-
1
-
-
0141484562
-
Biological Networks: The Tinkerer as an Engineer
-
10.1126/science.1089072
-
Alon U Biological Networks: The Tinkerer as an Engineer Science 2003, 3:1866-1867. 10.1126/science.1089072
-
(2003)
Science
, vol.3
, pp. 1866-1867
-
-
Alon, U.1
-
2
-
-
3543138827
-
Bifurcation analysis of the regulatory modules of the mammalian G1/S transition
-
10.1093/bioinformatics/bth110 15231543
-
Swat M Kel A Herzel H Bifurcation analysis of the regulatory modules of the mammalian G1/S transition Bioinformatics 2004, 20:1506-1511. 10.1093/ bioinformatics/bth110 15231543
-
(2004)
Bioinformatics
, vol.20
, pp. 1506-1511
-
-
Swat, M.1
Kel, A.2
Herzel, H.3
-
3
-
-
0037154231
-
Robustness of circadian rhythms with respect to molecular noise
-
117364 10.1073/pnas.022628299
-
Gonze D Halloy J Goldbeter A Robustness of circadian rhythms with respect to molecular noise Proc Natl Acad Sci USA 2002, 99:673-678. 117364 11792856 10.1073/pnas.022628299
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 673-678
-
-
Gonze, D.1
Halloy, J.2
Goldbeter, A.3
-
4
-
-
4344674786
-
Bistability analyses of a caspase activation model for receptor-induced apoptosis
-
10.1074/jbc.M404893200 15208304
-
Eissing T Conzelmann H Gilles ED Allgower F Bullinger E Scheurich P Bistability analyses of a caspase activation model for receptor-induced apoptosis J Biol Chem 2004, 279:36892-36897. 10.1074/jbc.M404893200 15208304
-
(2004)
J Biol Chem
, vol.279
, pp. 36892-36897
-
-
Eissing, T.1
Conzelmann, H.2
Gilles, E.D.3
Allgower, F.4
Bullinger, E.5
Scheurich, P.6
-
5
-
-
0034641918
-
The biochemistry of apoptosis
-
10.1038/35037710 11048727
-
Hengartner MO The biochemistry of apoptosis Nature 2000, 407:770-776. 10.1038/35037710 11048727
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
6
-
-
33646756222
-
Dissecting p53-dependent apoptosis
-
10.1038/sj.cdd.4401908 16543937
-
Chipuk JE Green DR Dissecting p53-dependent apoptosis Cell Death Differ 2006, 13:994-1002. 10.1038/sj.cdd.4401908 16543937
-
(2006)
Cell Death Differ
, vol.13
, pp. 994-1002
-
-
Chipuk, J.E.1
Green, D.R.2
-
7
-
-
9244224723
-
Intrinsic tumor suppression
-
10.1038/nature03098 15549092
-
Lowe SW Cepero E Evan G Intrinsic tumor suppression Nature 2004, 432:307-315. 10.1038/nature03098 15549092
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
8
-
-
0032512057
-
Mdm2 association with p53 targets its ubiquintination
-
10.1038/sj.onc.1202200 9824166
-
Fuchs SY Adler V Buschmann T Wu X Ronai Z Mdm2 association with p53 targets its ubiquintination Oncogene 1998, 17:2543-2547. 10.1038/ sj.onc.1202200 9824166
-
(1998)
Oncogene
, vol.17
, pp. 2543-2547
-
-
Fuchs, S.Y.1
Adler, V.2
Buschmann, T.3
Wu, X.4
Ronai, Z.5
-
9
-
-
26444558130
-
Pharmacological manipulation of Bcl-2 family members to control cell death
-
1236690
-
Letai A Pharmacological manipulation of Bcl-2 family members to control cell death J Clin Invest 2005 115 2648 2655 1236690 16200198 10.1172/ JCI26250
-
(2005)
J Clin Invest
, vol.115
, pp. 2648-2655
-
-
Letai, A.1
-
10
-
-
0345276414
-
Bcl-2-family proteins and the role of mitochondria in apoptosis
-
10.1016/j.ceb.2003.10.004 14644193
-
Kuwana T Newmeyer DD Bcl-2-family proteins and the role of mitochondria in apoptosis Curr Opin Cell Biol 2003, 15:691-699. 10.1016/ j.ceb.2003.10.004 14644193
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 691-699
-
-
Kuwana, T.1
Newmeyer, D.D.2
-
11
-
-
0034633702
-
Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
-
17186 10.1073/pnas.210171597
-
Bar-Or RL Maya R Segel LA Alon U Levine AJ Oren M Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study Proc Natl Acad Sci USA 2000, 97:11250-11255. 17186 11016968 10.1073/pnas.210171597
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11250-11255
-
-
Bar-Or, R.L.1
Maya, R.2
Segel, L.A.3
Alon, U.4
Levine, A.J.5
Oren, M.6
-
12
-
-
0043180477
-
Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays
-
10.1016/S0960-9822(03)00494-9 12932324
-
Monk NAM Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays Curr Biol 2003, 13:1409-1413. 10.1016/ S0960-9822(03)00494-9 12932324
-
(2003)
Curr Biol
, vol.13
, pp. 1409-1413
-
-
Monk, N.A.M.1
-
13
-
-
0842332406
-
Dynamics of the p53-Mdm2 feedback loop in individual cells
-
10.1038/ng1293 14730303
-
Lahav G Rosenfeld N Sigal A Geva-Zatorsky N Levine AJ Elowitz MB Alon U Dynamics of the p53-Mdm2 feedback loop in individual cells Nat Genet 2004, 36:147-150. 10.1038/ng1293 14730303
-
(2004)
Nat Genet
, vol.36
, pp. 147-150
-
-
Lahav, G.1
Rosenfeld, N.2
Sigal, A.3
Geva-Zatorsky, N.4
Levine, A.J.5
Elowitz, M.B.6
Alon, U.7
-
15
-
-
25444513462
-
Steady states and oscillations in the p53/Mdm2 network
-
15725723
-
Ciliberto A Novak B Tyson JJ Steady states and oscillations in the p53/ Mdm2 network Cell Cycle 2005, 4:488-493. 15725723
-
(2005)
Cell Cycle
, vol.4
, pp. 488-493
-
-
Ciliberto, A.1
Novak, B.2
Tyson, J.J.3
-
17
-
-
33846594408
-
Exploring Mechanisms of the DNA-Damage Response
-
17245126
-
Zhang T Brazhnik P Tyson JJ Exploring Mechanisms of the DNA-Damage Response Cell Cycle 2007, 6:85-94. 17245126
-
(2007)
Cell Cycle
, vol.6
, pp. 85-94
-
-
Zhang, T.1
Brazhnik, P.2
Tyson, J.J.3
-
18
-
-
33745451921
-
Oscillations and variability in the p53 system
-
2006.0033 1681500 10.1038/msb4100068
-
Geva-Zatorsky N Rosenfeld N Itzkovitz S Milo R Sigal A Dekel E Yarnitzky T Liron Y Polak P Lahav G Alon U Oscillations and variability in the p53 system Mol Syst Biol 2006, 2:2006.0033. 1681500 16773083 10.1038/ msb4100068
-
(2006)
Mol Syst Biol
, vol.2
-
-
Geva-Zatorsky, N.1
Rosenfeld, N.2
Itzkovitz, S.3
Milo, R.4
Sigal, A.5
Dekel, E.6
Yarnitzky, T.7
Liron, Y.8
Polak, P.9
Lahav, G.10
Alon, U.11
-
19
-
-
42949171936
-
Recurrent Initiation: A mechanism for triggering p53 pulses in response to DNA damage
-
2579769 10.1016/j.molcel.2008.03.016
-
Batchelor E Mock CS Bhan I Loewer A Lahav G Recurrent Initiation: A mechanism for triggering p53 pulses in response to DNA damage Mol Cell 2008, 30:277-289. 2579769 18471974 10.1016/j.molcel.2008.03.016
-
(2008)
Mol Cell
, vol.30
, pp. 277-289
-
-
Batchelor, E.1
Mock, C.S.2
Bhan, I.3
Loewer, A.4
Lahav, G.5
-
20
-
-
50149107827
-
Oscillations and bistability in the stochastic model of p53 regulation
-
10.1016/j.jtbi.2008.05.039 18577387
-
Puszynski K Hat B Lipniacki T Oscillations and bistability in the stochastic model of p53 regulation J Theor Biol 2008, 254:452-465. 10.1016/j.jtbi.2008.05.039 18577387
-
(2008)
J Theor Biol
, vol.254
, pp. 452-465
-
-
Puszynski, K.1
Hat, B.2
Lipniacki, T.3
-
21
-
-
53149144701
-
Explaining oscillations and variability in the p53-Mdm2 system
-
2553322 18706112 10.1186/1752-0509-2-75
-
Proctor CJ Gray DA Explaining oscillations and variability in the p53-Mdm2 system BMC Syst Biol 2008, 2:75. 2553322 18706112 10.1186/ 1752-0509-2-75
-
(2008)
BMC Syst Biol
, vol.2
, pp. 75
-
-
Proctor, C.J.1
Gray, D.A.2
-
22
-
-
0842332416
-
Monitoring p53's pulse
-
10.1038/ng0204-113 14752517
-
Tyson JJ Monitoring p53's pulse Nat Genet 2004, 36:113-114. 10.1038/ ng0204-113 14752517
-
(2004)
Nat Genet
, vol.36
, pp. 113-114
-
-
Tyson, J.J.1
-
23
-
-
27144517984
-
Interlinked fast and slow positive feedback loops drive reliable cell decisions
-
10.1126/science.1113834 16239477
-
Brandman O Ferrell JE Jr Li R Meyer T Interlinked fast and slow positive feedback loops drive reliable cell decisions Science 2005, 310:496-498. 10.1126/science.1113834 16239477
-
(2005)
Science
, vol.310
, pp. 496-498
-
-
Brandman, O.1
Ferrell Jr., J.E.2
Li, R.3
Meyer, T.4
-
24
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
10.1038/nature01368 12556884
-
Bakkenist CJ Kastan MB DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 2003, 421:499-506. 10.1038/nature01368 12556884
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
25
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinase
-
10.1101/gad.914401
-
Abraham RT Cell cycle checkpoint signaling through the ATM and ATR kinase Gene Dev 2001, 5:2177-2196. 10.1101/gad.914401
-
(2001)
Gene Dev
, vol.5
, pp. 2177-2196
-
-
Abraham, R.T.1
-
26
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
391059 10.1038/sj.emboj.7600145
-
Stommel JM Wahl GM Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation EMBO J 2004, 23:1547-1556. 391059 15029243 10.1038/sj.emboj.7600145
-
(2004)
EMBO J
, vol.23
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
27
-
-
34250350056
-
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
-
1877765 10.1529/biophysj.106.099606
-
Chen C Cui J Lu HZ Wang R Zhang S Shen PP Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision Biophys J 2007, 92:4304-4315. 1877765 17400705 10.1529/biophysj.106.099606
-
(2007)
Biophys J
, vol.92
, pp. 4304-4315
-
-
Chen, C.1
Cui, J.2
Lu, H.Z.3
Wang, R.4
Zhang, S.5
Shen, P.P.6
-
28
-
-
44849128902
-
Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch
-
2194625 10.1371/journal.pone.0001469
-
Cui J Chen C Lu HZ Sun TZ Shen PP Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch PLoS ONE 2008, 3:e1469 2194625 18213378 10.1371/journal.pone.0001469
-
(2008)
PLoS ONE
, vol.3
-
-
Cui, J.1
Chen, C.2
Lu, H.Z.3
Sun, T.Z.4
Shen, P.P.5
-
29
-
-
0037067656
-
p53: Good Cop/Bad Cop
-
10.1016/S0092-8674(02)00818-8 12150992
-
Sharpless NE DePinho RA p53: Good Cop/Bad Cop Cell 2002, 110:9-12. 10.1016/S0092-8674(02)00818-8 12150992
-
(2002)
Cell
, vol.110
, pp. 9-12
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
30
-
-
0031710597
-
Relaxed cell-cycle arrests and propagation of unrepaired chromosomal damage in cancer cell lines with wild-type p53
-
10.1002/(SICI)1098-2744(199809)23:1<1::AID-MC1>3.0.CO;2-Q
-
Olivier M Bautista S Vallès H Theillet C Relaxed cell-cycle arrests and propagation of unrepaired chromosomal damage in cancer cell lines with wild-type p53 Mol Carcinogen 1998, 23:1-12. 10.1002/ (SICI)1098-2744(199809)23:1<1::AID-MC1>3.0.CO;2-Q
-
(1998)
Mol Carcinogen
, vol.23
, pp. 1-12
-
-
Olivier, M.1
Bautista, S.2
Vallès, H.3
Theillet, C.4
-
31
-
-
0037452759
-
PUMA mediates the apoptotic response to p53 in colorectal cancer cell
-
149936 10.1073/pnas.2627984100
-
Yu J Wang Z Kinzler KW Vogelstein B Zhang L PUMA mediates the apoptotic response to p53 in colorectal cancer cell Proc Natl Acad Sci USA 2003, 100:1931-1936. 149936 12574499 10.1073/pnas.2627984100
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1931-1936
-
-
Yu, J.1
Wang, Z.2
Kinzler, K.W.3
Vogelstein, B.4
Zhang, L.5
-
33
-
-
0036902410
-
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
-
10.1038/ncb892
-
Richard A DiTullio Jr Tamara AM Monica Venere Jirina B Maxwell S Jiri Bartek Thanos DH 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer Nat Cell Biol 2002, 4:998-1002. 10.1038/ncb892 12447382
-
(2002)
Nat Cell Biol
, vol.4
, pp. 998-1002
-
-
Richard, A.1
DiTullio, Jr.2
Tamara, A.M.3
Monica, V.4
Jirina, B.5
Maxwell, S.6
Jiri, B.7
Thanos, D.H.8
-
34
-
-
35148812601
-
Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression
-
10.1093/carcin/bgm108 17522062
-
Paolo GN Chiara L Maria C Giuseppe P Fabrizio d'Adda di F Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression Carcinogenesis 2007, 28:2082-2088. 10.1093/carcin/ bgm108 17522062
-
(2007)
Carcinogenesis
, vol.28
, pp. 2082-2088
-
-
Paolo, G.N.1
Chiara, L.2
Maria, C.3
Giuseppe, P.4
Fabrizio d'Adda di, F.5
-
35
-
-
35848949304
-
DNA Damage Response as an Anti-Cancer Barrier
-
17700066
-
Jiri B Jiri L Jirina B DNA Damage Response as an Anti-Cancer Barrier Cell Cycle 2007, 6:2344-2347. 17700066
-
(2007)
Cell Cycle
, vol.6
, pp. 2344-2347
-
-
Jiri, B.1
Jiri, L.2
Jirina, B.3
-
36
-
-
10044225999
-
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
-
526470 15510216 10.1038/sj.emboj.7600455
-
Goodarzi AA Jonnalagadda JC Douglas P Young D Ye R Moorhead GBG Lees-Miller SP Khanna KK Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A EMBO J 2004, 23:4451-4461. 526470 15510216 10.1038/sj.emboj.7600455
-
(2004)
EMBO J
, vol.23
, pp. 4451-4461
-
-
Goodarzi, A.A.1
Jonnalagadda, J.C.2
Douglas, P.3
Young, D.4
Ye, R.5
Moorhead, G.B.G.6
Lees-Miller, S.P.7
Khanna, K.K.8
-
37
-
-
0032500792
-
Alterations of the PPP2R1B gene in human lung and colon cancer
-
10.1126/science.282.5387.284 9765152
-
Wang SS Esplin ED Li JL Huang LY Gazdar A Minna J Evans GA Alterations of the PPP2R1B gene in human lung and colon cancer Science 1998, 282:284-287. 10.1126/science.282.5387.284 9765152
-
(1998)
Science
, vol.282
, pp. 284-287
-
-
Wang, S.S.1
Esplin, E.D.2
Li, J.L.3
Huang, L.Y.4
Gazdar, A.5
Minna, J.6
Evans, G.A.7
-
38
-
-
1442310493
-
Identification of specific PP2A complexes involved in human cell transformation
-
10.1016/S1535-6108(04)00026-1 14998489
-
Chen W Possemato R Campbell KT Plattner CA Pallas DC Hahn WC Identification of specific PP2A complexes involved in human cell transformation Cancer Cell 2004, 5:127-136. 10.1016/ S1535-6108(04)00026-1 14998489
-
(2004)
Cancer Cell
, vol.5
, pp. 127-136
-
-
Chen, W.1
Possemato, R.2
Campbell, K.T.3
Plattner, C.A.4
Pallas, D.C.5
Hahn, W.C.6
-
40
-
-
33746685694
-
Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death
-
1563780 10.1529/biophysj.105.077693
-
Wee KB Aguda BD Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death Biophys J 2006, 91:857-865. 1563780 16648169 10.1529/biophysj.105.077693
-
(2006)
Biophys J
, vol.91
, pp. 857-865
-
-
Wee, K.B.1
Aguda, B.D.2
-
41
-
-
6344235257
-
Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis
-
15498930
-
Enns L Bogen KT Wizniak J Murtha AD Weinfeld M Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis Mol Cancer Res 2004, 2:557-566. 15498930
-
(2004)
Mol Cancer Res
, vol.2
, pp. 557-566
-
-
Enns, L.1
Bogen, K.T.2
Wizniak, J.3
Murtha, A.D.4
Weinfeld, M.5
-
42
-
-
33244474612
-
Induction of p21 CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells
-
Wendt J Radetzki S Haefen CV Hemmati PG Güner D Chulze-Osthoff K Dörken B Daniel PT Induction of p21 CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells Oncogene 2006, 25:5972-980.
-
(2006)
Oncogene
, vol.25
, pp. 5972-5980
-
-
Wendt, J.1
Radetzki, S.2
Haefen, C.V.3
Hemmati, P.G.4
Güner, D.5
Chulze-Osthoff, K.6
Dörken, B.7
Daniel, P.T.8
-
43
-
-
2442494082
-
Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation
-
10.1074/jbc.M400344200 14990579
-
Fujiuchi N Aglipay JA Ohtsuka T Maehara N Sahin F Su GH Lee SW Ouchi T Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation J Biol Chem 2004, 279:20339-20344. 10.1074/ jbc.M400344200 14990579
-
(2004)
J Biol Chem
, vol.279
, pp. 20339-20344
-
-
Fujiuchi, N.1
Aglipay, J.A.2
Ohtsuka, T.3
Maehara, N.4
Sahin, F.5
Su, G.H.6
Lee, S.W.7
Ouchi, T.8
-
44
-
-
28644438156
-
The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells
-
10.1158/0008-5472.CAN-04-4614 16288023
-
Wang T D Tamae T LeBon JE Shively Y Yen JJ Li The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells Cancer Res 2005, 65:10338-10346. 10.1158/0008-5472.CAN-04-4614 16288023
-
(2005)
Cancer Res
, vol.65
, pp. 10338-10346
-
-
Wang, T.1
Tamae, D.2
LeBon, L.3
Shively, J.E.4
Yen, Y.5
Li, J.J.6
-
45
-
-
0035899429
-
Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells
-
10.1038/sj.onc.1204659 11526489
-
Jänicke RU Engels IH Dunkern T Kaina B Schulze-Osthoff K Porter AG Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells Oncogene 2001, 20:5043-5053. 10.1038/sj.onc.1204659 11526489
-
(2001)
Oncogene
, vol.20
, pp. 5043-5053
-
-
Jänicke, R.U.1
Engels, I.H.2
Dunkern, T.3
Kaina, B.4
Schulze-Osthoff, K.5
Porter, A.G.6
-
46
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR Parganas E Lee Y Yang C Wang J Brennan J MacLean KH Han J Chittenden T Ihle JN McKinnon PJ Cleveland JL Zambetti GP Puma is an essential mediator of p53-dependent and -independent apoptotic pathways Mol Cell 2004, 4:321-328.
-
(2004)
Mol Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
Yang, C.4
Wang, J.5
Brennan, J.6
MacLean, K.H.7
Han, J.8
Chittenden, T.9
Ihle, J.N.10
McKinnon, P.J.11
Cleveland, J.L.12
Zambetti, G.P.13
-
47
-
-
0037047157
-
Apoptotic threshold is lowered by p53 transactivation of caspase-6
-
123168 10.1073/pnas.132241599
-
MacLachlan TK El-Deiry WS Apoptotic threshold is lowered by p53 transactivation of caspase-6 Proc Natl Acad Sci USA 2002, 99:9492-9497. 123168 12089322 10.1073/pnas.132241599
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9492-9497
-
-
MacLachlan, T.K.1
El-Deiry, W.S.2
-
48
-
-
17644409069
-
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
-
10.1126/science.1108297 15790808
-
Lee J-H Paull TT ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex Science 2005, 308:551-554. 10.1126/ science.1108297 15790808
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.-H.1
Paull, T.T.2
-
49
-
-
22144462810
-
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
-
10.1038/ncb1270 15965469
-
Difilippantonio S Celeste A Fernandez-Capetillo O Chen HT Martin BRS Laethem FV Yang YP Petukhova GV Eckhaus M Feigenbaum L Manova K Kruhlak M Camerini-Otero RD Sharan S Nussenzweig M Nussenzweig A Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models Nat Cell Biol 2005, 7:675-685. 10.1038/ncb1270 15965469
-
(2005)
Nat Cell Biol
, vol.7
, pp. 675-685
-
-
Difilippantonio, S.1
Celeste, A.2
Fernandez-Capetillo, O.3
Chen, H.T.4
Martin, B.R.S.5
Laethem, F.V.6
Yang, Y.P.7
Petukhova, G.V.8
Eckhaus, M.9
Feigenbaum, L.10
Manova, K.11
Kruhlak, M.12
Camerini-Otero, R.D.13
Sharan, S.14
Nussenzweig, M.15
Nussenzweig, A.16
-
50
-
-
22144438300
-
Nbs1 moving up in the world
-
10.1038/ncb0705-648 15990895
-
Stavridi ES Halazonetis TD Nbs1 moving up in the world Nat Cell Biol 2005, 7:648-650. 10.1038/ncb0705-648 15990895
-
(2005)
Nat Cell Biol
, vol.7
, pp. 648-650
-
-
Stavridi, E.S.1
Halazonetis, T.D.2
-
51
-
-
2642528031
-
DNA damage-induced activation of ATM and ATM-dependent signaling pathways
-
10.1016/j.dnarep.2004.03.029 15279774
-
Kurz EU Lees-Miller SP DNA damage-induced activation of ATM and ATM-dependent signaling pathways DNA Repair 2004, 3:889-900. 10.1016/ j.dnarep.2004.03.029 15279774
-
(2004)
DNA Repair
, vol.3
, pp. 889-900
-
-
Kurz, E.U.1
Lees-Miller, S.P.2
-
52
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
10.1046/j.1432-1327.2001.02225.x 11358490
-
Appella E Anderson CW Post-translational modifications and activation of p53 by genotoxic stresses Eur J Biochem 2001, 268:2764-2772. 10.1046/ j.1432-1327.2001.02225.x 11358490
-
(2001)
Eur J Biochem
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
53
-
-
11244344381
-
p53: Traffic Cop at the crossroads of DNA repair and recombination
-
10.1038/nrm1546 15688066
-
Sengupta S Harris CC p53: Traffic Cop at the crossroads of DNA repair and recombination Nat Rev Mol Cell Biol 2005, 6:44-55. 10.1038/nrm1546 15688066
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 44-55
-
-
Sengupta, S.1
Harris, C.C.2
-
54
-
-
0029612225
-
Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: Joining correct and incorrect end
-
40294 10.1073/pnas.92.26.12050
-
Löbrich M Rydberg B Cooper PK Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: Joining correct and incorrect end Proc Natl Acad Sci USA 1995, 92:12050-12054. 40294 8618842 10.1073/pnas.92.26.12050
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 12050-12054
-
-
Löbrich, M.1
Rydberg, B.2
Cooper, P.K.3
-
55
-
-
33746865877
-
p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints
-
10.1158/0008-5472.CAN-06-0511 16849542
-
Wang S El-Deiry WS p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints Cancer Res 2006, 66:6982-6989. 10.1158/0008-5472.CAN-06-0511 16849542
-
(2006)
Cancer Res
, vol.66
, pp. 6982-6989
-
-
Wang, S.1
El-Deiry, W.S.2
-
56
-
-
0027286616
-
The tumor suppressor p53 regulates its own transcription
-
359810 7684498
-
Deffie A Wu H Reinke V Lozano G The tumor suppressor p53 regulates its own transcription Mol Cell Biol 1993, 13:3415-3423. 359810 7684498
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3415-3423
-
-
Deffie, A.1
Wu, H.2
Reinke, V.3
Lozano, G.4
-
57
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
10.1038/sj.onc.1208615 15838523
-
Harris SL Levine AJ The p53 pathway: Positive and negative feedback loops Oncogene 2005, 24:2899-2908. 10.1038/sj.onc.1208615 15838523
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
58
-
-
31544457877
-
p53 Ubiquitination: Mdm2 and Beyond
-
10.1016/j.molcel.2006.01.020 16455486
-
Brooks LC Gu W p53 Ubiquitination: Mdm2 and Beyond Mol Cell 2006, 21:307-315. 10.1016/j.molcel.2006.01.020 16455486
-
(2006)
Mol Cell
, vol.21
, pp. 307-315
-
-
Brooks, L.C.1
Gu, W.2
-
59
-
-
0346455772
-
Posttranslational Modification of MDM2
-
14707285
-
Meek DW Knippschild U Posttranslational Modification of MDM2 Mol Cancer Res 2003, 1:1017-1026. 14707285
-
(2003)
Mol Cancer Res
, vol.1
, pp. 1017-1026
-
-
Meek, D.W.1
Knippschild, U.2
-
60
-
-
33751513394
-
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
-
10.1038/ncb1499 17115033
-
Kim H Rafiuddin-Shah M Tu HC Jeffers JR Zambetti GP Hsieh JJD Cheng EH-Y Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies Nat Cell Biol 2006, 8:1348-1358 1.0.1038/ncb1499 17115033
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1348-1358
-
-
Kim, H.1
Rafiuddin-Shah, M.2
Tu, H.C.3
Jeffers, J.R.4
Zambetti, G.P.5
Hsieh, J.J.D.6
Cheng, E.H.-Y.7
-
61
-
-
24644436766
-
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
10.1126/science.1114297 16151013
-
Chipuk JE Bouchier-Hayes L Kuwana T Newmeyer DD Green DR PUMA couples the nuclear and cytoplasmic proapoptotic function of p53 Science 2005, 309:1732-1935. 10.1126/science.1114297 16151013
-
(2005)
Science
, vol.309
, pp. 1732-1935
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Kuwana, T.3
Newmeyer, D.D.4
Green, D.R.5
-
62
-
-
33644657517
-
Bid, a BH3-only multi-functional molecule, is at the cross road of life and death
-
10.1016/j.gene.2005.10.038 16446060
-
Yin XM Bid, a BH3-only multi-functional molecule, is at the cross road of life and death Gene 2006, 369:7-19. 10.1016/j.gene.2005.10.038 16446060
-
(2006)
Gene
, vol.369
, pp. 7-19
-
-
Yin, X.M.1
-
63
-
-
3242690522
-
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
-
444865 10.1128/MCB.24.15.6728-6741.2004
-
Erster S Mihara M RH Kim Petrenko O UM Moll In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation Mol Cell Biol 2004, 24:6728-6741. 444865 15254240 10.1128/MCB.24.15.6728-6741.2004
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6728-6741
-
-
Erster, S.1
Mihara, M.2
Kim, R.H.3
Petrenko, O.4
Moll, U.M.5
|