-
1
-
-
47649124451
-
Tracheal branching morphogenesis in Drosophila: New insights into cell behavior and organ architecture
-
Affolter, M. & Caussinus, E. Tracheal branching morphogenesis in Drosophila: New insights into cell behavior and organ architecture. Development 135, 2055-2064 (2008).
-
(2008)
Development
, vol.135
, pp. 2055-2064
-
-
Affolter, M.1
Caussinus, E.2
-
2
-
-
0037815292
-
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
-
Gerhardt, H. et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161, 1163-1177 (2003).
-
(2003)
J. Cell Biol
, vol.161
, pp. 1163-1177
-
-
Gerhardt, H.1
-
3
-
-
0037108152
-
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
-
Ruhrberg, C. et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16, 2684-2698 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 2684-2698
-
-
Ruhrberg, C.1
-
4
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone, M. et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136, 839-851 (2009).
-
(2009)
Cell
, vol.136
, pp. 839-851
-
-
Mazzone, M.1
-
5
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in anti-angiogenic therapy
-
Jain, R. K. Normalization of tumor vasculature: An emerging concept in anti-angiogenic therapy. Science 307, 58-62 (2005).
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
6
-
-
57749173152
-
VEGF inhibition: Insights from preclinical and clinical studies
-
Crawford, Y. & Ferrara, N. VEGF inhibition: Insights from preclinical and clinical studies. Cell Tissue Res. 335, 261-269 (2009).
-
(2009)
Cell Tissue Res
, vol.335
, pp. 261-269
-
-
Crawford, Y.1
Ferrara, N.2
-
7
-
-
47949089077
-
VEGF-targeted therapy: Mechanisms of anti-tumor activity
-
Ellis, L. M. & Hicklin, D. J. VEGF-targeted therapy: Mechanisms of anti-tumor activity. Nat. Rev. Cancer 8, 579-591 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
8
-
-
0036174063
-
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
-
Stalmans, I. et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J. Clin. Invest. 109, 327-336 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 327-336
-
-
Stalmans, I.1
-
9
-
-
34547941252
-
Autocrine VEGF signaling is required for vascular homeostasis
-
Lee, S. et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell 130, 691-703 (2007).
-
(2007)
Cell
, vol.130
, pp. 691-703
-
-
Lee, S.1
-
10
-
-
0037370325
-
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
-
Eremina, V. et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J. Clin. Invest. 111, 707-716 (2003).
-
(2003)
J. Clin. Invest
, vol.111
, pp. 707-716
-
-
Eremina, V.1
-
11
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996).
-
(1996)
Nature
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
-
12
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380 435-439 (1996).
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
-
13
-
-
12344312042
-
Cellular abnormalities of blood vessels as targets in cancer
-
Baluk, P., Hashizume, H. & McDonald, D. M. Cellular abnormalities of blood vessels as targets in cancer. Curr. Opin. Genet. Dev. 15 102-111 (2005).
-
(2005)
Curr. Opin. Genet. Dev
, vol.15
, pp. 102-111
-
-
Baluk, P.1
Hashizume, H.2
McDonald, D.M.3
-
14
-
-
55249126800
-
The role of endothelial-to-mesenchymal transition in cancer progression
-
Potenta, S., Zeisberg, E. & Kalluri, R. The role of endothelial-to-mesenchymal transition in cancer progression. Br. J. Cancer 99, 1375-1379 (2008).
-
(2008)
Br. J. Cancer
, vol.99
, pp. 1375-1379
-
-
Potenta, S.1
Zeisberg, E.2
Kalluri, R.3
-
15
-
-
57649135172
-
A role for VEGF as a negative regulator of pericyte function and vessel maturation
-
Greenberg, J. I. et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 456, 809-813 (2008).
-
(2008)
Nature
, vol.456
, pp. 809-813
-
-
Greenberg, J.I.1
-
16
-
-
60649116477
-
Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited
-
Loges, S., Mazzone, M., Hohensinner, P. & Carmeliet, P. Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited. Cancer Cell 15, 167-170 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 167-170
-
-
Loges, S.1
Mazzone, M.2
Hohensinner, P.3
Carmeliet, P.4
-
17
-
-
60649106195
-
Anti-angiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes, M. et al. Anti-angiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
-
18
-
-
33845877157
-
Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis
-
Noguera-Troise, I. et al. Blockade of Dll4 inhibits tumor growth by promoting non-productive angiogenesis. Nature 444, 1032-1037 (2006).
-
(2006)
Nature
, vol.444
, pp. 1032-1037
-
-
Noguera-Troise, I.1
-
19
-
-
33845907380
-
Inhibition of Dll4 signaling inhibits tumor growth by deregulating angiogenesis
-
Ridgway, J. et al. Inhibition of Dll4 signaling inhibits tumor growth by deregulating angiogenesis. Nature 444, 1083-1087 (2006).
-
(2006)
Nature
, vol.444
, pp. 1083-1087
-
-
Ridgway, J.1
-
20
-
-
50849103301
-
Notch signaling regulates tumor angiogenesis by diverse mechanisms
-
Dufraine, J., Funahashi, Y. & Kitajewski, J. Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene 27, 5132-5137 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 5132-5137
-
-
Dufraine, J.1
Funahashi, Y.2
Kitajewski, J.3
-
21
-
-
47949085649
-
A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis
-
Funahashi, Y. et al. A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. Cancer Res. 68, 4727-4735 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 4727-4735
-
-
Funahashi, Y.1
-
22
-
-
50849100996
-
The many facets of Notch ligands
-
D'Souza, B., Miyamoto, A. & Weinmaster, G. The many facets of Notch ligands. Oncogene 27, 5148-5167 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 5148-5167
-
-
D'Souza, B.1
Miyamoto, A.2
Weinmaster, G.3
-
23
-
-
34250209506
-
Notch signaling in blood vessels: Who is talking to whom about what?
-
Hofmann, J. J. & Iruela-Arispe, M. L. Notch signaling in blood vessels: who is talking to whom about what? Circ. Res. 100, 1556-1568 (2007).
-
(2007)
Circ. Res
, vol.100
, pp. 1556-1568
-
-
Hofmann, J.J.1
Iruela-Arispe, M.L.2
-
24
-
-
58249094059
-
Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis
-
Phng, L. K. et al. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev. Cell 16, 70-82 (2009).
-
(2009)
Dev. Cell
, vol.16
, pp. 70-82
-
-
Phng, L.K.1
-
25
-
-
33847046849
-
Dll4 signaling through Notch1 regulates formation of tip cells during angiogenesis
-
Hellström, M. et al. Dll4 signaling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445, 776-780 (2007).
-
(2007)
Nature
, vol.445
, pp. 776-780
-
-
Hellström, M.1
-
26
-
-
33847607880
-
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
-
Suchting, S. et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl Acad. Sci. USA 104, 3225-3230 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 3225-3230
-
-
Suchting, S.1
-
27
-
-
33847039645
-
Notch signaling limits angiogenic cell behavior in developing zebrafish arteries
-
Siekmann, A. F. & Lawson, N. D. Notch signaling limits angiogenic cell behavior in developing zebrafish arteries. Nature 445, 781-784 (2007).
-
(2007)
Nature
, vol.445
, pp. 781-784
-
-
Siekmann, A.F.1
Lawson, N.D.2
-
28
-
-
34247479498
-
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
-
Scehnet, J. S. et al. Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 109, 4753-4760 (2007).
-
(2007)
Blood
, vol.109
, pp. 4753-4760
-
-
Scehnet, J.S.1
-
29
-
-
56049092014
-
Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
-
Poellinger, L. & Lendahl, U. Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr. Opin. Genet. Dev. 18, 449-454 (2008).
-
(2008)
Curr. Opin. Genet. Dev
, vol.18
, pp. 449-454
-
-
Poellinger, L.1
Lendahl, U.2
-
30
-
-
41649105534
-
Wnt/Notch signaling and information processing during development
-
Hayward, P., Kalmar, T. & Arias, A. M. Wnt/Notch signaling and information processing during development. Development 135, 411-424 (2008).
-
(2008)
Development
, vol.135
, pp. 411-424
-
-
Hayward, P.1
Kalmar, T.2
Arias, A.M.3
-
31
-
-
48349129069
-
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
-
Tammela, T. et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454, 656-660 (2008).
-
(2008)
Nature
, vol.454
, pp. 656-660
-
-
Tammela, T.1
-
32
-
-
43249091361
-
RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice
-
Dou, G. R. et al. RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice. FASEB J. 22, 1606-1617 (2008).
-
(2008)
FASEB J
, vol.22
, pp. 1606-1617
-
-
Dou, G.R.1
-
33
-
-
37049012486
-
Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
-
Li, J. L. et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res. 67, 11244-11253 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 11244-11253
-
-
Li, J.L.1
-
34
-
-
58249109346
-
Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types
-
Hu, X. B. et al. Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types. Neoplasia 11, 32-38 (2009).
-
(2009)
Neoplasia
, vol.11
, pp. 32-38
-
-
Hu, X.B.1
-
35
-
-
38549148417
-
Notch and cancer: A double-edged sword
-
Koch, U. & Radtke, F. Notch and cancer: A double-edged sword. Cell. Mol. Life Sci. 64, 2746-2762 (2007).
-
(2007)
Cell. Mol. Life Sci
, vol.64
, pp. 2746-2762
-
-
Koch, U.1
Radtke, F.2
-
36
-
-
0032897080
-
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
-
Xue, Y. et al. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum. Mol. Genet. 8, 723-730 (1999).
-
(1999)
Hum. Mol. Genet
, vol.8
, pp. 723-730
-
-
Xue, Y.1
-
37
-
-
41149156903
-
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
-
High, F. A. et al. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc. Natl Acad. Sci. USA 105, 1955-1959 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 1955-1959
-
-
High, F.A.1
-
38
-
-
22244460522
-
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
-
Zeng, Q. et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 8, 13-23 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 13-23
-
-
Zeng, Q.1
-
39
-
-
41749093830
-
Molecular biology and pathology of lymphangiogenesis
-
Karpanen, T. & Alitalo, K. Molecular biology and pathology of lymphangiogenesis. Annu. Rev. Pathol. 3, 367-397 (2008).
-
(2008)
Annu. Rev. Pathol
, vol.3
, pp. 367-397
-
-
Karpanen, T.1
Alitalo, K.2
-
40
-
-
24744449289
-
A genetic Xenopus laevis tadpole model to study lymphangiogenesis
-
Ny, A. et al. A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat. Med. 11, 998-1004 (2005).
-
(2005)
Nat. Med
, vol.11
, pp. 998-1004
-
-
Ny, A.1
-
41
-
-
0037024472
-
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
-
He, Y. et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J. Natl Cancer Inst. 94, 819-825 (2002).
-
(2002)
J. Natl Cancer Inst
, vol.94
, pp. 819-825
-
-
He, Y.1
-
42
-
-
0032582502
-
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
-
Dumont, D. J. et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282, 946-949 (1998).
-
(1998)
Science
, vol.282
, pp. 946-949
-
-
Dumont, D.J.1
-
43
-
-
36048978608
-
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
-
shawber, C. J. et al. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J. Clin. Invest. 117, 3369-3382 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 3369-3382
-
-
shawber, C.J.1
-
44
-
-
47949083776
-
Deletion of vascular endothelial growth factor C (veGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos
-
Haiko, P. et al. Deletion of vascular endothelial growth factor C (veGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol. Cell. Biol. 28, 4843-4850 (2008).
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 4843-4850
-
-
Haiko, P.1
-
45
-
-
41249088330
-
Blocking neuropilin-2 function inhibits tumor cell metastasis
-
Caunt, M. et al. Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell 13, 331-342 (2008).
-
(2008)
Cancer Cell
, vol.13
, pp. 331-342
-
-
Caunt, M.1
-
46
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor, T. T. et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11, 83-95 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
-
47
-
-
50149109090
-
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib
-
Padera, T. P. et al. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol. Cancer Ther. 7, 2272-2279 (2008).
-
(2008)
Mol. Cancer Ther
, vol.7
, pp. 2272-2279
-
-
Padera, T.P.1
-
48
-
-
47949102937
-
The semaphorins: Versatile regulators of tumor progression and tumor angiogenesis
-
Neufeld, G. & Kessler, O. The semaphorins: Versatile regulators of tumor progression and tumor angiogenesis. Nat. Rev. Cancer 8, 632-645 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 632-645
-
-
Neufeld, G.1
Kessler, O.2
-
49
-
-
33344474679
-
Neuropilins in neoplasms: Expression, regulation, and function
-
Bielenberg, D. R., Pettaway, C. A., Takashima, S. & Klagsbrun, M. Neuropilins in neoplasms: Expression, regulation, and function. Exp. Cell. Res. 312, 584-593 (2006).
-
(2006)
Exp. Cell. Res
, vol.312
, pp. 584-593
-
-
Bielenberg, D.R.1
Pettaway, C.A.2
Takashima, S.3
Klagsbrun, M.4
-
50
-
-
34250662228
-
Selective requirements for NRP1 ligands during neurovascular patterning
-
Vieira, J. M., Schwarz, Q. & Ruhrberg, C. Selective requirements for NRP1 ligands during neurovascular patterning. Development 134 1833-1843 (2007).
-
(2007)
Development
, vol.134
, pp. 1833-1843
-
-
Vieira, J.M.1
Schwarz, Q.2
Ruhrberg, C.3
-
51
-
-
43149106665
-
Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival
-
Wang, L. et al. Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival. PLoS ONE 2, e1161 (2007).
-
(2007)
PLoS ONE
, vol.2
-
-
Wang, L.1
-
52
-
-
33744483170
-
Selective regulation of arterial branching morphogenesis by synectin
-
Chittenden, T. W. et al. Selective regulation of arterial branching morphogenesis by synectin. Dev. Cell 10, 783-795 (2006).
-
(2006)
Dev. Cell
, vol.10
, pp. 783-795
-
-
Chittenden, T.W.1
-
53
-
-
13844253607
-
Guidance of vascular and neural network formation
-
Eichmann, A., Le Noble, F., Autiero, M. & Carmeliet, P. Guidance of vascular and neural network formation. Curr. Opin. Neurobiol. 15, 108-115 (2005).
-
(2005)
Curr. Opin. Neurobiol
, vol.15
, pp. 108-115
-
-
Eichmann, A.1
Le Noble, F.2
Autiero, M.3
Carmeliet, P.4
-
54
-
-
34347332447
-
Neuropilins in physiological and pathological angiogenesis
-
Staton, C. A., Kumar, I., Reed, M. W. & Brown, N. J. Neuropilins in physiological and pathological angiogenesis. J. Pathol. 212, 237-248 (2007).
-
(2007)
J. Pathol
, vol.212
, pp. 237-248
-
-
Staton, C.A.1
Kumar, I.2
Reed, M.W.3
Brown, N.J.4
-
55
-
-
0032549799
-
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
-
Soker, S., Takashima, S., Miao, H. Q., Neufeld, G. & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735-745 (1998).
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
Neufeld, G.4
Klagsbrun, M.5
-
56
-
-
33845991161
-
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
-
Pan, Q. et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell 11 53-67 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 53-67
-
-
Pan, Q.1
-
57
-
-
6944225400
-
Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
-
Gerhardt, H. et al. Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev. Dyn. 231, 503-509 (2004).
-
(2004)
Dev. Dyn
, vol.231
, pp. 503-509
-
-
Gerhardt, H.1
-
58
-
-
0033549556
-
Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165
-
Miao, H. Q. et al. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165. J. Cell Biol. 146, 233-242 (1999).
-
(1999)
J. Cell Biol
, vol.146
, pp. 233-242
-
-
Miao, H.Q.1
-
59
-
-
33845605915
-
In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick
-
McLennan, R. & Kulesa, P. M. In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick. Dev. Biol. 301, 227-239 (2007).
-
(2007)
Dev. Biol
, vol.301
, pp. 227-239
-
-
McLennan, R.1
Kulesa, P.M.2
-
60
-
-
41649088181
-
Modulation of VEGF signaling output by the Notch pathway
-
Siekmann, A. F., Covassin, L. & Lawson, N. D. Modulation of VEGF signaling output by the Notch pathway. Bioessays 30, 303-313 (2008).
-
(2008)
Bioessays
, vol.30
, pp. 303-313
-
-
Siekmann, A.F.1
Covassin, L.2
Lawson, N.D.3
-
61
-
-
18144423532
-
Negative feedback regulation of Met-dependent invasive growth by Notch
-
Stella, M. C., Trusolino, L., Pennacchietti, S. & Comoglio, P. M. Negative feedback regulation of Met-dependent invasive growth by Notch. Mol. Cell Biol. 25, 3982-3996 (2005).
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 3982-3996
-
-
Stella, M.C.1
Trusolino, L.2
Pennacchietti, S.3
Comoglio, P.M.4
-
62
-
-
39149123515
-
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells
-
Harrington, L. S. et al. Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvasc. Res. 75, 144-154 (2008).
-
(2008)
Microvasc. Res
, vol.75
, pp. 144-154
-
-
Harrington, L.S.1
-
63
-
-
0036141222
-
Neuropilin-1 participates in wound angiogenesis
-
Matthies, A. M., Low, Q. E., Lingen, M. W. & DiPietro, L. A. Neuropilin-1 participates in wound angiogenesis. Am. J. Pathol. 160, 289-296 (2002).
-
(2002)
Am. J. Pathol
, vol.160
, pp. 289-296
-
-
Matthies, A.M.1
Low, Q.E.2
Lingen, M.W.3
DiPietro, L.A.4
-
64
-
-
0036803751
-
Abnormal lymphatic vessel development in neuropilin 2 mutant mice
-
Yuan, L. et al. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 129, 4797-4806 (2002).
-
(2002)
Development
, vol.129
, pp. 4797-4806
-
-
Yuan, L.1
-
65
-
-
7444228009
-
Deficiency of neuropilin 2 suppresses VEGF-induced retinal neovascularization
-
Shen, J. et al. Deficiency of neuropilin 2 suppresses VEGF-induced retinal neovascularization. Mol. Med. 10, 12-18 (2004).
-
(2004)
Mol. Med
, vol.10
, pp. 12-18
-
-
Shen, J.1
-
66
-
-
58149356250
-
Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma
-
Dallas, N. A. et al. Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin. Cancer Res. 14 8052-8060 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 8052-8060
-
-
Dallas, N.A.1
-
67
-
-
0037703184
-
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
-
Autiero, M. et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat. Med. 9, 936-943 (2003).
-
(2003)
Nat. Med
, vol.9
, pp. 936-943
-
-
Autiero, M.1
-
68
-
-
56749174211
-
FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy?
-
Fischer, C., Mazzone, M., Jonckx, B. & Carmeliet, P. FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy? Nat. Rev. Cancer 8, 942-956 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 942-956
-
-
Fischer, C.1
Mazzone, M.2
Jonckx, B.3
Carmeliet, P.4
-
69
-
-
19244379078
-
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
-
Carmeliet, P. et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7 575-583 (2001).
-
(2001)
Nat. Med
, vol.7
, pp. 575-583
-
-
Carmeliet, P.1
-
70
-
-
44649128099
-
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
-
Kappas, N. C. et al. The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J. Cell Biol. 181 847-858 (2008).
-
(2008)
J. Cell Biol
, vol.181
, pp. 847-858
-
-
Kappas, N.C.1
-
71
-
-
44249115334
-
Gamma-secretase: A multifaceted regulator of angiogenesis
-
Boulton, M. E., Cai, J. & Grant, M. B. Gamma-secretase: A multifaceted regulator of angiogenesis. J. Cell. Mol. Med. 12, 781-795 (2008).
-
(2008)
J. Cell. Mol. Med
, vol.12
, pp. 781-795
-
-
Boulton, M.E.1
Cai, J.2
Grant, M.B.3
-
72
-
-
0036344495
-
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
-
Luttun, A. et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831-840 (2002).
-
(2002)
Nat. Med
, vol.8
, pp. 831-840
-
-
Luttun, A.1
-
73
-
-
28644432204
-
VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan, R. N. et al. VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438, 820-827 (2005).
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
-
74
-
-
35548982639
-
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
-
Fischer, C. et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131, 463-475 (2007).
-
(2007)
Cell
, vol.131
, pp. 463-475
-
-
Fischer, C.1
-
75
-
-
0037431536
-
Altered tumor vessel maturation and proliferation in placenta growth factor-producing tumors: Potential relationship to post-therapy tumor angiogenesis and recurrence
-
Taylor, A. P., Rodriguez, M., Adams, K., Goldenberg, D. M. & Blumenthal, R. D. Altered tumor vessel maturation and proliferation in placenta growth factor-producing tumors: Potential relationship to post-therapy tumor angiogenesis and recurrence. Int. J. Cancer 105, 158-164 (2003).
-
(2003)
Int. J. Cancer
, vol.105
, pp. 158-164
-
-
Taylor, A.P.1
Rodriguez, M.2
Adams, K.3
Goldenberg, D.M.4
Blumenthal, R.D.5
-
76
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W. G., Jr & Ratcliffe, P. J. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr, W.G.1
Ratcliffe, P.J.2
-
77
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
-
Carmeliet, P. et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature 394, 485-490 (1998).
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
-
78
-
-
45749145804
-
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene
-
Wu, S. et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther. 16, 1227-1234 (2008).
-
(2008)
Mol. Ther
, vol.16
, pp. 1227-1234
-
-
Wu, S.1
-
79
-
-
36348999185
-
A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia
-
Nangaku, M. et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler. Thromb. Vasc. Biol. 27, 2548-2554 (2007).
-
(2007)
Arterioscler. Thromb. Vasc. Biol
, vol.27
, pp. 2548-2554
-
-
Nangaku, M.1
-
80
-
-
0037090776
-
Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy
-
Dor, Y. et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J. 21, 1939-1947 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 1939-1947
-
-
Dor, Y.1
-
81
-
-
60549103097
-
Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth
-
Nasarre, P. et al. Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Res. 69, 1324-1333 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 1324-1333
-
-
Nasarre, P.1
-
82
-
-
40449100456
-
Perivascular nitric oxide gradients normalize tumor vasculature
-
Kashiwagi, S. et al. Perivascular nitric oxide gradients normalize tumor vasculature. Nat. Med. 14, 255-257 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 255-257
-
-
Kashiwagi, S.1
-
83
-
-
41849131420
-
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
-
Jones, C. A. et al. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med. 14, 448-453 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 448-453
-
-
Jones, C.A.1
-
84
-
-
43749112760
-
Vascular normalization in Rgs5-deficient tumors promotes immune destruction
-
Hamzah, J. et al. Vascular normalization in Rgs5-deficient tumors promotes immune destruction. Nature 453, 410-414 (2008).
-
(2008)
Nature
, vol.453
, pp. 410-414
-
-
Hamzah, J.1
-
85
-
-
57649112725
-
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
-
Stockmann, C. et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456 814-818 (2008).
-
(2008)
Nature
, vol.456
, pp. 814-818
-
-
Stockmann, C.1
-
86
-
-
58149339705
-
Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice
-
Chen, J. X. & Stinnett, A. Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice. Diabetes 57, 3335-3343 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 3335-3343
-
-
Chen, J.X.1
Stinnett, A.2
-
87
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler, F. et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6 553-563 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
-
88
-
-
33744466541
-
Anti-angiogenic therapy: A universal chemosensitization strategy for cancer?
-
Kerbel, R. S. Anti-angiogenic therapy: A universal chemosensitization strategy for cancer? Science 312, 1171-1175 (2006).
-
(2006)
Science
, vol.312
, pp. 1171-1175
-
-
Kerbel, R.S.1
-
89
-
-
0036892763
-
Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb
-
Sullivan, C. J., Doetschman, T. & Hoying, J. B. Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb. J. Appl. Physiol. 93, 2009-2017 (2002).
-
(2002)
J. Appl. Physiol
, vol.93
, pp. 2009-2017
-
-
Sullivan, C.J.1
Doetschman, T.2
Hoying, J.B.3
|