Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways

Stem Cells

Volumn 27, Issue 8, 2009, Pages 1963-1975

  Lee, Ji Seon ^a   Lee, M O ^b   Moon, Bo Hyun ^a   Shim, Sung Han ^b   Fornace Jr , Albert J ^c   Cha, Hyuk Jin ^a,b,d  

^a CHA Stem Cell Institute   (South Korea)

^b CHA University   (South Korea)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NONE   (South Korea)

Author keywords

Growth arrest; Human mesenchymal stem cells; P16Ink4a; Premature senescence; Reactive oxygen species; Wip1

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; PROTEIN WIP1; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; WILD TYPE P53 INDUCIBLE PHOSPHATASE 1;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL STRESS; CELL SURVIVAL; CELL THERAPY; CONTROLLED STUDY; DNA MODIFICATION; ENZYME INACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; PREMATURE SENESCENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENESCENCE; TISSUE SPECIFICITY;

ADIPOSE TISSUE; APOPTOSIS; CELL AGING; CELL CYCLE; CELL GROWTH PROCESSES; DOWN-REGULATION; GENES, P16; HUMANS; IMMUNOBLOTTING; MESENCHYMAL STEM CELLS; OSTEOGENESIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 69249109268     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.121     Document Type: Article

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