Scavenging roles of chemokine receptors: Chemokine receptor deficiency is associated with increased levels of ligand In circulation and tissues

Blood

Volumn 112, Issue 2, 2008, Pages 256-263

  Cardona, Astrid E ^a   Sasse, Margaret E ^b   Liu, Liping ^a   Cardona, Sandra M ^c   Mizutani, Makiko ^a   Savarin, Carine ^a   Hu, Taofang ^a   Ransohoff, Richard M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c Northeastern Ohio Medical University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; FRACTALKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; GAMMA INTERFERON INDUCIBLE PROTEIN 10; LIGAND; MONOCYTE CHEMOTACTIC PROTEIN 1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CHEMOKINE RECEPTOR DEFICIENCY; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN SECRETION; ANIMAL; BLOOD; BRAIN LEVEL; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; BRAIN CHEMISTRY; CHEMOKINE CCL2; CHEMOKINE CX3CL1; CHEMOKINE CXCL1; CHEMOKINE CXCL10; CHEMOKINE CXCL2; LIGANDS; MICE; MICE, KNOCKOUT; RECEPTORS, CHEMOKINE;

EID: 47649113481     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-10-118497     Document Type: Article

References (48)

1. Mackay CR. Chemokines: immunology's high impact factors. Nat Immunol. 2001;2:95-101.
2. Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N EnglJ Med. 2006;354:610-621.
3. Niess JH, Brand S, Gu X, et al. CX3GR1 mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005; 307:254-258.
4. Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003:19:71-82.
5. Geissmann F, Cameron TO. Sidobre S. et al. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 2005:3:650-661.
6. Abdi R, Means TK, Ito T, et al. Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J Immunol. 2004;172:767-775.
7. Airoldi I, Raffaghello L, Piovan E, et al. CXCL12 does not attract GXCR4+ human metastatic neuroblastoma cells: clinical implications. Clin Cancer Res. 2006;12:77-82.
8. Albright AV, Martin J, O'Connor M, Gonzalez-Scarano F. Interactions between HIV-1 gp120; chemokines, and cultured adult microglial cells. J Neurovirol. 2001:7:196-207.
9. Alcami A. Viral mimicry of cytokines, chemokines and their receptors. Nat Rev Immunol. 2003:3:36-50.
10. Alt C, Laschinger M, Engelhardt B. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL21 (SLC) at the blood-brain barrier suggests their involvement in G-proteindependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol. 2002; 32:2133-2144.
11. Anthony DC, Blond D, Dempster R, Perry VH. Chemokine targets in acute brain injury and disease. Prog Brain Res. 2001;132:507-524.
12. Tylaska LA, Boring L Weng W, et al. Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine. 2002;18:184-190.
13. Mahad D, Callahan MK, Williams KA, et al. Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis. Brain. 2006;129:212-223.
14. Ransohoff RM, Liu L, Cardona AE. Chemokines and chemokine receptors: multipurpose players in neuroinflammation. Int Rev Neurobiol. 2007; 82:187-204.
15. Huang D, Shi FD, Jung S, et al. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J. 2006;20:896-905.
16. Huang DR, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med. 2001;193:713-726.
17. Russell TD, Yan Q, Fan G, etal. IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1. J Immunol. 2003; 171:6866-6874.
18. Bacon KB. Chemokine receptor signal transduction. In: Ransohoff RM, Suzuki K, Proudfoot AEI, Hickey WF, Harrison JK. eds. Universes in Delicate Balance: Chemokines and the Nervous System. Amsterdam, The Netherlands: Elsevier; 2002:99-118.
19. Bacon K, Baggiolini M. Broxmeyer H, et al. Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res. 2002;22:1067-1068.
20. Mantovani A, Bonecchi R, Locati M. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol. 2006;6:907-918.
21. Mantovani A, Locati M, Vecchi A, Sozzani S, AIlavena P. Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines. Trends Immunol. 2001;22:328-336.
22. Miller LH, Mason SJ, Dvorak JA, McGinniss MH, Rothman IK. Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science. 1975:189:561-563.
23. Neote K, Darbonne W, Ogez J, Horuk R, Schall TJ. Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells. J Biol Chem. 1993;268:12247-12249.
24. Comerford I, Litchfield W, Harata-Lee Y, Nibbs RJ, McGoll SR. Regulation of chemotactic networks by 'atypical' receptors. Bioessays. 2007; 29:237-247.
25. Bonini JA, Martin SK, Dralyuk F, et al. Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3. DNA Cell Biol. 1997;16:1249-1256.
26. Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. J Biol Chem. 1997;272:32078-32083.
27. Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ. Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1 alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997;272:12495-12504.
28. Gosling J, Dairaghi DJ, Wang Y, et al. Cutting edge: identification of a novel chemokine receptor that binds dendritic celland T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000;164:2851-2856.
29. Nibbs RJ, Kriehuber E, Ponath PD, et al. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Am J Pathol. 2001;158:867-877.
30. Fra AM, Locati M, Otero K, et al. Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. J Immunol. 2003;170:2279-2282.
31. Martinez de la Torre Y, Locati M, Buracchi G, et al. Increased inflammation in mice deficient for the chemokine decoy receptor D6. Eur J Immunol. 2005;35:1342-1346.
32. Nibbs RJ, Gilchrist DS, King V, et al. The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J Clin Invest. 2007;117:1884-1892.
33. Borroni EM, Buracchi C, de la Torre YM, et al. The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses. Biochem Soc Trans. 2006;34:1014-1017.
34. Martinez de la TY, Buracchi C, Borroni EM, et al. Protection against inflammationand autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc Natl Acad Sci USA. 2007; 104:2319-2324.
35. Townson JR, Nibbs RJ. Characterization of mouse CCX-CKR, a receptor for the lymphocyteattracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR. Eur J Immunol. 2002;32:1230-1241.
36. Hansell CA, Simpson CV, Nibbs RJ. Chemokine sequestration by atypical chemokine receptors. Biochem Soc Trans. 2006;34:1009-1013.
37. Comerford I, Milasta S, Morrow V, Milligan G, Nibbs R. The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. Eur J Immunol. 2006;36:1904-1916.
38. Neel NF Schutyser E, Sai J, Fan GH, Richmond A. Chemokine receptor internalization and intracellular trafficking. Cytokine Growth Factor Rev. 2005;16:637-658.
39. Wiekowski MT Chen SC, Zalamea P, et al. Disruption of neutrophil migration in a conditional transgenic model: evidence for CXCR2 desensitization in vivo. J Immunol. 2001:167:7102-7110.
40. Mueller A, Kelly E, Strange PG. Pathways for internalization and recycling of the chemokine receptor CCR5. Blood. 2002;99:785-791.
41. Feniger-Barish R, Ran M, Zaslaver A, Ben Baruch A. Differential modes of regulation of cxc chemokine-induced internalization and recycling of human CXCR1 and CXCR2. Cytokine. 1999; 11:996-1009.
42. Mitsias Dl, Kapsogeorgou EK, Moutsopoulos HM. Sjogren's syndrome: why autoimmune epithelitis? Oral Dis. 2006;12:523-532.
43. Cuello C, Palladinetti P, Tedla N, et al. Chemokine expression and leucocyte infiltration in Sjogren's syndrome. Br J Rheumatol. 1998;37:779-783.
44. Sfriso P, Oliviero F, Galabrese F, et al. Epithelial CXCR3-B regulates chemokines bioavailability in normal, but not in Sjogren's syndrome, salivary glands. J Immunol. 2006;176:2581-2589.
45. Ariel A, Fredman G, Sun YP, et al. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol. 2006;7:1209-1216.
46. Mackay CR. Chemokines: what chemokine is that? Curr Biol. 1997;7:R384-R386.
47. Viola A, Luster AD. Chemokines and their receptors: drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol. 2008;48:171-197.
48. Castellani ML, Bhattacharya K, Tagen M, et al. Anti-chemokine therapy for inflammatory diseases. Int J Immunopathol Pharmacol. 2007;20: 447-453.