Phenotypic Changes in Dentition of Runx2 Homozygote-null Mutant Mice

Journal of Histochemistry and Cytochemistry

Volumn 52, Issue 1, 2004, Pages 131-139

  Åberg, Thomas ^a   Cavender, Adriana ^b   Gaikwad, Joel S ^b   Bronckers, Antonius L J J ^c   Wang, Xiuping ^a   Waltimo Sirén, Janna ^a   Thesleff, Irma ^a   D'Souza, Rena N ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Cleft palate; Epithelial mesenchymal interactions; Eyelid opening; Knockout mice; Matrix gene expression; Odontogenesis; Phenotypic analysis; Runx2

Indexed keywords

TRANSCRIPTION FACTOR RUNX2;

AMELOBLAST; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CLEFT PALATE; CLEIDOCRANIAL DYSPLASIA; CLINICAL FEATURE; DENTITION; EMBRYO; EPITHELIUM; EXTRACELLULAR MATRIX; EYELID; GENE EXPRESSION; HOMOZYGOTE; KIDNEY CAPSULE; MESENCHYME; MOLAR TOOTH; MORPHOGENESIS; MOUSE; MOUSE MUTANT; NONHUMAN; ODONTOBLAST; PHENOTYPIC VARIATION; PRIORITY JOURNAL; TOOTH DEVELOPMENT; TOOTH ERUPTION; TOOTH MALFORMATION;

ANIMALIA; MUS MUSCULUS;

EID: 0348048878     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540405200113     Document Type: Article

References (30)

1. Berkowitz EA, Seroogy KB, Schroeder JA, Russell WE, Evans EP, Riedel RF, Phillips HK, et al. (1996) Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. Cell Growth Differ 7:1271-1282
2. Bronckers AL, Engelse MA, Cavender A, Gaikwad J, D'Souza RN (2001) Cell-specific patterns of Cbfa1 mRNA and protein expression in postnatal murine dental tissues. Mech Dev 101:255-258
3. D'Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I (1999) Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126:2911-2920
4. D'Souza RN, Cavender A, Sunavala G, Alvarez J, Ohshima T, Kulkarni AB, MacDougall M (1997) Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. J Bone Miner Res 12:2040-2049
5. Ducy P (2000) Cbfa1: a molecular switch in osteoblast biology. Dev Dyn 219:461-471
6. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/ Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754
7. Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT (1998) Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev 12:2636-2649
8. Hoshi K, Komori T, Ozawa H (1999) Morphological characterization of skeletal cells in Cbfa1-deficient mice. Bone 25:639-651
9. Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M, et al. (1999) Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 214:279-290
10. Karsenty G, Wagner EF (2002) Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2:389-406
11. Kern B, Shen J, Starbuck M, Karsenty G (2000) Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem 276:7101-7107
12. Kim IS, Otto F, Zabel B, Mundlos S (1999) Regulation of chondrocyte differentiation by Cbfa1. Mech Dev 80:159-170
13. Komori T (2000) A fundamental transcription factor for bone and cartilage. Biochem Biophys Res Commun 276:813-816
14. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764
15. Kratochwil K, Dull M, Farinas I, Galceran J, Grosschedl R (1996) Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev 10:1382-1394
16. Kratochwil K, Ghaffari-Tabrizi N, Holzinger I, Harbers K (1993) Restricted expression of Mov13 mutant alpha 1(I) collagen gene in osteoblasts and its consequences for bone development. Dev Dyn 198:273-283
17. Kratochwil K, von der MK, Kollar EJ, Jaenisch R, Mooslehner K, Schwarz M, Haase K, et al. (1989) Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner. Cell 57:807-816
18. Lee SK, Krebsbach PH, Matsuki Y, Nanci A, Yamada KM, Yamada Y (1996) Ameloblastin expression in rat incisors and human tooth germs. Int J Dev Biol 40:1141-1150
19. Metsaranta M, Toman D, de Crombrugghe B, Vuorio E (1991) Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim Biophys Acta 1089:241-243
20. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, et al. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771
21. Qiu M, Bulfone A, Ghattas I, Meneses JJ, Christensen L, Sharpe PT, Presley R, et al. (1997) Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol 185:165-184
22. Smith JM, Sporn MB, Roberts AB, Derynck R, Winkler ME, Gregory H (1985) Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. Nature 315:515-516
23. Sunnarborg SW, Hinkle CL, Stevenson M, Russell WE, Raska CS, Peschon JJ, Castner BJ, et al. (2002) Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem 277:12838-12845
24. Takeda S, Bonnamy JP, Owen MJ, Ducy P, Karsenty G (2001) Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev 15:467-481
25. Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, Sharpe PT (1997) Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development 124:4811-4818
26. Tsuji K, Ito Y, Noda M (1998) Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22:87-92
27. Vainio S, Karavanova I, Jowett A, Thesleff I (1993) Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75:45-58
28. Yamaguchi A, Komori T, Suda T (2000) Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocrine Rev 21:393-411
29. Yamachika E, Tsujigiwa H, Ishiwari Y, Mizukawa N, Nagai N, Sugahara T (2001) Identification of a stop codon mutation in the CBFA1 runt domain from a patient with cleidocranial dysplasia and cleft lip. J Oral Pathol Med 30:381-383
30. Yamashiro T, Aberg T, Levanon D, Groner Y, Thesleff I (2002) Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Gene Express Patterns 2:109-112