QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 2, 2006, Pages 498-506

  Fossa, Anthony A ^a,b   Wisialowski, Todd ^a   Crimin, Kimberly ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 2 (4 TRIFLUOROMETHYL) N [2 OXO 5 PHENYL 1 (2,2,2 TRIFLUOROETHYL) 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 YL]ACETAMIDE; ACETAMIDE; L 768673; UNCLASSIFIED DRUG;

ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART ELECTROPHYSIOLOGY; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HYSTERESIS; MEMBRANE POLARIZATION AND DEPOLARIZATION; MOLECULAR DYNAMICS; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; QUANTITATIVE ANALYSIS; SINUS RHYTHM;

ACETAMIDES; ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; BENZODIAZEPINONES; DOGS; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; LONG QT SYNDROME; MALE; MYOCARDIAL CONTRACTION; PIPERIDINES; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES;

EID: 31144463035     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.095471     Document Type: Article

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