Immunobiology of human vascular endothelium

Immunologic Research

Volumn 19, Issue 2-3, 1999, Pages 225-232

  Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antigen presentation; Apoptosis; Inflammation; Transplantation

Indexed keywords

CD40 ANTIGEN; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE;

ANTIGEN PRESENTATION; CHIMERA; DISSEMINATED INTRAVASCULAR CLOTTING; HISTOCOMPATIBILITY; HUMAN; HYPOTHESIS; IMMUNE INJURY; IMMUNOBIOLOGY; IMMUNOGENETICS; IMMUNOLOGICAL MEMORY; IMMUNOSURVEILLANCE; INFECTION; LEUKOCYTE; MEMORY CELL; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

EID: 0032777788     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786490     Document Type: Review

References (42)

1. Cines DB, Pollak EA, Buck CA, Loscalzo J, Zimmerman GA, McKever RP, et al.: Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998;91:3527-3561.
2. Pober JS, Gimbrone MA, Jr., Cotran RS, Reiss CS, Burakoff SJ, Fiers W, et al.: Ia expression by vascular endothelium is inducible by activated T cells and by human gamma-interferon. J Exp Med 1983;157:1339-1353.
3. Messadi DV, Pober JS, Murphy GF: Effects of recombinant gamma Interferon on HLA-DR and DQ expression by skin cells in short term organ culture. Lab Invest 1988;58:61-67.
4. Wang M, Pober JS, Johnson DR: Interferon induction of TAP1: The phosphatase SHP-1 regulates crossover between the IFN-α/β and the IFN-γ signal tranduction pathways. Circulation Res 1998;80:815-823
5. Wang M, Pober JS, Johnson DR: Kinetically-coordinated induction of TAP1 and HLA class 1 by IFN-γ: the rapid induction of TAP1 by IFN-γ is mediated by STAT1α. J Immunol 1996;156:3174-3183.
6. Johnson DR, Pober JS: Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy and light chain genes in vascular endothelium. Proc Natl Acad Sci USA 1990;87:5183-5187.
7. Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, et al: Immune Interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci USA 1984;81:4917-4921.
8. Wagner CR, Vetto RM, Burger DR: The mechanism of antigen presentation by endothelial cells. Immunobiology 1984;168:453-469.
9. Epperson DE, Pober JS: Antigen- presenting function of human endothelial cells: direct activation of resting CD8 T cells. J Immunol 1994;153:5042-5412.
10. Pober JS, Collins T, Gimbrone MA, Jr., Cotran RS, Gitlin JD, Fiers W, et al.: Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature 1983;305:726-729.
11. Murray AG, Petzelbauer P, Hughes CCW, Costa J, Askenase P, Pober JS: Human T cell-mediated destruction of allogeneic dermal microvessels in a SCID mouse. Proc Natl Acad Sci USA 1994;91:9146-9150.
12. Karmann K, Hughes CCW, Schechner J, Fanslow WC, Pober JS: CD40 on human endothelial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 1995;92:4342-4346.
13. Maher SE, Karmann K, Min W, Hughes CCW, Pober JS, Bothwell ALM: Poreine endothelial CD86 is a major costimulator of xenogeneic human T cells: cloning, sequencing and functional expression in human endothelial cells. J Immunol 1996;157:3838-3844.
14. Ma W, Pober JS: Human endothelial cells effectively costimulate cytokine production by but not differentiation of naive CD4+ T cells. J Immunol 1998;161:2158-2167.
15. Valitutti S, Muller S, Cella M, Radovan E, Lanzavecchia A: Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 1995;375:148-151.
16. Hughes CCW, Savage COS, Pober JS: Endothelial cells augment T cell IL-2 production by a contact-dependent mechanism involving CD2:LFA-3 interaction. J Exp Med 1990;171:1453-1467.
17. Savage COS, Hughes CCW, Pepinsky RS, Wallner BP, Freedman AS, Pober JS: Endothelial cell lymphocyte function-associated antigen- 3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells. Cell Immunol 1991;137:150-163.
18. Karmann K, Hughes CCW, Fanslow WC, Pober JS: Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA-3 signaling pathway. Eur J Immunol 1996;26:610-617.
19. Biedermann B, Pober JS: Endothelial cells induce and regulate cytolytic T cell differentiation. J Immunol 1998; in press.
20. Murray AG, Schechner JS, Epperson DE, Sultan P, McNiff JM, Hughes CCW, et al.: Dermal microvascular injury in the human peripheral blood lymphocytes reconstituted-severe combined immunodeficient (HuPBL-SCID) mouse/ skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and rapamycin. Am J Pathol 1998;153:627-638.
21. Sultan P, Schechner JS, McNiff JM, Hochman PS, Hughes CCW, Lorber MI, et al.: Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras. Nature Biotechnology 1997; 15:759-762.
22. Pober JS, Cotran RS: Overview: the role of endothelial cells in inflammation. Transplantation 1990;50:537-544.
23. Pober JS, Cotran RS: Cytokines and endothelial cell biology. Physiol Rev 1990;70:427-451.
24. Stolpen AH, Guinan EC, Fiers W, Pober JS: Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am J Pathol 1986;123:16-24.
25. Petzelbauer P, Bender JR, Wilson J, Pober JS: Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. J Immunol 1993;151: 5062-5072.
26. DeLuca LG, Johnson DR, Whitley MZ, Collins T, Pober JS: cAMP and TNF competitively regulate transcriptional activation through and nuclear factor binding to the CRE/ATF element of the endothelial leukocyte adhesion molecule- 1 (E-selectin) promoter. J Biol Chem 1994;30: 19,193-19,196.
27. Karmann K, Wang M, Fanslow WC, Pober JS: Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin I. J Exp Med 1996; 184:173-182.
28. Wang M, Pober JS: TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-κB and TRAF-RAC/ CDC42-JNK-cJun/ATF-2 pathways. J Immunol 1997;159:3508-3518.
29. Slowik MR, DeLuca LG, Fiers W, Pober JS: Tumor necrosis factor (TNF) activates human endothelial cells through the p55 TNF receptor but the p75 receptor contributes to activation at low TNF concentration. Am J Pathol 1993; 134:1724-1730.
30. Jones SJ, Ledgerwood EC, Prins JB, Savidge J, Johnson DR, Pober JS, et al.: TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-RI. J Immunol 1998; in press.
31. Bradley JR, Thiru S, Pober JS: Disparate localization of 55kd and 75kd TNF receptors in human endothelial cells. Am J Pathol 1994;146:27-32.
32. Pober JS: Activation and injury of endothelial cells by cytokines. Pathol Biol 1998;46:159-163.
33. Wang M, Bradley JR, Galbraith JJ, Jones SJ, Ledgerwood EC, Pober JS: The N-terminal domains target TRAF2 to the nucleus and display transcriptional regulatory activity. J Immunol 1998;161: 319-324.
34. Ledgerwood EC, Prins JB, Bright N, Johnson DR, Wolfreys K, Pober JS, et al.: TNF is delivered to mitochondria where a TNF binding protein is localized. Lab Invest 1998; in press.
35. Doukas J, Pober JS: IFN-γ enhances endothelial activation induced by TNF but not IL-I. J Immunol 1990;145:1727-1733.
36. Kluger MS, Johnson DR, Pober JS: Mechanism of sustained E-seletin expression in cultured human dermal microvascular endothelial cells. J Immunol 1997;158:887-896.
37. Pober JS: Vascular endothelium in transplantation, inTilney NL, Strom TB, Paul LC (eds.): Transplantation Biology: Cellular & Molecular Aspects. New York, Raven Press. 1996, pp. 127-136.
38. Bombeli T, Karsan A, Tait JF, Harlan JM: Apoptotic vascular endothelial cells become procoagulant. Blood 1997;89: 2429-2442.
39. Slowik M, Wang. M, Ardito T, Karsan A, Kashgarian M, Pober JS: Evidence that TNF triggers apoptosis in human endothelial cells by ICE-Iike protease-dependent and -independent pathways. Lab Invest 1997;77:257-267.
40. Lorber MI, Wilson JH, Robert ME, Schecher JS, Kirkiles N, Qian HY, et al.: Human allogeneic vascular rejection after arterial transplantation and peripheral lymphoid reconstitution in SCID mice. Transplantation 1998; in press.
41. Murray AG, Khadadoust MM, Pober JS, Bothwell ALM: Porcine aortic endothelial cells strongly activate human T cells: direct presentation of swine MHC antigens and effective co-stimulation by swine ligands for human CD2 and CD28. Immunity 1994;1:57-63.
42. Sultan P, Murray AG, McNiff JM, Lorber MI, Askenase PW, Bothwell ALM, et al.: Pig but not human Interferon-γ initiates human cell- mediated rejection of pig tissue in vivo. Proc Natl Acad Sci (USA) 1997;94:8767-8772.