Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor α-independent mouse model

Annals of the Rheumatic Diseases

Volumn 68, Issue 5, 2009, Pages 721-728

  Plater Zyberk, C ^a   Joosten, L A B ^b   Helsen, M M A ^b   Koenders, M I ^b   Baeuerle, P A ^a   Van Den Berg, W B ^b  

^a MICROMET AG   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; BLD 400516; ETANERCEPT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 1 BETA MONOCLONAL ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; MM 425; MM 500CS; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 22E9; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; CXCL1 CHEMOKINE; CXCL1 PROTEIN, MOUSE; INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL WALL; C57BL 6 MOUSE; CARTILAGE INJURY; CHRONIC ARTHRITIS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG RESPONSE; INFLAMMATION; JOINT SWELLING; KNEE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STREPTOCOCCUS; WILD TYPE; ANIMAL; ARTHRITIS; ARTICULAR CARTILAGE; BIOSYNTHESIS; C57BL MOUSE; CHRONIC DISEASE; DRUG ANTAGONISM; IMMUNOLOGY; MOUSE MUTANT; PATHOLOGY; SIGNAL TRANSDUCTION; SYNOVIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CHEMOKINE CXCL1; CHRONIC DISEASE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-17; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-17; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 66149105578     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2007.085431     Document Type: Article

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