Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins

Journal of Biological Chemistry

Volumn 283, Issue 34, 2008, Pages 23084-23092

  Guo, Ruolin ^a   Yamashita, Motozo ^b   Zhang, Qian ^a   Zhou, Quan ^a   Chen, Di ^a   Reynolds, David G ^a   Awad, Hani A ^a   Yanoso, Laura ^a   Zhao, Lan ^a   Schwarz, Edward M ^a   Zhang, Ying E ^b   Boyce, Brendan F ^a   Xing, Lianping ^a,c  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Dept of Pathology and Laboratory Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICS; COMPUTERIZED TOMOGRAPHY; DEGRADATION; ENZYMES; GLYCOPROTEINS; MACROPHAGES; OSTEOBLASTS; PROTEINS; TUMORS;

BIOMECHANICAL PROPERTIES; BONE FORMATIONS; BONE HISTOMORPHOMETRY; BONE LOSSES; BONE MARROWS; BONE MORPHOGENETIC; BONE MORPHOGENETIC PROTEINS; BONE VOLUMES; CALVARIAL BONES; CHRONIC INFLAMMATORY; CYTOKINE; INFLAMMATORY DISORDERS; LONG BONES; OSTEOBLAST FUNCTIONS; OSTEOBLAST MARKERS; OSTEOCLAST RESORPTIONS; PROTEASOMAL DEGRADATIONS; PROTEASOME INHIBITORS; PROTEIN LEVELS; REGULATORY FACTORS; RHEUMATOID ARTHRITISES; SIGNALING PROTEINS; TRANSGENIC; TUMOR NECROSIS FACTORS; UBIQUITIN; UBIQUITIN LIGASE; UBIQUITINATION; VERTEBRAL BONES;

BONE;

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BONE MORPHOGENETIC PROTEIN; MESSENGER RNA; PROTEASOME; PROTEIN SMURF1; SMAD1 PROTEIN; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; RUNX2 PROTEIN, MOUSE; SMAD1 PROTEIN, MOUSE; SMURF1 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE STRENGTH; CONTROLLED STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENE DELETION; GENETICS; INFLAMMATION; METABOLISM; TRANSGENIC MOUSE;

MUS;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE DELETION; INFLAMMATION; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; OSTEOBLASTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, MESSENGER; SMAD1 PROTEIN; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 53149122891     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709848200     Document Type: Article

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