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Volumn 132, Issue 3, 2009, Pages 295-304

Breaking old paradigms: Th17 cells in autoimmune arthritis

Author keywords

IL 17; Rheumatoid arthritis; Th17

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE ANTIBODY; FLUINDOSTATIN; INFLIXIMAB; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR; RETINOIC ACID; SIMVASTATIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG;

EID: 67651175878     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.03.522     Document Type: Short Survey
Times cited : (73)

References (122)
  • 2
    • 0142244577 scopus 로고    scopus 로고
    • Exposure to receptor-activator of NFkB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation
    • Huang W., O'Keefe R.J., and Schwarz E.M. Exposure to receptor-activator of NFkB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation. Arthritis Res. Ther. 5 (2002) R49-R59
    • (2002) Arthritis Res. Ther. , vol.5
    • Huang, W.1    O'Keefe, R.J.2    Schwarz, E.M.3
  • 6
    • 65849467800 scopus 로고    scopus 로고
    • Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis
    • Nistala K., and Wedderburn L.R. Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis. Rheumatology (2009) kep028
    • (2009) Rheumatology
    • Nistala, K.1    Wedderburn, L.R.2
  • 10
    • 0033376090 scopus 로고    scopus 로고
    • Intracytoplasmic Th1 and Th2 cytokines in rheumatoid arthritis blood and synovial tissue
    • Bourg V., PortalËs P., Fiorito S., Combe B., Jorgensen C., Sany J., and Clot J. Intracytoplasmic Th1 and Th2 cytokines in rheumatoid arthritis blood and synovial tissue. J. Autoimmun. 13 (1999) 415-422
    • (1999) J. Autoimmun. , vol.13 , pp. 415-422
    • Bourg, V.1    PortalËs, P.2    Fiorito, S.3    Combe, B.4    Jorgensen, C.5    Sany, J.6    Clot, J.7
  • 11
    • 13444280103 scopus 로고    scopus 로고
    • RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells
    • Pang M., Martinez A.F., Jacobs J., Balkan W., and Troen B.R. RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells. Biochem. Biophys. Res. Commun. 328 (2005) 756-763
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 756-763
    • Pang, M.1    Martinez, A.F.2    Jacobs, J.3    Balkan, W.4    Troen, B.R.5
  • 12
    • 33644896862 scopus 로고    scopus 로고
    • Interleukin (IL)-12 mediates the anti-osteoclastogenic activity of CpG-oligodeoxynucleotides
    • Alla Amcheslavsky Z.B.-S. Interleukin (IL)-12 mediates the anti-osteoclastogenic activity of CpG-oligodeoxynucleotides. J. Cell. Physiol. 207 (2006) 244-250
    • (2006) J. Cell. Physiol. , vol.207 , pp. 244-250
    • Alla Amcheslavsky, Z.B.-S.1
  • 13
    • 49449100184 scopus 로고    scopus 로고
    • Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption
    • Tunyogi-Csapo M., Kis-Toth K., Radacs M., Farkas B., Jacobs J.J., Finnegan A., Mikecz K., and Glant T.T. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Arthritis Rheum. 58 (2008) 2397-2408
    • (2008) Arthritis Rheum. , vol.58 , pp. 2397-2408
    • Tunyogi-Csapo, M.1    Kis-Toth, K.2    Radacs, M.3    Farkas, B.4    Jacobs, J.J.5    Finnegan, A.6    Mikecz, K.7    Glant, T.T.8
  • 14
    • 42749086111 scopus 로고    scopus 로고
    • The dynamic interplay between osteoclasts and the immune system
    • Nakashima T., and Takayanagi H. The dynamic interplay between osteoclasts and the immune system. Arch. Biochem. Biophys. 473 (2008) 166-171
    • (2008) Arch. Biochem. Biophys. , vol.473 , pp. 166-171
    • Nakashima, T.1    Takayanagi, H.2
  • 15
    • 0035167691 scopus 로고    scopus 로고
    • Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine
    • Chen N.-J., Huang M.-W., and Hsieh S.-L. Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine. J. Immunol. 166 (2001) 270-276
    • (2001) J. Immunol. , vol.166 , pp. 270-276
    • Chen, N.-J.1    Huang, M.-W.2    Hsieh, S.-L.3
  • 18
    • 38449089583 scopus 로고    scopus 로고
    • Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response
    • Irmler I.M., Gajda M., and Brauer R. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. J. Immunol. 179 (2007) 6228-6236
    • (2007) J. Immunol. , vol.179 , pp. 6228-6236
    • Irmler, I.M.1    Gajda, M.2    Brauer, R.3
  • 19
    • 0141539382 scopus 로고    scopus 로고
    • IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints
    • Chu C.Q., Song Z., Mayton L., Wu B., and Wooley P.H. IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints. Ann. Rheum. Dis. 62 (2003) 983-990
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 983-990
    • Chu, C.Q.1    Song, Z.2    Mayton, L.3    Wu, B.4    Wooley, P.H.5
  • 21
    • 0034862856 scopus 로고    scopus 로고
    • Interleukin 10 (IL-10), not IL-4 or interferon-gamma production, correlates with progression of joint destruction in rheumatoid arthritis
    • Verhoef C.M., van Roon J.A., Vianen M.E., Bijlsma J.W., and Lafeber F.P. Interleukin 10 (IL-10), not IL-4 or interferon-gamma production, correlates with progression of joint destruction in rheumatoid arthritis. J. Rheumatol. 28 (2001) 1960-1966
    • (2001) J. Rheumatol. , vol.28 , pp. 1960-1966
    • Verhoef, C.M.1    van Roon, J.A.2    Vianen, M.E.3    Bijlsma, J.W.4    Lafeber, F.P.5
  • 23
    • 34247247352 scopus 로고    scopus 로고
    • Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17
    • Chu C.-Q., Swart D., Alcorn D., Tocker J., and Elkon K.B. Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17. Arthritis Rheum. 56 (2007) 1145-1151
    • (2007) Arthritis Rheum. , vol.56 , pp. 1145-1151
    • Chu, C.-Q.1    Swart, D.2    Alcorn, D.3    Tocker, J.4    Elkon, K.B.5
  • 24
    • 0034762869 scopus 로고    scopus 로고
    • Genetic ablation of interferon-gamma up-regulates interleukin-1 beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain
    • Guedez Y.B., Whittington K.B., Clayton J.L., Joosten L.A.B., van de Loo F.A.J., van den Berg W.B., and Rosloniec E.F. Genetic ablation of interferon-gamma up-regulates interleukin-1 beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum. 44 (2001) 2413-2424
    • (2001) Arthritis Rheum. , vol.44 , pp. 2413-2424
    • Guedez, Y.B.1    Whittington, K.B.2    Clayton, J.L.3    Joosten, L.A.B.4    van de Loo, F.A.J.5    van den Berg, W.B.6    Rosloniec, E.F.7
  • 30
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M., Durand J.M., Buchs N., Fossiez F., Page G., Frappart L., and Miossec P. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42 (1999) 963-970
    • (1999) Arthritis Rheum. , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3    Fossiez, F.4    Page, G.5    Frappart, L.6    Miossec, P.7
  • 32
    • 66149105578 scopus 로고    scopus 로고
    • Combined blockade of GM-CSF and IL-17 pathways potently suppresses chronic destructive arthritis in a TNF-alpha independent mouse model
    • ard.2007.085431
    • Plater-Zyberk C., Joosten L.A.B., Helsen M.M.A., Koenders M.I., Baeuerle P.A., and van den Berg W.B. Combined blockade of GM-CSF and IL-17 pathways potently suppresses chronic destructive arthritis in a TNF-alpha independent mouse model. Ann. Rheum. Dis. (2008) ard.2007.085431
    • (2008) Ann. Rheum. Dis.
    • Plater-Zyberk, C.1    Joosten, L.A.B.2    Helsen, M.M.A.3    Koenders, M.I.4    Baeuerle, P.A.5    van den Berg, W.B.6
  • 33
    • 26844554064 scopus 로고    scopus 로고
    • Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis
    • Koenders M.I., Kolls J.K., Oppers-Walgreen B., Van Den Bersselaar L., Joosten L.A.B., Schurr J.R., Schwarzenberger P., Van Den Berg W.B., and Lubberts E. Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis Rheum. 52 (2005) 3239-3247
    • (2005) Arthritis Rheum. , vol.52 , pp. 3239-3247
    • Koenders, M.I.1    Kolls, J.K.2    Oppers-Walgreen, B.3    Van Den Bersselaar, L.4    Joosten, L.A.B.5    Schurr, J.R.6    Schwarzenberger, P.7    Van Den Berg, W.B.8    Lubberts, E.9
  • 35
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S., Nambu A., Sudo K., and Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171 (2003) 6173-6177
    • (2003) J. Immunol. , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 38
    • 33847667225 scopus 로고    scopus 로고
    • The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
    • Afzali B., Lombardi G., Lechler R.I., and Lord G.M. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin. Exp. Immunol. 148 (2007) 32-46
    • (2007) Clin. Exp. Immunol. , vol.148 , pp. 32-46
    • Afzali, B.1    Lombardi, G.2    Lechler, R.I.3    Lord, G.M.4
  • 39
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NFkB- and PI3-kinase/Akt-dependent pathways
    • Hwang S.-Y., Kim J.-Y., Kim K.-W., Park M.-K., Moon Y., Kim W.-U., and Kim H.-Y. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NFkB- and PI3-kinase/Akt-dependent pathways. Arthritis Res. Ther. 6 (2004) R120-R128
    • (2004) Arthritis Res. Ther. , vol.6
    • Hwang, S.-Y.1    Kim, J.-Y.2    Kim, K.-W.3    Park, M.-K.4    Moon, Y.5    Kim, W.-U.6    Kim, H.-Y.7
  • 40
    • 40649083317 scopus 로고    scopus 로고
    • Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases
    • Agarwal S., Misra R., and Aggarwal A. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J. Rheumatol. 35 (2008) 515-519
    • (2008) J. Rheumatol. , vol.35 , pp. 515-519
    • Agarwal, S.1    Misra, R.2    Aggarwal, A.3
  • 41
    • 0028348850 scopus 로고
    • Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies
    • Bertazzolo N., Punzi L., Stefani M.P., Cesaro G., Pianon M., Finco B., and Todesco S. Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies. Inflamm. Res. 41 (1994) 90-92
    • (1994) Inflamm. Res. , vol.41 , pp. 90-92
    • Bertazzolo, N.1    Punzi, L.2    Stefani, M.P.3    Cesaro, G.4    Pianon, M.5    Finco, B.6    Todesco, S.7
  • 42
    • 0034672092 scopus 로고    scopus 로고
    • Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NFkB but not C/EBP-beta or c-Jun
    • Georganas C., Liu H., Perlman H., Hoffmann A., Thimmapaya B., and Pope R.M. Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NFkB but not C/EBP-beta or c-Jun. J. Immunol. 165 (2000) 7199-7206
    • (2000) J. Immunol. , vol.165 , pp. 7199-7206
    • Georganas, C.1    Liu, H.2    Perlman, H.3    Hoffmann, A.4    Thimmapaya, B.5    Pope, R.M.6
  • 43
    • 3042733572 scopus 로고    scopus 로고
    • Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha
    • Stamp L.K., Cleland L.G., and James M.J. Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha. J. Rheumatol. 31 (2004) 1246-1254
    • (2004) J. Rheumatol. , vol.31 , pp. 1246-1254
    • Stamp, L.K.1    Cleland, L.G.2    James, M.J.3
  • 44
    • 17044447324 scopus 로고    scopus 로고
    • Regulation of TNF-alpha and interleukin-10 production by prostaglandins I2 and E2: studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
    • Shinomiya S., Naraba H., Ueno A., Utsunomiya I., Maruyama T., Ohuchida S., Ushikubi F., Yuki K., Narumiya S., Sugimoto Y., Ichikawa A., and Oh-ishi S. Regulation of TNF-alpha and interleukin-10 production by prostaglandins I2 and E2: studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. Biochem. Pharmacol. 61 (2001) 1153-1160
    • (2001) Biochem. Pharmacol. , vol.61 , pp. 1153-1160
    • Shinomiya, S.1    Naraba, H.2    Ueno, A.3    Utsunomiya, I.4    Maruyama, T.5    Ohuchida, S.6    Ushikubi, F.7    Yuki, K.8    Narumiya, S.9    Sugimoto, Y.10    Ichikawa, A.11    Oh-ishi, S.12
  • 45
    • 0028109394 scopus 로고
    • Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2
    • Strassmann G., Patil-Koota V., Finkelman F., Fong M., and Kambayashi T. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med. 180 (1994) 2365-2370
    • (1994) J. Exp. Med. , vol.180 , pp. 2365-2370
    • Strassmann, G.1    Patil-Koota, V.2    Finkelman, F.3    Fong, M.4    Kambayashi, T.5
  • 47
    • 34547777299 scopus 로고    scopus 로고
    • Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis
    • Sheibanie A.F., Khayrullina T., Safadi F.F., and Ganea D. Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis. Arthritis Rheum. 56 (2007) 2608-2619
    • (2007) Arthritis Rheum. , vol.56 , pp. 2608-2619
    • Sheibanie, A.F.1    Khayrullina, T.2    Safadi, F.F.3    Ganea, D.4
  • 48
    • 47949122478 scopus 로고    scopus 로고
    • In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells
    • Khayrullina T., Yen J.-H., Jing H., and Ganea D. In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. J. Immunol. 181 (2008) 721-735
    • (2008) J. Immunol. , vol.181 , pp. 721-735
    • Khayrullina, T.1    Yen, J.-H.2    Jing, H.3    Ganea, D.4
  • 49
    • 0034069815 scopus 로고    scopus 로고
    • IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts
    • Katz Y., Nadiv O., Rapoport M.J., and Loos M. IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts. Clin. Exp. Immunol. 120 (2000) 22-29
    • (2000) Clin. Exp. Immunol. , vol.120 , pp. 22-29
    • Katz, Y.1    Nadiv, O.2    Rapoport, M.J.3    Loos, M.4
  • 50
    • 0022626174 scopus 로고
    • Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex
    • Mollnes T.E., Lea T., Mellbye O.J., Pahle J., Grand O., and Harboe M. Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex. Arthritis Rheum. 29 (1986) 715-721
    • (1986) Arthritis Rheum. , vol.29 , pp. 715-721
    • Mollnes, T.E.1    Lea, T.2    Mellbye, O.J.3    Pahle, J.4    Grand, O.5    Harboe, M.6
  • 52
    • 33746210208 scopus 로고    scopus 로고
    • Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis
    • Banda N.K., Thurman J.M., Kraus D., Wood A., Carroll M.C., Arend W.P., and Holers V.M. Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis. J. Immunol. 177 (2006) 1904-1912
    • (2006) J. Immunol. , vol.177 , pp. 1904-1912
    • Banda, N.K.1    Thurman, J.M.2    Kraus, D.3    Wood, A.4    Carroll, M.C.5    Arend, W.P.6    Holers, V.M.7
  • 53
    • 33845576001 scopus 로고    scopus 로고
    • Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NFkB- and p38 MAPK-dependent signalling pathways
    • Kim H.R., Cho M.L., Kim K.W., Juhn J.Y., Hwang S.Y., Yoon C.H., Park S.H., Lee S.H., and Kim H.Y. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NFkB- and p38 MAPK-dependent signalling pathways. Rheumatology 46 (2007) 57-64
    • (2007) Rheumatology , vol.46 , pp. 57-64
    • Kim, H.R.1    Cho, M.L.2    Kim, K.W.3    Juhn, J.Y.4    Hwang, S.Y.5    Yoon, C.H.6    Park, S.H.7    Lee, S.H.8    Kim, H.Y.9
  • 54
    • 38449102562 scopus 로고    scopus 로고
    • IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis
    • Yamaguchi Y., Fujio K., Shoda H., Okamoto A., Tsuno N.H., Takahashi K., and Yamamoto K. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J. Immunol. 179 (2007) 7128-7136
    • (2007) J. Immunol. , vol.179 , pp. 7128-7136
    • Yamaguchi, Y.1    Fujio, K.2    Shoda, H.3    Okamoto, A.4    Tsuno, N.H.5    Takahashi, K.6    Yamamoto, K.7
  • 55
    • 54449087291 scopus 로고    scopus 로고
    • Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis
    • Lai Kwan Lam Q., King Hung Ko O., Zheng B.J., and Lu L. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 14993-14998
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 14993-14998
    • Lai Kwan Lam, Q.1    King Hung Ko, O.2    Zheng, B.J.3    Lu, L.4
  • 57
    • 59749105357 scopus 로고    scopus 로고
    • APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response
    • Xiao Y., Motomura S., and Podack E.R. APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response. Eur. J. Immunol. 38 (2008) 3450-3458
    • (2008) Eur. J. Immunol. , vol.38 , pp. 3450-3458
    • Xiao, Y.1    Motomura, S.2    Podack, E.R.3
  • 60
    • 0033974809 scopus 로고    scopus 로고
    • Characterization of tissue outgrowth developed in vitro in patients with rheumatoid arthritis: involvement of T cells in the development of tissue outgrowth
    • Wakisaka S., Suzuki N., Nagafuchi H., Takeba Y., Kaneko A., Asai T., and Sakane T. Characterization of tissue outgrowth developed in vitro in patients with rheumatoid arthritis: involvement of T cells in the development of tissue outgrowth. Int. Arch. Allergy Immunol. 121 (2000) 68-79
    • (2000) Int. Arch. Allergy Immunol. , vol.121 , pp. 68-79
    • Wakisaka, S.1    Suzuki, N.2    Nagafuchi, H.3    Takeba, Y.4    Kaneko, A.5    Asai, T.6    Sakane, T.7
  • 63
    • 33645739379 scopus 로고    scopus 로고
    • IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes
    • Ryu S., Lee J., and Kim S. IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes. Clin. Rheumatol. 25 (2006) 16-20
    • (2006) Clin. Rheumatol. , vol.25 , pp. 16-20
    • Ryu, S.1    Lee, J.2    Kim, S.3
  • 64
    • 33646495723 scopus 로고    scopus 로고
    • Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts
    • Honorati M.C., Neri S., Cattini L., and Facchini A. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts. Osteoarthritis Cartilage 14 (2006) 345-352
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 345-352
    • Honorati, M.C.1    Neri, S.2    Cattini, L.3    Facchini, A.4
  • 68
    • 58149314577 scopus 로고    scopus 로고
    • IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa
    • Priebe G.P., Walsh R.L., Cederroth T.A., Kamei A., Coutinho-Sledge Y.S., Goldberg J.B., and Pier G.B. IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa. J. Immunol. 181 (2008) 4965-4975
    • (2008) J. Immunol. , vol.181 , pp. 4965-4975
    • Priebe, G.P.1    Walsh, R.L.2    Cederroth, T.A.3    Kamei, A.4    Coutinho-Sledge, Y.S.5    Goldberg, J.B.6    Pier, G.B.7
  • 69
    • 33646469851 scopus 로고    scopus 로고
    • IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation
    • Tan W., Huang W., Zhong Q., and Schwarzenberger P. IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J. Immunol. 176 (2006) 6186-6193
    • (2006) J. Immunol. , vol.176 , pp. 6186-6193
    • Tan, W.1    Huang, W.2    Zhong, Q.3    Schwarzenberger, P.4
  • 70
    • 0036232876 scopus 로고    scopus 로고
    • Expression, modulation and signaling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis
    • Kehlen A., Thiele K., Riemann D., and Langer J. Expression, modulation and signaling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Clin. Exp. Immunol. 127 (2002) 539-546
    • (2002) Clin. Exp. Immunol. , vol.127 , pp. 539-546
    • Kehlen, A.1    Thiele, K.2    Riemann, D.3    Langer, J.4
  • 74
    • 2342468719 scopus 로고    scopus 로고
    • Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
    • Numasaki M., Lotze M.T., and Sasaki H. Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Immunol. Lett. 93 (2004) 39-43
    • (2004) Immunol. Lett. , vol.93 , pp. 39-43
    • Numasaki, M.1    Lotze, M.T.2    Sasaki, H.3
  • 76
    • 0033496599 scopus 로고    scopus 로고
    • Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Harada S., Yamamura M., Okamoto H., Morita Y., Kawashima M., Aita T., and Makino H. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. 42 (1999) 1508-1516
    • (1999) Arthritis Rheum. , vol.42 , pp. 1508-1516
    • Harada, S.1    Yamamura, M.2    Okamoto, H.3    Morita, Y.4    Kawashima, M.5    Aita, T.6    Makino, H.7
  • 78
    • 3442875303 scopus 로고    scopus 로고
    • Pathogenesis of bone and cartilage destruction in rheumatoid arthritis
    • Goldring S. Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology 42 (2003)
    • (2003) Rheumatology , vol.42
    • Goldring, S.1
  • 79
    • 0035554955 scopus 로고    scopus 로고
    • Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo
    • Cai L., Yin J., Starovasnik M., Hogue D., Hillan K., Mort J., and Filvarorff E. Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. Cytokine 16 (2001) 10-21
    • (2001) Cytokine , vol.16 , pp. 10-21
    • Cai, L.1    Yin, J.2    Starovasnik, M.3    Hogue, D.4    Hillan, K.5    Mort, J.6    Filvarorff, E.7
  • 80
    • 0034044183 scopus 로고    scopus 로고
    • Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4
    • Lubberts E., Joosten L.A., van de Loo F.A., van den Gersselaar L.A., and van den Berg W.B. Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. Arthritis Rheum 43 (2000) 1300-1306
    • (2000) Arthritis Rheum , vol.43 , pp. 1300-1306
    • Lubberts, E.1    Joosten, L.A.2    van de Loo, F.A.3    van den Gersselaar, L.A.4    van den Berg, W.B.5
  • 82
    • 0031802932 scopus 로고    scopus 로고
    • Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines
    • Chabaud M., Fossiez F., Taupin J.-L., and Miossec P. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J. Immunol. 161 (1998) 409-414
    • (1998) J. Immunol. , vol.161 , pp. 409-414
    • Chabaud, M.1    Fossiez, F.2    Taupin, J.-L.3    Miossec, P.4
  • 83
    • 0031194918 scopus 로고    scopus 로고
    • Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis
    • Van de Loo F.A.J., Arntz O.J., and Van den Berg W.B. Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis. Cytokine 9 (1997) 453-462
    • (1997) Cytokine , vol.9 , pp. 453-462
    • Van de Loo, F.A.J.1    Arntz, O.J.2    Van den Berg, W.B.3
  • 84
    • 0036021158 scopus 로고    scopus 로고
    • Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown
    • Cai L., Suboc P., Hogue D.A., Fei D.T., and Filvaroff E.H. Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown. J. Rheumatol. 29 (2002) 1725-1736
    • (2002) J. Rheumatol. , vol.29 , pp. 1725-1736
    • Cai, L.1    Suboc, P.2    Hogue, D.A.3    Fei, D.T.4    Filvaroff, E.H.5
  • 86
    • 0035048597 scopus 로고    scopus 로고
    • IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
    • Chabaud M., Lubberts E., Joosten L., van den Berg W., and Miossec P. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res. 3 (2001) 168-177
    • (2001) Arthritis Res. , vol.3 , pp. 168-177
    • Chabaud, M.1    Lubberts, E.2    Joosten, L.3    van den Berg, W.4    Miossec, P.5
  • 87
    • 0032538551 scopus 로고    scopus 로고
    • Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NFkB
    • Shalom-Barak T., Quach J., and Lotz M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NFkB. J. Biol. Chem. 273 (1998) 27467-27473
    • (1998) J. Biol. Chem. , vol.273 , pp. 27467-27473
    • Shalom-Barak, T.1    Quach, J.2    Lotz, M.3
  • 89
    • 0346725002 scopus 로고    scopus 로고
    • Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes
    • Sylvester J., Liacini A., Li W.Q., and Zafarullah M. Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes. Cell. Signal. 16 (2004) 469-476
    • (2004) Cell. Signal. , vol.16 , pp. 469-476
    • Sylvester, J.1    Liacini, A.2    Li, W.Q.3    Zafarullah, M.4
  • 90
    • 0034041595 scopus 로고    scopus 로고
    • Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis
    • Jovanovic D.V., Martel-Pelletier J., Di B.J.A., Mineau F., Jolicoeur F.C., Benderdour M., and Pelletier J.-P. Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis. Arthritis Rheum. 43 (2000) 1134-1144
    • (2000) Arthritis Rheum. , vol.43 , pp. 1134-1144
    • Jovanovic, D.V.1    Martel-Pelletier, J.2    Di, B.J.A.3    Mineau, F.4    Jolicoeur, F.C.5    Benderdour, M.6    Pelletier, J.-P.7
  • 92
    • 0035997484 scopus 로고    scopus 로고
    • Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines
    • Koshy P.J., Henderson N., Logan C., Life P.F., Cawston T.E., and Rowan A.D. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann. Rheum. Dis. 61 (2002) 704-713
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. 704-713
    • Koshy, P.J.1    Henderson, N.2    Logan, C.3    Life, P.F.4    Cawston, T.E.5    Rowan, A.D.6
  • 93
    • 0033926254 scopus 로고    scopus 로고
    • Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis
    • Chabaud M., Garnero P., Dayer J.M., Guerne P.A., Fossiez F., and Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 12 (2000) 1092-1099
    • (2000) Cytokine , vol.12 , pp. 1092-1099
    • Chabaud, M.1    Garnero, P.2    Dayer, J.M.3    Guerne, P.A.4    Fossiez, F.5    Miossec, P.6
  • 96
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S., Sato K., Kim K.J., Takahashi N., Udagawa N., Nakamura I., Yamaguchi A., Kishimoto T., Suda T., and Kashiwazaki S. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J. Bone Miner. Res. 11 (1996) 88-95
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3    Takahashi, N.4    Udagawa, N.5    Nakamura, I.6    Yamaguchi, A.7    Kishimoto, T.8    Suda, T.9    Kashiwazaki, S.10
  • 97
    • 0036172368 scopus 로고    scopus 로고
    • Involvement of receptor activator of NFkB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis
    • Romas E., Gillespie M.T., and Martin T.J. Involvement of receptor activator of NFkB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. Bone 30 (2002) 340-346
    • (2002) Bone , vol.30 , pp. 340-346
    • Romas, E.1    Gillespie, M.T.2    Martin, T.J.3
  • 98
    • 36448931232 scopus 로고    scopus 로고
    • IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    • Yago T., Nanke Y., Kawamoto M., Furuya T., Kobashigawa T., Kamatani N., and Kotake S. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res. Ther. 9 (2007) R96
    • (2007) Arthritis Res. Ther. , vol.9
    • Yago, T.1    Nanke, Y.2    Kawamoto, M.3    Furuya, T.4    Kobashigawa, T.5    Kamatani, N.6    Kotake, S.7
  • 99
    • 54449101331 scopus 로고    scopus 로고
    • IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17
    • Hashizume M., Hayakawa N., and Mihara M. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. Rheumatology 47 (2008) 1635-1640
    • (2008) Rheumatology , vol.47 , pp. 1635-1640
    • Hashizume, M.1    Hayakawa, N.2    Mihara, M.3
  • 101
    • 0032546449 scopus 로고    scopus 로고
    • Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha, 25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone
    • Tsukii K., Shima N., Mochizuki S., Yamaguchi K., Kinosaki M., Yano K., Shibata O., Udagawa N., Yasuda H., Suda T., and Higashio K. Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha, 25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone. Biochem. Biophys. Res. Commun. 246 (1998) 337-341
    • (1998) Biochem. Biophys. Res. Commun. , vol.246 , pp. 337-341
    • Tsukii, K.1    Shima, N.2    Mochizuki, S.3    Yamaguchi, K.4    Kinosaki, M.5    Yano, K.6    Shibata, O.7    Udagawa, N.8    Yasuda, H.9    Suda, T.10    Higashio, K.11
  • 102
    • 0035033873 scopus 로고    scopus 로고
    • Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB (RANK)/RANK ligand signaling?
    • Van Bezooijen R.L., Papapoulos S.E., and Löwik C.W. Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB (RANK)/RANK ligand signaling?. Bone 28 (2001) 378-386
    • (2001) Bone , vol.28 , pp. 378-386
    • Van Bezooijen, R.L.1    Papapoulos, S.E.2    Löwik, C.W.3
  • 104
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    • Feldmann M., and Maini R.N. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?. Ann. Rev. Immunol. 19 (2001) 163-196
    • (2001) Ann. Rev. Immunol. , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 105
  • 107
    • 58149166804 scopus 로고    scopus 로고
    • Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    • Notley C.A., Inglis J.J., Alzabin S., McCann F.E., McNamee K.E., and Williams R.O. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J. Exp. Med. 205 (2008) 2491-2497
    • (2008) J. Exp. Med. , vol.205 , pp. 2491-2497
    • Notley, C.A.1    Inglis, J.J.2    Alzabin, S.3    McCann, F.E.4    McNamee, K.E.5    Williams, R.O.6
  • 108
    • 38449114897 scopus 로고    scopus 로고
    • A new orally active anti-rheumatic drug targets IL-15 and IL-17
    • Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi 30 (2007) 375-382
    • (2007) Nihon Rinsho Meneki Gakkai Kaishi , vol.30 , pp. 375-382
    • Chiba, K.1
  • 109
    • 53149137849 scopus 로고    scopus 로고
    • Retinoic acid increases Foxp3+ regulatory t cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
    • Xiao S., Jin H., Korn T., Liu S.M., Oukka M., Lim B., and Kuchroo K. Retinoic acid increases Foxp3+ regulatory t cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J. Immunol. 181 (2008) 2277-2284
    • (2008) J. Immunol. , vol.181 , pp. 2277-2284
    • Xiao, S.1    Jin, H.2    Korn, T.3    Liu, S.M.4    Oukka, M.5    Lim, B.6    Kuchroo, K.7
  • 110
    • 38949164425 scopus 로고    scopus 로고
    • Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
    • Elias K.M., Laurence A., Davidson T.S., Stephens G., Kanno Y., Shevach E.M., and O'Shea J.J. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111 (2008) 1013-1020
    • (2008) Blood , vol.111 , pp. 1013-1020
    • Elias, K.M.1    Laurence, A.2    Davidson, T.S.3    Stephens, G.4    Kanno, Y.5    Shevach, E.M.6    O'Shea, J.J.7
  • 113
    • 41949140776 scopus 로고    scopus 로고
    • Statin treatment for rheumatoid arthritis: a promising novel indication
    • Paraskevas K.I. Statin treatment for rheumatoid arthritis: a promising novel indication. Clin. Rheumatol. 27 (2008) 281-287
    • (2008) Clin. Rheumatol. , vol.27 , pp. 281-287
    • Paraskevas, K.I.1
  • 114
    • 32444440805 scopus 로고    scopus 로고
    • Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis
    • Nagashima T., Okazaki H., Yudoh K., Matsuno H., and Minota S. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. Arthritis Rheum. 54 (2006) 579-586
    • (2006) Arthritis Rheum. , vol.54 , pp. 579-586
    • Nagashima, T.1    Okazaki, H.2    Yudoh, K.3    Matsuno, H.4    Minota, S.5
  • 115
    • 39549106513 scopus 로고    scopus 로고
    • High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Yokota K., Miyoshi F., Miyazaki T., Sato K., Yoshida Y., Asanuma Y., Akiyama Y., and Mimura T. High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J. Rheumatol. 35 (2008) 193-200
    • (2008) J. Rheumatol. , vol.35 , pp. 193-200
    • Yokota, K.1    Miyoshi, F.2    Miyazaki, T.3    Sato, K.4    Yoshida, Y.5    Asanuma, Y.6    Akiyama, Y.7    Mimura, T.8
  • 116
    • 33644696725 scopus 로고    scopus 로고
    • Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • Yokota K., Miyazaki T., Hirano M., Akiyama Y., and Mimura T. Simvastatin inhibits production of interleukin 6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-alpha in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J. Rheumatol. 33 (2006) 463-471
    • (2006) J. Rheumatol. , vol.33 , pp. 463-471
    • Yokota, K.1    Miyazaki, T.2    Hirano, M.3    Akiyama, Y.4    Mimura, T.5
  • 118
    • 45549102525 scopus 로고    scopus 로고
    • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes
    • Zhang X., Jin J., Peng X., Ramgolam S., and Markovic-Plese S. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J. Immunol. 180 (2008) 6988-6996
    • (2008) J. Immunol. , vol.180 , pp. 6988-6996
    • Zhang, X.1    Jin, J.2    Peng, X.3    Ramgolam, S.4    Markovic-Plese, S.5
  • 119
    • 47249166438 scopus 로고    scopus 로고
    • Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    • Zheng S.G., Wang J., and Horwitz D.A. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 180 (2008) 7112-7116
    • (2008) J. Immunol. , vol.180 , pp. 7112-7116
    • Zheng, S.G.1    Wang, J.2    Horwitz, D.A.3
  • 121
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology
    • McGeachy M.J., Bak-Jensen K.S., Chen Y., Tato C.M., Blumenschein W., McClanahan T., and Cua D.J. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology. Nat. Immunol. 8 (2007) 1390-1397
    • (2007) Nat. Immunol. , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1    Bak-Jensen, K.S.2    Chen, Y.3    Tato, C.M.4    Blumenschein, W.5    McClanahan, T.6    Cua, D.J.7
  • 122
    • 46949086111 scopus 로고    scopus 로고
    • A rush to judgment on Th17
    • Steinman L. A rush to judgment on Th17. J. Exp. Med. 205 (2008) 1517-1522
    • (2008) J. Exp. Med. , vol.205 , pp. 1517-1522
    • Steinman, L.1


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