Melatonin, human aging, and age-related diseases

Experimental Gerontology

Volumn 39, Issue 11-12 SPEC. ISS., 2004, Pages 1723-1729

  Karasek, M ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Age related diseases; Aging; Antioxidants; Circadian rhythms; Free radicals; Melatonin; Sleep disorders

Indexed keywords

MELATONIN; SCAVENGER;

AGING; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; CANCER; CIRCADIAN RHYTHM; CLINICAL TRIAL; COGNITIVE DEFECT; CONFERENCE PAPER; DIET SUPPLEMENTATION; DISEASE SEVERITY; DRUG EFFECT; ECONOMIC ASPECT; GERIATRIC DISORDER; HORMONE RELEASE; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENCE; IMMUNOMODULATION; INSOMNIA; LIFE EXPECTANCY; LIFESPAN; LONGEVITY; NONHUMAN; PARKINSON DISEASE; PENSION; PINEAL BODY; PRIORITY JOURNAL; QUALITY OF LIFE; REJUVENATION; SLEEP; SLEEP DISORDER; SOCIAL PROBLEM; THEORY;

AGED; AGING; ANTIOXIDANTS; CIRCADIAN RHYTHM; FEMALE; HUMANS; IMMUNOCOMPETENCE; LONGEVITY; MALE; MELATONIN; MIDDLE AGED; NEURODEGENERATIVE DISEASES; PINEAL GLAND; SLEEP DISORDERS;

EID: 9644289754     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2004.04.012     Document Type: Conference Paper

References (81)

1. D. Acuna-Castroviejo, A. Coto-Montes, M.G. Monti, G.G. Ortiz, and R.J. Reiter Melatonin is protective against MPTP-induced striatal and hyppocampal lesions Life Sci. 60 1997 PL23 PL29
2. J. Arendt Melatonin and the Mammalian Pineal Gland 1995 Chapman and Hall London
3. S.M. Armstrong Melatonin: the internal Zietgeber of mammals? Pineal Res. Rev. 7 1989 157 202
4. S.M. Armstrong, and J.R. Redman Melatonin: a chronobiotic with anti-aging properties Med. Hypotheses 34 1991 300 309
5. D. Avery, M. Lenz, and C. Landis Guidelines for prescribing melatonin Ann. Med. 30 1998 122 130
6. C. Bartsch, H. Bartsch, K.R. Laumas, and L. Wetterberg Urinary melatonin levels in human breast cancer patients J. Neural Transm. 52 1981 281 294
7. C. Bartsch, H. Bartsch, S.H. Flüchter, R. Harzmann, A. Attanasio, K.H. Bichler, and D. Gupta Circadian rhythms of serum melatonin, prolactin and growth hormone in patients with benign and malignant tumours of the prostate and in non-tumor controls Neuroendocrinol. Lett. 5 1983 377 386
8. C. Bartsch, H. Bartsch, U. Fuchs, T.H. Lippert, O. Bellmann, and D. Gupta Stage-dependent depression of melatonin in patients with primary breast cancer Cancer 64 1989 426 433
9. C. Bartsch, H. Bartsch, O. Bellman, and T.H. Lippert Depression of serum melatonin in patients with primary breast cancer is not due to an increased peripheral metabolism Cancer 67 1991 1681 1684
10. C. Bartsch, H. Bartsch, A. Schmidt, S. Ilg, K.H. Bichler, and S.H. Flüchter Melatonin and 6-sulfatoxymelatonin circadian rhythms in serum and urine of primary prostate cancer patients: evidence for reduced pineal activity and relevance of urinary determinations Clin. Chim. Acta 209 1992 153 176
11. C. Bartsch, H. Bartsch, and M. Karasek Melatonin in clinical oncology Neuroendocrinol. Lett. 23 Suppl. 1 2002 30 38
12. J.J. Baskett, P.C. Wood, J.B. Broad, J.R. Duncan, J. English, and J. Arendt Melatonin in older people with age-related sleep maintenance problems: a comparison with age-matched normal sleepers Sleep 24 2001 418 424
13. S. Benot, R. Goberna, R.J. Reiter, E. Garcia-Maurino, C. Osuna, and J.M. Guerrero Physiological levels of melatonin contribute to the antioxidant capacity of human serum J. Pineal Res. 27 1999 59 64
14. J.D. Bergiannaki, C.R. Soldatos, T.J. Paparrigopoulos, M. Syrengelas, and C.N. Stefanis Low and high melatonin excretors among healthy individuals J. Pineal Res. 18 1995 159 164
15. H.K. Biesalski Free radical theory of aging Curr. Opin. Clin. Nutr. Metab. Care 5 2002 5 10
16. D.E. Blask Melatonin in oncology H.S. Yu R.J. Reiter Melatonin - Biosynthesis, Physiological Effects and Perspectives 1993 CRC Press Boca Raton 447 475
17. L.I. Brusco, M. Marquez, and D.P. Cardinali Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease Neuroendocrinol. Lett. 19 1998 111 115
18. D.A. Buterfield, K. Hersley, M. Harris, M.P. Mattson, and J.M. Carney β-Amyloid peptide free radical fragments initiate lipoperoxidation in a sequence specific fashion: implications to Alzheimer's disease Biochem. Biophys. Res. Commun. 2000 1994 710 715
19. C. Cajochen, K. Kräuchi, and A. Wirz-Justice Role of melatonin in the regulation of human circadian rhythms and sleep J. Neuroendocrinol. 15 2003 432 437
20. D.P. Cardinali, L.I. Brusco, C. Liberczuk, and A.M. Furio The use of melatonin in Anzheimer's disease Neuroendocrinol. Lett. 23 Suppl. 1 2002 20 23
21. D.P. Cardinali, L.I. Brusco, S.P. Lloret, and A.M. Furio Melatonin in sleep disorders and jet-lag Neuroendocrinol. Lett. 23 Suppl. 1 2002 9 13
22. M. Chen, and H.L. Fernandez Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency Front. Biosci. 6 2001 e1 e11
23. W.M.V. Daniels, S.J. van Rensburg, J.M. van Zyl, and J.J.F. Tuljaard Melatonin prevents β-amyloid-induced lipid peroxidation J. Pineal Res. 24 1998 78 82
24. S. Fahn, and G. Cohen The oxidant stress hypothesis in Parkinson's disease: evidence supporting it Ann. Neurobiol. 32 1992 804 812
25. J. Ghiso, and B. Frangione Amyloidosis and Alzheimer's disease Adv. Drug Deliv. Rev. 54 2002 1539 1551
26. K. Ginaldi, M. De Martinis, A. D'Ostilio, L. Marini, M.F. Loreto, M.D. Corso, and D. Quoglino The immune system in the elderly: I. Specific humoral immunity Immunol. Res. 20 1999 101 108
27. K. Ginaldi, M. De Martinis, A. D'Ostilio, L. Marini, M.F. Loreto, and D. Quoglino The immune system in the elderly: II. Specific cellular immunity Immunol. Res. 20 1999 109 115
28. K. Ginaldi, M. De Martinis, A. D'Ostilio, L. Marini, M.F. Loreto, V. Martorelli, and D. Quoglino The immune system in the elderly: III. Innate immunity Immunol. Res. 20 1999 117 126
29. B.R. Grad, and R. Rozencweig The role of melatonin and serotonin in aging: update Psychoneuroendocrinology 18 1993 283 295
30. J.M. Gurrero, S. Garcia-Maurino, D. Pozo, A. Garcia-Perganeda, A. Carrillo-Vico, P. Molinero, C. Osuna, and J.R. Calvo Mechanisms involved in the immunomodulatory effects of melatonin on the human immune system C. Bartsch H. Bartsch D.E. Blask D.P. Cardinali W.J.M. Hrushesky D. Mecke The Pineal Gland and Cancer 2001 Springer Berlin 408 416
31. D. Harman Ageing: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
32. D. Harman Free radical theory of aging Mutat. Res. 275 1992 257 266
33. W.J.M. Hrushesky Melatonin cancer therapy C. Bartsch H. Bartsch D.E. Blask D.P. Cardinali W.J.M. Hrushesky D. Mecke The Pineal Gland and Cancer 2001 Springer Berlin 476 508
34. M. Karasek Relationship between the pineal gland and experimentally- induced malignant tumors Front. Horm. Res. 23 1997 99 106
35. M. Karasek Melatonin in humans: where we are 40 years after its discovery Neuroendocrinol. Lett. 20 1999 179 188
36. M. Karasek, and M. Pawlikowski Pineal gland, melatonin and cancer Neuroendocrinol. Lett. 20 1999 139 144
37. M. Karasek, W. Dec, A.J. Kowalski, H. Bartsch, and C. Bartsch Serum melatonin circadian profile in women with adenocarcinoma of uterine corpus Int. J. Thymol. 4 Suppl. 1 1996 80 83
38. M. Karasek, A.J. Kowalski, and K. Zylinska Serum melatonin circadian profile in women suffering from the genital tract cancers Neuroendocrinol. Lett. 21 2000 109 113
39. M. Karasek, R.J. Reiter, D.P. Cardinali, and M. Pawlikowski Future of melatonin as a therapeutic agent Neuroendocrinol. Lett. 23 Suppl. 1 2002 118 121
40. R. Khoory, and D. Stemme Plasma melatonin levels in patients suffering from colorectal carcinoma J. Pineal Res. 5 1988 251 258
41. P.E. Kloeden, R. Rössler, and O.E. Rössler Does centralized clock for aging exist? Gerontology 36 1991 314 322
42. P.E. Kloeden, R. Rössler, and O.E. Rössler Time-keeping in genetically programmed aging Exp. Gerontol. 28 1993 109 118
43. T.V. Kvetnaya, I.M. Kvetnoy, H. Bartsch, C. Bartsch, and D. Mecke Melatonin in patients with cancer of extra-reproductive location C. Bartsch H. Bartsch D.E. Blask D.P. Cardinali W.J.M. Hrushesky D. Mecke The Pineal Gland and Cancer 2001 Springer Berlin 177 196
44. P. Lissoni Efficacy of melatonin in the immunotherapy of cancer using interleukin-2 C. Bartsch H. Bartsch D.E. Blask D.P. Cardinali W.J.M. Hrushesky D. Mecke The Pineal Gland and Cancer 2001 Springer Berlin 465 475
45. P. Lissoni, S. Viviani, E. Bajetta, R. Buzzoni, A. Barreca, R. Mauri, M. Resentini, F. Morabito, D. Esposti, G. Esposti, and F. Fraschini A clinical study of the pineal gland activity in oncologic patients Cancer 57 1986 837 842
46. G.J.M. Maestroni The immunotherapeutic potential of melatonin Exp. Opin. Invest. Drugs 10 2001 467 476
47. G.J.M. Maestroni, A. Conti, and W. Pierpaoli Pineal melatonin, its fundamental immunoregulatory role in aging and cancer Ann. NY Acad. Sci. 521 1988 140 147
48. J.C. Mayo, R.M. Sainz, H. Uria, I. Antonin, M.M. Esteban, and C. Rodriguez Melatonin prevents apoptosis induced by 6-hydroxydopamine in neuronal cells: implications for Parkinson's disease J. Pineal Res. 24 1998 179 192
49. J.C. Mayo, R.M. Sainz, H. Uria, I. Antonin, M.M. Esteban, and C. Rodriguez Inhibition of cell proliferation: a mechanism likely to mediate prevention of neuronal death by melatonin J. Pineal Res. 25 1998 12 18
50. L.E. Miles, and W.C. Dement Sleep and aging Sleep 3 1980 119 220
51. J.W. Miller, J. Selhub, and J.A. Joseph Oxidative damage caused by free radicals produced during catocholamine autooxidation: protective effects of O-methylation and melatonin Free Radical Biol. Med. 21 1996 241 249
52. K. Mishima, T. Tozawa, K. Satoh, Y. Matsumoto, Y. Hishikawa, and M. Okawa Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking Biol. Psychiatr. 15 1999 417 421
53. J.M. Monti, and D.P. Cardinali A critical assessment of the melatonin effect on sleep in humans Biol. Signals Recept. 9 2000 328 339
54. Y. Morita, K. Uchida, and N. Okamoto Melatonin rhythm of Alzheimer patients Front. Horm. Res. 21 1996 180 185
55. S.R. Pandi-Perumal, L.K. Seils, L. Kayumov, M.R. Ralph, A. Lowe, H. Moller, and D.F. Swaab Senescence, sleep, and circadian rhythms Aging Res. Rev. 1 2002 559 604
56. A. Panzer, and M. Viljoen Urinary 6-sulfatoxymelatonin levels in osteosarcoma: a case-control study Med. Sci. Res. 26 1998 43 45
57. M.A. Pappola, M. Sas, R.A. Omar, R.J. Bick, D.L.M. Hickson-Bick, and R.J. Reiter Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide J. Neurosci. 17 1997 1683 1690
58. M.A. Pappola, M. Sas, R.A. Omar, R.J. Bick, D.L.M. Hickson-Bick, R.J. Reiter, S. Efthimiopoulous, K. Sambamurti, and N.K. Rubakis Oxidative damage and cell death induced by an amyloid peptide fragment is completely prevented by melatonin K. Iqbal B. Winblad T. Nishimura M. Takeda H.M. Wisniewski Alzheimer's Disease: Biology, Diagnosis and Therapeutics 1997 Willey New York 741 749
59. M.A. Pappola, Y.J. Chyan, B. Poeggeler, B. Frangione, G. Wilson, J. Ghiso, and R.J. Reiter An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease J. Neural. Transm. 107 2000 203 231
60. M. Pawlikowski, M. Kolomecka, A. Wojtczak, and M. Karasek Effects of six months melatonin treatment on sleep quality and serum concentrations of estradiol, cortisol, dehydroepiandrosterone sulfate, and somatomedin C in elderly women Neuroendocrinol. Lett. 23 Suppl. 1 2002 17 19
61. M. Pawlikowski, K. Winczyk, and M. Karasek Oncostatic action of melatonin: facts and question marks Neuroendocrinol. Lett. 23 Suppl. 1 2002 24 29
62. D.P. Perl Neuropathology of Alzheimer's disease and related disorders Neurol. Clin. 18 2000 847 864
63. N. Petrovsky, and L.C. Harrison Diurnal rhythmicity of human cytokine production J. Immunol. 158 1997 5163 5168
64. W. Pierpaoli, and V. Lesnikov Theoretical considerations on the nature of the pineal 'aging clock' Gerontology 43 1997 20 25
65. W. Pierpaoli, and W. Regelson Pineal control of aging: effects of melatonin and pineal grafting in aging mice Proc. Natl Acad. Sci. USA 91 1994 787 791
66. W. Pierpaoli, A. Dall'Ara, E. Pedrinis, and W. Regelson The pineal control of aging: the effects of melatonin and pineal grafting on survival of older mice Ann. NY Acad. Sci. 621 1991 291 313
67. R.J. Reiter Oxidative damage in the central nervous system: protection by melatonin Prog. Neurobiol. 56 1998 359 384
68. R.J. Reiter, B. Poegeler, D.X. Tan, L.D. Chen, L.C. Manchester, and J.M. Guerrero Antioxidant capacity of melatonin: a novel action not requiring a receptor Neuroendocrinol. Lett. 15 1993 103 116
69. R.J. Reiter, D.X. Tan, and M. Allegra Melatonin: reducing molecular pathology and dysfunction die to free radicals and associated reactants Neuroendocrinol. Lett. 23 Suppl. 1 2002 3 8
70. R.J. Reiter, D.X. Tan, R.M. Sainz, J.C. Mayo, and S. Lopez-Burillo Melatonin: reducing the toxicity and increasing the efficacy of drugs J. Pharm. Pharmacol. 54 2002 1299 1321
71. R. Rozencweig, B.R. Grad, and J. Ochoa The role of melatonin and serotonin in aging Med. Hypotheses 23 1987 337 352
72. C. Schulman, and B. Lunefeld The aging male World J. Urol. 20 2002 4 10
73. M.L.V. Seabra, M. Bignotto, L.R. Pinto Jr, and C. Tufic Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment J. Pineal Res. 29 2000 193 200
74. C. Siegrist, C. Benedetti, A. Orlando, J.M. Beltran, L. Tuchsherr, C.J.M. Noseda, L.I. Brusco, and D.P. Cardinali Lack of changes in serum prolactin, FSH, TSH, and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed, middle aged, and elderly patients J. Pineal Res. 30 2001 34 42
75. C. Singer, R.E. Tractenbergh, J. Kaye, K. Schafer, A. Gamst, M. Grundman, R. Thomas, and L.J. Thal A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease Sleep 26 2003 893 901
76. M.A. Smith, C.A. Rottkamp, A. Nunomura, A.K. Raina, and G. Perry Oxidative stress in Alzheimer's disease Biochim. Biophys. Acta 1502 2000 139 144
77. K. Skwarlo-Sonta Melatonin in immunity: comparative aspects Neuroendocrinol. Lett. 23 Suppl. 1 2002 61 66
78. United Nations Department of Economic and Social Affairs. World Population Ageing: 1950-2050 2001 United Nations New York
79. United Nations Population Division, Department of Economic and Social Affairs. World Population Prospects: the 2000 Revision. Highlights 2001 United Nations New York
80. E.J.W. Van Someren Circadian and sleep disturbances in the elderly Exp. Gerontol. 35 2000 1229 1237
81. N. Zisapel The use of melatonin for the treatment of insomnia Biol. Signals Recept. 8 1999 84 89