Effects of the diuretic agent indapamide on Na+, transient outward, and delayed rectifier currents in canine atrial myocytes

Circulation Research

Volumn 83, Issue 2, 1998, Pages 158-166

  Lu, Yanjie ^b   Yue, Lixia ^b,c   Wang, Zhiguo ^a,b   Nattel, Stanley ^a,b,c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MONTREAL HEART INSTITUTE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Cardiac antiarrhythmic drug; ECG; Heart electrophysiology; Ion channel blocker

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; BOVINE SERUM ALBUMIN; CADMIUM CHLORIDE; CALCIUM ION; COLLAGENASE; DIURETIC AGENT; DOFETILIDE; INDAPAMIDE; NIFEDIPINE; POTASSIUM HYDROXIDE; POTASSIUM ION; RYANODINE; SODIUM HYDROXIDE; SODIUM ION; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DOG; DRUG EFFECT; FEMALE; HEART ATRIUM MUSCLE; HEART DEPOLARIZATION; HEART MUSCLE POTENTIAL; MALE; MICROELECTRODE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM TRANSPORT; VOLTAGE CLAMP;

EID: 0032572593     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.83.2.158     Document Type: Article

References (22)

1. + current in ventricular myocytes of the guinea pig type: theoretical formulation and their role in repolarization. Circ Res. 1995;77:140-152.
2. Noble D, Tsien RW. Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J Physiol (Lond). 1969; 200:205-231.
3. + current: differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol. 1990;96:195-215.
4. + current is composed of two currents in guinea pig atrial cells. Am J Physiol. 1991;260:H393-H399.
5. Kr potassium channel. Cell. 1995;81:299-307.
6. Ks cardiac potassium current. Nature. 1996;384:78-80.
7. Ks potassium channel. Nature. 1996;384:80-83.
8. + current, by the diuretic agent indapamide in guinea pig myocytes. Circ Res. 1994; 75:879-886.
9. Turgeon J, Fiset C, Kingma ML, Lacoursiere L, Kingma JG Jr. Influence of indapamide and chlorthalidone on reperfusion-induced ventricular fibrillation in isolated guinea pig hearts. J Cardiovasc Pharmacol. 1995; 26:518-523.
10. Ks by the diuretic agent indapamide modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J Pharmacol Exp Ther. 1997; 283:148-156.
11. Yue L, Feng J, Li GR, Nattel S. Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization. J Physiol (Lond). 1996;496:3:647-662.
12. + current in human ventricular myocytes. Circ Res. 1996;78:689-696.
13. sK channels by the chromanol 293B. Pflugers Arch. 1996;432:1094-1096.
14. Ks) in human and guinea pig ventricle [abstract]. J Am Coll Cardiol. 1997;29:512A.
15. Salata JJ, Jurkiewicz NK, Sanguinetti MC, Siegl PK, Claremon DA, Remy DC, Elliot JM, Libby BE. The novel class III antiarrhythmic agent, L-735,821 is a potent and selective blocker of IKs in guinea pig ventricular myocytes [abstract]. Circulation. 1996;94(suppl I):I-528.
16. Keren A, Tzivoni D, Gavish D, Levi J, Gottlieb S, Benhorin J, Stern S. Etiology, warning signs and therapy of torsade de pointes. A study of 10 patients. Circulation. 1981;64:1167-1174.
17. Fofar JC, Gribbin B. Torsades de pointes after amiodarone withdrawal: effects of mild hypokaliemia on repolarization. Eur Heart J. 1984;5: 510-512.
18. McKibbin JK, Pocock WA, Barlow JB, Millar RNS, Obel IWP. Sotalol, hypokalemia, syncope, and torsades de pointes. Br Heart J. 1984;51: 157-162.
19. Siegel D, Hulley SB, Black DM, Chettlin MD, Sebastian A, Seeley DG, Hearst N, Fine R. Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA. 1992;267: 1083-1089.
20. K) in guinea pig ventricular myocytes. Circ Res. 1994;74: 1114-1120.
21. Snyders DJ, Ycola SW. Determinants of antiarrhythmic drug action: electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel. Circ Res. 1995;77:575-583.
22. + channels by local anesthetics. Science. 1994;265:1724-1728.