Fission yeast Tel1ATM and Rad3ATR promote telomere protection and telomerase recruitment

PLoS Genetics

Volumn 5, Issue 8, 2009, Pages

  Moser, Bettina A ^a   Subramanian, Lakxmi ^a   Khair, Lyne ^a   Chang, Ya Ting ^a   Nakamura, Toru M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE RAD3; TELOMERASE; TRANSCRIPTION FACTOR ETV6; CARRIER PROTEIN; CCQ1 PROTEIN, S POMBE; CELL CYCLE PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAD3 PROTEIN, S POMBE; SCHIZOSACCHAROMYCES POMBE PROTEIN; TEL1 PROTEIN, S POMBE; TPZ1 PROTEIN, S POMBE;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME REGULATION; ENZYME SUBUNIT; FISSION YEAST; FUNGAL STRAIN; GENE EXPRESSION REGULATION; GENE LOSS; HOMOLOGOUS RECOMBINATION; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; TELOMERE; ENZYMOLOGY; GENETICS; METABOLISM; SCHIZOSACCHAROMYCES;

ARABIDOPSIS; MAMMALIA; SCHIZOSACCHAROMYCETACEAE;

CARRIER PROTEINS; CELL CYCLE PROTEINS; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERASE; TELOMERE;

EID: 70149121335     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000622     Document Type: Article

References (49)

1. Palm W, de Lange T (2008) How shelterin protects mammalian telomeres. Annu Rev Genet 42: 301-334.
2. Gilson E, Geli V (2007) How telomeres are replicated. Nat Rev Mol Cell Biol 8: 825-838.
3. O'Connor MS, Safari A, Xin H, Liu D, Songyang Z (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci U S A 103: 11874-11879. (Pubitemid 44215779)
4. Denchi EL, de Lange T (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448: 1068-1071.
5. Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, et al. (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445: 506-510. (Pubitemid 46197626)
6. Xin H, Liu D, Wan M, Safari A, Kim H, et al. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445: 559-562. (Pubitemid 46197638)
7. Miyoshi T, Kanoh J, Saito M, Ishikawa F (2008) Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320: 1341-1344. (Pubitemid 351929470)
8. Bianchi A, Shore D (2008) How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex. Mol Cell 31: 153-165. (Pubitemid 352005819)
9. Sabourin M, Zakian VA (2008) ATM-like kinases and regulation of telomerase: lessons from yeast and mammals. Trends Cell Biol 18: 337-346.
10. Ferreira MG, Miller KM, Cooper JP (2004) Indecent exposure: when telomeres become uncapped. Mol Cell 13: 7-18.
11. Kanoh J, Ishikawa F (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr Biol 11: 1624-1630. (Pubitemid 32978530)
12. Chikashige Y, Hiraoka Y (2001) Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr Biol 11: 1618-1623. (Pubitemid 32978529)
13. Miller KM, Rog O, Cooper JP (2006) Semi-conservative DNA replication through telomeres requires Taz1. Nature 440: 824-828.
14. Tomita K, Cooper JP (2008) Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller. Genes Dev 22: 3461-3474.
15. Martin V, Du LL, Rozenzhak S, Russell P (2007) Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci U S A 104: 14038-14043. (Pubitemid 350003331)
16. Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14: 208-214. (Pubitemid 46355575)
17. Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, et al. (2009) Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J 28: 810-820.
18. Song X, Leehy K, Warrington RT, Lamb JC, Surovtseva YV, et al. (2008) STN1 protects chromosome ends in Arabidopsis thaliana. Proc Natl Acad Sci U S A 105: 19815-19820.
19. Naito T, Matsuura A, Ishikawa F (1998) Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat Genet 20: 203-206. (Pubitemid 28455457)
20. Ritchie KB, Mallory JC, Petes TD (1999) Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol 19: 6065-6075.
21. Vespa L, Couvillion M, Spangler E, Shippen DE (2005) ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis. Genes Dev 19: 2111-2115. (Pubitemid 41330313)
22. Oikemus SR, Queiroz-Machado J, Lai K, McGinnis N, Sunkel C, et al. (2006) Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet 2: e71. doi:10.1371/journal.pgen.0020071. (Pubitemid 43794319)
23. Bi X, Srikanta D, Fanti L, Pimpinelli S, Badugu R, et al. (2005) Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc Natl Acad Sci U S A 102: 15167-15172. (Pubitemid 41513353)
24. Tseng SF, Lin JJ, Teng SC (2006) The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation. Nucleic Acids Res 34: 6327-6336.
25. Chan SW, Chang J, Prescott J, Blackburn EH (2001) Altering telomere structure allows telomerase to act in yeast lacking ATM kinases. Curr Biol 11: 1240-1250. (Pubitemid 32774080)
26. Nakamura TM, Moser BA, Russell P (2002) Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics 161: 1437-1452.
27. Subramanian L, Moser BA, Nakamura TM (2008) Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast. Mol Cell Biol 28: 1443-1455.
28. Miller KM, Ferreira MG, Cooper JP (2005) Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. EMBO J 24: 3128-3135.
29. Wang X, Baumann P (2008) Chromosome fusions following telomere loss are mediated by single-strand annealing. Mol Cell 31: 463-473.
30. Baumann P, Cech TR (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292: 1171-1175. (Pubitemid 32440940)
31. Sugiyama T, Cam HP, Sugiyama R, Noma K, Zofall M, et al. (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128: 491-504. (Pubitemid 46198892)
32. Bunch JT, Bae NS, Leonardi J, Baumann P (2005) Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability. Mol Cell Biol 25: 5567-5578. (Pubitemid 40853591)
33. Alfa C, Fantes P, Hyams J, McLoed M, Warbrick E (1993) Experiments with Fission Yeast. Cold Spring Harbor. NY: Cold Spring Harbor Laboratory Press.
34. Muris DF, Vreeken K, Carr AM, Broughton BC, Lehmann AR, et al. (1993) Cloning the RAD51 homologue of Schizosaccharomyces pombe. Nucleic Acids Res 21: 4586-4591. (Pubitemid 23292725)
35. Miyoshi T, Sadaie M, Kanoh J, Ishikawa F (2003) Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. J Biol Chem 278: 1924-1931. (Pubitemid 36801433)
36. Cooper JP, Nimmo ER, Allshire RC, Cech TR (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385: 744-747. (Pubitemid 27098098)
37. Webb CJ, Zakian VA (2008) Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Nat Struct Mol Biol 15: 34-42.
38. Noguchi E, Noguchi C, McDonald WH, Yates JR 3rd, Russell P (2004) Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol 24: 8342-8355.
39. Krawchuk MD, Wahls WP (1999) High-efficiency gene targeting in Schizosaccharomyces pombe using a modular, PCR-based approach with long tracts of flanking homology. Yeast 15: 1419-1427.
40. Sato M, Dhut S, Toda T (2005) New drug-resistant cassettes for gene disruption and epitope tagging in Schizosaccharomyces pombe. Yeast 22: 583-591. (Pubitemid 40932159)
41. Bähler J, Wu JQ, Longtine MS, Shah NG, McKenzie A 3rd, et al. (1998) Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14: 943-951.
42. Bentley NJ, Holtzman DA, Flaggs G, Keegan KS, DeMaggio A, et al. (1996) The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J 15: 6641-6651. (Pubitemid 26413796)
43. Basi G, Schmid E, Maundrell K (1993) TATA box mutations in the Schizosaccharomyces pombe nmt1 promoter affect transcription efficiency but not the transcription start point or thiamine repressibility. Gene 123: 131-136. (Pubitemid 23035805)
44. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, et al. (1997) Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959.
45. Garvik B, Carson M, Hartwell L (1995) Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol Cell Biol 15: 6128-6138.
46. Tomita K, Matsuura A, Caspari T, Carr AM, Akamatsu Y, et al. (2003) Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres. Mol Cell Biol 23: 5186-5197. (Pubitemid 36950874)
47. Nakamura TM, Cooper JP, Cech TR (1998) Two modes of survival of fission yeast without telomerase. Science 282: 493-496.
48. Nimmo ER, Pidoux AL, Perry PE, Allshire RC (1998) Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature 392: 825-828.
49. Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N (2003) The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint. Mol Cell Biol 23: 6564-6573. (Pubitemid 37075767)