Ang-1 gene therapy inhibits hypoxia-inducible Factor-1α (HIF-1α)-prolyl-4-hydroxylase-2, stabilizes HIF-1α expression, and normalizes immature vasculature in db/db mice

Diabetes

Volumn 57, Issue 12, 2008, Pages 3335-3343

  Chen, Jian Xiong ^a   Stinnett, Amanda ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN I; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1 ALPHA PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG; VASCULOTROPIN; ANGIOPOIETIN 1; HIF1A PROTEIN, MOUSE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENE OVEREXPRESSION; GENE THERAPY; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SMOOTH MUSCLE; VASCULARIZATION; ANGIOGENESIS; ANIMAL; ANOXIA; C57BL MOUSE; CARDIOMEGALY; DIABETIC ANGIOPATHY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; METHODOLOGY; PATHOLOGY;

ANGIOPOIETIN-1; ANIMALS; ANOXIA; BLOOD GLUCOSE; CARDIOMEGALY; DIABETIC ANGIOPATHIES; ENDOMYOCARDIAL FIBROSIS; GENE THERAPY; HEME OXYGENASE-1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; PROCOLLAGEN-PROLINE DIOXYGENASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 58149339705     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0503     Document Type: Article

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