Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment

Journal of Biological Chemistry

Volumn 284, Issue 32, 2009, Pages 21647-21658

  Legleiter, Justin ^a,b,d   Lotz, Gregor P ^a,b   Miller, Jason ^a   Ko, Jan ^c   Ng, Cheping ^a   Williams, Geneva L ^a   Finkbeiner, Steve ^a,b,c   Patterson, Paul H ^c   Muchowski, Paul J ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATE FORMATION; CONFORMATIONAL EPITOPES; FIBRIL FORMATION; HUNTINGTIN; HUNTINGTON DISEASE; INCLUSION BODIES; MULTIPLE CONFORMATIONS; MUTANT HUNTINGTIN; N-TERMINALS; NEURODEGENERATIVE DISORDERS; POLYGLUTAMINE; POLYGLUTAMINE (POLYQ); POLYPROLINE; STRUCTURAL BASIS;

ATOMIC FORCE MICROSCOPY; SURFACE PLASMON RESONANCE;

MONOCLONAL ANTIBODIES;

EPITOPE; HUNTINGTIN; HUNTINGTIN ANTIBODY; MONOCLONAL ANTIBODY; POLYGLUTAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; EXON; GROWTH INHIBITION; MOLECULAR RECOGNITION; MUTANT; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN STABILITY; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; EPITOPES; HUNTINGTON DISEASE; MICROSCOPY, ATOMIC FORCE; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 69249139853     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.016923     Document Type: Article

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