Genetic susceptibility to the respiratory effects of air pollution

Postgraduate Medical Journal

Volumn 85, Issue 1006, 2009, Pages 428-436

  Yang, I A ^a,b   Fong, K M ^a,b   Zimmerman, P V ^a,b   Holgate, S T ^c   Holloway, J W ^c,d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b THE PRINCE CHARLES HOSPITAL   (Australia)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; NITROGEN DIOXIDE; OZONE; SULFUR DIOXIDE;

AIR POLLUTANT; AIR POLLUTION; ASTHMA; BREEDING; DISEASE COURSE; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; FAMILY; GENE; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HEREDITY; HUMAN; LUNG INJURY; MEXICO; NONHUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; PEDIGREE; PHENOTYPE; RAGWEED POLLEN; RESPIRATORY FUNCTION; RESPIRATORY TRACT DISEASE; REVIEW; RISK ASSESSMENT;

EID: 68249093090     PISSN: 00325473     EISSN: 14690756     Source Type: Journal    
DOI: 10.1136/thx.2007.079426     Document Type: Review

References (100)

1. Brunekreef B, Holgate ST. Air pollution and health. Lancet 2002;360:1233-1242
2. Viegi G, Maio S, Pistelli F, et al. Epidemiology of chronic obstructive pulmonary disease: health effects of air pollution. Respirology 2006;11:523-532 (Pubitemid 44186256)
3. Künzli N, Kaiser R, Medina S, et al. Public-health impact of outdoor and traffic-related air pollution: a European assessment. Lancet 2000;356:795-801. (Pubitemid 30706676)
4. Hoek G, Brunekreef B, Goldbohm S, et al. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 2002;360:1203-1209 (Pubitemid 35232719)
5. Annesi-Maesano I, Agabiti N, Pistelli R, et al. Subpopulations at increased risk of adverse health outcomes from air pollution. Eur Respir J Suppl 2003;40:57s-63. (Pubitemid 36565584)
6. Gauderman WJ, Avol E, Gilliland F, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 2004;351:1057-1067 (Pubitemid 39167510)
7. McDonnell WF 3rd, Horstman DH, Abdul-Salaam S, et al. Reproducibility of individual responses to ozone exposure. Am Rev Respir Dis 1985;131:36-40.
8. Holz O, Jörres RA, Timm P, et al. Ozone-induced airway inflammatory changes differ between individuals and are reproducible. Am J Respir Crit Care Med 1999;159:776-784 (Pubitemid 29137773)
9. Kleeberger SR. Genetic aspects of susceptibility to air pollution. Eur Respir J Suppl 2003;40:52s-6.
10. Kleeberger SR. Genetic aspects of pulmonary responses to inhaled pollutants. Exp Toxicol Pathol 2005;57(Suppl 1):147-153
11. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994;265:2037-2048
12. Dawn Teare M, Barrett JH. Genetic linkage studies. Lancet 2005;366:1036-1044
13. Cordell HJ, Clayton DG. Genetic association studies. Lancet 2005;366:1121-1131
14. Campbell H, Rudan I. Interpretation of genetic association studies in complex disease. Pharmacogenomics J 2002;2:349-360 (Pubitemid 36175797)
15. Yang IA, Holgate ST, Holloway JW. Toll-like receptor polymorphisms and allergic disease: interpreting the evidence from genetic studies. Clin Exp Allergy 2004;34:163-166
16. Tabor HK, Risch NJ, Myers RM. Opinion: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet 2002;3:391-397
17. Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet 2003;33(Suppl):228-237 (Pubitemid 36278833)
18. Subramanian G, Adams MD, Venter JC, et al. Implications of the human genome for understanding human biology and medicine. JAMA 2001;286:2296-2307 (Pubitemid 33069373)
19. Guttmacher AE, Collins FS. Genomic medicine - a primer. N Engl J Med 2002;347:1512-1520
20. Uysal N, Schapira RM. Effects of ozone on lung function and lung diseases. Curr Opin Pulm Med 2003;9:144-150 (Pubitemid 36184566)
21. Churg A. Interactions of exogenous or evoked agents and particles: the role of reactive oxygen species. Free Radic Biol Med 2003;34:1230-1235 (Pubitemid 36513965)
22. Becker S, Fenton MJ, Soukup JM. Involvement of microbial components and tolllike receptors 2 and 4 in cytokine responses to air pollution particles. Am J Respir Cell Mol Biol 2002;27:611-618 (Pubitemid 35307123)
23. Li N, Wang M, Oberley TD, et al. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol 2002;169:4531-4541 (Pubitemid 35178231)
24. Todd JA. Statistical false positive or true disease pathway? Nat Genet 2006;38:731-733
25. Cardon LR, Bell JI. Association study designs for complex diseases. Nat Rev Genet 2001;2:91-99 (Pubitemid 33674000)
26. Lohmueller KE, Pearce CL, Pike M, et al. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003;33:177-182 (Pubitemid 36177070)
27. Ioannidis JP, Trikalinos TA, Ntzani EE, et al. Genetic associations in large versus small studies: an empirical assessment. Lancet 2003;361:567-571
28. Colhoun HM, McKeigue PM, Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 2003;361:865-872
29. Healy DG. Case-control studies in the genomic era: a clinician's guide. Lancet Neurol 2006;5:701-707
30. Hall IP, Blakey JD. Genetic association studies in Thorax. Thorax 2005;60:357-359
31. Hall IP, Blakey JD, Al Balushi KA, et al. Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet 2006;368:771-779
32. Lee SL, Wong WH, Lau YL. Association between air pollution and asthma admission among children in Hong Kong. Clin Exp Allergy 2006;36:1138-1146 (Pubitemid 44342928)
33. Medina-Ramon M, Zanobetti A, Schwartz J. The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease: a national multicity study. Am J Epidemiol 2006;163:579-588
34. Sunyer J, Basagana X, Belmonte J, et al. Effect of nitrogen dioxide and ozone on the risk of dying in patients with severe asthma. Thorax 2002;57:687-693 (Pubitemid 34864524)
35. Bell ML, McDermott A, Zeger SL, et al. Ozone and short-term mortality in 95 US urban communities, 1987-2000. JAMA 2004;292:2372-2378 (Pubitemid 39491922)
36. Gryparis A, Forsberg B, Katsouyanni K, et al. Acute effects of ozone on mortality from the "air pollution and health: a European approach" project. Am J Respir Crit Care Med 2004;170:1080-1087 (Pubitemid 39488620)
37. Filleul L, Cassadou S, Medina S, et al. The relation between temperature, ozone, and mortality in nine French cities during the heat wave of 2003. Environ Health Perspect 2006;114:1344-1347 (Pubitemid 44314755)
38. McConnell R, Berhane K, Gilliland F, et al. Asthma in exercising children exposed to ozone: a cohort study. Lancet 2002;359:386-391 (Pubitemid 34158945)
39. Jörres R, Nowak D, Magnussen H. The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. Am J Respir Crit Care Med 1996;153:56-64. (Pubitemid 26026827)
40. Jörres RA, Holz O, Zachgo W, et al. The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. Am J Respir Crit Care Med 2000;161:1855-1861 (Pubitemid 30418120)
41. Holz O, Mücke M, Paasch K, et al. Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or asthma. Clin Exp Allergy 2002;32:681-689 (Pubitemid 34534012)
42. Krishna MT, Madden J, Teran LM, et al. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. Eur Respir J 1998;11:1294-1300 (Pubitemid 28298591)
43. Stenfors N, Pourazar J, Blomberg A, et al. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir Med 2002;96:352-358
44. Mudway IS, Krishna MT, Frew AJ, et al. Compromised concentrations of ascorbate in fluid lining the respiratory tract in human subjects after exposure to ozone. Occup Environ Med 1999;56:473-481
45. Avissar NE, Reed CK, Cox C, et al. Ozone, but not nitrogen dioxide, exposure decreases glutathione peroxidases in epithelial lining fluid of human lung. Am J Respir Crit Care Med 2000;162(4 Pt 1):1342-1347 (Pubitemid 30826152)
46. Kelly FJ. Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med 2003;60:612-616
47. Devlin RB, McKinnon KP, Noah T, et al. Ozone-induced release of cytokines and fibronectin by alveolar macrophages and airway epithelial cells. Am J Physiol 1994;266(6 Pt 1):L612-19. (Pubitemid 2110871)
48. Rusznak C, Devalia JL, Sapsford RJ, et al. Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium. Eur Respir J 1996;9:2298-2305 (Pubitemid 26366657)
49. Bayram H, Sapsford RJ, Abdelaziz MM, et al. Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients in vitro. J Allergy Clin Immunol 2001;107:287-294 (Pubitemid 32173906)
50. Backus-Hazzard GS, Howden R, Kleeberger SR. Genetic susceptibility to ozone-induced lung inflammation in animal models of asthma. Curr Opin Allergy Clin Immunol 2004;4:349-353 (Pubitemid 39274074)
51. Kleeberger SR, Levitt RC, Zhang LY, et al. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nat Genet 1997;17:475-478 (Pubitemid 27518401)
52. Cho HY, Zhang LY, Kleeberger SR. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Am J Physiol Lung Cell Mol Physiol 2001;280:L537-46.
53. Shore SA, Schwartzman IN, Le Blanc B, et al. Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in mice. Am J Respir Crit Care Med 2001;164:602-607 (Pubitemid 32807685)
54. Prows DR, Shertzer HG, Daly MJ, et al. Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice. Nat Genet 1997;17:471-474
55. Prows DR, Daly MJ, Shertzer HG, et al. Ozone-induced acute lung injury: genetic analysis of F(2) mice generated from A/J and C57BL/6J strains. Am J Physiol 1999;277(2 Pt 1):L372-80.
56. Kleeberger SR, Reddy S, Zhang LY, et al. Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am J Respir Cell Mol Biol 2000;22:620-627 (Pubitemid 30319549)
57. Kleeberger SR, Reddy SP, Zhang LY, et al. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 2001;280:L326-33.
58. Bergamaschi E, De Palma G, Mozzoni P, et al. Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects. Am J Respir Crit Care Med 2001;163:1426-1431 (Pubitemid 32506611)
59. Corradi M, Alinovi R, Goldoni M, et al. Biomarkers of oxidative stress after controlled human exposure to ozone. Toxicol Lett 2002;134:219-225 (Pubitemid 35007304)
60. Otto-Knapp R, Jurgovsky K, Schierhorn K, et al. Antioxidative enzymes in human nasal mucosa after exposure to ozone. Possible role of GSTM1 deficiency. Inflamm Res 2003;52:51-55 (Pubitemid 36286701)
61. Larsen JE, Colosimo ML, Yang IA, et al. CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. Carcinogenesis 2006;27:525-532
62. David GL, Romieu I, Sienra-Monge JJ, et al. Nicotinamide adenine dinucleotide (phosphate) reduced: quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma. Am J Respir Crit Care Med 2003;168:1199-1204 (Pubitemid 37421836)
63. Romieu I, Sienra-Monge JJ, Ramirez M, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax 2004;59:8-10. (Pubitemid 38067964)
64. Romieu I, Ramirez-Aguilar M, Sienra-Monge JJ, et al. GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone. Eur Respir J 2006;28:953-959 (Pubitemid 46331964)
65. Yang IA, Holz O, Jorres RA, et al. Association of tumour necrosis factor-alpha polymorphisms and ozone-induced change in lung function. Am J Respir Crit Care Med 2005;171:171-176 (Pubitemid 40105417)
66. Li YF, Gauderman WJ, Avol E, et al. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med 2006;173:970-976
67. Winterton DL, Kaufman J, Keener CV, et al. Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma. Ann Allergy Asthma Immunol 2001;86:232-238 (Pubitemid 32167851)
68. Bayley JP, Ottenhoff TH, Verweij CL. Is there a future for TNF promoter polymorphisms? Genes Immun 2004;5:315-329
69. Samet JM, Dominici F, Curriero FC, et al. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med 2000;343:1742-1749 (Pubitemid 32369215)
70. Katsouyanni K, Touloumi G, Samoli E, et al. Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project. Epidemiology 2001;12:521-531 (Pubitemid 32761993)
71. Laden F, Schwartz J, Speizer FE, et al. Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. Am J Respir Crit Care Med 2006;173:667-672 (Pubitemid 43363809)
72. Trenga CA, Sullivan JH, Schildcrout JS, et al. Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study. Chest 2006;129:1614-1622
73. Atkinson RW, Anderson HR, Sunyer J, et al. Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach. Am J Respir Crit Care Med 2001;164(10 Pt 1):1860-1866
74. D'Amato G, Liccardi G, D'Amato M, et al. Outdoor air pollution, climatic changes and allergic bronchial asthma. Eur Respir Mon 2002;21:30-51.
75. Salvi S, Blomberg A, Rudell B, et al. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 1999;159:702-709 (Pubitemid 29137763)
76. Nightingale JA, Maggs R, Cullinan P, et al. Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med 2000;162:161-166 (Pubitemid 30469814)
77. Salvi SS, Nordenhall C, Blomberg A, et al. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med 2000;161(2 Pt 1):550-557 (Pubitemid 30129466)
78. Pourazar J, Frew AJ, Blomberg A, et al. Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects. Respir Med 2004;98:821-825 (Pubitemid 39069329)
79. Donaldson K, Stone V, Borm PJ, et al. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM(10)). Free Radic Biol Med 2003;34:1369-1382 (Pubitemid 36570410)
80. Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med 2001;7:20-26 (Pubitemid 32003169)
81. MacNee W, Donaldson K. Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD. Eur Respir J Suppl 2003;40:47s-51. (Pubitemid 36565582)
82. Gilmour PS, Rahman I, Donaldson K, et al. Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am J Physiol Lung Cell Mol Physiol 2003;284:L533-40. (Pubitemid 36231732)
83. Takizawa H, Abe S, Ohtoshi T, et al. Diesel exhaust particles up-regulate expression of intercellular adhesion molecule-1 (ICAM-1) in human bronchial epithelial cells. Clin Exp Immunol 2000;120:356-362 (Pubitemid 30304234)
84. Ohtoshi T, Takizawa H, Okazaki H, et al. Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J Allergy Clin Immunol 1998;101(6 Pt 1):778-785 (Pubitemid 28293185)
85. Bayram H, Devalia JL, Sapsford RJ, et al. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol 1998;18:441-448 (Pubitemid 128354103)
86. Ohtsuka Y, Brunson KJ, Jedlicka AE, et al. Genetic linkage analysis of susceptibility to particle exposure in mice. Am J Respir Cell Mol Biol 2000;22:574-581 (Pubitemid 30319544)
87. Prows DR, McDowell SA, Aronow BJ, et al. Genetic susceptibility to nickel-induced acute lung injury. Chemosphere 2003;51:1139-1148 (Pubitemid 36569466)
88. Gilliland FD, Li YF, Saxon A, et al. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363:119-125 (Pubitemid 38068328)
89. Gilliland FD, Li YF, Gong H Jr, et al. Glutathione S-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke. Am J Respir Crit Care Med 2006;174:1335-1341
90. Schildcrout JS, Sheppard L, Lumley T, et al. Ambient air pollution and asthma exacerbations in children: an eight-city analysis. Am J Epidemiol 2006;164(:505-17. (Pubitemid 44412779)
91. Kleeberger SR, Zhang L-Y, Jakab GJ. Differential susceptibility to oxidant exposure in inbred strains of mice: nitrogen dioxide versus ozone. Inhal Toxicol 1997;9:601-621
92. Christiani DC, Sharp RR, Collman GW, et al. Applying genomic technologies in environmental health research: challenges and opportunities. J Occup Environ Med 2001;43:526-533
93. Mattick JS. The human genome and the future of medicine. Med J Aust 2003;179:212-216
94. Samet JM, Hatch GE, Horstman D, et al. Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am J Respir Crit Care Med 2001;164:819-825 (Pubitemid 32884241)
95. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. Am J Respir Crit Care Med 2002;166:703-709 (Pubitemid 34971854)
96. Zeka A, Schwartz J. Estimating the independent effects of multiple pollutants in the presence of measurement error: an application of a measurement-error-resistant technique. Environ Health Perspect 2004;112:1686-1690 (Pubitemid 40017290)
97. Bernstein JA, Alexis N, Barnes C, et al. Health effects of air pollution. J Allergy Clin Immunol 2004;114:1116-1123
98. Carroll WD, Lenney W, Child F, et al. Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatr Allergy Immunol 2005;16:32-39 (Pubitemid 40313961)
99. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007;8:253-262
100. Kinnula VL. Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax 2005;60:693-700.