From the global to the local: Possible pathways for the transduction of Indo-Sino-Tibetan cognitive-behavioral practices into site-specific, tissue-regenerative effects

Annals of the New York Academy of Sciences

Volumn 1172, Issue , 2009, Pages 74-87

  Bushell, William C ^a   Spector, Novera Herbert ^b   Theise, Neil D ^c,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Amer Inst Neuroimmunomodulation R   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

Acupuncture; Bioelectromagnetic; Innervation; Meditation; Melatonin; Pranayama; Regeneration; Stem cells; Yoga

Indexed keywords

CORTICOSTEROID; MELATONIN; PRASTERONE;

ACUPUNCTURE; AGING; BIOENERGY; CELL MIGRATION; CELL PROLIFERATION; CELL REGENERATION; COGNITIVE THERAPY; CONFERENCE PAPER; ELECTROMAGNETIC FIELD; ENERGY BALANCE; HORMONE BLOOD LEVEL; HUMAN; HUMORAL IMMUNITY; INNERVATION; MEDITATION; MOLECULAR MECHANICS; NERVOUS SYSTEM DEVELOPMENT; NEUROMODULATION; NONHUMAN; SIGNAL TRANSDUCTION; TISSUE REGENERATION; UPREGULATION; YOGA;

EID: 69549138199     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04412.x     Document Type: Conference Paper

References (130)

1. Conboy, I.M. et al. 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433 : 780 784.
2. Conboy, I.M. & T.A. Rando. 2005. Aging, stem cells, and tissue regeneration. Cell Cycle 4-3 : 407 410.
3. Bushell, W.C. 2005. Model: potential cognitive-behavioral stem cell activation in multiple niches. Presented at the "Stem Cell Biology & Human Disease" conference (UCSD /Salk Institute/Nature Medicine). La Jolla, CA, March 17-19, 2005.
4. Reiter, R.J. et al. 1998. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann. N. Y. Acad. Sci. 854 : 410 424.
5. Abbasoglu, O. et al. 1995. The effect of the pineal gland on liver regeneration in rats. J. Hepatol. 23 : 578 581.
6. Esrefoglu, M. et al. 2005. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats. J. Pineal Res. 39 : 231 237.
7. Kobayashi, H. et al. 2005. A role of melatonin in neuroectodermal- mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J. 19 : 1710 1712.
8. Slominski, A. et al. 2005. On the role of melatonin in skin physiology and pathology. Endocrine 27 : 137 148.
9. Niles, L.P. et al. 2004. Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers. BMC Neurosci. 5 : 41.
10. Tan, D.X. et al. 1999. Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. Biochim. Biophys. Acta 1472 : 206 214.
11. Conti, A. et al. 2000. Evidence for melatonin synthesis in mouse and human bone marrow cells. J. Pineal Res. 28 : 193 202.
12. Tan, D. et al. 1999. High physiological levels of melatonin in the bile of mammals. Life Sci. 65 : 2523 2529.
13. Cardinali, D.P. et al. 2003. Melatonin effects on bone: experimental facts and clinical perspectives. J. Pineal Res. 34 : 81 87.
14. Bushell, W.C. 2005. From molecular biology to anti-aging cognitive-behavioral practices: the pioneering research of Walter Pierpaoli on the pineal and bone marrow foreshadows the contemporary revolution in stem cell and regenerative biology. Ann. N. Y. Acad. Sci. 1057 : 29 42.
15. Feng, Z. et al. 2006. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. Free Radic. Biol. Med. 40 : 101 109.
16. Dundar, K. et al. 2005. Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain. Clin. Exp. Pharmacol. Physiol. 32 : 926 930.
17. Yi, C. et al. 2005. Effects of melatonin in age-related macular degeneration. Ann. N. Y. Acad. Sci. 1057 : 384 391.
18. Girotti, L. et al. 2003. Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure. Endocrine 22 : 245 248.
19. Castagnino, H.E. et al. 2002. Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining. Neurol. Endocrinol. Lett. 23 : 391 395.
20. Bubenik, G.A. 2002. Gastrointestinal melatonin: localization, function, and clinical relevance. Digest. Dis. Sci. 47 : 2336 2348.
21. Bellipanni, G. et al. 2005. Effects of melatonin in perimenopausal and menopausal women: our personal experience. Ann. N. Y. Acad. Sci. 1057 : 393 402.
22. Erkanli, K. et al. 2005. Melatonin protects against ischemia/reperfusion injury in skeletal muscle. J. Pineal Res. 39 : 238 242.
23. Escames, G. et al. 2006. Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice. J. Pineal Res. 40 : 71 78.
24. Sainz, R.M. et al. 2003. Melatonin and cell death: differential actions on normal and cancer cells. Cell. Mol. Life Sci. 60 : 1407 1426.
25. Wolfler, A. et al. 2001. Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells. FEBS Lett. 502 : 127 131.
26. Karasek, M. 2004. Melatonin, human aging, and age-related diseases. Exp. Gerontol. 39 : 1723 1729.
27. Lesnikov, V.A. & Pierpaoli W. 1994. Pineal cross-transplantation (old-to-young and young-to-old) as evidence for an endogenous "aging clock." Ann. N. Y. Acad. Sci. 719 : 456 460.
28. Pierpaoli, W. 1998. Neuroimmunomodulation of aging: a program in the pineal gland. Ann. N. Y. Acad. Sci. 840 : 491 497.
29. Pierpaoli, W. & Maestroni, G.J.M. 1987. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects. Immunol. Lett. 16 : 355 362.
30. Maestroni, G.J.M. et al. 1988. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer. Ann. N. Y. Acad. Sci. 521 : 140 148.
31. Ramachandran, A.V. & Ndukuba P.I. 1989. Parachlorophenylalanine retards tail regeneration in the gekkonid lizard Hemidactylus flaviviridis exposed to continuous light. J. Exp. Biol. 143 : 235 243.
32. Tilden, A.R. et al. 1997. Melatonin cycle in the fiddler crab Uca pugilator and influence of melatonin on limb regeneration. J. Pineal Res. 23 : 142 147.
33. Csaba, G. 1993. Presence in and effects of pineal indoleamines at very low level of phylogeny. Experientia 49 : 627 634.
34. Danilova, N. et al. 2004. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. FASEB J. 18 : 751 753.
35. Turgut, M. et al. 2006. Effects of constant lightness, darkness and parachlorophenylalanine treatment on tail regeneration in the lizard Ophisops elegans macrodactylus: macroscopic, biochemical and histological changes. Anat. Histol. Embryol. 35 : 155 161.
36. Hinson, J.P., A. Brooke & P.W. Raven. 2003. Therapeutic uses of dehydroepiandrosterone. Curr. Opin. Investig. Drugs 4 : 1205 1208.
37. Schmidt, M. et al. 2000. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages. J. Endocrinol. 164 : 161 169.
38. Mills, S.J. et al. 2005. The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors. J. Investig. Dermatol. 125 : 1053 1062.
39. Karishma, K.K. & J. Herbert. 2002. Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression. Eur. J. Neurosci. 16 : 445 453.
40. Roth, G.S. et al. 2002. Physiological markers of dietary caloric restriction in animals predict longevity in humans. Science 297 : 811 817.
41. Bushell, W.C. 2001. Evidence that a specific meditational regimen may induce adult neurogenesis. Dev. Brain Res. 132 : A26 [abstract].
42. Strie, K. et al. 2004. Proinflammatory cytokine impairment of insulin-like growth factor-I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology 145 : 4592 4602.
43. French, R.A. et al. 2002. Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinology 143 : 690 699.
44. Linke, A. et al. 2002. Mobilization of cardiac stem cells (CSC) by growth factors promotes repair of infarcted myocardium improving regional and global cardiac function in conscious dogs. Circulation 106 : II 52.
45. Arsenijevic, Y. et al. 2001. Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2. J. Neurosci. 21 : 7194 7202.
46. Muller, A.F. & A.J. Van Der Lely. 2004. Insights from growth hormone receptor blockade. Curr. Opin. Investig. Drugs 5 : 1072 1079.
47. Harman, S.M. & Blackman M.R. 2004. Use of growth hormone for prevention or treatment of effects of aging. J. Gerontol. Ser. A Biol. Med. Sci. 59 : 652 659.
48. Scicchitano, B.M. et al. 2002. AVP induces myogenesis through the transcriptional activation of the myocyte enhancer factor 2. Mol. Endocrinol. 16 : 1407 1416.
49. Tribollet, E. et al. 1994. Axotomy induces the expression of vasopressin receptors in cranial and spinal motor nuclei in the adult rat. Proc. Natl. Acad. Sci. U.S. 91 : 9636 9640.
50. Tribollet, E. et al. 1998. Vasopressin binding sites in the central nervous system: distribution and regulation. Progr. Brain Res. 119 : 45 55.
51. Zhou, A.W. et al. 1997. Facilitation of AVP(4-8) on gene expression of BDNF and NGF in rat brain. Peptides 18 : 1179 1187.
52. Guarente, L. 2005. NO link between calorie restriction and mitochondria. Nat. Chem. Biol. 1 : 355 356.
53. Stefano, G.B. & T. Esch. 2005. Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide. Int. J. Mol. Med. 16 : 621 630.
54. Kim, D.H. et al. 2005. Effect of Zen meditation on serum nitric oxide activity and lipid peroxidation. Prog. Neuropsychopharmacol. Biol. Psychiatry 29 : 327 331.
55. Bushell, W.C. 1995. Psychophysiological and comparative analysis of ascetico-meditational discipline: toward a new theory of asceticism. In: V.L. Wimbush & R. Valantasis, (eds.). Asceticism; Oxford University Press Reference Series. Oxford University Press. New York.
56. Thurman, R.A.F. 1995. Tibetan Buddhist perspectives on asceticism. In : V.L. Wiimbush & R. Valantasis, (eds.). Asceticism; Oxford University Reference Series. Oxford University Press. New York.
57. Olson, A.K. et al. 2006. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 16 : 250 260.
58. Laufs, U. et al. 2004. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109 : 220 226.
59. Mattson, M.P. et al. 2002. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol. Rev. 82 : 637 672.
60. Lee, J. et al. 2000. Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J. Mol. Neurosci. 15 : 99 108.
61. Gould, E. et al. 1998. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. PNAS 95 : 3168 3171.
62. Epel, E.S. et al. 2004. Accelerated telomere shortening in response to life stress. Proc. Natl. Acad. Sci. U.S. 101 : 17312 17315.
63. Epel, E.S. et al. 2005. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31 : 277 287.
64. Wong, E.Y.H. & J. Herbert. 2004. The corticoid environment: a determining factor for neural progenitors' survival in the adult hippocampus. Eur. J. Neurosci. 20 : 2491 2498.
65. Walton, K.G. et al. 2004. Lowering cortisol and CVD risk in postmenopausal women: a pilot study using the transcendental meditation program. Ann. N. Y. Acad. Sci. 1032 : 211 215.
66. Schneider, R.H. et al. 2005. Long-term effects of stress reduction on mortality in persons > or = 55 years of age with systemic hypertension. Am. J. Cardiol. 95 : 1060 1064.
67. Benson, H. et al. 1982. Body temperature changes during the practice of g Tum-mo yoga. Nature 295 : 234 236.
68. Benson, H. et al. 1990. Three case reports of the metabolic and electroencephalogaphic changes during advanced Buddhist meditation techniques. Behav. Med. 16 : 90 95.
69. Steptoe, A. et al. 2005. Positive affect and health-related neuroendoctrine, cardiovascular, and inflammatory responses. Proc. Natl. Acad. Sci. U.S. 102 : 6508 6512.
70. Duman, R.S. 2005. Neurotrophic factors and regulation of mood: role of exercise, diet, and metabolism. Neurobiol. Aging 26 (Suppl 1) 88 93.
71. Warner-Schmidt, J.L. & R.S. Duman. 2006. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus 16 : 239 249.
72. Teasdale, J.D., Z. Segal & J.M. Williams. 1995. How does cognitive therapy prevent depressive relapse and why should attentional control (mindfulness) training help? Behav. Res. Ther. 33 : 25 39.
73. Teasdale, J.D. et al. 2000. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J. Consult. Clin. Psychol. 68 : 615 623.
74. Lazar, S.W. et al. 2005. Meditation experience is associated with increased cortical thickness. NeuroReport 16 : 1893 1897.
75. Bhatt, R. et al. 2003. Effects of kindled seizures upon hematopoeisis in rats. Epilepsy Research 54 : 209 219.
76. Steidl, U. et al. 2004. Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators. Blood 104 : 81 88.
77. Goolsby, J. et al. 2003. Hematopoietic progenitors express neural genes. Proc. Natl. Acad. Sci. U.S. 100 : 14926 14931.
78. Cassiman, D. et al. 2002. The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3. Am. J. Pathol. 161 : 521 530.
79. Oben, J.A. et al. 2003. Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury. Hepatology 38 : 664 673.
80. Katayama, Y. et al. 2006. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124 : 407 421.
81. Zanchi, A. et al. 2005. Innervation of an intra-organ hepatic progenitor cell "niche" in normal human liver. Hepatology 42 : A143 [Abstract].
82. Giese, G. 2006. Electron transfer through DNA and peptides. Bioorg. Med. Chem. 14 : 6139 6143.
83. Burgstahler, A.D. & M.H. Nathanson. 1998. Coordination of calcium waves among hepatocytes: teamwork gets the job done. Hepatology 27 : 634 635.
84. Rosch, P.J. 1995. Future Directions in Psychoneuroimmunology: Psychoelectroneuroimmunology? In: B. Leonard & K. Miller, (eds.). Stress, the Immune System and Psychiatry. John Wiley & Sons. New York.
85. Rosch, P.J. & M.S. Markov. eds. 2004. Bioelectromagnetic Medicine. Marcel Dekker. New York.
86. Zhao, M. et al. 2006. Electrical signals control wound healing through phospha-tidylinositol-3-OH kinase-gamma and PTEN. Nature 442 : 457 460.
87. Rosch, P.J. 2004. Preface. In: P.J. Rosch & M.S. Markov, (eds.). Bioelectromagnetic Medicine. Marcel Dekker. New York.
88. Zuyin, L. 1997. L. Hui & D. Ming, (Trans/eds.). Scientific Qigong Exploration. Amber Leaf Press. Malvern, PA.
89. Fukushima, R. et al. 2001. Evidence of Qi-gong energy and its biological effect on the enhancement of the phagocytic activity of human polymorphonuclear leukocytes. Am. J. Chin. Med. 29 : 1 16.
90. Shang, C. 2001. Emerging paradigms in mind-body medicine. J. Altern. Complement. Med. 7 : 83 91.
91. Miura, K. 1989. The revival of qi: qigong in contemporary China. In: L. Kohn, (ed.). Taoist Meditation and Longevity Techniques (Michigan Monographs in Chinese Studies, Vol 61). University of Michigan Press. Ann Arbor, MI.
92. Muehsam, D.J. et al. 1994. Effects of qigong on cell-free myosin phosphorylation: preliminary experiments. Subtle Energ. 5 : 93 108.
93. Lee, M.S. et al. 2003. Retrospective survey on therapeutic efficacy of qigong in Korea. Am. J. Chin. Med. 31 : 809 815.
94. Yount, G. et al. 2004. In vitro test of external qigong. BMC Complement. Altern. Med. 4 : 5 12.
95. Minigawa, M. et al. 2000. Intensive expansion of natural killer T cells in the early phase of hepatocyte regeneration after partial hepatectomy in mice and its association with sympathetic nerve activation. Hepatology 31 : 907 915.
96. Czura, C.J. & K.J. Tracey. 2005. Autonomic neural regulation of immunity. J. Intern. Med. 257 : 156 166.
97. Pavlov, V.A. & K.J. Tracey. 2006. Controlling inflammation: the cholinergic anti-inflammatory pathway. Biochem. Soc. Trans. 34 : 1037 1040.
98. Riether, C. et al. 2008. Behavioural conditioning of immune functions: how the central nervous system controls peripheral immune responses by evoking associative learning processes. Rev. Neurosci. 19 : 1 17.
99. Spector, N.H. 1996. Neuroimmunomodulation: a brief review. Can conditioning of natural killer cell activity reverse cancer and/or aging? Regul. Toxicol. Pharmacol. 24 : S32 S38.
100. Spector, N.H. 2004. Neuroimmunomodulation. In : G. Adelman & B. Smith, (eds.). Encyclopedia of Neuroscience, 3rd edition. The Health Foundation. New York.
101. Ghanta, V.K. et al. 1985. Neural and environmental influences on neoplasia and conditioning of NK activity. J. Immunol. 135 : 848s 852s.
102. Klosterhalfen, W. & S. Klosterhalfen. 1983. Pavlovian conditioning of immunosuppression modifies adjuvant arthritis in rats. Behav. Neurosci. 97 : 663 666.
103. Ader, R. 2000. Classical conditioning in the treatment of psoriasis. Cutis 66 : 370 372.
104. Olness, K. & R. Ader. 1992. Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus. J. Dev. Behav. Pediatr. 13 : 124 125.
105. Exton, M.S. et al. 2000. Pavlovian conditioning of immune function: animal investigation and the challenge of human application. Behav. Brain Res. 110 : 129 141.
106. Goebel, M.U. et al. 2002. Behavioral conditioning of immunosuppression is possible in humans. FASEB J. 16 : 1869 1873.
107. Inoue, T. et al. 1998. Spontaneous regeneration of the pyramidal tract after transection in young rats. Neurosci. Lett. 247 : 151 154.
108. Herzog, E.L., L. Chai & D.S. Krause. 2003. Plasticity of marrow-derived stem cells. Blood 102 : 3483 3493.
109. Theise, N.D. & I. Wilmut. 2003. Cell plasticity: flexible arrangement. Nature 425 : 21.
110. Krause, D.S. et al. 2001. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105 : 369 377.
111. Theise, N.D. et al. 2000. Liver from bone marrow in humans. Hepatology 32 : 11 16.
112. Houghton, J. et al. 2004. Gastric cancer originating from bone marrow-derived cells. Science 306 : 1568 1571.
113. Theise, N.D. et al. 2002. Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Exp. Hematol. 30 : 1333 1338.
114. Grove, J.E. et al. 2006. Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells 24 : 1986 1992.
115. Borue, X. et al. 2004. Bone marrow-derived cells contribute to epithelial engraftment during wound healing. Am. J. Pathol. 165 : 1767 1772.
116. Ianus, I.A. et al. 2003. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111 : 843 850.
117. Orlic, D. et al. 2001. Bone marrow cells regenerate infarcted myocardium. Nature 10 : 701 705.
118. Kale, S. et al. 2003. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. J. Clin. Invest. 112 : 42 49.
119. Theise, N.D. & D.S. Krause. 2001. Suggestions for a new paradigm of cell differentiative potential. Blood Cells Mol. Dis. 27 : 625 631.
120. Theise, N.D. & D.S. Krause. 2002. Toward a new paradigm of cell plasticity. Leukemia 16 : 542 548.
121. Theise, N.D. 2006. Implications of 'post-modern biology' for pathology: the cell doctrine. Lab. Invest. 86 : 335 344.
122. Lagasse, E. et al. 2000. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6 : 1229 1234.
123. Blau, H.M. et al. 1985. Plasticity of the differentiated state. Science 230 : 758 766.
124. Dixon, I.M. 2006. Much ado about bone marrow stem cells: Role in post-myocardial infarct repair. Cardiovasc. Res. 71 : 609 611.
125. Heber-Katz, E. et al. 2004. The scarless heart and the MRL mouse. Philos. Trans. R. Soc. Lond. B 359 : 785 793.
126. Hampton, D.W. et al. 2004. Altered CNS response to injury in the MRL/MpJ mouse. Neuroscience 127 : 821 832.
127. Harty, M. et al. 2003. Regeneration or scarring: an immunologic perspective. Dev. Dynam. 226 : 268 279.
128. Jackson, J.E. 2009. The cross-cultural evidence on "extreme behaviors": what can it tell us Ann. N. Y. Acad. Sci. doi : 10.1111/j.1749-6632.2009.04536.x.
129. Jovanova-Nesic, K., M. Eric-Jovicic & N.H. Spector. 2006. Magnetic stimulation of the brain increases Na+, K+-ATPase activity decreased by injection of AlCl3 into nucleus basalis magnocellularis of rats. Int. J. Neurosci. 116 : 681 695.
130. Jankovic, B.D. et al. 1993. Brain-applied magnetic fields and immune response: role of the pineal gland. Int. J. Neurosci. 70 : 127 134.