STN1 protects chromosome ends in Arabidopsis thaliana

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19815-19820

  Song, Xiangyu ^a   Leehy, Katherine ^a   Warrington, Ross T ^a   Lamb, Jonathan C ^a   Surovtseva, Yulia V ^a   Shippen, Dorothy E ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Anaphase bridges; G overhang; Oligonucleotide oligosaccharide binding fold; Telomere

Indexed keywords

DNA; OLIGONUCLEOTIDE; OLIGOSACCHARIDE; STN1 PROTEIN; UNCLASSIFIED DRUG; ARABIDOPSIS PROTEIN; NONHISTONE PROTEIN; STN1 PROTEIN, ARABIDOPSIS;

AMINO ACID SEQUENCE; ARABIDOPSIS; ARTICLE; CHROMOSOME; FERTILITY; GENE; GENE FUSION; GENE IDENTIFICATION; GENETIC RECOMBINATION; GROWTH DISORDER; MORPHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; STN1 GENE; TELOMERE; YEAST; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; MUTATION; PLANT CHROMOSOME; ULTRASTRUCTURE;

ARABIDOPSIS; ARABIDOPSIS THALIANA; EUKARYOTA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; VERTEBRATA;

AMINO ACID SEQUENCE; ARABIDOPSIS; ARABIDOPSIS PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, PLANT; MOLECULAR SEQUENCE DATA; MUTATION; TELOMERE;

EID: 58149401191     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0807867105     Document Type: Article

References (49)

1. de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110.
2. Palm W, de Lange T (2008) How shelterin protects mammalian telomeres. Annu Rev Genet 42:301-314.
3. van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
4. Yang Q, Zheng YL, Harris CC (2005) POT1 and TRF2 cooperate to maintain telomeric integrity. Mol Cell Biol 25:1070-1080.
5. Hockemeyer D, Daniels JP, Takai H, de Lange T (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126:63-77.
6. Wu L, et al. (2006) Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126:49-62.
7. Ferreira MG, Cooper JP (2001) The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol Cell 7:55-63.
8. Kanoh J, Ishikawa F (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr Biol 11:1624-1630.
9. Chikashige Y, Hiraoka Y (2001) Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr Biol 11:1618-1623.
10. Baumann P, Cech TR (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292:1171-1175.
11. Miyoshi T, Kanoh J, Saito M, Ishikawa F (2008) Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320:1341-1344.
12. Lustig AJ (2001) Cdc13 subcomplexes regulate multiple telomere functions. Nat Struct Mol Biol 8:297-299.
13. Pennock E, Buckley K, Lundblad V (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104:387-396.
14. Lundblad V (2006) in Telomeres, eds de Lange T, Lundblad V, and Blackburn EH (Cold Spring Harbor Laboratory Press), pp 345-386.
15. Martin V, Du LL, Rozenzhak S, Russell P (2007) Protection of telomeres by a conserved Stn1-Ten1 complex. Proc Natl Acad Sci USA 104:14038-14043.
16. Grandin N, Damon C, Charbonneau M (2001) Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J 20:1173-1183.
17. Gao H, Cervantes RB, Mandell EK, Otero JH, Lundblad V (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14:208-214.
18. Riha K, McKnight TD, Griffing LR, Shippen DE (2001) Living with genome instability: plant responses to telomere dysfunction. Science 291:1797-1800.
19. Fitzgerald MS, et al. (1999) Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc Natl Acad Sci USA 96:14813-14818.
20. McGuffin LJ, Bryson K, Jones DT (2000) The PSIPRED protein structure prediction server. Bioinformatics 16:404-405.
21. Armstrong SJ, Franklin FCH, Jones GH (2001) Nucleolus-associated telomere clustering and pairing precede meiotic chromosome synapsis in Arabidopsis thaliana. J Cell Sci 114:4207-4217.
22. Heacock M, Spangler E, Riha K, Puizina J, Shippen DE (2004) Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. EMBO J 23:2304-2313.
23. Herbert BS, Hochreiter AE, Wright WE, Shay JW (2006) Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc 1:1583-1590.
24. Kannan K, Nelson ADL, Shippen DE (2008) Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance. Mol Cell Biol 28:2332-2341.
25. Grandin N, Reed SI, Charbonneau M (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev 11:512-527.
26. Nugent CI, Hughes TR, Lue NF, Lundblad V (1996) Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274:249-252.
27. Iyer S, Chadha AD, McEachern MJ (2005) A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast. Mol Cell Biol 25:8064-8073.
28. Lustig AJ (2003) Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletion. Nat Rev Genet 4:916-923.
29. Zellinger B, Akimcheva S, Puizina J, Schirato M, Riha K (2007) Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis. Mol Cell 27:163-169.
30. McClintock B (1939) The behavior in successive nuclear divisions of a chromosome broken at meiosis. Proc Natl Acad Sci USA 25:405-416.
31. Lei M, Podell ER, Baumann P, Cech TR (2003) DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature 426:198-203.
32. Petreaca RC, Chiu HC, Nugent CI (2007) The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p. Genetics 177:1459-1474.
33. Puglisi A, Bianchi A, Lemmens L, Damay P, Shore D (2008) Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition. EMBO J 27:2328-2339.
34. Karamysheva ZN, Surovtseva YV, Vespa L, Shakirov EV, Shippen DE (2004) A C-terminal myb extension domain defines a novel family of double-strand telomeric DNA-binding proteins in Arabidopsis. J Biol Chem 279:47799-47807.
35. Shakirov EV, Surovtseva YV, Osbun N, Shippen DE (2005) The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection. Mol Cell Biol 25:7725-7733.
36. Surovtseva YV, et al. (2007) Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. EMBO J 26:3653-3661.
37. Hong JP, et al. (2007) Suppression of RICE TELOMERE BINDING PROTEIN1 results in severe and gradual developmental defects accompanied by genome instability in rice. Plant Cell 19:1770-1781.
38. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321-1325.
39. Denchi EL, de Lange T (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448:1068-1071.
40. Shippen DE (2006) in Telomeres, eds de Lange T, Lundblad V, and Blackburn EH (Cold Spring Harbor Laboratory Press), pp 525-550.
41. Liu D, et al. (2004) PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol 6:673-680.
42. O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (2004) The human Rap1 protein complex and modulation of telomere length. J Biol Chem 279:28585-28591.
43. Ye JZ-S, et al. (2004) TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 279:47264-47271.
44. Onodera Y, et al. (2005) Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation. Cell 120:613-622.
45. Kato A, Lamb JC, Birchler JA (2004) Chromosome painting using repetitive DNA sequences as probes for somatic chromosome identification in maize. Proc Natl Acad Sci USA 101:13554-13559.
46. Cocciolone SM, Cone KC (1993) Pl-Bh, an anthocyanin regulatory gene of maize that leads to variegated pigmentation. Genetics 135:575-588.
47. Grant JD, et al. (2001) Telometric: a tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels. BioTechniques 31:1314-1318.
48. Shakirov EV, Shippen DE (2004) Length regulation and dynamics of individual telomere tracts in wild-type Arabidopsis. Plant Cell 16:1959-1967.
49. Heacock ML, Idol RA, Friesner JD, Britt AB, Shippen DE (2007) Telomere dynamics and fusion of critically shortened telomeres in plants lacking DNA ligase IV. Nucleic Acids Res 35:6490-6500.