Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation

Journal of Pharmacological and Toxicological Methods

Volumn 52, Issue 1, 2005, Pages 123-135

  Guo, Liang ^a   Guthrie, Heather ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Cardiac safety; CHO cells; hERG; Methods; PatchXpress 7000A; QT prolongation

Indexed keywords

AMIODARONE; AMITRIPTYLINE; ASTEMIZOLE; BEPRIDIL; CISAPRIDE; DOFETILIDE; FLUOXETINE; HALOPERIDOL; IMIPRAMINE; OLANZAPINE; QUINIDINE; SIBUTRAMINE; TERFENADINE; THIORIDAZINE; VERAPAMIL;

ACCURACY; ANIMAL CELL; ARTICLE; AUTOMATION; CELL LINE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HYDROPHOBICITY; MEDICAL TECHNOLOGY; NONHUMAN; PARAMETER; PATCH CLAMP; POTASSIUM CURRENT; QT PROLONGATION; QUALITATIVE ANALYSIS; RELIABILITY; STEADY STATE; VOLTAGE CLAMP;

ANIMALS; CARDIOVASCULAR AGENTS; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTROPHYSIOLOGY; INHIBITORY CONCENTRATION 50; LONG QT SYNDROME; PATCH-CLAMP TECHNIQUES; PHARMACEUTICAL PREPARATIONS; POTASSIUM CHANNELS, VOLTAGE-GATED; ROBOTICS; TORSADES DE POINTES;

EID: 22444443481     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.04.002     Document Type: Article

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