Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution

Endocrinology

Volumn 143, Issue 2, 2002, Pages 690-699

  French, Richard A ^a,d   Broussard, Suzanne R ^a   Meier, William A ^b   Minshall, Christian ^a   Arkins, Sean ^a,e   Zachary, James F ^b   Dantzer, Robert ^c   Kelley, Keith W ^a,b  

^a Laboratory of Immunophysiology   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c INSERM   (France)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

EOSIN; FORMALDEHYDE; GROWTH HORMONE; HEMATOXYLIN; HUMAN GROWTH HORMONE;

ADIPOCYTE; ADRENAL GLAND; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CELL LOSS; COLONY FORMING UNIT; CONTROLLED STUDY; ERYTHROCYTE; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; GRANULOCYTE; GROWTH HORMONE BLOOD LEVEL; HEMATOPOIETIC CELL; HISTOPATHOLOGY; LEUKOCYTE; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; REGENERATION; SPLEEN; THYMUS;

EID: 0036153393     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.2.8612     Document Type: Article

References (71)

1. The endocrinology of aging
2. The aging immune system: Primer and prospectus
3. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy
4. In vivo effects of growth hormone on thymus function in aging mice
5. 3 pituitary adenoma cells can reverse thymic aging in rats
6. Effects of growth hormone on thymocyte development from progenitor cells in the bone marrow
7. Growth hormone treatment stimulates thymulin production in aged dogs
8. Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice
9. Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in an increased incidence of human Epstein Barr virus-induced B-cell lymphoma
10. Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo
11. Immunologic and hematologic effects of neuroendocrine hormones. Studies on DW/J dwarf mice
12. Differential effects of growth hormone and prolactin on murine T cell development and function
13. Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue
14. Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine
15. Enhancement of thymic recovery after cyclosporine by recombinant human growth hormone and insulin-like growth factor 1
16. Role of growth hormone in regulating T-dependent immune events in aged, nude, and transgenic rodents
17. - lymphocytes in thymus glands of aged rats
18. Strain polymorphism in progression of aging: Changes in CD4, CD8 bearing subpopulations
19. Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry
20. Growth hormone receptors and immunocompetent cells
21. Type I insulin-like growth factor receptor expression in different developmental stages of human thymocytes
22. Specific binding sites for growth hormone in cultured mouse thymic epithelial cells
23. Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells
24. Quantitative analysis of bone marrow thymic progenitors in young and aged mice
25. Bone marrow-thymus axis in senescence
26. Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice
27. Pituitary dependence of bone marrow function
28. Recombinant human growth hormone promotes hematopoietic reconstitution after syngeneic bone marrow transplantation in mice
29. Effects of growth hormone and prolactin on hematopoiesis
30. Use of neuroendocrine hormones to promote reconstitution after bone marrow transplantation
31. The immune-endocrine loop during aging: Role of growth hormone and insulin-like growth factor-I
32. Interferongamma-induced priming for secretion of superoxide anion and tumor necrosis factor-α declines in macrophages from aged rats
33. Observations on leukemia in Wistar Furth rats
34. The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis
35. Dual expression of p80 type I and p68 type II interleukin-I receptors on anterior pituitary cells synthesizing growth hormone
36. Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice
37. In vitro clonal assays for murine multi-potential and lineage restricted myeloid progenitor cells
38. Growth hormone replacement therapy improves body composition and increases bone metabolism in elderly patients with pituitary disease
39. The somatopause: To treat or not to treat?
40. The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: Insights from genetic models of hormone and hormone receptor deficiency
41. Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo
42. Increase in haemoglobin concentrations in growth hormone deficient adults during human recombinant growth hormone replacement therapy
43. Prolactin, growth hormone, and insulin-like growth factor-I in the immune system
44. Identification of SP3 as a negative regulatory transcription factor in the monocyte expression of growth hormone
45. Prenatal and adult growth hormone gene expression in rat lymphoid organs
46. Production of peptide hormones and neuro-transmitters by the immune system
47. Involvement of insulin-like growth factors in early T cell development: A study using fetal thymic organ cultures
48. The biology of somatotropin in adipose tissue growth and nutrient partitioning
49. Leptin in the regulation of immunity, inflammation, and hematopoiesis
50. The control of hematopoiesis and leukemia: From basic biology to the clinic
51. The haematopoietic effects of growth hormone and insulin-like growth factor-I
52. Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
53. KIPI inhibitor characterize early development of promyeloid cells into macrophages
54. Activation of phosphatidylinositol 3'-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes
55. Phosphatidylinositol 3'-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors
56. Activation of protein kinase C-ζ and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
57. Thymic involution in aging
58. The human thymus during aging
59. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
60. IL-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice
61. Thymic involution with ageing: Obsolescence or good housekeeping?
62. Immune enhancing effect of a growth hormone secretagogue
63. A novel role of growth hormone and insulin-like growth factor-I. Priming neutrophils for superoxide anion secretion
64. Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor
65. A newly defined property of somatotropin: Priming of macrophages for production of superoxide anion
66. The pituitary gland is required for protection against lethal effects of Salmonella typhimurium
67. Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: Reversal by the combination of gamma interferon and growth hormone
68. The growth hormone/insulin-like growth factor axis in critical illness
69. Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice
70. Growth hormone as an immunomodulating therapeutic agent