PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation

Journal of Cell Science

Volumn 122, Issue 9, 2009, Pages 1382-1389

  Zhang, Ming ^a   Xie, Rong ^b   Hou, Wei ^b,c   Wang, Baoli ^b   Shen, Run ^b   Wang, Xiumei ^b   Wang, Qing ^a   Zhu, Tianhui ^a   Jonason, Jennifer H ^b   Chen, Di ^b  

^a NANKAI UNIVERSITY   (China)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Chondrocyte; Cyclin D1; PTHrP; Runx2; Runx3

Indexed keywords

ALANINE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; GLUTAMIC ACID; MYC PROTEIN; PARATHYROID HORMONE RELATED PROTEIN; SERINE; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR RUNX3;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GROWTH PLATE; IN VITRO STUDY; MESENCHYMAL STEM CELL; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; REPORTER GENE; UBIQUITINATION; WILD TYPE;

ANIMALS; CERCOPITHECUS AETHIOPS; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTOR ALPHA 3 SUBUNIT; COS CELLS; CYCLIN D1; DOWN-REGULATION; HUMANS; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; MUTATION; PARATHYROID HORMONE-RELATED PROTEIN; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT FUSION PROTEINS; SERINE; UBIQUITINATION;

MUS;

EID: 67650538541     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.040709     Document Type: Article

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