Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

Neuropharmacology

Volumn 46, Issue 7, 2004, Pages 907-917

  Higgins, Guy A ^a,c   Ballard, Theresa M ^a   Kew, James N C ^a,d   Richards, J Grayson ^a   Kemp, John A ^a,e   Adam, Geo ^a   Woltering, Thomas ^a   Nakanishi, Shigetada ^b   Mutel, Vincent ^a,f  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b KYOTO UNIVERSITY   (Japan)

^c MERCK RESEARCH LABORATORIES   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

^e Evotec Technologies GmbH   (Germany)

^f ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

Delayed (non)matching to position; Electrophysiology; Metabotropic glutamate receptors; mGluR2 knockout mice; Morris water maze; Radioautography; Rat

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; EGLUMETAD; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 2 AGONIST; METABOTROPIC RECEPTOR 2 ANTAGONIST; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG INDICATION; DRUG POTENCY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; KNOCKOUT MOUSE; LEARNING; MALE; MAZE TEST; MOUSE; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; PHARMACOLOGICAL BLOCKING; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RODENT; TOXICOKINETICS;

AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY POSTSYNAPTIC POTENTIALS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PSYCHOMOTOR PERFORMANCE; RATS; REACTION TIME; RECEPTORS, METABOTROPIC GLUTAMATE; XANTHENES;

EID: 1842664372     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2004.01.018     Document Type: Article

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