Runx2(Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth

Journal of Dental Research

Volumn 84, Issue 2, 2005, Pages 138-143

  Wang, X P ^a   Aberg T ^a   James, M J ^a   Levanon, D ^b   Groner, Y ^b   Thesleff, I ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Cleidocranial dysplasia; Deciduous teeth; Permanent teeth; Tooth morphogenesis; Tooth replacement

Indexed keywords

DNA BINDING PROTEIN; RUNX3 PROTEIN, MOUSE; SHH PROTEIN, MOUSE; SIGNAL PEPTIDE; SONIC HEDGEHOG PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR RUNX3; TUMOR PROTEIN;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DECIDUOUS TOOTH; DENTITION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; MANDIBLE; MAXILLA; METABOLISM; MOLAR TOOTH; MOUSE; MOUSE MUTANT; PHYSIOLOGY; PRENATAL DEVELOPMENT; TOOTH DEVELOPMENT; TOOTH FLORA;

ANIMALS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR ALPHA 3 SUBUNIT; DENTITION, PERMANENT; DENTITION, PRIMARY; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MANDIBLE; MAXILLA; MICE; MICE, KNOCKOUT; MOLAR; NEOPLASM PROTEINS; ODONTOGENESIS; TOOTH GERM; TOOTH, DECIDUOUS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 15544385745     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910508400206     Document Type: Article

References (22)

1. Åberg T, Cavender A, Gaikwad JS, Bronckers AL, Wang X, Waltimo-Siren J, et al (2004a). Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem 52:131-139.
2. Åberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, et al. (2004b). Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270:76-93.
3. Cobourne MT, Hardcastle Z, Sharpe PT (2001). Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J Dent Res 80:1974-1979.
4. Cobourne MT, Miletich I, Sharpe PT (2004). Restriction of sonic hedgehog signalling during early tooth development. Development 131:2875-2885.
5. D'Souza RN, Åberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, et al. (1999). Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126:2911-2920.
6. Dassule HR, McMahon AP (1998). Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol 202:215-227.
7. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997). Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754.
8. Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT (1998). Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev 12:2636-2649.
9. Ferguson CA, Tucker AS, Heikinheirao K, Nomura M, Oh P, Li E, et al. (2001). The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development 128:4605-4613.
10. Gritli-Linde A, Bei M, Maas R, Zhang XM, Linde A, McMahon AP (2002). Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129:5323-5337.
11. Jensen BL, Kreiborg S (1990). Development of the dentition in cleidocranial dysplasia. J Oral Pathol Med 19:89-93.
12. Jernvall J, Thesleff I (2000). Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 92:19-29.
13. Kettunen P, Karavanova I, Thesleff I (1998). Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9. Dev Genet 22:374-385.
14. Levanon D, Bettoun D, Harris-Cerruti C, Woolf E, Negreanu V, Eilam R, et al. (2002). The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J 21:3454-3463.
15. Lukinmaa PL, Jensen BL, Thesleff I, Andreasen JO, Kreiborg S (1995). Histological observations of teeth and peridental tissues in cleidocranial dysplasia imply increased activity of odontogenic epithelium and abnormal bone remodeling. J Craniofac Genet Dev Biol 15:212-221.
16. Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, et al. (1997). Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell 89:773-779.
17. Nakamura M, Matzuk MM, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, et al. (2003). Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J 17:497-499.
18. Nanci A (2003). Ten Cate's oral histology: development, structure, and function. 6th rev. ed. St. Louis, MO: Mosby.
19. Peterkova R, Peterka M, Viriot L, Lesot H (2002). Development of the vestigial tooth primordia as part of mouse odontogenesis. Connect Tissue Res 43:120-128.
20. Thesleff I (2003). Developmental biology and building a tooth. Quintessence Int 34:613-620.
21. Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, et al. (1997). Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development 124:4811-4818.
22. Wilkinson D, Green J (1990). In situ hybridization and the three-dimensional reconstruction of serial sections. In: Postimplantation mammalian embryos. Copp AJ, Cole DE, editors. London: Oxford Univ. Press, pp. 155-171.