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Volumn 35, Issue 3, 2009, Pages 227-231

C/EBPα in leukemogenesis: Identity and origin of the leukemia-initiating cell

Author keywords

C EBP ; Cancer stem cell; Hematopoiesis; Leukemia

Indexed keywords

ENHANCER BINDING PROTEIN ALPHA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN ALPHA;

EID: 69149086081     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.36     Document Type: Review
Times cited : (8)

References (52)
  • 1
    • 0035798414 scopus 로고    scopus 로고
    • McBindall-a better name for CCAAT/enhancer binding proteins?
    • McKnight, S. L. (2001) McBindall-a better name for CCAAT/enhancer binding proteins? Cell. 107, 259-261.
    • (2001) Cell , vol.107 , pp. 259-261
    • McKnight, S.L.1
  • 2
    • 0036683653 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding proteins: Structure, function and regulation
    • Ramji, D. P. and Foka, P. (2002) CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 365, 561-575.
    • (2002) Biochem. J. , vol.365 , pp. 561-575
    • Ramji, D.P.1    Foka, P.2
  • 3
    • 28344438648 scopus 로고    scopus 로고
    • A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPαlpha regulates human granulopoiesis
    • Fazi, F., Rosa, A., Fatica, A., Gelmetti, V., De Marchis, M. L., Nervi, C., and Bozzoni, I. (2005) A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPαlpha regulates human granulopoiesis. Cell. 123, 819-831.
    • (2005) Cell , vol.123 , pp. 819-831
    • Fazi, F.1    Rosa, A.2    Fatica, A.3    Gelmetti, V.4    De Marchis, M.L.5    Nervi, C.6    Bozzoni, I.7
  • 4
    • 4444233646 scopus 로고    scopus 로고
    • C/EBPαlpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo
    • Heath, V., Suh, H. C., Holman, M., Renn, K., Gooya, J. M., et al. (2004) C/EBPαlpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo. Blood. 104, 1639-1647.
    • (2004) Blood , vol.104 , pp. 1639-1647
    • Heath, V.1    Suh, H.C.2    Holman, M.3    Renn, K.4    Gooya, J.M.5
  • 6
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T., and Tenen, D. G. (1998) CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol. Cell. Biol. 18, 4301-4314.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4301-4314
    • Radomska, H.S.1    Huettner, C.S.2    Zhang, P.3    Cheng, T.4    Scadden, D.T.5    Tenen, D.G.6
  • 7
    • 33746861562 scopus 로고    scopus 로고
    • C/EBPαlpha: A tumour suppressor in multiple tissues?
    • Schuster, M. B. and Porse, B. T. (2006) C/EBPαlpha: a tumour suppressor in multiple tissues? Biochim. Biophys. Acta. 1766, 88-103.
    • (2006) Biochim. Biophys. Acta. , vol.1766 , pp. 88-103
    • Schuster, M.B.1    Porse, B.T.2
  • 8
    • 0033564978 scopus 로고    scopus 로고
    • C/EBPαlpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
    • Wang, X., Scott, E., Sawyers, C. L., and Friedman, A. D. (1999) C/EBPαlpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood. 94, 560-571.
    • (1999) Blood , vol.94 , pp. 560-571
    • Wang, X.1    Scott, E.2    Sawyers, C.L.3    Friedman, A.D.4
  • 9
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang, D. E., Zhang, P., Wang, N. D., Hetherington, C. J., Darlington, G. J., and Tenen, D. G. (1997) Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc. Natl. Acad. Sci. USA. 94, 569-574.
    • (1997) Proc. Natl. Acad. Sci. USA. , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 10
    • 0032555932 scopus 로고    scopus 로고
    • Upregulation of interleukin 6 and granulocyte colony- stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis
    • Zhang, P., Iwama, A., Datta, M. W., Darlington, G. J., Link, D. C., and Tenen, D. G. (1998) Upregulation of interleukin 6 and granulocyte colony- stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis. J. Exp. Med. 188, 1173-1184.
    • (1998) J. Exp. Med. , vol.188 , pp. 1173-1184
    • Zhang, P.1    Iwama, A.2    Datta, M.W.3    Darlington, G.J.4    Link, D.C.5    Tenen, D.G.6
  • 12
    • 22344437854 scopus 로고    scopus 로고
    • Loss of C/ EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage
    • Porse, B. T., Bryder, D., Theilgaard-Monch, K., Hasemann, M. S., Anderson, K., Damgaard, I., Jacobsen, S. E., and Nerlov, C. (2005) Loss of C/ EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. J. Exp. Med. 202, 85-96.
    • (2005) J. Exp. Med. , vol.202 , pp. 85-96
    • Porse, B.T.1    Bryder, D.2    Theilgaard-Monch, K.3    Hasemann, M.S.4    Anderson, K.5    Damgaard, I.6    Jacobsen, S.E.7    Nerlov, C.8
  • 13
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPαlpha is required for adipogenesis and granulopoiesis in vivo.
    • Porse, B. T., Pedersen, T. A., Xu, X., Lindberg, B., Wewer, U. M., Friis- Hansen, L., and Nerlov, C. (2001) E2F repression by C/EBPαlpha is required for adipogenesis and granulopoiesis in vivo. Cell. 107, 247-258.
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1    Pedersen, T.A.2    Xu, X.3    Lindberg, B.4    Wewer, U.M.5    Friis- Hansen, L.6    Nerlov, C.7
  • 16
    • 1442356729 scopus 로고    scopus 로고
    • Mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Frohling, S., Schlenk, R. F., Stolze, I., Bihlmayr, J., Benner, A., Kreitmeier, S., Tobis, K., Dohner, H., and Dohner, K. (2004) Mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J. Clin. Oncol. 22, 624-633.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 624-633
    • Frohling, S.1    Schlenk, R.F.2    Stolze, I.3    Bihlmayr, J.4    Benner, A.5    Kreitmeier, S.6    Tobis, K.7    Dohner, H.8    Dohner, K.9
  • 17
    • 0037082508 scopus 로고    scopus 로고
    • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    • Gombart, A. F., Hofmann, W. K., Kawano, S., Takeuchi, S., Krug, U., Kwok, S. H., Larsen, R. J., Asou, H., Miller, C. W., Hoelzer, D., and Koeffler, H. P. (2002) Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. Blood. 99, 1332-1340.
    • (2002) Blood , vol.99 , pp. 1332-1340
    • Gombart, A.F.1    Hofmann, W.K.2    Kawano, S.3    Takeuchi, S.4    Krug, U.5    Kwok, S.H.6    Larsen, R.J.7    Asou, H.8    Miller, C.W.9    Hoelzer, D.10    Koeffler, H.P.11
  • 20
    • 20044388101 scopus 로고    scopus 로고
    • Characterization of CEBPA mutations in acute myeloid leukemia: Most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells
    • Lin, L. I., Chen, C. Y., Lin, D. T., Tsay, W., Tang, J. L., Yeh, Y. C., Shen, H. L., Su, F. H., Yao, M., Huang, S. Y., and Tien, H. F. (2005) Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells. Clin. Cancer. Res. 11, 1372-1379.
    • (2005) Clin. Cancer. Res. , vol.11 , pp. 1372-1379
    • Lin, L.I.1    Chen, C.Y.2    Lin, D.T.3    Tsay, W.4    Tang, J.L.5    Yeh, Y.C.6    Shen, H.L.7    Su, F.H.8    Yao, M.9    Huang, S.Y.10    Tien, H.F.11
  • 21
    • 33644836787 scopus 로고    scopus 로고
    • C/EBPαlpha and the pathophysiology of acute myeloid leukemia
    • Mueller, B. U. and Pabst, T. (2006) C/EBPαlpha and the pathophysiology of acute myeloid leukemia. Curr. Opin. Hematol. 13, 7-14
    • (2006) Curr. Opin. Hematol. , vol.13 , pp. 7-14
    • Mueller, B.U.1    Pabst, T.2
  • 22
    • 2342544921 scopus 로고    scopus 로고
    • C/EBPαlpha mutations in acute myeloid leukaemias
    • Nerlov, C. (2004) C/EBPαlpha mutations in acute myeloid leukaemias. Nat. Rev. Cancer.4, 394-400.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 394-400
    • Nerlov, C.1
  • 23
    • 55549133272 scopus 로고    scopus 로고
    • Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia
    • Pabst, T., Eyholzer, M., Haefliger, S., Schardt, J., and Mueller, B. U. (2008) Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. J. Clin. Oncol. 26, 5088-5093.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5088-5093
    • Pabst, T.1    Eyholzer, M.2    Haefliger, S.3    Schardt, J.4    Mueller, B.U.5
  • 24
    • 0035093813 scopus 로고    scopus 로고
    • Dominant- negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPαlpha), in acute myeloid leukemia
    • Pabst, T., Mueller, B. U., Zhang, P., Radomska, H. S., Narravula, S., Schnittger, S., Behre, G., Hiddemann, W., and Tenen, D. G. (2001) Dominant- negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPαlpha), in acute myeloid leukemia. Nat. Genet. 27, 263-270.
    • (2001) Nat. Genet. , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5    Schnittger, S.6    Behre, G.7    Hiddemann, W.8    Tenen, D.G.9
  • 26
    • 21744438305 scopus 로고    scopus 로고
    • Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia
    • Sellick, G. S., Spendlove, H. E., Catovsky, D., Pritchard-Jones, K., and Houlston, R. S. (2005) Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia. Leukemia. 19, 1276-1278.
    • (2005) Leukemia , vol.19 , pp. 1276-1278
    • Sellick, G.S.1    Spendlove, H.E.2    Catovsky, D.3    Pritchard-Jones, K.4    Houlston, R.S.5
  • 27
    • 16344370044 scopus 로고    scopus 로고
    • Heterogeneous patterns of CEBPalpha mutation status in the progression of myelodysplastic syndrome and chronic myelomonocytic leukemia to acute myelogenous leukemia
    • Shih, L. Y., Huang, C. F., Lin, T. L., Wu, J. H., Wang, P. N., Dunn, P., Kuo, M. C., and Tang, T. C. (2005) Heterogeneous patterns of CEBPalpha mutation status in the progression of myelodysplastic syndrome and chronic myelomonocytic leukemia to acute myelogenous leukemia. Clin. Cancer. Res. 11, 1821-1826.
    • (2005) Clin. Cancer. Res. , vol.11 , pp. 1821-1826
    • Shih, L.Y.1    Huang, C.F.2    Lin, T.L.3    Wu, J.H.4    Wang, P.N.5    Dunn, P.6    Kuo, M.C.7    Tang, T.C.8
  • 34
    • 73249147266 scopus 로고    scopus 로고
    • Aberrant DNA methylation of the transcription factor C/EBPαlpha in acute myelogenous leukemia
    • in press
    • Jost, E. O. N. D., Wilop, S., Herman, J. G., Osieka, R., and Galm, O. Aberrant DNA methylation of the transcription factor C/EBPαlpha in acute myelogenous leukemia. Leuk. Res., in press.
    • Leuk. Res.
    • Jost, E.O.N.D.1    Wilop, S.2    Herman, J.G.3    Osieka, R.4    Galm, O.5
  • 35
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • Ayton, P. M. and Cleary, M. L. (2003) Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes. Dev. 17, 2298-2307.
    • (2003) Genes. Dev. , vol.17 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 36
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo.
    • Blair, A., Hogge, D. E., Ailles, L. E., Lansdorp, P. M., and Sutherland, H. J. (1997) Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood. 89, 3104-3112.
    • (1997) Blood , vol.89 , pp. 3104-3112
    • Blair, A.1    Hogge, D.E.2    Ailles, L.E.3    Lansdorp, P.M.4    Sutherland, H.J.5
  • 37
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D. and Dick, J. E. (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730-737.
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 40
    • 33751210076 scopus 로고    scopus 로고
    • The cancer stem cell hypothesis: A work in progress
    • Tan, B. T., Park, C. Y., Ailles, L. E., and Weissman, I. L. (2006) The cancer stem cell hypothesis: a work in progress. Lab. Invest. 86, 1203-1207.
    • (2006) Lab. Invest. , vol.86 , pp. 1203-1207
    • Tan, B.T.1    Park, C.Y.2    Ailles, L.E.3    Weissman, I.L.4
  • 45
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio, A., Passegue, E., Ayton, P. M., Karsunky, H., Cleary, M. L., and Weissman, I. L. (2003) Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes. Dev. 17, 3029-3035.
    • (2003) Genes. Dev. , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 48
    • 35948964020 scopus 로고    scopus 로고
    • Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
    • Wong, P., Iwasaki, M., Somervaille, T. C., So, C. W., and Cleary, M. L. (2007) Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes. Dev. 21, 2762-2774.
    • (2007) Genes. Dev. , vol.21 , pp. 2762-2774
    • Wong, P.1    Iwasaki, M.2    Somervaille, T.C.3    So, C.W.4    Cleary, M.L.5
  • 49
    • 9344257318 scopus 로고    scopus 로고
    • Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia
    • Miyamoto, T., Nagafuji, K., Akashi, K., Harada, M., Kyo, T., Akashi, T., Takenaka, K., Mizuno, S., Gondo, H., Okamura, T., Dohy, H., and Niho, Y. (1996) Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Blood. 87, 4789-4796.
    • (1996) Blood , vol.87 , pp. 4789-4796
    • Miyamoto, T.1    Nagafuji, K.2    Akashi, K.3    Harada, M.4    Kyo, T.5    Akashi, T.6    Takenaka, K.7    Mizuno, S.8    Gondo, H.9    Okamura, T.10    Dohy, H.11    Niho, Y.12
  • 50
    • 0034691092 scopus 로고    scopus 로고
    • AML1/ETOexpressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
    • Miyamoto, T., Weissman, I. L., and Akashi, K. (2000) AML1/ETOexpressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc. Natl. Acad. Sci. USA. 97, 7521-7526.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7521-7526
    • Miyamoto, T.1    Weissman, I.L.2    Akashi, K.3
  • 52
    • 34547133494 scopus 로고    scopus 로고
    • The C/EBP family of transcription factors: A paradigm for interaction between gene expression and proliferation control
    • Nerlov, C. (2007) The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. Trends. Cell. Biol. 17, 318-324.
    • (2007) Trends. Cell. Biol. , vol.17 , pp. 318-324
    • Nerlov, C.1


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