Synthesis, SARs, and pharmacological characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4893-4909

  Nakazato, A ^a   Kumagai, T ^a   Sakagami, K ^a   Yoshikawa, R ^a   Suzuki, Y ^a   Chaki, S ^a   Ito, H ^b   Taguchi, T ^b   Nakanishi, S ^c   Okuyama, S ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 FLUOROBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; 2 AMINO 6 FLUORO 4 OXOBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR AGONIST; PHENCYCLIDINE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL BINDING; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG CONFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; HYPERACTIVITY; NONHUMAN; RAT; STEREOISOMERISM;

ADMINISTRATION, ORAL; ANIMALS; ANTIPSYCHOTIC AGENTS; BICYCLO COMPOUNDS; CALCIUM; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; DICARBOXYLIC ACIDS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; INOSITOL 1,4,5-TRISPHOSPHATE; RADIOLIGAND ASSAY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SCHIZOPHRENIA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034649605     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000346k     Document Type: Article

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