Expression of the PEBP2αA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells

Bone

Volumn 22, Issue 2, 1998, Pages 87-92

  Tsuji, K ^a   Ito, Y ^b   Noda, M ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Bone morphogenic protein; Collagen; Gene expression; Osteoblast; Osteocalcin; PEBP2 A AML3 CBFA1

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COLLAGEN TYPE 1; MESSENGER RNA; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN; DNA BINDING PROTEIN; OSTEOGENIC PROTEIN 1; RUNX2 PROTEIN, MOUSE; SIALOGLYCOPROTEIN; SPP1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MESENCHYME CELL; OSTEOBLAST; PHENOTYPE; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; CELL STRAIN 3T3; COMPARATIVE STUDY; DRUG EFFECT; GENETICS; MESODERM; METABOLISM; MOUSE; NORTHERN BLOTTING;

3T3 CELLS; ANIMALS; BLOTTING, NORTHERN; BONE MORPHOGENETIC PROTEINS; COLLAGEN; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; MESODERM; MICE; NEOPLASM PROTEINS; OSTEOBLASTS; OSTEOCALCIN; OSTEOPONTIN; PHENOTYPE; RNA, MESSENGER; SIALOGLYCOPROTEINS; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031594665     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00267-6     Document Type: Article

References (32)

1. Akamatsu Y., Tsukumo S., Kagoshima H., Tsurushita N., Shigesada K. A simple screening for mutant DNA binding proteins Application to murine transcription factor PEBP2α subunit, a founding member of the runt domain protein family . Gene. 185:1997;111-117.
2. Bae S.-C., Yamaguchi-Iwai Y., Ogawa E., Maruyama M., Inuzuka M., Kagoshima H., Shigesada K., Satake M., Ito Y. Isolation of PEBP2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene. 8:1993;809-814.
3. Bae S.-C., Takahashi E., Zhang Y. W., Ogawa E., Shigesada K., Namba Y., Satake M., Ito Y. Cloning, mapping, and expression of PEBP2αC, a third gene encoding the mammalian runt domain. Gene. 159:1995;245-248.
4. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thioglycolate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
5. Ducy P., Zhang R., Geoffroy V., Ridall A. L., Karsenty G. Osf2/Cbfa1 A transcriptional activator of osteoblast differentiation . Cell. 89:1997;747-754.
6. Escalante-Alcalde D., Recillas-Targa F., Hernandez-Garcia D., Castro-Obregon S., Terao M., Garattini E., Covarrubias L. Retinoic acid and methylation cis-regulatory elements control the mouse tissue nonspecific alkaline phosphatase gene expression. Mech Dev. 57:1996;21-32.
7. Hijiya N., Setoguchi M., Matsuura K., Higuchi Y., Akizuki S., Yamamoto S. Cloning and characterization of the human osteopontin gene and its promoter. Biochem J. 303:1994;255-262.
8. Hiraki Y., Inoue H., Sigeno C., Sanma Y., Bentz H., Rosen D. M., Asada A., Suzuki F. Bone morphogenic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitro. J Bone Miner Res. 6:1991;1373-1385.
9. Ito Y. Structural alternations in the transcription factor PEBP2/CBF linked to four different types of leukemia. J Cancer Res Clin Oncol. 122:1996;266-274.
10. Kania M. A., Bonner A. S., Duffy J. B., Gergen J. P. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 4:1990;1701-1713.
11. Katagiri T., Yamaguchi A., Ikeda T., Yoshiki S., Wozney J. M., Rosen V., Wang E. A., Tanaka H., Omura S., Suda T. The nonosteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenic protein-2. Biochem Biophys Res Commun. 172:1990;295-299.
12. Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T., Rosen V., Wozney J. M., Fujisawa-Sehara A., Suda T. Bone morphogenic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol. 127:1994;1755-1766.
13. Komori Y., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R. T., Gao Y.-H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., Kishimoto T. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 89:1997;755-764.
14. Levanon D., Negreanu V., Bernstein Y., Bar-Am I., Avivi L., Groner Y. AML1, AML2, and AML3, the human members of the runt domain gene family cDNA structure, expression, and chromosomal localization . Genomics. 23:1994;425-432.
15. Merriman H. L., van Wijnen A. J., Hiebert S., Bidwell J. P., Fey E., Lian J., Stein J., Stein G. S. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family Interactions with the osteocalcin gene promoter . Biochem. 34:1995;13125-13132.
16. Miyoshi H., Shimizu K., Kozu T., Maseki N., Kaneko Y., Ohki M. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. Proc Natl Acad Sci USA. 88:1991;10431-10434.
17. Ogawa E., Inuzuka M., Maruyama M., Satake M., Naito-Fujimoto M., Ito Y., Shigesada K. Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α Virology. 194:1993;314-331.
18. Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K., Ito Y. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and human AML1 gene. Proc Natl Acad Sci USA. 90:1993;6859-6863.
19. Okuda T., van Deursen J., Hiebert S. W., Grosveld G., Downing J. R. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 84:1996;321-330.
20. Otto F., Thornell A. P., Crompton T., Denzel A., Gilmour K. C., Rosewell I. R., Stamp G. W. H., Beddington R. S. P., Mundlos S., Olsen B. R., Selby P. B., Owen M. J. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 89:1997;765-771.
21. Rossert J. A., Chen S. S., Eberspaecher H., Smith C. N., de Crombrugghe B. Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and binds a protein selectively present in osteoblasts. Proc Natl Acad Sci USA. 93:1996;1027-1031.
22. Sasaki K., Yagi H., Bronson R. T., Tominaga K., Matsunashi T., Deguchi K., Tani Y., Kishimoto T., Komori T. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor β Proc Natl Acad Sci USA. 93:1996;12359-12363.
23. Satake M., Inuzuka M., Shigesada K., Oikawa T., Ito Y. Differential expression of subspecies of polyomavirus enhancer core binding protein, PEBP2, in various hematopoietic cells. Jpn J Cancer Res. 83:1992;714-722.
24. Stein G. S., Lian J. B. Molecular mechanisms mediating developmental and hormone regulated expression of genes in osteoblasts An integrated relationship of cell growth and differentiation . Noda M. Cellular and Molecular Biology of Bone. 1993;47-95 Academic, New York.
25. Suzuki A., Kaneko E., Maeda J., Ueno N. Mesoderm induction by BMP-4 and BMP-7 heterodimers. Biochem Biophys Res Commun. 232:1997;153-156.
26. Takuwa Y., Ohse C., Wang E. A., Wozney J. M., Yamashita K. Bone morphogenic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1. Biochem Biophys Res Commun. 174:1991;96-101.
27. Towler D. A., Bennett C. D., Rodan G. A. Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motif. Mol Endocrinol. 8:1994;614-624.
28. Wang Q., Stacy T., Binder M., Marin-Padilla M., Sharpe A. H., Speck N. A. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci USA. 93:1996;3444-3449.
29. Wang Q., Stacy T., Miller J. D., Lewis A. F., Gu T.-L., Huang X., Bushweller J. H., Bories J.-C., Alt F. W., Ryan G., Liu P. P., Wynshaw-Boris A., Binder M., Marin-Padilla M., Sharpe A. H., Speck N. A. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo. Cell. 87:1996;697-708.
30. Wang S., Wang Q., Crute B. E., Melnikova I. N., Keller S. R., Speck N. A. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 13:1993;3324-3339.
31. Wijmenga C., Speck N. A., Dracopoli N. C., Hofker M. H., Liu P., Collins F. S. Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. Genomics. 26:1995;611-614.
32. Yeageau D. A., Hetherington C. J., Wang Q., Zhang P., Sharpe A. H., Binder M., Marin-Padilla M., Tenen D. G., Speck N. A., Zhang D.-E. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nature Genet. 15:1997;303-306.