Pavlovian conditioning of immune function: Animal investigation and the challenge of human application

Behavioural Brain Research

Volumn 110, Issue 1-2, 2000, Pages 129-141

  Exton, Michael S ^a   Von Auer, Anne Kristin ^b   Buske Kirschbaum, Angelika ^b   Stockhorst, Ursula ^c   Göbel, Ulrich ^c   Schedlowski, Manfred ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF TRIER   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Behavioral conditioning; Human; Psychoneuroimmunology; Rat; Sympathetic nervous system

Indexed keywords

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; CONDITIONED REFLEX; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOMODULATION; LATENT PERIOD; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CONDITIONING, CLASSICAL; HUMANS; IMMUNITY; NEUROSECRETORY SYSTEMS; RATS;

EID: 0034016086     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(99)00191-6     Document Type: Conference Paper

References (69)

1. Ader R., Cohen N. Behaviorally conditioned immunosuppression. Psychosom. Med. 37:1975;333-340.
2. Ader R., Cohen N. Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus. Science. 215:1982;1534-1536.
3. Ader R., Cohen N. Psychoneuroimmunology: conditioning and stress. Annu. Rev. Psychol. 44:1993;53-85.
4. Benschop R.J., Rodriguez-Feuerhahn M., Schedlowski M. Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav. Immun. 10:1996;77-91.
5. Bernstein I.L. Neural mediation of food aversions and anorexia induced by tumor necrosis factor and tumors. Neurosci. Biobehav. Rev. 20:1996;177-181.
6. Besedovsky H.O., del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocrine Rev. 17:1996;1-39.
7. Bolles RC. Learning Theory, New York: Holt, Rinehart & Winston, 1979, 250 pp.
8. Booth R.J., Petrie K.J., Brook R.J. Conditioning allergic skin responses in humans: a controlled trial. Psychosom. Med. 57:1995;492-495.
9. Bovbjerg D., Ader R., Cohen N. Acquisition and extinction of conditioned suppression of a graft-vs-host response. J. Immunol. 132:1984;111-113.
10. Bovbjerg D.H., Redd W.H., Maier L.A., Holland J.C., Lesko L.M., Niedzwiecki D., Rubin S.C., Hakes T.B. Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer. J. Consult. Clin. Psychol. 58:1990;153-157.
11. Buske-Kirschbaum A., Grota L., Kirschbaum C., Bienen T., Moynihan J., Ader R., Blair M.L., Hellhammer D.H., Felten D.H. Conditioned increase in peripheral blood mononuclear cell (PBMC) number and corticosterone secretion in the rat. Pharmacol. Biochem. Behav. 55:1996;27-32.
12. Buske-Kirschbaum A., Kirschbaum C., Stierle H., Jabaij L., Hellhammer D.H. Conditioned manipulation of natural killer (NK) cells in humans unsing a discriminative learning protocol. Biol. Psychol. 38:1994;143-155.
13. Buske-Kirschbaum A., Kirschbaum C., Stierle H., Lehnert H., Hellhammer D.H. Conditioned increase of natural killer cell activity (NKCA) in humans. Psychosom. Med. 54:1992;123-132.
14. Calne R. Impact of immunosuppressants on host tissues and tolerance. Transplant. Proc. 26:1994;3065-3070.
15. Croiset G., Heijnen C.J., van der Wal W.E., de Boer S.F., de Wied D. A role for the autonomic nervous system in modulating the immune response during mild emotional stimuli. Life Sci. 46:1990;419-425.
16. Exton M.S., von Hörsten S., Schult M. et al. Behaviorally conditioned immunosuppression using cyclosporin A: central nervous system reduces IL-2 production via splenic innervation. J. Neuroimmunol. 88:1998;182-191.
17. Exton M.S., Schult M., Donath S., Strubel T., Bode U., del Rey A., Westermann J., Schedlowski M. Conditioned immunosuppression makes subtherapeutic cyclosporin effective via splenic innervation. Am. J. Physiol. 276:1999;R1710-R1717.
18. Felten D.L., Felten S.Y., Bellinger D.L., Carlson S.L., Ackerman K.D., Madden K.S., Olschowka J.A., Livnat S. Noradrenergic sympathetic neural interactions with the immune system: structure and function. Immunol. Rev. 100:1987;225-260.
19. Fredrikson M., Fürst C.J., Lekander M., Rotstein S., Blomgren H. Trait anxiety and anticipatory immune reactions in women receiving adjuvant chemotherapy for breast cancer. Brain Behav. Immun. 7:1993;79-90.
20. Fuchs B.A., Campbell K.S., Munson A.E. Norepinephrine and serotonin content of the murine spleen: its relationship to lymphocyte β-adrenergic receptor density and the humoral immune response in vivo and in vitro. Cell. Immunol. 117:1988;339-351.
21. Gauci M., Husband A.J., Saxarra H., King M.G. Pavlovian conditioning of nasal tryptase release in human subjects with allergic rhinitis. Physiol. Behav. 55:1994;821-825.
22. Ghanta V., Hiramoto R.N., Solvason B., Spector N.H. Influence of conditioned natural immunity on tumor growth. Ann. N.Y. Acad. Sci. 496:1987;637-646.
23. Giang D.W., Goodman A.D., Schiffer R.B., Mattson D.H., Petrie M., Cohen N., Ader R. Conditioning of cyclophosphamide-induced leukopenia in humans. J. Neuropsychol. Clin. Neurosci. 8:1996;194-201.
24. Gorczynski R.M., Macrae S., Kennedy M. Conditioned immune response associated with allogeneic skin grafts in mice. J. Immunol. 129:1982;704-709.
25. Grochowicz P.M., Schedlowski M., Husband A.J., King M.G., Hibberd A.D., Bowen K.M. Behavioral conditioning prolongs heart allograft survival in rats. Brain Behav. Immun. 5:1991;349-356.
26. Herberman R.B., Ortaldo J.R. Natural killer cells: their role in defenses against disease. Science. 214:1981;24-30.
27. Hill LE. Philosophy of a Biologist. London: Arnold, 1930 88 pp.
28. Hiramoto R.N., Hiramoto N.S., Rish M.E., Soong S.J., Miller D.M., Ghanta V.K. Role of immune cells in the Pavlovian conditioning of specific resistance to cancer. Int. J. Neurosci. 59:1991;101-117.
29. Hsueh C.M., Chen S.F., Ghanta V.K., Hiramoto R.N. Expression of the conditioned NK cell activity is β-endorphin dependent. Brain Res. 678:1995;76-82.
30. Jetschmann J.-U., Benschop R.J., Jacobs R., Oberbeck R., Schmidt R.E., Schedlowski M. Expression and in-vivo modulation of α- and β-adrenoceptors on human natural killer (CD16+) cells. J. Neuroimmunol. 74:1997;159-164.
31. Kahan B.D. Cyclosporine. New Eng. J. Med. 321:1989;1725-1738.
32. Kappel M., Poulsen T.D., Galbo H., Pedersen B.K. Influence of minor increases in plasma catecholamines on natural killer cell activity. Horm. Res. 49:1998;22-26.
33. Katafuchi T., Ichijo T., Take S., Hori T. Hypothalamic modulation of splenic natural killer cell activity in rats. J. Physiol. 471:1993;209-221.
34. Klosterhalfen S., Klosterhalfen W. Classically conditioned effects of cyclophosphamide on white blood cell counts in rats. Ann. N.Y. Acad. Sci. 496:1987;569-577.
35. Klosterhalfen S., Klosterhalfen W. Conditioned cyclosporine effects but not conditioned taste aversion in immunized rats. Behav. Neurosci. 104:1990;716-724.
36. Lekander M., Fürst C.J., Rotstein S., Blomgren H., Fredrikson M. Does informed adjuvant placebo chemotherapy for breast cancer elicit immune changes? Oncol. Rep. 1:1994;699-703.
37. Lekander M., Fürst C.J., Rotstein S., Blomgren H., Fredrikson M. Anticipatory immune changes in women treated with chemotherapy for ovarian cancer. Int. J. Behav. Med. 2:1995;1-12.
38. Luecken L.J., Lysle D.T. Evidence for the involvement of β-adrenergic receptors in conditioned immunomodulation. J. Neuroimmunol. 38:1992;209-220.
39. Lysle D.T., Luecken L.J., Maslonek K.A. Modulation of immune status by a conditioned aversive stimulus: evidence for the involvement of endogenous opioids. Brain Behav. Immun. 6:1992;179-188.
40. Mackenzie J.N. The production of the so-called 'rose cold' by means of an artifical rose. Am. J. Med. Sci. 91:1896;45-57.
41. Madden K.S., Sanders V.M., Felten D.L. Catecholamine influences and sympathetic neural modulation of immune responsiveness. Ann. Rev. Pharmacol. Toxicol. 35:1995;417-448.
42. Mageed A.A., Findley H.W., Franco C., Singhapakdi S., Alvarado C., Chan W.C., Ragab A.H. Natural killer cells in children with acute leukemia. Cancer. 60:1987;2913-2918.
43. Maier S.F., Watkins L.R. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol. Rev. 105:1998;83-107.
44. Mehta B.A., Satam M.N., Advani S.H., Nadkarni J.J. In vitro modulation of natural killer cell activity in non-Hodgkin's lymphoma patients after therapy. Cancer Immunol. Immunother. 28:1989;148-152.
45. Miller A.D., Nonaka S., Jakuš J. Brain areas essential or non-essential for emesis. Brain Res. 647:1994;255-264.
46. Okamoto S., Ibaraki K., Hayashi S., Saito M. Ventromedial hypothalamus suppresses splenic lymphocyte activity through sympathetic innervation. Brain Res. 739:1996;308-313.
47. Ono K., Lindsey E.S. Improved technique of heart transplantation in rats. J. Thorac. Cardiovasc. Surg. 57:1969;225-229.
48. Perez L., Lysle D.T. Conditioned immunomodulation: investigations of the role of endogenous activity at μ, κ, and δ opioid receptor subtypes. J. Neuroimmunol. 79:1997;101-112.
49. Ramsay D.S., Woods S.C. Biological consequences of drug administration: implications for acute and chronic tolerance. Psychol. Rev. 104:1997;170-193.
50. Rogers M.P., Reich P., Strom T.B., Carpenter C.B. Behaviorally conditioned immunosuppression: replication of a recent study. Psychosom. Med. 38:1976;447-451.
51. Rosenberg S.A. The development of new immunotherapies for the treatment of cancer using interleukin-2. Ann. Surg. 208:1988;121-135.
52. 2-adrenergic mechanisms. J. Immunol. 156:1996;93-99.
53. Schedlowski M., Falk A., Rohne A., Wagner T.O.F., Jacobs R., Tewes U., Schmidt R.E. Catecholamines induce alterations of distribution and activity of human natural killer (NK) cells. J. Clin. Immunol. 13:1993;344-355.
54. Schedlowski M, Tewes U. Psychoneuroimmunology: An Interdisciplinary Introduction. New York: Kluwer Academic/Plenum Publishers, 1999, 582 pp.
55. Schumacher A., Nordheim A. Progress towards a molecular understanding of cyclosporin A-mediated immunosuppression. Clin. Invest. 70:1992;773-779.
56. Shimuzu N., Kaizuka Y., Hori T., Nakane H. Immobilization increases norepinephrine release and reduces NK cytotoxicity in spleen of conscious rat. Am. J. Physiol. 271:1996;R537-R544.
57. Smith G.R., Sandra M., McDaniels S.M. Psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans. Psychosom. Med. 45:1983;65-70.
58. Stockhorst U., Klosterhalfen S., Klosterhalfen W., Winkelmann M., Steingrüber H.J. Anticipatory nausea in cancer patients receiving chemotherapy: classical conditioning etiology and therapeutical implications. Integr. Physiol. Behav. Sci. 28:1993;177-181.
59. Stockhorst U., Klosterhalfen S., Steingrüber H.J. Conditioned nausea and further side-effects in cancer chemotherapy: a review. J. Psychophysiol. 12(Suppl. 1):1998;14-33.
60. Stockhorst U, Spennes S, Körholz D, Göbel U, Schneider EM, Steingrüber HJ, Klosterhalfen S. Anticipatory symptoms and anticipatory immune responses in pediatric cancer patients receiving chemotherapy: features of a classically conditioned response. Brain Behav. Immun. 1999, in press.
61. Stockhorst U., Wiener J.A., Klosterhalfen S., Klosterhalfen W., Aul C., Steingrüber H.J. Effects of overshadowing on conditioned nausea in cancer patients: an experimental study. Physiol. Behav. 64:1998;743-753.
62. Straub R.H., Westermann J., Schölmerich J., Falk W. Communication between CNS and immune system in lymphoid organs: synaptic dialogue with macrophages and lymphocytes. Immunol. Today. 19:1998;409-413.
63. Strutsovskaya A.L. An experiment on the formation of conditioned phagocytic reaction in children. Zhurnal Vyssej Nervnoj Dejatel Nosti Imeni I.P. Pavlova. 3:1953;238-246.
64. Take S., Mori T., Katafuchi T., Hori T. Central interferon-α inhibits natural killer cell activity through sympathetic innervation. Am. J. Physiol. 268:1995;R1406-R1410.
65. Tønnesen E., Tønnesen J., Christensen N.J. Augmentation of cytotoxicity by natural killer (NK) cells after adrenaline administration in man. Acta Pathol. Microbiol. Immunol. Scand. C92:1984;81-83.
66. Van Valen F., Winkelmann W., Burdach S., Göbel U., Jürgens H. Interferon γ and tumour necrosis factor α induce a synergistic antiproliferative response in human Ewing's sarcoma cells in vitro. J. Cancer Res. Clin. Oncol. 119:1993;615-621.
67. Wan W., Vriend C.Y., Wetmore L., Gartner J.G., Greenberg A.H., Nance D.M. The effects of stress on splenic immune function are mediated by the splenic nerve. Brain Res. Bull. 30:1993;101-105.
68. Wayner E.A., Flannery G.R., Singer G. Effects of taste aversion conditioning on the primary antibody response to sheep red blood cells and Brucella abortus in the albino rat. Physiol. Behav. 21:1978;995-1000.
69. Whiteside T.L., Vujanovic N.L., Herberman R.B. Natural killer cells and tumor therapy. Curr. Top. Microbiol. Immunol. 230:1998;221-244.