Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 9, 2009, Pages 1363-1369

  Gerber, Scott A ^a,b   Yatsula, Bogdan ^a   Maier, Cheryl L ^a   Sadler, Timothy J ^a,c   Whittaker, Laurence W ^a,c   Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Endothelial cells; HIF 1 ; Hypoxia; IFN ; PHD3; Signaling

Indexed keywords

DESFERROXAMINE; DIMETHYLOXALLYL GLYCINE; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 3; RECOMBINANT GAMMA INTERFERON; SMALL INTERFERING RNA; STAT1 PROTEIN; UNCLASSIFIED DRUG; ALPHA INTERFERON; DEFEROXAMINE; DICARBOXYLIC AMINO ACID; DIOXYGENASE; EGLN3 PROTEIN, HUMAN; GAMMA INTERFERON; HIF1A PROTEIN, HUMAN; JANUS KINASE; MESSENGER RNA; OXALYLGLYCINE; STAT1 PROTEIN, HUMAN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CELL HYPOXIA; DRUG ANTAGONISM; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; IMMEDIATE EARLY GENE; METABOLISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME;

AMINO ACIDS, DICARBOXYLIC; CELL HYPOXIA; CELLS, CULTURED; DEFEROXAMINE; DIOXYGENASES; ENDOTHELIAL CELLS; ENZYME INDUCTION; ENZYME INHIBITORS; GENES, IMMEDIATE-EARLY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERFERON-ALPHA; INTERFERON-GAMMA; JANUS KINASES; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 69849100880     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.192542     Document Type: Article

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