Opposite effects of Zn on the in vitro binding of [3H]LYS54740 to recombinant and native metabotropic glutamate 2 and 3 receptors

Journal of Neurochemistry

Volumn 94, Issue 1, 2005, Pages 150-160

  Malherbe, Pari ^a,c   Richards, J Grayson ^a   Broger, Clemens ^a   Zenner, Marie Thérèse ^a   Messer, Jürg ^a   Kratzeisen, Claudia ^a   Nakanishi, Shigetada ^b   Mutel, Vincent ^a,d  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b KYOTO UNIVERSITY   (Japan)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

Knockout; Metabotropic glutamate receptor; Mutagenesis chimeric approaches; Receptor binding studies; Zn effect

Indexed keywords

ASPARTIC ACID; EGLUMETAD; HISTIDINE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; RECOMBINANT RECEPTOR; TRITIUM; ZINC;

AGONIST; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN REGION; CHIMERA; CONTROLLED STUDY; DENTATE GYRUS; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KNOCKOUT MOUSE; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY;

AMINO ACID SEQUENCE; ANIMALS; BICYCLO COMPOUNDS; BINDING SITES; CELL LINE; CHLORIDES; EXCITATORY AMINO ACID AGONISTS; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN BINDING; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; TRITIUM; ZINC COMPOUNDS;

EID: 21344472565     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03176.x     Document Type: Article

References (50)

1. 2+ from brain tissue during activity. Nature. 308, 734-736.
2. Chaki S., Yoshikawa R., Hirota S. et al. (2004) MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 46, 457-467.
3. 2+ inhibition of the NMDA receptor. Neuron. 23, 171-180.
4. 2+. Neuron. 5, 781-788.
5. Eichenbaum H. (2000) A cortical-hippocampal system for declarative memory. Nat. Rev. Neurosci. 1, 41-50.
6. 2+ binding to NMDA receptors. Neuron. 25, 683-694.
7. Frederickson C. J., Suh S. W., Silva D. and Thompson R. B. (2000) Importance of zinc in the central nervous system: the zinc-containing neuron. J. Nutr. 130, 1471S-1483S.
8. Frederickson C. J., Maret W., Cuajungco M. P., Suh S. W., Silva D. and Thompson R. B. (2004) Zinc and excitotoxic brain injury: a new model. Neuroscientist. 10, 18-25.
9. Gerber P. R. and Muller K. (1995) MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry. J. Comput. Aided Mol. Des. 9, 251-268.
10. Grillon C., Cordova J., Levine L. R. and Morgan C. A. (2003) Anxiolytic effects of a novel group 11 metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology (Berl) 168, 446-454.
11. Higgins G. A., Ballard T. M., Kew J. N., Richards J. G., Kemp J. A., Adam G., Weltering T., Nakanishi S. and Mutel V. (2004) Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent. Neuropharmacology. 46, 907-917.
12. Holst B., Elling C. E. and Schwartz T. W. (2002) Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. J. Biol. Chem. 277, 47 662-47 670.
13. Horton R. M., Hunt H. D., Ho S. N., Pullen J. K. and Pease L. R. (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene. 77, 61-68.
14. Kay A. R. (2003) Evidence for chelatable zinc in the extracellular space of the hippocampus, but little evidence for synaptic release of Zn. J. Neurosci. 23, 6847-6855.
15. Kew J. N., Ducarre J. M., Pflimlin M. C., Mutel V. and Kemp J. A. (2001) Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1. Neuropharmacology. 40, 20-27.
16. Kew J. N., Pflimlin M. C., Kemp J. A. and Mutel V. (2002) Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2-/- mice. Neuropharmacology. 43, 215-221.
17. 2+-sensing function of the metabotropic glutamate receptors. Science. 279, 1722-1725.
18. Kunishima N., Shimada Y., Tsuji Y., Sato T., Yamamoto M., Kumasaka T., Nakanishi S., Jingami H. and Morikawa K. (2000) Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 407, 971-977.
19. 2+. J. Neurophysiol. 86, 2597-2604.
20. Maes M., De Vos N., Demedts P., Wauters A. and Neels H. (1999) Lower serum zinc in major depression in relation to changes in serum acute phase proteins. J. Affect. Disord. 56, 189-194.
21. Malherbe P., Kratzeisen C., Lundstrom K., Richards J. G., Faull R. L. M. and Mutel V. (1999) Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Mol. Brain Res. 67, 201-210.
22. Malherbe P., Knoflach F., Broger C., Ohresser S., Kratzeisen C., Adam G., Stadler H., Kemp J. A. and Mutel V. (2001) Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor. Mol. Pharmacol. 60, 944-954.
23. 3H]- dicarboxycyclopropyl) glycine binding in rat brain. J. Neurochem. 71, 2558-2564.
24. 3 production following G-protein-coupled-receptor activation. Biochem. J. 356, 137-142.
25. Nowak G., Szewczyk B., Wieronska J. M., Branski P., Palucha A., Pile A., Sadlik K. and Piekoszewski W. (2003) Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res. Bull. 61, 159-164.
26. Nowak G., Legutko B., Szewczyk B., Papp M., Sanak M. and Pile A. (2004) Zinc treatment induces cortical brain-derived neurotrophic factor gene expression. Eur. J. Pharmacol. 492, 57-59.
27. O'Hara P. J., Sheppard P. O., Thogersen H., Venezia D., Haldeman B. A., McGrane V., Houamed K. M., Thomsen C., Gilbert T. L. and Mulvihill E. R. (1993) The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11, 41-52.
28. Ohishi H., Shigemoto R., Nakanishi S. and Mizuno N. (1993a) Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience. 53, 1009-1018.
29. Ohishi H., Shigemoto R., Nakanishi S. and Mizuno N. (1993b) Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. J. Comp. Neurol. 335, 252-266.
30. Ohishi H., Neki A. and Mizuno N. (1998) Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody. Neurosci. Res. 30, 65-82.
31. Paoletti P., Perin-Dureau F., Fayyazuddin A., Le Goff A., Callebaut I. and Neyton J. (2000) Molecular organization of a zinc binding N-terminal modulatory domain in a NMDA receptor subunit. Neuron. 28, 911-925.
32. Pin J. P. and Acher F. (2002) The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr. Drug Target CNS Neurol. Disord. 1, 297-317.
33. Pin J. P., Galvez T. and Prezeau L. (2003) Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol. Ther. 98, 325-354.
34. Rachline J., Perin-Dureau F., Le Goff A., Neyton J. and Paoletti P. (2005) The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. J. Neurosci. 25, 308-317.
35. Romano C., Miller J. K., Hyrc K., Dikranian S., Mennerick S., Takeuchi Y., Goldberg M. P. and O'Malley K. L. (2001) Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization. Mol. Pharmacol. 59, 46-53.
36. Sack J. S., Saper M. A. and Quiocho F. A. (1989) Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine. J. Mol. Biol. 206, 171-191.
37. 2+ on type 1alpha metabotropic glutamate receptor-mediated signalling. Neuropharmacology. 37, 273-276.
38. 3H]LY354740, in rat brain. Mol. Pharmacol. 53, 228-233.
39. Schoepp D. D., Johnson B. G., Wright R. A. et al. (1997) LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology. 36, 1-11.
40. Schoepp D. D., Wright R. A., Levine L. R., Gaydos B. and Potter W. Z. (2003) LY354740, an mGlu2 and mGlu3 receptor agonist as a novel approach to treat anxiety/stress. Stress. 6, 189-197.
41. Schweitzer C., Kratzeisen C., Adam G., Lundstrom K., Malherbe P., Ohresser S., Stadler H., Wichmann J., Weltering T. and Mutel V. (2000) Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 39, 1700-1706.
42. Shigemoto R., Kinoshita A., Wada E. et al. (1997) Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci. 17, 7503-7522.
43. Smart T. G., Hosie A. M. and Miller P. S. (2004) Zn ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist. 10, 432-442.
44. Swaminath G., Steenhuis J., Kobilka B. and Lee T. W. (2002) Allosteric modulation of beta2-adrenergic receptor by Zn(2+). Mol. Pharmacol. 61, 65-72.
45. Tamaru Y., Nomura S., Mizuno N. and Shigemoto R. (2001) Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Neuroscience. 106, 481-503.
46. Vallee B. L. and Falchuk K. H. (1993) The biochemical basis of zinc physiology. Physiol. Rev. 73, 79-118.
47. Vogt K., Mellor J., Tong G. and Nicoll R. (2000) The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron. 26, 187-196.
48. Weiss J. H., Sensi S. L. and Koh J. Y. (2000) Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 21, 395-401.
49. Yokoi M., Kobayashi K., Manabe T. et al. (1996) Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 273, 645-647.
50. Yoshimizu T. and Chaki S. (2004) Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039. Biochem. Biophys. Res. Commun. 315, 493-496.