Tooth morphogenesis and cell differentiation

Current Opinion in Cell Biology

Volumn 8, Issue 6, 1996, Pages 844-850

  Thesleff, Irma ^a   Nieminen, Pekka ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; CELL DIFFERENTIATION; CELL INTERACTION; ENAMEL; EPITHELIUM; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYME; MORPHOGENESIS; MOUTH MUCOSA; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TOOTH DEVELOPMENT;

ANIMALIA; MAMMALIA; VERTEBRATA;

EID: 0030560840     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(96)80086-X     Document Type: Article

References (53)

1. Ruch JV. Tooth crown morphogenesis and cytodifferentiations: candid questions and critical comments. of special interest Connect Tissue Res. 32:1995;1-8 A thoughtful review on mechanisms of tooth development. Includes also aspects that were left out of our review because of lack of space, such as the early acquisition of 'tooth specificity', and cytodifferentiation of odontoblasts and ameloblasts.
2. Thesleff I, Vaahtokari A, Partanen AM. Regulation of organogenesis. Common molecular mechanism regulating the development of teeth and other organs. Int J Dev Biol. 39:1995;35-50.
3. Ten Cate AR. Oral History: Development, Structure and Function. 1994;Mosby-Year Book, St Louis.
4. Lumsden AG. Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development. 103:1988;155-169. (Suppl).
5. Mina M, Koller EJ. The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium. Arch Oral Biol. 32:1987;123-127.
6. Kollar EJ, Baird GR. Tissue interactions in embryonic mouse tooth germs. II. The inductive role of the dental papilla. J Embr Exp Morphol. 24:1970;173-186.
7. Jernvall J, Kettunen P, Karavanova I, Martin LB, Thesleff I. Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. Int J Dev Biol. 38:1994;463-469.
8. Vaahtokari A, Aberg T, Thesleff I. Apoptosis in the developing tooth - association with an embryonic signaling center and suppression by EGF and FGF-4. of outstanding interest Development. 122:1996;121-129 First description, using Tunel staining and serial paraffin sections, of the occurrence of apoptosis throughout tooth morphogenesis. It is particularly interesting that apoptosis occurs in the enamel knot, and it is suggested that this is the mechanism by which the signaling function of this putative organizing center is terminated. Tissue-recombination experiments show that epithelial - mesenchymal interactions prevent apoptosis at the tissue interface, and that EGF and FGF prevent apoptosis in vitro.
9. Thesleff I, Sahlberg C. Growth factors as inductive signals regulating tooth morphogenesis. Semin Cell Dev Biol. 7:1996;185-193.
10. Thesleff I, Vaahtokari A, Kettunen P, Aberg T. Epithelial - mesenchymal signaling during tooth development. Connect Tissue Res. 32:1995;9-15.
11. Iseki S, Osumiyamashita N, Miyazono K, Franzen P, Ichijo H, Ohtani H, Hayashi Y, Eto K. Localization of transforming growth factor-beta type I and type II receptors in mouse development. Exp Cell Res. 219:1995;339-347.
12. Hellmich HL, Kos L, Cho ES, Mahon CA, Zimmer A. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial - mesenchymal interactions. Mech Dev. 54:1996;95-105.
13. Luukko K, Moshnyakov M, Sainio K, Saarma M, Seriola H, Thesleff I. Expression of neurotrophin receptors during rat tooth development is developmentally regulated, independent of innervation, and suggests functions in the regulation of morphogenesis and innervation. Dev Dyn. 206:1996;87-99.
14. Mitsiadis T, Muramatsu T, Thesleff I. Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial - mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol. 129:1995;267-281.
15. Mitsiadis T, Lardelli M, Lendahl U, Thesleff I. Expression of Notch 1, 2 and 3 is regulated by epithelial - mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J Cell Biol. 130:1995;407-418.
16. Bitgood MJ, McMahon AP. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell - cell interaction in the mouse embryo. of special interest Dev Biol. 172:1995;126-138 The expression of three hh (hedgehog) genes and three Bmp genes is localized during mouse organogenesis. The expression patterns of Indian hedgehog, Desert hedgehog and Shh are not overlapping, and Shh expression is described in epithelial at numerous sites of epithelial - mesenchymal interactions, including the tooth. Bmp-2, Bmp-4 and Bmp-6 are localized at similar sites, suggesting roles for Hh/Bmp interactions in signaling during organogenesis.
17. Iseki S, Araga A, Ohuchi H, Nohno T, Yoshioka H, Hayashi F, Noji S. Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth. of special interest Biochem Biophys Res Commun. 218:1996;688-693 Shh is expressed at many stages of tooth morphogenesis. In teeth and in derivatives of the skin, the expression of Shh is confined to epithelial cells.
18. Vaahtokari A, Åberg T, Jernvall J, Keränen S, Thesleff I. The enamel knot as a signaling center in the developing mouse tooth. of outstanding interest Mech Dev. 54:1996;39-43 Nested patterns of Shh, Bmp-2, Bmp-4 and Bmp-7 expression are described in the enamel knots using a three-dimensional reconstruction of serial sections after in situ hybridization. The suggestion is put forward that the epithelial enamel knots act as signaling or organizing centers regulating tooth shape. This is the first demonstration of putative signaling or organizing centers in epithelial - mesenchymal organs.
19. Vainio S, Karavanova I, Jowett A, Thesleff I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 75:1993;45-58.
20. Kratochwil K, Dull M, Farinas I, Galceran J, Grosschedl R. Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. of outstanding interest Genes Dev. 10:1996;1382-1394 Describes a series of elegant tissue-recombination experiments in which tissues of Lef-1 knockout mouse embryos (which lack teeth and hair) and wild-type mouse embryos were combined to analyze hair and tooth development. It is demonstrated that the requirement for Lef-1 function in the tooth germ is more limited than anticipated from expression patterns. Lef-1 expression is necessary in the early epithelium and its effect is transmitted from epithelium to mesenchyme. During more advanced stages, mutant epithelium was able to form normal teeth, and to differentiate into ameloblasts if combined with wild-type mesenchyme, indicating that Lef-1 function is needed for epithelial morphogenesis but not for cell differentiation.
21. Kettunen P, Thesleff I. FGF-4 stimulates expression of Msx-1 and syndecan-1 in mouse dental mesenchyme. J Dent Res. 75:1996;361.
22. Heikinheimo M, Lawshe A, Shackleford GM, Wilson DB, MacArthur CA. FGF-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev. 48:1994;129-138.
23. Davidson EH. Molecular biology of embryonic development: how far have we come in the last ten years? Bioessays. 16:1994;603-615.
24. Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature. 374:1995;360-363.
25. Matzuk MM, Kumar TR, Vassalli A, Bickenbach JR, Roop DR, Jaenisch R, Bradley A. Functional analysis of activins during mammalian development. Nature. 374:1995;354-356.
26. Tabata MJ, Kim K, Liu JG, Yamashita K, Matsumura T, Kato J, Iwamoto M, Wakisaka S, Matsumoto K, Nakamura T, et al. Hepatocyte growth factor is involved in the morphogenesis of tooth germ in murine molars. Development. 122:1996;1243-1251.
27. Weil M, Itin A, Keshet E. A role for mesenchyme-derived tachykinins in tooth and mammary gland morphogenesis. of special interest Development. 121:1995;2419-2428 An unexpected new role for tachykinins, which are traditionally known as neurotransmitters, has been discovered. Intense expression is seen transiently in dental mesenchyme, and antisense oligonucleotides prevent tooth morphogenesis in vitro. This suggests that tachykinins may act as mesenchymal signals that regulate tooth morphogenesis after the bud stage.
28. Partanen AM, Ekblom P, Thesleff I. Epidermal growth factor inhibits morphogenesis and cell differentiation in cultured mouse embryonic teeth. Dev Biol. 111:1985;84-94.
29. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. of special interest Nature. 376:1995;337-341 The targeted disruption of the EGF receptor gene results in impaired epithelial development of several organs, including the skin, lung and gastrointestinal tract, but tooth development appears to be unaffected. See also [30,31].
30. Sibilia M, Wagner EF. Strain-dependent epithelial defects in mice lacking the EGF receptor. of special interest Science. 269:1995;234-238 See annotation [29].
31. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, Lamantia C, Mourton T, Herrup K, Harris RC, et al. Targeted disruption of mouse EGF receptor - effect of genetic background on mutant phenotype. of special interest Science. 269:1995;230-234 See annotation [29].
32. Kere J, Srivastava AK, Montonen O, Zonana J, Thomas N, Ferguson B, Munoz F, Morgan D, Clarke A, Baybayan P, et al. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. of special interest Nat Genet. 13:1996;409-416 Describes the positional cloning of the human gene that is involved in EDA (anhidrotic ectodermal dysplasia), a condition with impaired development of hair, sweat glands and teeth. The gene codes for a novel transmembrane protein, apparently in type II orientation, with no apparent homology to any previously known gene. The gene contains an exceptionally long intron (of 200 kilobases).
33. Blecher SR, Kapalanga J, Lalonde D. Induction of sweet glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature. 345:1990;542-544.
34. Satokata I, Maas R. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet. 6:1994;348-356.
35. Van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R. Development of several organs that require inductive epithelial - mesenchymal interactions is impaired in Lef-1 deficient mice. Genes Dev. 15:1994;2691-2703.
36. Vastardis H, Karimbux N, Guthua SW, Seidman JG, Seidman CE. A human MSX1 homeodomain missense mutation causes selective both agenesis. of special interest Nat Genet. 13:1996;417-421 Describes the identification of a single nucleotide missense mutation in the homeobox of the human MSX1 gene. All individuals of a large family who had missing teeth (at least eight teeth missing) had this mutation within one copy of the MSX1 gene.
37. Nieminen P, Arte S, Pirinen S, Peltonen L, Thesleff I. Gene defect in hypodontia - exclusion of MSX1 and MSX2 as candidate genes. Hum Genet. 96:1995;305-308.
38. Thesleff I. Two genes for missing teeth. Nat Genet. 13:1996;379-380.
39. Zhou P, Byrne C, Jacobs J, Fuchs E. Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. of outstanding interest Genes Dev. 9:1995;700-713 When Lef-1 was overexpressed in the epithelium of transgenic mouse embryos using a keratin promoter, increased invaginations of epithelium and the formation of extra hair follicles and tooth-like structures resulted. As Lef-1-knock-out mice fail to develop teeth and hair [35], these studies together indicate that Lef-1 expression is positively associated with morphogenesis. As Lef-1 was misexpressed in epithelial cells, this study shows that the epithelium has the capacity to instruct hair and tooth morphogenesis in underlying mesenchyme.
40. Jernvall J. Mammalian molar cusp patterns: developmental mechanisms of diversity. of outstanding interest Acta Zool Fennica. 198:1995;1-61 An excellent review of the evolution and development of mammalian dentition. Includes descriptions of variation of cusp patterns among mammalian species and analysis of enamel knots in different teeth. This is the first attempt to explain how the evolution of mammalian molar tooth cusp patterns is related to changes in regulatory molecular mechanisms.
41. Tickle C. Vertebrate limb development. of special interest Curr Opin Genet Dev. 5:1995;478-484 An excellent review of the molecular regulation of limb development.
42. Koyama E, Yamaai T, Iseki S, Ohuchi H, Nohno T, Yoshioka H, Hayashi Y, Leatherman JL, Golden EB, Noji S, Pacifici M. Polarizing activity, sonic hedgehog, and tooth development in embryonic and postnatal mouse. Dev Dyn. 206:1996;59-72.
43. Marti E, Takada R, Bumcrot DA, Sasaki H, McMahon AP. Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development. 121:1995;2537-2547.
44. Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice - induction of a mouse patched gene by hedgehog. Genes Dev. 10:1996;301-312.
45. Crossley PH, Martinez S, Martin GR. Midbrain development induced by FGF8 in the chick embryo. Nature. 380:1996;66-68.
46. Placzek M, Furley A. Neural development - patterning cascades in the neural tube. Curr Biol. 6:1996;526-529.
47. Dudley AT, Lyons KM, Robertson EJ. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. of special interest Genes Dev. 9:1995;2795-2807 Targeted inactivation of the Bmp-7 gene results in severe defects in the development of some organ systems, including the kidney, eye and skeleton. There is an apparent lack of phenotypic effect in teeth and in many other tissues that naturally express Bmp-7, which may be due to overlapping expression patterns and redundancy among different BMP family members. See also [48].
48. Luo G, Hofmann C, Bronckers ALJJ, Sohocki M, Bradley A, Karsenty G. Bmp-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. of special interest Genes Dev. 9:1995;2808-2820 See annotation [47].
49. Lyons CM, Hogan BLM. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development. 109:1990;833-844.
50. Winnier G, Blessing M, Labosky PA, Hogan BLM. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9:1995;2105-2116.
51. Feldman B, Poueymirou W, Papaioannou VE, DeChiara TM, Goldfarb M. Requirement of FGF-4 for postimplantation mouse development. Science. 267:1995;246-249.
52. Thomas BL, Porteus MH, Rubenstein JL, Sharpe PT. The spatial localization of Dix-2 during tooth development. Connect Tissue Res. 32:1995;27-34.
53. Tissier-Seta JP, Mucchielli ML, Mark M, Mattei MG, Goridis C, Brunet JF. Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach. Mech Dev. 51:1995;3-15.