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Volumn 4, Issue 7, 2009, Pages 1086-1094

Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist 3H-HYDIA

(7) Lundström, Linda a Kuhn, Bernd a Beck, Jennifer a Borroni, Edilio a Wettstein, Joseph G a Woltering, Thomas J a Gatti, Silvia a

a F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

HYDIA; LY354740; Metabotropic glutamate receptor; mGlu2; Molecular modeling; Mutagenesis

Indexed keywords

2 AMINO 3 (3,4 DICHLOROBENZYLOXY) 6 FLUOROBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 2 AMINO 3 HYDROXYBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; EGLUMETAD; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; MGS 0008; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; CONTROLLED STUDY; DEPRESSION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; BICYCLO COMPOUNDS; BINDING SITES; CELL LINE; DICARBOXYLIC ACIDS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, METABOTROPIC GLUTAMATE; TRITIUM;

EID: 67749144068 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200900028 Document Type: Article

Times cited : (12)

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