Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction

Journal of Experimental Medicine

Volumn 191, Issue 2, 2000, Pages 275-285

  Kobayashi, Kanichiro ^a   Takahashi, Naoyuki ^a   Jimi, Eijiro ^a   Udagawa, Nobuyuki ^a   Takami, Masamichi ^a   Kotake, Shigeru ^b   Nakagawa, Nobuaki ^c   Kinosaki, Masahiko ^c   Yamaguchi, Kyoji ^c   Shima, Nobuyuki ^c   Yasuda, Hisataka ^c   Morinaga, Tomonori ^c   Higashio, Kanji ^c   Martin, T John ^d   Suda, Tatsuo ^a  

^a SHOWA UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

^d ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Bone resorption; Interleukin 1; Macrophage colony stimulating factor; Nuclear factor B; Tumor necrosis factor receptor

Indexed keywords

ACID PHOSPHATASE; COLONY STIMULATING FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; BONE DISEASE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACID PHOSPHATASE; ANIMALS; ANTIGENS, CD; BONE MARROW CELLS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION; HUMANS; INTERLEUKIN-1; ISOENZYMES; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034677177     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.2.275     Document Type: Article

References (54)

1. Suda, T., N. Takahashi, and T.J. Martin. 1992. Modulation of osteoclast differentiation. Endocr. Rev. 13:66-80.
2. Chambers, T.J., P.A. Revell, K. Fuller, and N.A. Athanasou. 1984. Resorption of bone by isolated rabbit osteoclasts. J. Cell Sci. 66:383-399.
3. Takahashi, N., N. Udagawa, and T. Suda. 1999. A new member of TNF ligand family, ODF/OPGL/TRANCE/ RANKL, regulates osteoclast differentiation and function. Biochem. Biophys. Res. Commun. 256:449-455.
4. Suda, T., N. Takahashi, N. Udagawa, E. Jimi, M.T. Gillespie, and T.J. Martin. 1999. Modulation of osteoclast differentiation and function by the new members of the TNF receptor and ligand families. Endocr. Rev. 20:345-357.
5. Yasuda, H., N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki, S. Mochizuki, A. Tomoyasu, K. Yano, M. Goto, A. Murakami, et al. 1998. Osteoclast differentiation factor is a ligand tor osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA. 95:3597-3602.
6. Lacey, D.L., E. Timms, H.L. Tan, M.J. Kelley, C.R. Dunstan, T. Burgess, K. Elliott, A. Colombero, G. Elliott, S. Scully, et al. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165-176.
7. Wong, B.R., J. Rho, J. Arron, E. Robinson, J. Orlinick, M. Chao, S. Kalachikov, E. Cayani, F.S. Bartlett III, W.N. Frankel, et al. 1997. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272:25190-25194.
8. Anderson, D.M., E. Maraskovsky, W.L. Billingsley, W.C. Dougall, M.E. Tometsko, E.R. Roux, M.C. Teepe, R.F. DuBose, D. Cosman, and L. Galibert. 1997. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 390:175-179.
9. Jimi, E., S. Akiyama, T. Tsurukai, N. Okahashi, K. Kobayashi, N. Udagawa, T. Nishihara, N. Takahashi, and T. Suda. 1999. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J. Immunol. 163:434-442.
10. Nakagawa, N., M. Kinosaki, K. Yamaguchi, N. Shima, H. Yasuda, K. Yano, T. Morinaga, and K. Higashio. 1998. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem. Biophys. Res. Commun. 253:395-400.
11. Hsu, H., D.L. Lacey, C.R. Dunstan, I. Solovyev, A. Colombero, E. Timms, H.L. Tan, G. Elliott, M.J. Kelley, I. Sarosi, et al. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. USA. 96:3540-3545.
12. Kodama, H., M. Nose, S. Niida, and A. Yamasaki. 1991. Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. J. Exp. Med. 173:1291-1294.
13. Hattersley, G., J. Owens, A.M. Flanagan, and T.J. Chambers. 1991. Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitro. Biochem. Biophys. Res. Commun. 177:526-531.
14. Simonet, W.S., D.L. Lacey, C.R. Dunstan, M. Kelley, M.-S. Chang, R. Lüthy, H.Q. Nguyen, S. Wooden, L. Bennett, T. Boone, et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 89:309-319.
15. Tsuda, E., M. Goto, S. Mochizuki, K. Yano, F. Kobayashi, T. Morinaga, and K. Higashio. 1997. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem. Biophys. Res. Commun. 234:137-142.
16. Yasuda, H., N. Shima, N. Nakagawa, S.-I. Mochizuki, K. Yano, N. Fujise, Y. Sato, M. Goto, K. Yamaguchi, M. Kuriyama, et al. 1998. Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrioalogy. 139:1329-1337.
17. Tan, K.B., J. Harrop, M. Reddy, P. Young, J. Terrett, J. Emery, G. Moore, and A. Truneh. 1997. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. Gene (Amst.). 204:35-46.
18. Kwon, B.S., S. Wang, N. Udagawa, V. Haridas, Z.H. Lee, K.K. Kim, K.O. Oh, J. Greene, Y. Li, J. Su, et al. 1998. TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. FASEB J. 12:845-854.
19. Jimi, E., I. Nakamura, H. Amano, Y. Taguchi, T. Tsurukai, M. Tamura, N. Takahashi, and T. Suda. 1996. Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact. Endocrinology. 137:2187-2190.
20. Suda, T., I. Nakamura, E. Jimi, and N. Takahashi. 1997. Regulation of osteoclast function. J. Bone Miner. Res. 12: 869-879.
21. Jimi, E., I. Nakamura, L.T. Duong, T. Ikebe, N. Takahashi, G.A. Rodan, and T. Suda. 1999. Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp. Cell Res. 247:84-93.
22. Fuller, K., B. Wong, S. Fox, Y. Choi, and T.J. Chambers. 1998. TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts. J. Exp. Med. 188:997-1001.
23. Burgess, T.L., Y. Qian, S. Kaufman, B.D. Ring, G. Van, C. Capparelli, M. Kelley, H. Hsu, W.J. Boyle, C.R. Dunstan, et al. 1999. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J. Cell Biol. 145:527-538.
24. Merkel, K.D., J.M. Erdmann, K.P. McHugh, Y. Abu-Amer, F.P. Ross, and S.L. Teitelbaum. 1999. Tumor necrosis factor a mediates orthopedic implant osteolysis. Am. J. Pathol. 154: 203-210.
25. Pacifici, R., C. Brown, E. Puscheck, E. Friedrich, E. Slatopolsky, D. Maggio, R. McCracken, and L.V. Avioli. 1991. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc. Natl. Acad. Sci. USA. 88:5134-5138.
26. Assuma, R., T. Oates, D. Cochran, S. Amar, and D.T. Graves. 1998. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J. Immunol. 160:403-409.
27. Abu-Amer, Y., F.P. Ross, J. Edwards, and S.L. Teitelbaum. 1997. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its p55 receptor. J. Clin. Inivst. 100:1557-1565.
28. Pfeilschifter, J., C. Chenu, A. Bird, G.R. Mundy, and G.D. Roodman. 1989. Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast-like cells in vitro. J. Bone Miner. Res. 4:113-118.
29. Lewis, M., L.A. Tartaglia, A. Lee, G.L. Bennett, G.C. Rice, G.H. Wong, E.Y. Chen, and D.V. Goeddel. 1991. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA. 88:2830-2834.
30. Tartaglia, L.A., and D.V. Goeddel. 1992. Two TNF receptors. Immunol. Today. 13:151-153.
31. Smith, C.A., T. Farrah, and R.G. Goodwill. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell. 76:959-962.
32. Kruppa, G., B. Thoma, T. Machleidt, K. Wiegimnn, and M. Kronke. 1992. Inhibition of tumor necrosis factor (TNF)-mediated NF-κB activation by selective blockade of the human 55-kDa TNF receptor. J. Immunol. 148:3152-3157.
33. Baldwin, A.S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
34. Finco, T.S., and A.S. Baldwin. 1995. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity. 3:263-272.
35. Vernia, I.M., J.K. Stevenson, E.M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
36. Tartaglia, L.A., T.M. Ayres, G.H. Wong, and D.V. Goeddel. 1993. A novel domain within the 55 kd TNF receptor signals cell death. Cell. 74:845-853.
37. Tartaglia, L.A., M. Rothe, Y.F. Hu, and D.V. Goeddel. 1993. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell. 73:213-216.
38. 3, in osteoclast differentiation and function. Methods Enzymol. 282:223-235.
39. Jimi, E., I. Nakamura, T. Ikebe, S. Akiyama, N. Takahashi, and T. Suda. 1998. Activation of NF-κB is involved in the survival of osteoclasts promoted by interleukin-1. J. Biol. Chem. 273:8799-8805.
40. Kong, Y.Y., H. Yoshida, I. Sarosi, H.L. Tan, E. Timms, C. Capparelli, S. Morony, A.J. Oliveira-dos-Santos, G. Van, A. Tie, et al. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397:315-323.
41. Takeda, S., T. Yoshizawa, Y. Nagai, H. Yamato, S. Fukumoto, K. Sekine, S. Kato, T. Matsumoto, and T. Fujita. 1999. Stimulation of osteoclast formation by 1,25-dihydroxy-vitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice. Endocrinology. 140:1005-1008.
42. Sheehan, K.C., J.K. Pinckard, C.D. Arthur, L.P. Dehner, D.V. Goeddel, and R.D. Schreiber. 1995. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J. Exp. Med. 181:607-617.
43. Arch, R.H., R.W. Gedrich, and C.B. Thompson. 1998. Tumor necrosis factor receptor-associated factors (TKAFs) - a family of adapter proteins that regulates life and death. Genes Dev. 12:2821-2830.
44. Yeh. W.-C., A. Shahinian, D. Speiser, J. Kraunus, F. Billia, A. Wakeham, J.L. de la Pompa, D. Ferrick, B. Hum, N. Iscove, et al. 1997. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity. 7:715-725.
45. Wong, B.R., R. Josien, S.Y. Lee, M. Vologodskaia, R.M. Steinman, and Y. Choi. 1998. The TRAF family of signal transducers mediates NF-κB activation by the TRANCE receptor. J. Biol. Chem. 273:28355-28359.
46. Galibert, L., M.E. Tometsko, D.M. Anderson, D. Cosman, and W.C. Dougall. 1998. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator or NF-κB, a member of the TNFR superfamily. J. Biol. Chem. 273: 34120-34127.
47. Kim, H.H., D.E. Lee, J.N. Shin, Y.S. Lee, Y.M. Jeon, C.H. Chung, J. Ni, B.S. Kwon, and Z.H. Lee. 1999. Receptor activator of NF-κB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Lett. 443:297-302.
48. Darnay, B.G., J. Ni, P.A. Moore, and B.B. Aggarwal. 1999. Activation ot NF-κB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-κB-inducing kinase. Identification of a novel TRAF6 interaction motif. J. Biol. Chem. 274:7724-7731.
49. Lomaga, M.A., W.C. Yeh, I. Sarosi, G.S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, et al. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13:1015-10124.
50. Naito, A., S. Azuma, S. Tanaka, T. Miyazaki, S. Takaki, K. Takatsu, K. Nakao, K. Nakamura, M. Katsuki, T. Yamamoto, and J.I. Inoue. 1999. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells, 4:353-362.
51. Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D.V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Nature. 383:443-446.
52. 3. J. Bone Miner. Res. 14:1478-1485.
53. 2, or parathyroid hormone in the microenvironment of bone. Biochem. Biophys. Res. Commun. 1246:337-341.
54. Ammann, P., R. Rizzoli, J.P. Bonjour, S. Bourrin, J.M. Meyer, V. Vassalli, and I. Garcia. 1997. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J. Clin. Invest. 99:1699-1703.