Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects

European Respiratory Journal

Volumn 11, Issue 6, 1998, Pages 1294-1300

  Krishna, M T ^a,d   Madden, J ^a   Teran, L M ^a   Biscione, G L ^a   Lau, L C K ^a   Withers, N J ^a   Sandstrom T ^c   Mudway, I ^b   Kelly, F J ^b   Walls, A ^a   Frew, A J ^a   Holgate, S T ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Air Pollution; Chemokines; Inflammation; Ozone; T cells

Indexed keywords

OZONE;

ARTICLE; BRONCHITIS; BRONCHUS MUCOSA; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG FUNCTION; LUNG LAVAGE; NEUTROPHIL; OZONE LAYER; PRIORITY JOURNAL;

ADULT; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CELL ADHESION MOLECULES; CELL COUNT; CHYMASES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FLOW CYTOMETRY; HISTAMINE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; INTERLEUKIN-8; MALE; MUCOUS MEMBRANE; NEUTROPHILS; ONCOGENE PROTEINS; OXIDANTS, PHOTOCHEMICAL; OZONE; PEROXIDASE; RECEPTORS, INTERLEUKIN-2; SERINE ENDOPEPTIDASES; T-LYMPHOCYTE SUBSETS; TRYPTASES;

EID: 14444280167     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.11061294     Document Type: Article

References (26)

1. Koren HS, Devlin RB, Graham DE, et al. Ozone induced inflammation in the lower airways of human subjects. Am Rev Respir Dis 1989; 139: 407-415.
2. Devlin RB, McDonnell WF, Mann R, et al. Exposure of humans to ambient ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol 1991; 4: 72-81
3. Aris RM, Christian C, Hearne PQ, Kerr K, Finkbeiner WE, Balmes JR. Ozone induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am Rev Respir Dis 1993; 148: 1363-1372.
4. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-2101.
5. Krishna MT, Blomberg A, Biscione GL, et al. Short-term ozone exposure upregulates P-selectin in normal human airways. Am J Respir Crit Care Med 1997; 155: 1798-1803.
6. Montefort S, Gratziou C, Goulding D, et al. Bronchial biopsy evidence for leucocyte infiltration and upregulation of leucocyte-endothelial adhesion molecules 6 hours after local allergen challenge of sensitised asthmatic airways. J Clin Invest 1994; 93: 1411-1421.
7. Bleavins MR, Sargent NE, Dziedzic D. Effect of cyclosporin A on ozone induced pulmonary lesion formation: pharmacological elimination of T-lymphocyte regulatory response. Arch Environ Contam Toxicol 1995; 28: 240-247.
8. Krishna MT, Springall DR, Meng QH, et al. Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans. Am J Respir Crit Care Med 1997; 156: 943-950.
9. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the phenol reagent. J Biol Chem 1951 ; 193: 265-275.
10. Smith PK, Krohn RI, Hermanson GT, et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 150: 76-85.
11. Britten KM, Howarth PH, Roche WR. Immunohistochemistry on resin sections: a comparison of resin embedding techniques on small mucosal biopsies. Biotech Histochem 1993; 68: 271-280.
12. Krug N, Madden J, Redington AK, et al. T-Cell cytokine profile evaluated at single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996; 14: 319-326.
13. Schelegle ES, Siefken AD, McDonald R. Time course of ozone induced neutrophilia in normal humans. Am Rev Respir Dis 1991; 43: 1353-1358.
14. Aris R, Ferrando R, Chen LC, Christian D, Balmes JR. Increased ICAM expression on human bronchial epithelium after acute exposure to ozone. Am J Respir Crit Care Med 1995; 151: A26.
15. Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA Jr. Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest 1985: 76: 2003-2011.
16. Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, Gimbrone MA Jr. Two distinct monokines, interleukin 1 and tumor necrosis factor, independently induce biosynthesis and transient expression of same antigen on the surface of cultured human vascular endothelial cells. J Immunol 1986; 136: 1680-1687.
17. Pober JSM, Gimbrone MA Jr, Lapierre LA, et al. Overlapping patterns of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 1986; 137: 1893-1896.
18. Rice GE, Bevilacqua MP. An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science 1989; 246: 1303-1306.
19. Masinovsky B, Urdal D, Gallatin WM, IL-4 acts synergistically with IL-1β to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J Immunol 1990; 145: 2886-2895.
20. Hu SC, Ben-Jebria A, Ultman JS. Longitudinal distribution of ozone absorption in the lung. Quiet respiration in healthy subjects. J Appl Physiol 1992; 73: 1665-1661.
21. Gerrity TR, Biscardi F, Strong A, et al. Bronchoscopic determination of ozone uptake in humans. J Appl Physiol 1995; 79: 852-860.
22. Teran LM, Davies DE. The chemokines: Their potential role in allergic inflammation. Clin Exp Allergy 1996; 26: 1005-1019.
23. Teran LM, Carroll MP, Frew AT, et al. Leukocyte recruitment after endobronchial allergen challenge in asthma. Relationship to procedure and airway interleukin-8 release. Am J Respir Crit Care Med 1996; 154: 469-476.
24. Villard J, DayerPastore F, Harnacher J, Aubert JD, Schlegelharrater S, Nichod LP. Gro-alpha and interleukin-8 in pneumocystis carinii or bacterial pneumonia and acute respiratory distress syndrome. Am J Respir Crit Care Med 1995; 152: 1549-1554.
25. Balmes JR, Chen LL, Scannell C, et al. Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 1996; 153: 904-909.
26. Scannell C, Chen L, Aris RM, et al. Greater ozone-induced inflammatory responses in subjects with asthma. Am J Respir Crit Care Med 1996; 154: 24-29.