211
    • Bianchi, L.1    Zannoli, A.2    Pizzala, R.3    Stivala, L.A.4    Chiesara, E.5
  • 96
    • 0020322126 scopus 로고
    • Meiotic diploid progeny and meiotic non-disjunction in Saccharomyces cerevisiae
    • Sora S., Lucchini G., Magni G.E. Meiotic diploid progeny and meiotic non-disjunction in Saccharomyces cerevisiae. Genetics. 101:1982;17-33.
    • (1982) Genetics , vol.101 , pp. 17-33
    • Sora, S.1    Lucchini, G.2    Magni, G.E.3
  • 97
    • 0005014154 scopus 로고
    • Lethal and genetic effects of the systemic fungicide benomyl on Saccharomyces cerevisiae
    • Bandas E.L. Lethal and genetic effects of the systemic fungicide benomyl on Saccharomyces cerevisiae. Soviet Genet. 15:1979;883-884.
    • (1979) Soviet Genet. , vol.15 , pp. 883-884
    • Bandas, E.L.1
  • 98
    • 0001117346 scopus 로고
    • Induced sectoring in diploid Aspergillus nidulans as a criterion of fungitoxicity by interference with hereditary processes
    • Georgopoulos S.G., Kappas A., Hastie A.C. Induced sectoring in diploid Aspergillus nidulans as a criterion of fungitoxicity by interference with hereditary processes. Phytopathology. 66:1976;217-220.
    • (1976) Phytopathology , vol.66 , pp. 217-220
    • Georgopoulos, S.G.1    Kappas, A.2    Hastie, A.C.3
  • 99
    • 0011155368 scopus 로고
    • The genotoxicity of benomyl
    • Kappas A. The genotoxicity of benomyl. Prog. Mutat. Res. 2:1981;59-67.
    • (1981) Prog. Mutat. Res. , vol.2 , pp. 59-67
    • Kappas, A.1
  • 100
    • 0018975635 scopus 로고
    • Different test systems in Aspergillus nidulans for the evaluation of mitotic gene conversion, crossing-over and non-disjunction
    • de Bertoldi M., Griselli M., Barale R. Different test systems in Aspergillus nidulans for the evaluation of mitotic gene conversion, crossing-over and non-disjunction. Mutat. Res. 74:1980;303-324.
    • (1980) Mutat. Res. , vol.74 , pp. 303-324
    • De Bertoldi, M.1    Griselli, M.2    Barale, R.3
  • 101
    • 0017749634 scopus 로고
    • Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans
    • Bignami M., Aulicino F., Velcich A., Carere A., Morpurgo G. Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans. Mutat. Res. 46:1977;395-402.
    • (1977) Mutat. Res. , vol.46 , pp. 395-402
    • Bignami, M.1    Aulicino, F.2    Velcich, A.3    Carere, A.4    Morpurgo, G.5
  • 102
    • 0017892918 scopus 로고
    • On the mechanisms of induced somatic recombination by certain fungicides in Aspergillus nidulans
    • Kappas A. On the mechanisms of induced somatic recombination by certain fungicides in Aspergillus nidulans. Mutat. Res. 51:1978;189-197.
    • (1978) Mutat. Res. , vol.51 , pp. 189-197
    • Kappas, A.1
  • 103
    • 0005050695 scopus 로고
    • Mutation induction by benomyl in Saccharomyces cerevisiae
    • Gunasekaran P., Tauro P. Mutation induction by benomyl in Saccharomyces cerevisiae. Curr. Sci. 51:1982;469-470.
    • (1982) Curr. Sci. , vol.51 , pp. 469-470
    • Gunasekaran, P.1    Tauro, P.2
  • 104
    • 0019365065 scopus 로고
    • Induction of point mutations by benomyl in DNA-repair-deficient Aspergillus nidulans
    • Kappas A., Bridges B.A. Induction of point mutations by benomyl in DNA-repair-deficient Aspergillus nidulans. Mutat. Res. 91:1981;115-118.
    • (1981) Mutat. Res. , vol.91 , pp. 115-118
    • Kappas, A.1    Bridges, B.A.2
  • 105
    • 0023931146 scopus 로고
    • Effect of treatment medium on induction of aneuploidy by nocodazole in Saccharomyces cerevisiae
    • Taylor-Mayer R.E., Mayer V.W., Goin C.J. Effect of treatment medium on induction of aneuploidy by nocodazole in Saccharomyces cerevisiae. Environ. Mol. Mutagen. 11:1988;323-331.
    • (1988) Environ. Mol. Mutagen. , vol.11 , pp. 323-331
    • Taylor-Mayer, R.E.1    Mayer, V.W.2    Goin, C.J.3
  • 107
    • 0025736440 scopus 로고
    • Reevaluation of the nine compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae
    • Albertini S. Reevaluation of the nine compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae. Mutat. Res. 260:1991;165-180.
    • (1991) Mutat. Res. , vol.260 , pp. 165-180
    • Albertini, S.1
  • 109
    • 0021144972 scopus 로고
    • Induction of somatic segregation by halogenated aliphatic hydrocarbons in Aspergillus nidulans
    • Crebelli R., Conti G., Conti L., Carere A. Induction of somatic segregation by halogenated aliphatic hydrocarbons in Aspergillus nidulans. Mutat. Res. 138:1984;33-38.
    • (1984) Mutat. Res. , vol.138 , pp. 33-38
    • Crebelli, R.1    Conti, G.2    Conti, L.3    Carere, A.4
  • 110
    • 0020471088 scopus 로고
    • Cytogenetic hazards from agricultural chemicals. IV. Sequential screening in the barley progeny test for cytogenetic activity of some systemic fungicides and a metabolite
    • Behera B.N., Sahu R.K., Sharma C.B.S.R. Cytogenetic hazards from agricultural chemicals. IV. Sequential screening in the barley progeny test for cytogenetic activity of some systemic fungicides and a metabolite. Toxicol. Lett. 10:1982;195-203.
    • (1982) Toxicol. Lett. , vol.10 , pp. 195-203
    • Behera, B.N.1    Sahu, R.K.2    Sharma, C.B.S.R.3
  • 111
    • 0005051668 scopus 로고
    • Cytogenetic effects from agricultural chemicals. V. Clastogenic effects of some benzimidazole fungicides on root meristems
    • Sahu R.K., Behera B.N., Sharma C.B.S.R. Cytogenetic effects from agricultural chemicals. V. Clastogenic effects of some benzimidazole fungicides on root meristems. Environ. Exp. Bot. 23:1983;79-83.
    • (1983) Environ. Exp. Bot. , vol.23 , pp. 79-83
    • Sahu, R.K.1    Behera, B.N.2    Sharma, C.B.S.R.3
  • 112
    • 0002605428 scopus 로고
    • Cytogenetic effects of Benlate fungicide on Allium cepa and Secale cereale
    • Boyle W.S. Cytogenetic effects of Benlate fungicide on Allium cepa and Secale cereale. J. Hered. 64:1973;49-50.
    • (1973) J. Hered. , vol.64 , pp. 49-50
    • Boyle, W.S.1
  • 113
    • 0000426393 scopus 로고
    • Benomyl-induced mitotic disturbances in Hordeum vulgare
    • Nicoloff H., Kappas A. Benomyl-induced mitotic disturbances in Hordeum vulgare. Mutat. Res. 189:1987;271-275.
    • (1987) Mutat. Res. , vol.189 , pp. 271-275
    • Nicoloff, H.1    Kappas, A.2
  • 114
    • 0016699012 scopus 로고
    • Cytogenetic activity of some common fungicides in higher plants
    • Zutshi U., Kaul B.L. Cytogenetic activity of some common fungicides in higher plants. Cytobios. 12:1975;61-67.
    • (1975) Cytobios , vol.12 , pp. 61-67
    • Zutshi, U.1    Kaul, B.L.2
  • 115
    • 0019775855 scopus 로고
    • Studies on genetical effect of pesticides in Drosophila melanogaster
    • Paradi E., Lovenyak M. Studies on genetical effect of pesticides in Drosophila melanogaster. Acta Biol. Acad. Sci. Hung. 32:1981;119-122.
    • (1981) Acta Biol. Acad. Sci. Hung. , vol.32 , pp. 119-122
    • Paradi, E.1    Lovenyak, M.2
  • 116
    • 0018966271 scopus 로고
    • An investigation of some genetic toxicological effects of the fungicide benomyl
    • Lamb M.J., Lilly L.J. An investigation of some genetic toxicological effects of the fungicide benomyl. Toxicology. 17:1980;83-95.
    • (1980) Toxicology , vol.17 , pp. 83-95
    • Lamb, M.J.1    Lilly, L.J.2
  • 118
    • 0024350940 scopus 로고
    • Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: A new and rapid assay for identifying aneuploidy-inducing agents
    • Eastmond D.A., Tucker J.D. Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: a new and rapid assay for identifying aneuploidy-inducing agents. Mutat. Res. 224:1989;517-525.
    • (1989) Mutat. Res. , vol.224 , pp. 517-525
    • Eastmond, D.A.1    Tucker, J.D.2
  • 119
    • 0024388827 scopus 로고
    • Micronuclei, kinetochores and hypoploidy: Tests with some agents
    • Sternes K.L., Baldev K.V. Micronuclei, kinetochores and hypoploidy: tests with some agents. Mutagenesis. 4:1989;425-431.
    • (1989) Mutagenesis , vol.4 , pp. 425-431
    • Sternes, K.L.1    Baldev, K.V.2
  • 120
    • 0028178273 scopus 로고
    • Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture
    • Piatti E., Marabini L., Chiesara E. Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture. Mutat. Res. 324:1994;59-64.
    • (1994) Mutat. Res. , vol.324 , pp. 59-64
    • Piatti, E.1    Marabini, L.2    Chiesara, E.3
  • 121
    • 0024216379 scopus 로고
    • A monochromosomal hybrid cell assay for evaluating the genotoxicity of environmental chemicals
    • Sandhu S.S., Gudi R.D., Athwal R.S. A monochromosomal hybrid cell assay for evaluating the genotoxicity of environmental chemicals. Cell Biol. Toxicol. 4:1988;495-506.
    • (1988) Cell Biol. Toxicol. , vol.4 , pp. 495-506
    • Sandhu, S.S.1    Gudi, R.D.2    Athwal, R.S.3
  • 122
    • 0023118815 scopus 로고
    • Analysis by BrUdR-labelling technique of induced aneuploidy in mammalian cells in culture
    • Rainaldi G., Flori L., Colella C.M., Mariani T., Piras A., Simi S., Simili M. Analysis by BrUdR-labelling technique of induced aneuploidy in mammalian cells in culture. Mutat. Res. 177:1987;255-260.
    • (1987) Mutat. Res. , vol.177 , pp. 255-260
    • Rainaldi, G.1    Flori, L.2    Colella, C.M.3    Mariani, T.4    Piras, A.5    Simi, S.6    Simili, M.7
  • 123
    • 0025094463 scopus 로고
    • Use of a cell hybrid test system to demonstrate that benomyl induces aneuploidy and polyploidy
    • Zelesco P.A., Barbieri I., Marshall Graves J.A. Use of a cell hybrid test system to demonstrate that benomyl induces aneuploidy and polyploidy. Mutat. Res. 242:1990;329-335.
    • (1990) Mutat. Res. , vol.242 , pp. 329-335
    • Zelesco, P.A.1    Barbieri, I.2    Marshall Graves, J.A.3
  • 124
    • 0028922325 scopus 로고
    • Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo (SHE) cell transformation assay
    • Gibson D.P., Aardema M.J., Kerckaert G.A., Carr G.J., Brauninger R.M., LeBoeuf R.A. Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo (SHE) cell transformation assay. Mutat. Res. 343:1995;7-24.
    • (1995) Mutat. Res. , vol.343 , pp. 7-24
    • Gibson, D.P.1    Aardema, M.J.2    Kerckaert, G.A.3    Carr, G.J.4    Brauninger, R.M.5    LeBoeuf, R.A.6
  • 125
    • 0026779031 scopus 로고
    • Sister chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture
    • Dolara P., Salvadori M., Capobianco T., Torricelli F. Sister chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture. Mutat. Res. 283:1992;113-118.
    • (1992) Mutat. Res. , vol.283 , pp. 113-118
    • Dolara, P.1    Salvadori, M.2    Capobianco, T.3    Torricelli, F.4
  • 126
    • 0030955904 scopus 로고    scopus 로고
    • Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations
    • Bianchi-Santamaria A., Gobbi M., Cembran M., Arnaboldi A. Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations. Mutat. Res. 388:1997;27-32.
    • (1997) Mutat. Res. , vol.388 , pp. 27-32
    • Bianchi-Santamaria, A.1    Gobbi, M.2    Cembran, M.3    Arnaboldi, A.4
  • 127
    • 0005097291 scopus 로고
    • Investigation of the cytogenetic action of the pesticides captan and benomyl in a culture of human peripheral blood lymphocytes in the absence and in the presence of a system of metabolic activation
    • Pilinskaya M.A. Investigation of the cytogenetic action of the pesticides captan and benomyl in a culture of human peripheral blood lymphocytes in the absence and in the presence of a system of metabolic activation. Tsitol. Genet. 17:1983;29-33.
    • (1983) Tsitol. Genet. , vol.17 , pp. 29-33
    • Pilinskaya, M.A.1
  • 128
    • 0017142494 scopus 로고
    • The mutagenicity of benzimidazole and benzimidazole derivatives. VI. Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster
    • Seiler J.P. The mutagenicity of benzimidazole and benzimidazole derivatives. VI. Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster. Mutat. Res. 40:1976;339-348.
    • (1976) Mutat. Res. , vol.40 , pp. 339-348
    • Seiler, J.P.1
  • 129
    • 0024516795 scopus 로고
    • Aneuploidy assays on interphase nuclei by means of in situ hybridization with DNA probes
    • Raimondi E., Scariolo S., De Sario A., De Carli L. Aneuploidy assays on interphase nuclei by means of in situ hybridization with DNA probes. Mutagenesis. 4:1989;165-169.
    • (1989) Mutagenesis , vol.4 , pp. 165-169
    • Raimondi, E.1    Scariolo, S.2    De Sario, A.3    De Carli, L.4
  • 130
    • 0020565321 scopus 로고
    • Double Y as an indicator in a test of mitotic non-disjunction in cultured human lymphocytes
    • Tenchini M.L., Mottura A., Velicogna M., Pessina M., Rainaldi G., De Carli L. Double Y as an indicator in a test of mitotic non-disjunction in cultured human lymphocytes. Mutat. Res. 121:1983;139-146.
    • (1983) Mutat. Res. , vol.121 , pp. 139-146
    • Tenchini, M.L.1    Mottura, A.2    Velicogna, M.3    Pessina, M.4    Rainaldi, G.5    De Carli, L.6
  • 131
    • 0033984316 scopus 로고    scopus 로고
    • Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization
    • Bentley K.S., Kirkland D., Murphy M., Marshall R. Evaluation of thresholds for benomyl- and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization. Mutat. Res. 464:2000;41-51.
    • (2000) Mutat. Res. , vol.464 , pp. 41-51
    • Bentley, K.S.1    Kirkland, D.2    Murphy, M.3    Marshall, R.4
  • 134
    • 0023685078 scopus 로고
    • Genotoxic effects of some systemic pesticides: In vivo chromosomal aberrations in bone marrow cells in rats
    • Adhikari N., Grover I.S. Genotoxic effects of some systemic pesticides: in vivo chromosomal aberrations in bone marrow cells in rats. Environ. Mol. Mutagen. 12:1988;235-242.
    • (1988) Environ. Mol. Mutagen. , vol.12 , pp. 235-242
    • Adhikari, N.1    Grover, I.S.2
  • 135
    • 0005051016 scopus 로고
    • Preliminary evaluation of the cytogenetic activity and potential mutagenic hazard of 22 pesticides
    • Pilinskaya M.A., Kurinyi A.I., L'vova T.S., German I.V. Preliminary evaluation of the cytogenetic activity and potential mutagenic hazard of 22 pesticides. Cytol. Genet. 14:1980;38-43.
    • (1980) Cytol. Genet. , vol.14 , pp. 38-43
    • Pilinskaya, M.A.1    Kurinyi, A.I.2    L'vova, T.S.3    German, I.V.4
  • 136
    • 0026695195 scopus 로고
    • Benomyl-induced aneuploidy in mouse oocytes
    • Mailhes J.B., Aardema M.J. Benomyl-induced aneuploidy in mouse oocytes. Mutagenesis. 7:1992;303-309.
    • (1992) Mutagenesis , vol.7 , pp. 303-309
    • Mailhes, J.B.1    Aardema, M.J.2
  • 137
    • 0020579746 scopus 로고
    • Reproductive toxicity of methyl-1-(butylcarbamoyl)-2-benzimidazole
    • Barnes T.B., Verlangieri A.J., Wilson M.C. Reproductive toxicity of methyl-1-(butylcarbamoyl)-2-benzimidazole. Toxicology. 28:1983;103-115.
    • (1983) Toxicology , vol.28 , pp. 103-115
    • Barnes, T.B.1    Verlangieri, A.J.2    Wilson, M.C.3
  • 138
    • 0016735216 scopus 로고
    • Reproduction, teratogenic, and mutagenic studies with benomyl
    • Sherman H., Culik R., Jackson R.A. Reproduction, teratogenic, and mutagenic studies with benomyl. Toxicol. Appl. Pharmacol. 32:1975;305-315.
    • (1975) Toxicol. Appl. Pharmacol. , vol.32 , pp. 305-315
    • Sherman, H.1    Culik, R.2    Jackson, R.A.3
  • 139
    • 0020665016 scopus 로고
    • An assessment of the potential testicular toxicity of 10 pesticides using the mouse-sperm morphology assay
    • Osterloh J., Letz G., Pond S., Becker C. An assessment of the potential testicular toxicity of 10 pesticides using the mouse-sperm morphology assay. Mutat. Res. 116:1983;407-415.
    • (1983) Mutat. Res. , vol.116 , pp. 407-415
    • Osterloh, J.1    Letz, G.2    Pond, S.3    Becker, C.4
  • 140
    • 0005024688 scopus 로고
    • Final report; study no. not listed, Unpublished report by Institute on Environmental Toxicology, MRID no. 00154670 reviewed in HED document no. 005531
    • Y. Shirasu, M. Moriya, K. Watanabe, Mutagenicity Testing on Fungicide 1991 Metabolite (MBC) in Microbial Systems, Final report; study no. not listed, Unpublished report by Institute on Environmental Toxicology, MRID no. 00154670 reviewed in HED document no. 005531, 1977.
    • (1977) Mutagenicity Testing on Fungicide 1991 Metabolite (MBC) in Microbial Systems
    • Shirasu, Y.1    Moriya, M.2    Watanabe, K.3
  • 141
    • 0005046112 scopus 로고
    • Final report; study no. 290-83, Unpublished report by Haskell Laboratory, MRID no. 00154668 reviewed in HED document no. 005531
    • G. Arce, Mutagenicity Evaluation in Salmonella typhimurium, Final report; study no. 290-83, Unpublished report by Haskell Laboratory, MRID no. 00154668 reviewed in HED document no. 005531, 1983.
    • (1983) Mutagenicity Evaluation in Salmonella typhimurium
    • Arce, G.1
  • 142
    • 0005046112 scopus 로고
    • Final report; study no. 291-83, Unpublished report by Haskell Laboratory, MRID no. 00154669 reviewed in HED document no. 005531
    • G.T. Arce, A.M. Sarrif, Mutagenicity evaluation in Salmonella typhimurium, Final report; study no. 291-83, Unpublished report by Haskell Laboratory, MRID no. 00154669 reviewed in HED document no. 005531, 1983.
    • (1983) Mutagenicity Evaluation in Salmonella typhimurium
    • Arce, G.T.1    Sarrif, A.M.2
  • 145
    • 0005046112 scopus 로고
    • Final report; study no. 179-83, Unpublished report by Haskell Laboratory, MRID no. 00154753 reviewed in HED document no. 005531
    • J.F. Russell, G.T. Arce, A.M. Sarrif, Mutagenicity Evaluation in Salmonella typhimurium, Final report; study no. 179-83, Unpublished report by Haskell Laboratory, MRID no. 00154753 reviewed in HED document no. 005531, 1983.
    • (1983) Mutagenicity Evaluation in Salmonella typhimurium
    • Russell, J.F.1    Arce, G.T.2    Sarrif, A.M.3
  • 149
    • 0005068436 scopus 로고
    • Final report; study no. 660-80, Unpublished report by Haskell Laboratory, MRID no. 00154671 reviewed in HED document nos. 003744, 005531
    • J.C. Waterer, D.F. Krahn, Chinese Hamster Ovary Cell Assay for Mutagenicity, Final report; study no. 660-80, Unpublished report by Haskell Laboratory, MRID no. 00154671 reviewed in HED document nos. 003744, 005531, 1980.
    • (1980) Chinese Hamster Ovary Cell Assay for Mutagenicity
    • Waterer, J.C.1    Krahn, D.F.2
  • 150
    • 0005041334 scopus 로고
    • Final report; study no. LSU-7558, Unpublished report by SRI International, MRID no. 00154673 reviewed in HED document nos. 004679, 005531
    • +/-, Final report; study no. LSU-7558, Unpublished report by SRI International, MRID no. 00154673 reviewed in HED document nos. 004679, 005531, 1980.
    • (1980) +/-
    • Jotz, M.M.1    Rundle, D.D.2    Mitchell, A.D.3
  • 152
    • 0005015687 scopus 로고
    • Final report; study no. T8791.337:BD-049-89:89023, Unpublished report by Microbiological Associates, MRID no. 43205505 reviewed in HED document no. 011116
    • D. Putman, M. Morris, Chromosome Aberrations in Chinese Hamster Ovary (CHO) Cells with BCM Technical, Final report; study no. T8791.337:BD-049-89:89023, Unpublished report by Microbiological Associates, MRID no. 43205505 reviewed in HED document no. 011116, 1990.
    • (1990) Chromosome Aberrations in Chinese Hamster Ovary (CHO) Cells with BCM Technical
    • Putman, D.1    Morris, D.2
  • 154
    • 0017142494 scopus 로고
    • The mutagenicity of benzimidazole and benzimidazole derivatives VI Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster, MRID no. 41051510 reviewed in HED document no. 004679
    • Seiler J.P. The mutagenicity of benzimidazole and benzimidazole derivatives VI Cytogenetic effects of benzimidazole derivatives in the bone marrow of the mouse and the Chinese hamster, MRID no. 41051510 reviewed in HED document no. 004679. Mutat. Res. 40:1976;339-348.
    • (1976) Mutat. Res. , vol.40 , pp. 339-348
    • Seiler, J.P.1
  • 156
    • 0024327006 scopus 로고
    • Influence of different factors on the induction of chromosome malsegregation in Saccharomyces cerevisiae D61.M by bavistan and assessment of its genotoxic property in the Ames test and in Saccharomyces cerevisiae D7
    • Albertini S. Influence of different factors on the induction of chromosome malsegregation in Saccharomyces cerevisiae D61.M by bavistan and assessment of its genotoxic property in the Ames test and in Saccharomyces cerevisiae D7. Mutat. Res. 216:1989;327-340.
    • (1989) Mutat. Res. , vol.216 , pp. 327-340
    • Albertini, S.1
  • 157
    • 0023839868 scopus 로고
    • Assessment of the mutagenic potential of a fungicide bavistin using multiple assays
    • Pandita T.K. Assessment of the mutagenic potential of a fungicide bavistin using multiple assays. Mutat. Res. 204:1988;627-643.
    • (1988) Mutat. Res. , vol.204 , pp. 627-643
    • Pandita, T.K.1
  • 158
    • 0025008357 scopus 로고
    • The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: Effects of methyl benzimidazol-2-ylcarbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate
    • Whittaker S.G., Moser S.F., Maloney D.H., Piegorsch W.W., Resnick M.A., Fogel S. The detection of mitotic and meiotic chromosome gain in the yeast Saccharomyces cerevisiae: effects of methyl benzimidazol-2-ylcarbamate, methyl methanesulfonate, ethyl methanesulfonate, dimethyl sulfoxide, propionitrile and cyclophosphamide monohydrate. Mutat. Res. 242:1990;231-258.
    • (1990) Mutat. Res. , vol.242 , pp. 231-258
    • Whittaker, S.G.1    Moser, S.F.2    Maloney, D.H.3    Piegorsch, W.W.4    Resnick, M.A.5    Fogel, S.6
  • 160
    • 0026086189 scopus 로고
    • Aneuploidy in Drosophila. II. Further validation of the FIX and ZESTE genetic test systems employing female Drosophila melanogaster
    • Osgood C., Zimmering S., Mason J.M. Aneuploidy in Drosophila. II. Further validation of the FIX and ZESTE genetic test systems employing female Drosophila melanogaster. Mutat. Res. 259:1991;147-163.
    • (1991) Mutat. Res. , vol.259 , pp. 147-163
    • Osgood, C.1    Zimmering, S.2    Mason, J.M.3
  • 161
    • 17044462015 scopus 로고    scopus 로고
    • DNA damaging effects of pesticides measured by the single cell gel electrophoresis assay (comet assay) and the chromosomal aberration test, in CHOK1 cells
    • Vigreux C., Poul J.M., Deslandes E., Lebailly P., Godard T., Sichel F., Henry-Amar M., Gauduchon P. DNA damaging effects of pesticides measured by the single cell gel electrophoresis assay (comet assay) and the chromosomal aberration test, in CHOK1 cells. Mutat. Res. 419:1998;79-90.
    • (1998) Mutat. Res. , vol.419 , pp. 79-90
    • Vigreux, C.1    Poul, J.M.2    Deslandes, E.3    Lebailly, P.4    Godard, T.5    Sichel, F.6    Henry-Amar, M.7    Gauduchon, P.8
  • 163
    • 0031885745 scopus 로고    scopus 로고
    • Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay
    • Elhajouji A., Cunha M.K.-V.M. Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay. Mutagenesis. 13:1998;193-198.
    • (1998) Mutagenesis , vol.13 , pp. 193-198
    • Elhajouji, A.1    Cunha, M.K.-V.M.2
  • 164
    • 0031009605 scopus 로고    scopus 로고
    • Assessment of DNA damage induced in vitro by etoposide and two fungicides (cabendazim and chlorothalonil) in human lymphocytes with the comet assay
    • Lebailly P., Vigreux C., Godard T., Sichel F., Bar E., LeTalaer J.Y., Henry-Amar M., Gauduchon P. Assessment of DNA damage induced in vitro by etoposide and two fungicides (cabendazim and chlorothalonil) in human lymphocytes with the comet assay. Mutat. Res. 375:1997;205-217.
    • (1997) Mutat. Res. , vol.375 , pp. 205-217
    • Lebailly, P.1    Vigreux, C.2    Godard, T.3    Sichel, F.4    Bar, E.5    LeTalaer, J.Y.6    Henry-Amar, M.7    Gauduchon, P.8
  • 165
    • 0021794416 scopus 로고
    • Mutagenicity of methyl 2-benzimidazole carbamate, diethylstilbestrol and estradiol: Structural chromosomal aberrations, sister chromatid exchanges, C-mitosis, polyploidies and micronuclei
    • Banduhn N., Obe G. Mutagenicity of methyl 2-benzimidazole carbamate, diethylstilbestrol and estradiol: structural chromosomal aberrations, sister chromatid exchanges, C-mitosis, polyploidies and micronuclei. Mutat. Res. 156:1985;199-218.
    • (1985) Mutat. Res. , vol.156 , pp. 199-218
    • Banduhn, N.1    Obe, G.2
  • 166
    • 0030466741 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization with chromosome-specific centromeric probes: A sensitive method to detect aneuploidy
    • Marshall R.R., Murphy M., Kirkland D.J., Bentley K.S. Fluorescence in situ hybridization with chromosome-specific centromeric probes: a sensitive method to detect aneuploidy. Mutat. Res. 372:1996;233-245.
    • (1996) Mutat. Res. , vol.372 , pp. 233-245
    • Marshall, R.R.1    Murphy, M.2    Kirkland, D.J.3    Bentley, K.S.4
  • 167
    • 0030985954 scopus 로고    scopus 로고
    • Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes
    • Elhajouji A., Tibaldi F., Kirsch-Volders M. Indication for thresholds of chromosome non-disjunction versus chromosome lagging induced by spindle inhibitors in vitro in human lymphocytes. Mutagenesis. 12:1997;133-140.
    • (1997) Mutagenesis , vol.12 , pp. 133-140
    • Elhajouji, A.1    Tibaldi, F.2    Kirsch-Volders, M.3
  • 168
    • 0028854316 scopus 로고
    • Clastogenic and aneugenic effects of three benzimidazole derivatives in the in vitro micronucleus test using human lymphocytes
    • Van Hummelen P., Elhajouji A., Kirsch-Volders M. Clastogenic and aneugenic effects of three benzimidazole derivatives in the in vitro micronucleus test using human lymphocytes. Mutagenesis. 10:1995;23-29.
    • (1995) Mutagenesis , vol.10 , pp. 23-29
    • Van Hummelen, P.1    Elhajouji, A.2    Kirsch-Volders, M.3
  • 169
    • 0029590246 scopus 로고
    • Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes
    • Elhajouji A., Van Hummelen P., Kirsch-Volders M. Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen. 26:1995;292-304.
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 292-304
    • Elhajouji, A.1    Van Hummelen, P.2    Kirsch-Volders, M.3
  • 170
    • 0029067552 scopus 로고
    • Aneugen-induced micronuclei (MN) in human lymphocytes may be discerned using image analysis techniques when cell-cycle stage is taken into account
    • Van Hummelen P., Nusse M., Castelain Ph., Kirsch-Volders M. Aneugen-induced micronuclei (MN) in human lymphocytes may be discerned using image analysis techniques when cell-cycle stage is taken into account. Environ. Mol. Mutagen. 25:1995;269-278.
    • (1995) Environ. Mol. Mutagen. , vol.25 , pp. 269-278
    • Van Hummelen, P.1    Nusse, M.2    Castelain, Ph.3    Kirsch-Volders, M.4
  • 171
    • 0032703152 scopus 로고    scopus 로고
    • Increased frequencies of diploid sperm detected by multicolour FISH after treatment of rats with carbendazim without micronucleus induction in peripheral blood erythrocytes
    • de Stoppelaar J.M., van de Kuil T., Bedaf M., Verharen H.W., Slob W., Mohn G.R., Hoebee B., van Benthem J. Increased frequencies of diploid sperm detected by multicolour FISH after treatment of rats with carbendazim without micronucleus induction in peripheral blood erythrocytes. Mutagenesis. 14:1999;621-631.
    • (1999) Mutagenesis , vol.14 , pp. 621-631
    • De Stoppelaar, J.M.1    Van de Kuil, T.2    Bedaf, M.3    Verharen, H.W.4    Slob, W.5    Mohn, G.R.6    Hoebee, B.7    Van Benthem, J.8
  • 172
    • 0030138439 scopus 로고    scopus 로고
    • Acute exposure of female hamsters to carbendazim (MBC) during meiosis results in aneuploid oocytes with subsequent arrest of embryonic cleavage and implantation
    • Jeffay S.C., Libbus B.L., Barbee R.R., Perreault S.D. Acute exposure of female hamsters to carbendazim (MBC) during meiosis results in aneuploid oocytes with subsequent arrest of embryonic cleavage and implantation. Reprod. Toxicol. 10:1996;183-189.
    • (1996) Reprod. Toxicol. , vol.10 , pp. 183-189
    • Jeffay, S.C.1    Libbus, B.L.2    Barbee, R.R.3    Perreault, S.D.4
  • 173
    • 0028880282 scopus 로고
    • Carbendazim (MBC) disrupts oocyte spindle function and induces aneuploidy in hamsters exposed during fertilization (meiosis II)
    • Zuelke K.A., Perreault S.D. Carbendazim (MBC) disrupts oocyte spindle function and induces aneuploidy in hamsters exposed during fertilization (meiosis II). Mol. Reprod. Dev. 42:1995;200-209.
    • (1995) Mol. Reprod. Dev. , vol.42 , pp. 200-209
    • Zuelke, K.A.1    Perreault, S.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.