Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates

Journal of Pharmacological and Toxicological Methods

Volumn 60, Issue 2, 2009, Pages 130-151

  Guo, Liang ^a   Dong, Zedong ^a   Guthrie, Heather ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Arrhythmia; Cardiotoxicity; ECG; Guinea pig; Hemodynamic; Langendorff heart; Methods; Monophasic action potential; QT QTc; Torsade de Pointes

Indexed keywords

ACONITINE; AMOXICILLIN; ARSENIC TRIOXIDE; BEPRIDIL; CAPTOPRIL; CISAPRIDE; CLOZAPINE; DIPHENHYDRAMINE; DOFETILIDE; ERYTHROMYCIN; FLECAINIDE; HALOPERIDOL; IMIPRAMINE; INDAPAMIDE; KETOCONAZOLE; OLANZAPINE; OUABAIN; PENTAMIDINE; PINACIDIL; PROPRANOLOL; QUINIDINE; SOTALOL; TERFENADINE; THIORIDAZINE; VERAPAMIL;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CARDIOTOXICITY; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR RISK; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; CORONARY ARTERY PRESSURE; DRUG BLOOD LEVEL; DRUG SAFETY; DRUG SCREENING; ELECTROCARDIOGRAM; GUINEA PIG; HEART ARRHYTHMIA; HEART BEAT; HEART ELECTROPHYSIOLOGY; HEART HEMODYNAMICS; HEART LEFT VENTRICLE PRESSURE; HEART PERFUSION; HEART RATE; HEART REPOLARIZATION; IC 50; ISOLATED HEART; NONHUMAN; QRS COMPLEX; QT PROLONGATION; RISK ASSESSMENT; SCORING SYSTEM; SINUS RHYTHM; TORSADE DES POINTES; VALIDATION STUDY;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIOVASCULAR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; GUINEA PIGS; HEART; INHIBITORY CONCENTRATION 50; LONG QT SYNDROME; MALE; PHARMACEUTICAL PREPARATIONS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TORSADES DE POINTES;

CAVIA;

EID: 68549133107     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.07.002     Document Type: Article

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