[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: Characterization of binding to membranes of mGlu receptor subtype expressing cells

Neuropharmacology

Volumn 38, Issue 10, 1999, Pages 1519-1529

  Johnson, Bryan G ^a   Wright, Rebecca A ^a   Arnold, M Brian ^a   Wheeler, William J ^a   Ornstein, Paul L ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Excitatory amino acid; LY341495; Metabotropic glutamate receptors; Radioligand

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPY 1 YL) 3 (XANTH 9 YL)PROPIONIC ACID; 2 AMINO 2 (2 CARBOXYPROPAN 1 YL) 3 (DIBENZOPYRAN 4 YL)PROPANOIC ACID; EGLUMETAD; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; RADIOLIGAND; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; AMINO ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; CALCIUM; RECOMBINANT PROTEIN; TRITIUM; XANTHENE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CELL MEMBRANE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; ISOTOPE LABELING; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; ANIMAL; BINDING COMPETITION; CLASSIFICATION; GENETIC TRANSFECTION; HUMAN; KINETICS; METABOLISM; RADIOASSAY;

AMINO ACIDS; ANIMALS; BINDING, COMPETITIVE; CALCIUM; CELL MEMBRANE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; KINETICS; RADIOLIGAND ASSAY; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; TRANSFECTION; TRITIUM; XANTHENES;

EID: 0032589508     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00053-2     Document Type: Article

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