Molecular characterization of spontaneous mesenchymal stem cell transformation

PLoS ONE

Volumn 3, Issue 1, 2008, Pages

  Rubio, Daniel ^a   Garcia, Silvia ^a   Paz, Maria F ^a   de la Cueva, Teresa ^a   Lopez Fernandez, Luiz A ^b   Lloyd, Alison C ^c   Garcia Castro, Javier ^a,d   Bernard, Antonio ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Andalusian Stem Cell Bank   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; CELL CYCLE PROTEIN; CELL PROTEIN; MYC PROTEIN; PROTEIN INK4A; PROTEIN P16; RETINOBLASTOMA PROTEIN; TELOMERASE; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ARTICLE; CELL AGING; CELL CYCLE REGULATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; MITOCHONDRIAL RESPIRATION; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; UNINDEXED SEQUENCE; UPREGULATION; VALIDATION PROCESS; CYTOLOGY; DNA MICROARRAY; METABOLISM;

CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; GENE EXPRESSION; MESENCHYMAL STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 38849149592     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001398     Document Type: Article

References (43)

1. Hahn WC, Weinberg RA (2002) Rules for making human tumor cells. N Engl J Med 347: 1593-1603.
2. Hahn WC, Weinberg RA (2002) Modelling the molecular circuitry of cancer. Nat Rev Cancer 2: 331-341.
3. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem Cells, cancer, and cancer stem cells. Nature 414: 105-111.
4. Dalerba P, Cho RW, Clarke MF (2007) Cancer stem cells: models and concepts. Annu Rev Med. 58: 267-284.
5. Pardal R, Clarke MF, Morrison SJ (2003) Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3: 895-902.
6. Rubio D, Garcia-Castro J, Martin MC, de la Fuente R, Cigudosa JC, et al. (2005) Spontaneous human adult stem cell transformation. Cancer Res 65: 3035-3039.
7. Miura M, Miura Y, Padilla-Nash HM, Molinolo AA, Fu B, et al. (2006) Accumulated Chromosomal Instability in Murine Bone Marrow Mesenchymal Stem Cells Leads to Malignant Transformation. Stem Cells 24: 1095-1103.
8. Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, et al. (2006) Sarcoma Derived from Cultured Mesenchymal Stem Cells. Stem Cells 25: 371-379.
9. Wang Y, Huso DL, Harrington J, Kellner J, Jeong DK, et al. (2005) Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy 7: 509-519.
10. Zhou YZ, Bosch-Marce M, Okuyama H, Krishnamachary B, Kimura H, et al. (2006) Spontaneous Transformation of Cultured Mouse Bone Marrow-Derived Stromal Cells 66: 10849-10854.
11. Li H, Fan X, Kovi RC, Jo Y, Moquin B, et al. (2007) Spontaneous Expression of Embryonic Factors and p53 Point Mutations in Aged Mesenchymal Stem Cells: A Model of Age-Related Tumorigenesis In Mice. Cancer Res 67: 10889-10898.
12. Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, et al. (2007) Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A 104: 6223-6228.
13. Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrodder H, et al. (2004) Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 23: 5095-5098.
14. Kastan ME, Bartek J (2004) Cell-cycle checkpoints and cancer. Nature 432: 316-323.
15. Jacobs JJ, Kieboorn K, Marino S, DePinho RA, van Lohuizen M (1999) The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168.
16. Mund C, Beier V, Bewerunge P, Dahms M, Lyko F, et al. (2005) Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p161NK4A promoter in colon carcinoma cell lines. Nucleic Acids Res 33: e73.
17. Xing EP, Nie Y, Wang LD, Yang GY, Yang CS (1999) Aberrant methylation of p161NK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China. Carcinogenesis 20: 77-84.
18. Sherr CJ, McCormick F (2002) The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
19. Prockop DJ, Olson SD (2007) Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions. Blood 109: 3147-3151.
20. Tremain N, Korkko J, Ibberson D, Kopen GC, DiGirolamo C, et al. (2001) MicroSAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells 19: 408-418.
21. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, et al. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
22. Shay JW, Wright WE (1996) Telomerase activity in human cancer. Curr. Opin. Oncol. 8: 66-71.
23. Shay JW, Zou Y, Hiyama E, Wright WE (2001) Telomerase and cancer. Hum Mol Genet. 10: 677-685.
24. Serakinci N, Hoare SF, Kassem M, Atkinson SP, Keith WN (2006) Telomerase promoter reprogramming and interaction with general transcription factors in die human mesenchymal stem cell. Regen Med. 1: 125-131.
25. Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, et al. (2004) Signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol. 6: 308-318.
26. Daser A, Rabbitts TH (2004) Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. Genes Dev 18: 965-974.
27. Daibata M, Nemoto Y, Komatsu N, Machida H, Miyoshi I, et al. (2000) Constitutional t(3;11)(p21;q23) in a family, including one member with lymphoina: establishment of novel cell lines with this translocation. Cancer Genet Cytogenet 117: 28-31.
28. Pegram LD, Megonigal MD, Lange BJ, Nowell PC, Rowley JD, et al. (2000) t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5′ monophosphate synthetase) gene. Blood 96: 4360-4362.
29. Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, et al. (2000) Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor evidence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci U S A 97: 2145-2150.
30. Chau BN, Wang JY (2003) Coordinated regulation of life and death by RB. Nat Rev Cancer 3: 130-138.
31. Gorgoulis VG, Zacharatos, P, Kotsinas A, Liloglou T, Kyroudi A, et al. (1998) Alterations of the p16-pRb pathway and the chromosome lecus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression. Am J Pathol 153: 1749-1765.
32. Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, et al. (2005) Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res. 65: 3126-3135.
33. Sharpless NE (2005) INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res 576: 22-38.
34. Matheu A, Pantoja C, Efeyan A, Criado LM, Martin-Caballero J, et al. (2004) Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev 18: 2736-2746.
35. Rea MA, Zhou L, Qin Q, Barrandon Y, Easley KW, et al. (2006) Spontaneous immortalization of human epidermal cells with naturally elevated telomerase. J Invest Dermatol. 126: 2507-2515.
36. Gil J, Kerai P, Lleonart M, Bernard D, Cigudosa JC, et. al. (2005) Immortalization of primary human prostate epithelial cells bry c-Myc. Cancer Res. 65: 2179-2185.
37. Tsutsui T, Kumakura S, Yamamoto A, Kanai H, Tamura, et al. (2002) Association of p16(INK4a) and pRb inactivation with immortalization of human cells Carcinogenesis. 23: 2111-2117.
38. Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, et al. (2003) Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res. 63: 7147-7157.
39. Zongaro S, de Stanchina E, Colombo T, D'Incalci M, Giulotto E, et al. (2005) Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line. Cancer Res. 65: 11411-11418.
40. Benanti JA, Wang ML, Myers HE, Robinson KL, Grandori C, et al. (2007) Epigenetic Down-Regulation of ARF Expression Is a Selection Step in Immortalization of Human Fibroblasts by c-Myc Mol Cancer Res 5: OE1-OF9.
41. Wettenhall JM, Smyth GK (2004) LimmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 20: 3705-3706.
42. Ruiz JF, Lucas D, Garcia-Palomero E, Saez AI, Gonzalez MA, et al. (2004) Overexpression of human DNA polymerase mu (Pol ma) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Nucleic Acids Res 32: 5861-5873.
43. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93: 9821-9826.