Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switch

PLoS ONE

Volumn 3, Issue 1, 2008, Pages

  Cui, Jun ^a   Chen, Chun ^a   Lu, Haizhu ^a   Sun, Tingzhe ^a   Shen, Pingping ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL POPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; MATHEMATICAL MODEL; POSITIVE FEEDBACK; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN LOCALIZATION; STOCHASTIC MODEL; DRUG EFFECT; PHYSIOLOGY; THEORETICAL MODEL;

APOPTOSIS; MODELS, THEORETICAL; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 44849128902     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001469     Document Type: Article

References (40)

1. Saikumar P, Dong Z, Mikailov V, Denton M, Weinberg JM, et al. (1999) Apoptosis: Definition, Mechanisms and Relevance to Disease. Am J Med 107: 489-506.
2. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407: 770-6.
3. Danial NN, Korsmeyer SJ (2004) Cell death: critical control points, Cell 116: 205-219.
4. Nair VD, Yuen T, Olanow CW, Scalfon SC (2004) Early single cell bifurcation of pro- and anti-apoptotic states during oxidative stress. J Biol Chem 279: 27494-27501.
5. Green DR, Kroemer G (2005) Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest 115: 2610-2617.
6. Loo G, Saelens X, Gurp M, MacFarlane M, Martin SJ, et al. (2002) The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ 9: 1031-1042.
7. Chipuk JE, Bouchier-Hayes L, Green DR (2006) Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ 13: 1396-1402.
8. Kuwana T, Newmeyer DD (2003) Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 15: 691-699.
9. Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337.
10. Galonek HL, Hardwick JM (2006) Upgrading the BCL-2 network. Nat Cell Biol 8: 1317-1319.
11. Kim H, Rafiuddin-Shah M, Tu H, Jeffers JR, Zambetti GP, et al. (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8: 1348-135.
12. Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315: 856-859.
13. Youle RJ (2007) Cellular demolition and the rules of engagement. Science 315: 776-777.
14. Chen C, Cui J, Zhang W, Shen PP (2007) Robustness analysis identifies the plausible model of Bcl-2 apoptotic switch. FEBS Iett 581: 5143-5150.
15. Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, et al. (2006) Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J 25: 2287-96.
16. Peng J, Tan CB, Roberts GJ, Nikolaeva O, Zhang Z, et al. (2006) tBid Elicits a Conformational Alteration in Membrane-bound Bcl-2 Such That It Inhibits Bax Pore Formation. J Biol Chem 281: 35802-35811.
17. Tan C, Dlugosz PJ, Peng J, Zhang Z, Lapolla SM, et al. (2006) Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem 281: 14764-14775.
18. Ruffolo SC, Shore GC (2003) BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization. J Biol Chem 278: 25039-25045.
19. Willis SN, Adams JM (2005) Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617-625.
20. Li B, Dou QP (2000) Bax degradation by the ubiquitin/ proteasome-dependent pathway: involvement in tumor survival and progression. Proc Natl Acad Sci USA 97; 3850-3855.
21. Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, et al. (2005) Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Mol Biol Cell 16: 2424-2432.
22. Zi Z, Cho K, Sung M, Xia X, Zheng J, et al. (2005) In silico identification of the key components and steps in IFN-γ induce JAK-STAT signaling pathway. FEBS Lett 579: 1101-1108.
23. Chen C, Cui J, Lu H, Wang R, Zhang S, et al. (2007) Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision. Biophys J 92: 4304-4315.
24. Ferrell JM, Xiong W (2001) Bistability in cell signaling: how to make continuous processes discontinuous, and reversible processes irreversible. Chaos 11: 227-238.
25. Eißing T, Waldherr S, Allgöwer F, Scheurich P, Bollinger E (2007) Response to Bistability in Apoptosis: Roles of Bax, Bcl-2, and Mitochondrial Permeability Transition Pores. Biophys J 92: 3332-3334.
26. Bhalla US (2004) Signaling in small subcellular volumes. II. Stochastic and diffusion effects on synaptic network properties. Biophys J 87: 745-753.
27. Eißing T, Allgöwer F, Bullinger E (2005) Robustness properties of apoptosis models with respect to parameter variations and intrinsic noise. IEE Proc-Syst Biol 152: 221-228.
28. Eskes R, Desagher S, Antonsson B, Martinou JC (2000) Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane. Mol Cell Biol 20: 929-935.
29. Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, et al. (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192.
30. Gómez-Benito M, Marzo, I, Anel A, Naval J (2005) Farnesyltransferase Inhibitor BMS-214662 Induces Apoptosis in Myeloma Cells through PUMA Up-Regulation, Bax and Bak Activation, and Mcl-I Maturation. Mol Pharmacol 67: 1991-1998.
31. Fischer SF, Vier J, Kirschnek S, Klos A, Hess S, et al. (2004) Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins. J Exp Med 200: 905-916.
32. Willis SN, Chen L, Dewson G, Wei A, Naik E, et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes & Dev 19: 1294-1305.
33. Bagei EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I (2005) Bistability in apoptosis: roles of Bax, Bcl-2 and mitochondrial permeability transition pores. Biophys J 90: 1546-1559.
34. Legewie S, Bluthgen N, Herzel H (2006) Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Comput Biol 2(9): e 120.
35. Eissing T, Conzelmann H, Gilles ED, Allgöwer F, Bollinger E, et al. (2004) Bistability Analyses of a Caspase Activation Model for Receptor-induced Apoptosis. J Biol Chem 279: 36892-36897.
36. Bouchier-Hayes L, Lartigue L, Newmeyer DD (2005) Mitochondria: pharmacological manipulation of cell death. J Clin Invest 115: 2640-2647.
37. Valentijn AJ, Metcalfe, AD, Kott J, Streuli CH, Gilmore AP (2003) Spatial and temporal changes in Bax subcellular localization during anoikis. J Cell Biol 162: 599-612.
38. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, et al. (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumors. Nature 435: 677-681.
39. van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, et al. (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-I is neutralized. Cancer Cell 10: 389-99.
40. Hua F, Cornejo MG, Cardone MH, Stokes CL, Lauffenburger DA (2005) Effects of Bcl-2 levels on Fas signaling-induced Capase-3 activation: molecular genetic tests of computational model predictions. J Immunol 175: 985-995.