Assessment of the performance of the Ames II™ assay: A collaborative study with 19 coded compounds

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 558, Issue 1-2, 2004, Pages 181-197

  Fluckiger Isler S ^a   Baumeister, M ^b   Braun, K ^c   Gervais, V ^d   Hasler Nguyen, N ^e   Reimann, R ^f   Van Gompel, J ^g   Wunderlich, H G ^h   Engelhardt, G ⁱ  

^a Xenometrix   (Switzerland)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^e Department of Toxicology   (Switzerland)

^f BAYER PHARMA AG   (Germany)

^g JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^h UMWELTBUNDESAMT   (Germany)

ⁱ BASF SE   (Germany)

Author keywords

Ames II test; Salmonella mutagenicity test; Validation study

Indexed keywords

2 NAPHTHYLAMINE; 4 NITROQUINOLINE 1 OXIDE; 4,4' METHYLENEBIS(2 CHLOROANILINE); 7,12 DIMETHYLBENZ[A]ANTHRACENE; AMITROLE; ANTHRACENE; AZOXY DERIVATIVE; AZOXYBENZENE; BENZIDINE; BENZO[A]PYRENE; CHLORPROPHAM; CYCLOPHOSPHAMIDE; DIETHYLSTILBESTROL; DIPHENYLNITROSAMINE; METHIONINE; MUTAGENIC AGENT; N (2 FLUORENYL)ACETAMIDE; PYRENE; SUCROSE; TETRAMETHYLBENZIDINE; UNCLASSIFIED DRUG; URETHAN;

ACCURACY; AMES TEST; ANALYTIC METHOD; ARTICLE; BACTERIAL STRAIN; CHEMICAL MUTAGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENOTYPE; INTERMETHOD COMPARISON; METABOLIC ACTIVATION; MUTAGEN TESTING; NONHUMAN; OBSERVER VARIATION; PRIORITY JOURNAL;

SALMONELLA;

EID: 1242339717     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2003.12.001     Document Type: Article

References (7)

1. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Res. 31:1975;217-233.
2. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutation Res. 113:1983;173-215.
3. Gee P., Maron D.M., Ames B.N. Detection and classification of mutagens: a set of base-specific Salmonella tester strains. Proc. Natl. Acad. Sci. U.S.A. 91:1994;11606-11610.
4. Gee P., Sommers C.H., Melick A.S., Gidrol X.M., Todd M.D., Burris R.B., Nelson M.E., Klemm R.C., Zeiger E. Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: the result of a validation study. Mutation Res. 412:1998;115-130.
5. Engelhardt G., Jacob E., Jäckh R. Ames II assay: results of a validation study. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;179.
6. B.A. Bridges, D. MacGregor, E. Zeiger, Summary report on the performance of bacterial mutation assays, in: F.J. de Serres, J. Ashby (Eds.), Progress in Mutation Research, vol. 1, Evaluation of Short-term Tests for Carcinogens, Report of the International Collaborative Program, Elsevier, Amsterdam, The Netherlands, 1981, pp. 49-67.
7. I. Rowland, B. Severn, Mutagenicity of carcinogens and noncarcinogens in the Salmonella/microsome test, in: F.J. de Serres, J. Ashby (Eds.) Progress in Mutation Research, vol. 1, Evaluation of Short-term Tests for Carcinogenesis, Report of the International Collaborative Program, Elsevier, Amsterdam, The Netherlands, 1981, pp. 323-332.