Glutamate receptor subtypes: Promising new pharmacotherapeutic targets

Psychopharmacology

Volumn 179, Issue 1, 2005, Pages 1-3

  Higgins, Guy A ^a   Miczek, Klaus A ^b  

^a NPS Pharmaceuticals   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CINACALCET; DIZOCILPINE; EGLUMETAD; GLUTAMATE RECEPTOR; KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE;

ALLOSTERISM; ALZHEIMER DISEASE; ANXIETY DISORDER; CENTRAL NERVOUS SYSTEM; EDITORIAL; GENE IDENTIFICATION; HUMAN; HYPERPARATHYROIDISM; MOLECULAR DYNAMICS; NEUROPROTECTION; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; SUBSTANCE ABUSE;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; RECEPTORS, GLUTAMATE; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 17744381347     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-2246-y     Document Type: Editorial

References (12)

1. Anis NA, Berry SC, Burton NR, Lodge D (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol 79:565-575
2. Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H. (2003) Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci 11:2409-2417
3. Gasparini F, Lingenhohl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Velicelebi G, Kuhn R. (1999) 2-Methyl-6- (phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacol 38:1493-1503
4. Kemp JA, McKernan RM (2002) NMDA receptor pathways as drug targets. Nat Neurosci 5:1039-1042
5. Kew JNC (2004) Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential. Pharmacol Ther 104:233-244
6. Linden AM, Johnson BG, Peters SC, Shannon HE, Tian M, Wang Y, Yu JL, Koster A, Baez M, Schoepp DD (2002) Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor. Neuropharmacology 43:251-259
7. Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, Tizzano JP, Schoepp DD (1999) Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem 42:1027-1040
8. Nemeth EF, Heaton WH, Miller M, Fox J, Balandrin M, Van Wagenan BC, Colloton M, Karbon W, Scherrer J, Shatzen E, Rishton G, Scully S, Qi M, Harris R, Lacey D, Martin D (2004) Pharmacodynamics of the type II calcimimetic compound Cinacalcet HCl. J Pharm Exp Ther. 308:627-635
9. Sladeczek F, Pin JP, Recasens M, Bockaert J, Weiss S (1985) Glutamate stimulates inositol phosphate formation in striatal neurones. Nature 317:717-719
10. Spooren W, Ballard T, Gasparini F, Amalric M, Mutel V, Schreiber R (2003) Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders. Behav Pharmacol 14:257-77
11. Watkins JC (1984) Excitatory amino acids and central synaptic transmission. Trends Pharmacol Sci 5:373-376
12. Wong EH, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL (1986) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:7104-7108