Fission yeast pot1-Tpp1 protects telomeres and regulates telomere length

Science

Volumn 320, Issue 5881, 2008, Pages 1341-1344

  Miyoshi, Tomoichiro ^a   Kanoh, Junko ^a   Saito, Motoki ^a   Ishikawa, Fuyuki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CHROMOSOME PROTEIN; DOUBLE STRANDED DNA; FUNGAL PROTEIN; GUANINE; PROTECTION OF TELOMERES 1; PROTEIN CCQ1; PROTEIN POZ1; PROTEIN TAZ1; PROTEIN TPP1; PROTEIN TPZ1; RAP1 PROTEIN; SHELTERIN; SINGLE STRANDED DNA; TELOMERASE; CARRIER PROTEIN; CCQ1 PROTEIN, S POMBE; FUNGAL DNA; POT1 PROTEIN, S POMBE; POZ1 PROTEIN, S POMBE; RAP1 PROTEIN, S POMBE; SCHIZOSACCHAROMYCES POMBE PROTEIN; TELOMERE BINDING PROTEIN; TPZ1 PROTEIN, S POMBE;

CHROMOSOME; DNA; MAMMAL; PROTEIN; YEAST;

ARTICLE; COMPLEX FORMATION; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; ENZYME REGULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PULSED FIELD GEL ELECTROPHORESIS; SCHIZOSACCHAROMYCES POMBE; SOUTHERN BLOTTING; TELOMERE; YEAST; AMINO ACID SEQUENCE; CHEMISTRY; CHROMATIN IMMUNOPRECIPITATION; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SCHIZOSACCHAROMYCES; TWO HYBRID SYSTEM; ULTRASTRUCTURE;

MAMMALIA; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CHROMATIN IMMUNOPRECIPITATION; DNA, FUNGAL; IMMUNOPRECIPITATION; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 45549090631     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1154819     Document Type: Article

References (23)

1. D. E. Gottschling, V. A. Zakian, Cell 47, 195 (1986).
2. C. M. Price, T. R. Cech, Genes Dev. 1, 783 (1987).
3. M. P. Horvath, V. L. Schweiker, J. M. Bevilacqua, J. A. Ruggles, S. C. Schultz, Cell 95, 963 (1998).
4. P. Baumann, T. R. Cech, Science 292, 1171 (2001).
5. M. Lei, E. R. Podell, P. Baumann, T. R. Cech, Nature 426, 198 (2003).
6. L. Wu et al., Cell 126, 49 (2006).
7. D. Hockemeyer, J. P. Daniels, H. Takai, T. de Lange, Cell 126, 63 (2006).
8. F. Wang et al., Nature 445, 506 (2007).
9. H. Xin et al., Nature 445, 559 (2007).
10. T. de Lange, Genes Dev. 19, 2100 (2005).
11. D. Loayza, T. de Lange, Nature 423, 1013 (2003).
12. T. Sugiyama et al., Cell 128, 491 (2007).
13. M. R. Flory, A. R. Carson, E. G. Muller, R. Aebersold, Mol. Cell 16, 619 (2004).
14. T. M. Nakamura, J. P. Cooper, T. R. Cech, Science 282, 493 (1998).
15. T. Naito, A. Matsuura, F. Ishikawa, Nat. Genet. 20, 203 (1998).
16. D. Hockemeyer et al., Nat. Struct. Mol. Biol. 14, 754 (2007).
17. J. P. Cooper, E. R. Nimmo, R. C. Allshire, T. R. Cech, Nature 385, 744 (1997).
18. J. Kanoh, F. Ishikawa, Curr. Biol. 11, 1624 (2001).
19. Y. Chikashige, Y. Hiraoka, Curr. Biol. 11, 1618 (2001).
20. J. E. Croy, E. R. Podell, D. S. Wuttke, J. Mol. Biol. 361, 80 (2006).
21. Materials and methods are available as supporting material on Science Online.
22. C. H. Haering, T. M. Nakamura, P. Baumann, T. R. Cech, Proc. Natl. Acad. Sci. U.S.A. 97, 6367 (2000).
23. We thank M. Tamura and A. Hagiwara for technical assistance; P. Baumann, T. M. Nakamura, M. Yanagida, M. Shirakawa, and M. Katahira for discussions and materials; and A. Katayama and M. Sasaki for assistance. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas ( J.K.) and for Cancer Research (F.I.) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.