메뉴 건너뛰기




Volumn 11, Issue 1, 2007, Pages 53-67

Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

Author keywords

CELLCYCLE

Indexed keywords

MONOCLONAL ANTIBODY; NEUROPILIN 1; PLEXIN; SEMAPHORIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 2;

EID: 33845991161     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2006.10.018     Document Type: Article
Times cited : (454)

References (53)
  • 1
    • 0035422178 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    • Bachelder R.E., Crago A., Chung J., Wendt M.A., Shaw L.M., Robinson G., and Mercurio A.M. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 61 (2001) 5736-5740
    • (2001) Cancer Res. , vol.61 , pp. 5736-5740
    • Bachelder, R.E.1    Crago, A.2    Chung, J.3    Wendt, M.A.4    Shaw, L.M.5    Robinson, G.6    Mercurio, A.M.7
  • 2
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk P., Hashizume H., and McDonald D.M. Cellular abnormalities of blood vessels as targets in cancer. Curr. Opin. Genet. Dev. 15 (2005) 102-111
    • (2005) Curr. Opin. Genet. Dev. , vol.15 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 3
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin L.E., Hemo I., and Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 125 (1998) 1591-1598
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 4
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., and Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111 (2003) 1287-1295
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 6
    • 0033179591 scopus 로고    scopus 로고
    • Cloning and characterization of neuropilin-1-interacting protein: A PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1
    • Cai H., and Reed R.R. Cloning and characterization of neuropilin-1-interacting protein: A PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J. Neurosci. 19 (1999) 6519-6527
    • (1999) J. Neurosci. , vol.19 , pp. 6519-6527
    • Cai, H.1    Reed, R.R.2
  • 7
    • 22444447946 scopus 로고    scopus 로고
    • Common mechanisms of nerve and blood vessel wiring
    • Carmeliet P., and Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature 436 (2005) 193-200
    • (2005) Nature , vol.436 , pp. 193-200
    • Carmeliet, P.1    Tessier-Lavigne, M.2
  • 10
    • 0032514630 scopus 로고    scopus 로고
    • GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP
    • De Vries L., Lou X., Zhao G., Zheng B., and Farquhar M.G. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc. Natl. Acad. Sci. USA 95 (1998) 12340-12345
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12340-12345
    • De Vries, L.1    Lou, X.2    Zhao, G.3    Zheng, B.4    Farquhar, M.G.5
  • 11
    • 33646869290 scopus 로고    scopus 로고
    • Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina
    • Dorrell M.I., and Friedlander M. Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina. Prog. Retin. Eye Res. 25 (2006) 277-295
    • (2006) Prog. Retin. Eye Res. , vol.25 , pp. 277-295
    • Dorrell, M.I.1    Friedlander, M.2
  • 12
    • 0033602091 scopus 로고    scopus 로고
    • Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
    • Dougher M., and Terman B.I. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 18 (1999) 1619-1627
    • (1999) Oncogene , vol.18 , pp. 1619-1627
    • Dougher, M.1    Terman, B.I.2
  • 13
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R., Thurnher A., Katsen A.D., Groth G., Kerger H., Hammes H.P., Menger M.D., Ullrich A., and Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 18 (2004) 338-340
    • (2004) FASEB J. , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 14
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 15
    • 0032557564 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
    • Gerber H.P., Dixit V., and Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 273 (1998) 13313-13316
    • (1998) J. Biol. Chem. , vol.273 , pp. 13313-13316
    • Gerber, H.P.1    Dixit, V.2    Ferrara, N.3
  • 17
    • 6944225400 scopus 로고    scopus 로고
    • Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    • Gerhardt H., Ruhrberg C., Abramsson A., Fujisawa H., Shima D., and Betsholtz C. Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev. Dyn. 231 (2004) 503-509
    • (2004) Dev. Dyn. , vol.231 , pp. 503-509
    • Gerhardt, H.1    Ruhrberg, C.2    Abramsson, A.3    Fujisawa, H.4    Shima, D.5    Betsholtz, C.6
  • 18
    • 18144427143 scopus 로고    scopus 로고
    • Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors
    • Gray M.J., Wey J.S., Belcheva A., McCarty M.F., Trevino J.G., Evans D.B., Ellis L.M., and Gallick G.E. Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res. 65 (2005) 3664-3670
    • (2005) Cancer Res. , vol.65 , pp. 3664-3670
    • Gray, M.J.1    Wey, J.S.2    Belcheva, A.3    McCarty, M.F.4    Trevino, J.G.5    Evans, D.B.6    Ellis, L.M.7    Gallick, G.E.8
  • 19
    • 0037124068 scopus 로고    scopus 로고
    • Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165
    • Gu C., Limberg B.J., Whitaker G.B., Perman B., Leahy D.J., Rosenbaum J.S., Ginty D.D., and Kolodkin A.L. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J. Biol. Chem. 277 (2002) 18069-18076
    • (2002) J. Biol. Chem. , vol.277 , pp. 18069-18076
    • Gu, C.1    Limberg, B.J.2    Whitaker, G.B.3    Perman, B.4    Leahy, D.J.5    Rosenbaum, J.S.6    Ginty, D.D.7    Kolodkin, A.L.8
  • 21
    • 1442329388 scopus 로고    scopus 로고
    • Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract
    • Hansel D.E., Wilentz R.E., Yeo C.J., Schulick R.D., Montgomery E., and Maitra A. Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract. Am. J. Surg. Pathol. 28 (2004) 347-356
    • (2004) Am. J. Surg. Pathol. , vol.28 , pp. 347-356
    • Hansel, D.E.1    Wilentz, R.E.2    Yeo, C.J.3    Schulick, R.D.4    Montgomery, E.5    Maitra, A.6
  • 22
    • 0030847193 scopus 로고    scopus 로고
    • Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    • He Z., and Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90 (1997) 739-751
    • (1997) Cell , vol.90 , pp. 739-751
    • He, Z.1    Tessier-Lavigne, M.2
  • 23
    • 0034756449 scopus 로고    scopus 로고
    • Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
    • Herzog Y., Kalcheim C., Kahane N., Reshef R., and Neufeld G. Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins. Mech. Dev. 109 (2001) 115-119
    • (2001) Mech. Dev. , vol.109 , pp. 115-119
    • Herzog, Y.1    Kalcheim, C.2    Kahane, N.3    Reshef, R.4    Neufeld, G.5
  • 24
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T., Mancuso M., Hashizume H., Baffert F., Haskell A., Baluk P., Hu-Lowe D.D., Shalinsky D.R., Thurston G., Yancopoulos G.D., and McDonald D.M. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am. J. Pathol. 165 (2004) 35-52
    • (2004) Am. J. Pathol. , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3    Baffert, F.4    Haskell, A.5    Baluk, P.6    Hu-Lowe, D.D.7    Shalinsky, D.R.8    Thurston, G.9    Yancopoulos, G.D.10    McDonald, D.M.11
  • 25
  • 26
    • 33744965754 scopus 로고    scopus 로고
    • Characterisation of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signalling
    • Jia H., Bagherzadeh A., Hartzoulakis B., Jarvis A., Lohr M., Shaikh S., Aqil R., Cheng L., Tickner M., Esposito D., et al. Characterisation of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signalling. J Biol Chem. 281 (2006) 13493-13502
    • (2006) J Biol Chem. , vol.281 , pp. 13493-13502
    • Jia, H.1    Bagherzadeh, A.2    Hartzoulakis, B.3    Jarvis, A.4    Lohr, M.5    Shaikh, S.6    Aqil, R.7    Cheng, L.8    Tickner, M.9    Esposito, D.10
  • 28
    • 0037110615 scopus 로고    scopus 로고
    • Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma
    • Kawakami T., Tokunaga T., Hatanaka H., Kijima H., Yamazaki H., Abe Y., Osamura Y., Inoue H., Ueyama Y., and Nakamura M. Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma. Cancer 95 (2002) 2196-2201
    • (2002) Cancer , vol.95 , pp. 2196-2201
    • Kawakami, T.1    Tokunaga, T.2    Hatanaka, H.3    Kijima, H.4    Yamazaki, H.5    Abe, Y.6    Osamura, Y.7    Inoue, H.8    Ueyama, Y.9    Nakamura, M.10
  • 30
    • 0035692285 scopus 로고    scopus 로고
    • Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches
    • Kerbel R.S., Yu J., Tran J., Man S., Viloria-Petit A., Klement G., Coomber B.L., and Rak J. Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches. Cancer Metastasis Rev. 20 (2001) 79-86
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 79-86
    • Kerbel, R.S.1    Yu, J.2    Tran, J.3    Man, S.4    Viloria-Petit, A.5    Klement, G.6    Coomber, B.L.7    Rak, J.8
  • 31
    • 0036933684 scopus 로고    scopus 로고
    • The role of neuropilin in vascular and tumor biology
    • Klagsbrun M., Takashima S., and Mamluk R. The role of neuropilin in vascular and tumor biology. Adv. Exp. Med. Biol. 515 (2002) 33-48
    • (2002) Adv. Exp. Med. Biol. , vol.515 , pp. 33-48
    • Klagsbrun, M.1    Takashima, S.2    Mamluk, R.3
  • 33
    • 0034688871 scopus 로고    scopus 로고
    • VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms
    • Latil A., Bieche I., Pesche S., Valeri A., Fournier G., Cussenot O., and Lidereau R. VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms. Int. J. Cancer 89 (2000) 167-171
    • (2000) Int. J. Cancer , vol.89 , pp. 167-171
    • Latil, A.1    Bieche, I.2    Pesche, S.3    Valeri, A.4    Fournier, G.5    Cussenot, O.6    Lidereau, R.7
  • 34
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • Liang W.C., Wu X., Peale F.V., Lee C.V., Meng Y.G., Gutierrez J., Fu L., Malik A.K., Gerber H.P., Ferrara N., and Fuh G. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J. Biol. Chem. 281 (2006) 951-961
    • (2006) J. Biol. Chem. , vol.281 , pp. 951-961
    • Liang, W.C.1    Wu, X.2    Peale, F.V.3    Lee, C.V.4    Meng, Y.G.5    Gutierrez, J.6    Fu, L.7    Malik, A.K.8    Gerber, H.P.9    Ferrara, N.10    Fuh, G.11
  • 35
    • 33845969276 scopus 로고    scopus 로고
    • Function blocking antibodies to Neuropilin-1 generated from a designed human synthetic antibody phage library
    • 10.1016/j.jmb.2006.11.021 in press
    • Liang W.-C., Dennis M.S., Stawicki S., Chanthery Y., Pan Q., Chen Y., Eigenbrot C., Yin J., Koch A.W., Wu X., et al. Function blocking antibodies to Neuropilin-1 generated from a designed human synthetic antibody phage library. J. Mol. Biol. (2007) 10.1016/j.jmb.2006.11.021 in press
    • (2007) J. Mol. Biol.
    • Liang, W.-C.1    Dennis, M.S.2    Stawicki, S.3    Chanthery, Y.4    Pan, Q.5    Chen, Y.6    Eigenbrot, C.7    Yin, J.8    Koch, A.W.9    Wu, X.10
  • 36
    • 31344472259 scopus 로고    scopus 로고
    • Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF
    • Liu W., Parikh A.A., Stoeltzing O., Fan F., McCarty M.F., Wey J., Hicklin D.J., and Ellis L.M. Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF. Cytokine 32 (2005) 206-212
    • (2005) Cytokine , vol.32 , pp. 206-212
    • Liu, W.1    Parikh, A.A.2    Stoeltzing, O.3    Fan, F.4    McCarty, M.F.5    Wey, J.6    Hicklin, D.J.7    Ellis, L.M.8
  • 37
    • 0033549556 scopus 로고    scopus 로고
    • Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165
    • Miao H.Q., Soker S., Feiner L., Alonso J.L., Raper J.A., and Klagsbrun M. Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: Functional competition of collapsin-1 and vascular endothelial growth factor-165. J. Cell Biol. 146 (1999) 233-242
    • (1999) J. Cell Biol. , vol.146 , pp. 233-242
    • Miao, H.Q.1    Soker, S.2    Feiner, L.3    Alonso, J.L.4    Raper, J.A.5    Klagsbrun, M.6
  • 38
    • 0033674846 scopus 로고    scopus 로고
    • Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression
    • Miao H.Q., Lee P., Lin H., Soker S., and Klagsbrun M. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J. 14 (2000) 2532-2539
    • (2000) FASEB J. , vol.14 , pp. 2532-2539
    • Miao, H.Q.1    Lee, P.2    Lin, H.3    Soker, S.4    Klagsbrun, M.5
  • 39
    • 14944344614 scopus 로고    scopus 로고
    • Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
    • 10.1182/blood-2004-07-2598 Published online November 2, 2004
    • Murga M., Fernandez-Capetillo O., and Tosato G. Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2. Blood. 105 (2005) 1992-1999 10.1182/blood-2004-07-2598 Published online November 2, 2004
    • (2005) Blood. , vol.105 , pp. 1992-1999
    • Murga, M.1    Fernandez-Capetillo, O.2    Tosato, G.3
  • 40
    • 0042121208 scopus 로고    scopus 로고
    • Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: The role of fibroblasts and Angiopoietin-1
    • Nakatsu M.N., Sainson R.C., Aoto J.N., Taylor K.L., Aitkenhead M., Perez-del-Pulgar S., Carpenter P.M., and Hughes C.C. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: The role of fibroblasts and Angiopoietin-1. Microvasc. Res. 66 (2003) 102-112
    • (2003) Microvasc. Res. , vol.66 , pp. 102-112
    • Nakatsu, M.N.1    Sainson, R.C.2    Aoto, J.N.3    Taylor, K.L.4    Aitkenhead, M.5    Perez-del-Pulgar, S.6    Carpenter, P.M.7    Hughes, C.C.8
  • 41
    • 0030734010 scopus 로고    scopus 로고
    • p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
    • Rousseau S., Houle F., Landry J., and Huot J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene 15 (1997) 2169-2177
    • (1997) Oncogene , vol.15 , pp. 2169-2177
    • Rousseau, S.1    Houle, F.2    Landry, J.3    Huot, J.4
  • 43
    • 0037021414 scopus 로고    scopus 로고
    • Akt signaling mediates VEGF/VPF vascular permeability in vivo
    • Six I., Kureishi Y., Luo Z., and Walsh K. Akt signaling mediates VEGF/VPF vascular permeability in vivo. FEBS Lett. 532 (2002) 67-69
    • (2002) FEBS Lett. , vol.532 , pp. 67-69
    • Six, I.1    Kureishi, Y.2    Luo, Z.3    Walsh, K.4
  • 44
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S., Takashima S., Miao H.Q., Neufeld G., and Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92 (1998) 735-745
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 45
    • 0036009760 scopus 로고    scopus 로고
    • VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding
    • Soker S., Miao H.Q., Nomi M., Takashima S., and Klagsbrun M. VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding. J. Cell. Biochem. 85 (2002) 357-368
    • (2002) J. Cell. Biochem. , vol.85 , pp. 357-368
    • Soker, S.1    Miao, H.Q.2    Nomi, M.3    Takashima, S.4    Klagsbrun, M.5
  • 46
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi T., Ueno H., and Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18 (1999) 2221-2230
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 47
    • 0035355472 scopus 로고    scopus 로고
    • A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
    • Takahashi T., Yamaguchi S., Chida K., and Shibuya M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20 (2001) 2768-2778
    • (2001) EMBO J. , vol.20 , pp. 2768-2778
    • Takahashi, T.1    Yamaguchi, S.2    Chida, K.3    Shibuya, M.4
  • 50
    • 1542571789 scopus 로고    scopus 로고
    • Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    • Wang L., Zeng H., Wang P., Soker S., and Mukhopadhyay D. Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J. Biol. Chem. 278 (2003) 48848-48860
    • (2003) J. Biol. Chem. , vol.278 , pp. 48848-48860
    • Wang, L.1    Zeng, H.2    Wang, P.3    Soker, S.4    Mukhopadhyay, D.5
  • 51
    • 33845678052 scopus 로고    scopus 로고
    • C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis
    • Wang L., Mukhopadhyay D., and Xu X. C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis. FASEB J. 20 (2006) 1513-1515
    • (2006) FASEB J. , vol.20 , pp. 1513-1515
    • Wang, L.1    Mukhopadhyay, D.2    Xu, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.