Characterization of the effects of Ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

Progress in Biophysics and Molecular Biology

Volumn 96, Issue 1-3, 2008, Pages 452-464

  Nikmaram, Mohammed R ^a   Liu, Jie ^c   Abdelrahman, Mohamed ^c   Dobrzynski, Halina ^b   Boyett, Mark R ^b   Lei, Ming ^b  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

"Rapidly activating" delayed rectifier K+ current (iKr); Atrioventricular node; Pacemaking; Sinoatrial node; TTX sensitive neuronal Na+ current (iNa); Ultrarapid delayed rectifier potassium current (IKur)

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 4 AMINOPYRIDINE; ANTIARRHYTHMIC AGENT; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PYRIDINE DERIVATIVE; RYANODINE; TETRODOTOXIN;

ANIMAL; DRUG EFFECT; HEART ATRIOVENTRICULAR NODE; METABOLISM; MOUSE; PHYSIOLOGY; REVIEW; SINUS NODE;

4-AMINOPYRIDINE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIOVENTRICULAR NODE; MICE; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; RYANODINE; SINOATRIAL NODE; TETRODOTOXIN;

EID: 43049146576     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2007.07.003     Document Type: Review

References (28)

1. Bassani R.A., Bassani J.W., Lipsius S.L., and Bers D.M. Diastolic SR Ca efflux in atrial pacemaker cells and Ca-overloaded myocytes. Am. J. Physiol. 273 (1997) H886-H892
2. Bassani J.W., Godoy C.M., and Bassani R.A. Effect of ryanodine on sinus node recovery time determined in vitro. Braz. J. Med. Biol. Res. 32 (1999) 1039-1043
3. 2+ exchanger: molecular partners in pacemaker regulation. Circ. Res. 88 (2001) 1254-1258
4. Boyett M.R., Honjo H., and Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc. Res. 47 (2000) 658-687
5. Cho H.-S., Takano M., and Noma A. The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J. Physiol. (Lond.) 550 (2003) 169-180
6. + current regulates pacemaker activity in adult mouse sinoatrial node cells. Am. J. Physiol. 286 (2004) H1757-H1766
7. Dobrzynski H., Nikolski V.P., Sambelashvili A.T., Greener I.D., Yamamoto M., Boyett M.R., and Efimov I.R. Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart. Circ. Res. 93 (2003) 1102-1110
8. Efimov I.R., Nikolski V.P., Rothenberg F., Greener I.D., Li J., Dobrzynski H., and Boyett M. Structure-function relationship in the AV junction. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 280 2 (2004) 952-965
9. + current in cultured adult human atrial myocytes. Circ. Res. 80 (1997) 572-579
10. 2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ. Res. 92 (2003) e41-e44
11. 2+ release contributes to automaticity in cat atrial pacemaker cells. J. Physiol. (Lond.) 524 Pt. 2 (2000) 415-422
12. Irisawa H., Brown H.F., and Giles W. Cardiac pacemaking in the sinoatrial node. Physiol. Rev. 73 (1993) 197-227
13. Kleber A.G., and Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol. Rev. 84 (2004) 431-488
14. 2+ and pacemaking within the rabbit sinoatrial node: heterogeneity of role and control. J. Physiol. (Lond.) 556 (2004) 481-494
15. Lei M., Jones S.A., Liu J., Lancaster M.K., Fung S.S.-M., Dobrzynski H., Camelliti P., Maier S.K.G., Noble D., and Boyett M.R. Requirement of neuronal- and cardiac-type sodium channels for murine sinoatrial node pacemaking. J. Physiol. (Lond.) 559 (2004) 835-848
16. Lipsius S.L. Triggered rhythms in atrial muscle. J. Electrocardiol. 20 (1987) 33-37
17. Liu J., Dobrzynski H., Abdelrahman M., Boyett M., and Lei M. Organization of the mouse sinoatrial node: structure and expression of HCNs. Cardiovasc. Res. 73 (2006) 729
18. Maier S.K., Westenbroek R.E., Schenkman K.A., Feigl E.O., Scheuer T., and Catterall W.A. An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc. Natl. Acad. Sci. USA 99 (2002) 4073-4078
19. Maier S.K., Westenbroek R.E., Yamanushi T.T., Dobrzynski H., Boyett M.R., Catterall W.A., and Scheuer T. An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node. Proc. Natl. Acad. Sci. USA 100 (2003) 3507-3512
20. Marionneau C., Couette B., Liu J., Li H., Mangoni M.E., Nargeot J., Lei M., Escande D., and Demolombe S. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J. Physiol. (Lond.) 562 (2005) 223-234
21. Meijler F.L., and Jalife J. Electrophysiology of the atrioventricular node during atrial fibrillation. I. Ventricular rhythm. Ned. Tijdschr. Geneeskd. 143 (1999) 1245-1252
22. Meijler F.L., and Janse M.J. Morphology and electrophysiology of the mammalian atrioventricular node. Physiol. Rev. 68 2 (1988) 608-647
23. Rigg L., and Terrar D.A. Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node. Exp. Physiol. 81 (1996) 877-880
24. Tse W.W. Evidence of presence of automatic fibers in the canine atrioventricular node. Am. J. Physiol. 225 3 (1973) 716-723
25. 2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick. Ann. N. Y. Acad. Sci. 1047 (2005) 138-156
26. Yamamoto M., Honjo H., Niwa R., and Kodama I. Low-frequency extracellular potentials recorded from the sinoatrial node. Cardiovasc. Res. 39 (1998) 360-372
27. + channel isoforms at the atrioventricular junction and atrioventricular node in the rat. Circulation 114 (2006) 1360-1371
28. Yue L., Feng J., Li G.R., and Nattel S. Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization. J. Physiol. (Lond.) 496 (1996) 647-662